UBQLN2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UBQLN2
Entrez Gene ID	29978
Full Name	ubiquilin 2
Synonyms	ALS15,CHAP1,DSK2,HRIHFB2157,N4BP4,PLIC2
General protein information	Preferred Names ubiquilin 2 Names ubiquilin-2 Nedd4 binding protein 4 protein linking IAP with cytoskeleton 2 ubiquitin-like product Chap1/Dsk2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp11.21
Summary	This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009].
Disorder MIM:	300264
Disorder Html:	Amyotrophic lateral sclerosis 15, with or without frontotemporal dementia, 300857 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_013444.3	NP_038472.2	ubiquilin-2

Pathways from BioSystems

Homologies

Homo sapiens (human)	UBQLN2	NP_038472.2
Rattus norvegicus (Norway rat)	Ubqln2	NP_001101721.1
Bos taurus (cattle)	UBQLN2	NP_001192611.1
Mus musculus (house mouse)	Ubqln2	NP_061268.2
Caenorhabditis elegans (roundworm)	ubql-1	NP_740883.1
Arabidopsis thaliana (thale cress)	AT2G17190	NP_565407.1
Oryza sativa (rice)	Os10g0542200	NP_001065193.1
	LOC707967	XP_001096401.2
Pan troglodytes (chimpanzee)	UBQLN2	XP_003317539.1
Canis lupus familiaris (dog)	UBQLN2	XP_549029.3
Arabidopsis thaliana (thale cress)	DSK2	NP_179311.1
Oryza sativa (rice)	Os03g0131300	NP_001048862.1

Gene Ontology
Bibliography

Related articles in PubMed

The MTM1-UBQLN2-HSP complex mediates degradation of misfolded intermediate filaments in skeletal muscle.
Gavriilidis C, Laredj L, Solinhac R, Messaddeq N, Viaud J, Laporte J, Sumara I, Hnia K
Nature cell biology(2018 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We analyzed mutations in the UBQLN2 gene in a Chinese cohort with sporadic ALS (sALS). A novel missense mutation was detected in one sALS patient. The p.M392V mutation substitutes a highly conserved residue, has not been reported in the population databases, and previously, at the same residue, a missense mutation p.M392I was detected in two Turkey ALS patients and was considered to be pathogenic.
Title: No Evidence for Pathogenic Role of UBQLN2 Mutations in Sporadic Amyotrophic Lateral Sclerosis in the Mainland Chinese Population.

Its mutation is a cause of amyotrophic lateral sclerosis in New Zealand.
Title: C9ORF72 and UBQLN2 mutations are causes of amyotrophic lateral sclerosis in New Zealand: a genetic and pathologic study using banked human brain tissue.

excess UBQLN2 is toxic rather than protective to neurons and that uncontrolled enhancement of UBQLN2 function is involved in UBQLN2 pathogenesis
Title: Increased Ubqln2 expression causes neuron death in transgenic rats.

The structures of proteasome substrate receptor complexes with the shuttle factors that deliver ubiquitinated proteins to proteasomes have been solved, namely human Rpn13 complexed with PLIC2 and Saccharomyces cerevisiae Rpn1 with Rad23.
Title: Structures of Rpn1 T1:Rad23 and hRpn13:hPLIC2 Reveal Distinct Binding Mechanisms between Substrate Receptors and Shuttle Factors of the Proteasome.

Ubiquilins are a family of chaperones for cytosolically exposed transmembrane domains and use ubiquitin to triage clients for degradation via coordinated intra- and intermolecular interactions.
Title: Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation.

The following UBQLN2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UBQLN2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu18192	NM_013444.3 Latest version!	Homo sapiens ubiquilin 2 (UBQLN2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UBQLN2 ( NM_013444.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_038472.2 Homo sapiens ubiquilin 2 (UBQLN2), mRNA.

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CloneID	OHu18192
Clone ID Related Accession (Same CDS sequence)	NM_013444.3
Accession Version	NM_013444.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1875bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	ubiquilin-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI602998.1, AF189009.1, BC069237.1 and AU310783.1. This sequence is a reference standard in the RefSeqGene project. On Oct 29, 2009 this sequence version replaced NM_013444.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGAGA ATGGCGAGAG CAGCGGCCCC CCGCGCCCCT CCCGCGGCCC TGCTGCGGCC 
CAAGGCTCGG CTGCTGCCCC GGCTGAGCCT AAAATCATCA AAGTCACGGT GAAGACTCCC 
AAAGAGAAAG AGGAGTTCGC GGTGCCCGAG AACAGCTCGG TTCAGCAGTT TAAGGAAGCG 
ATTTCGAAAC GCTTCAAATC CCAAACCGAT CAGCTAGTGC TGATTTTTGC CGGAAAAATC 
TTAAAAGATC AAGATACCTT GATCCAGCAT GGCATCCATG ATGGGCTGAC TGTTCACCTT 
GTCATCAAAA GCCAGAACCG ACCTCAGGGC CAGTCCACGC AGCCTAGCAA TGCCGCGGGA 
ACTAACACTA CCTCGGCGTC GACTCCCAGG AGTAACTCCA CACCTATTTC CACAAATAGC 
AACCCGTTTG GGTTGGGGAG CCTGGGAGGA CTTGCAGGCC TTAGCAGCCT GGGCTTGAGC 
TCGACCAACT TCTCTGAGCT CCAGAGCCAG ATGCAGCAGC AGCTTATGGC CAGCCCTGAG 
ATGATGATCC AAATAATGGA AAATCCCTTT GTTCAGAGCA TGCTTTCGAA TCCCGATCTG 
ATGAGGCAGC TCATTATGGC TAATCCACAG ATGCAGCAAT TGATTCAGAG AAACCCAGAA 
ATCAGTCACC TGCTCAACAA CCCAGACATA ATGAGGCAGA CACTCGAAAT TGCCAGGAAT 
CCAGCCATGA TGCAAGAGAT GATGAGAAAT CAAGACCTGG CTCTTAGCAA TCTAGAAAGC 
ATCCCAGGTG GCTATAATGC TTTACGGCGC ATGTACACTG ACATTCAAGA GCCGATGCTG 
AATGCCGCAC AAGAGCAGTT TGGGGGTAAT CCATTTGCCT CCGTGGGGAG TAGTTCCTCC 
TCTGGGGAAG GTACGCAGCC TTCCCGCACA GAAAATCGCG ATCCACTACC CAATCCATGG 
GCACCACCGC CAGCTACCCA GAGTTCTGCA ACTACCAGCA CGACCACAAG CACTGGTAGT 
GGGTCTGGCA ATAGTTCCAG CAATGCTACT GGGAACACCG TTGCTGCCGC TAATTATGTC 
GCCAGCATCT TTAGTACCCC AGGCATGCAG AGCCTGCTGC AACAGATAAC TGAAAACCCC 
CAGCTGATTC AGAATATGCT GTCGGCGCCC TACATGAGAA GCATGATGCA GTCGCTGAGC 
CAGAATCCAG ATTTGGCTGC ACAGATGATG CTGAATAGCC CGCTGTTTAC TGCAAATCCT 
CAGCTGCAGG AGCAGATGCG GCCACAGCTC CCAGCCTTCC TGCAGCAGAT GCAGAATCCA 
GACACACTAT CAGCCATGTC AAACCCAAGA GCAATGCAGG CTTTAATGCA GATCCAGCAG 
GGGCTACAGA CATTAGCCAC TGAAGCACCT GGCCTGATTC CGAGCTTCAC TCCAGGTGTG 
GGGGTGGGGG TGCTGGGAAC CGCTATAGGC CCTGTAGGCC CAGTCACCCC CATAGGCCCC 
ATAGGCCCTA TAGTCCCTTT TACCCCCATA GGCCCCATTG GGCCCATAGG ACCCACTGGC 
CCTGCAGCCC CCCCTGGCTC CACCGGCTCT GGTGGCCCCA CGGGGCCTAC TGTGTCCAGC 
GCTGCACCTA GTGAAACCAC GAGTCCTACA TCAGAATCTG GACCCAACCA GCAGTTCATT 
CAGCAAATGG TGCAGGCCCT GGCTGGAGCA AATGCTCCAC AGCTGCCGAA TCCAGAAGTC 
AGATTTCAGC AACAACTGGA ACAGCTCAAC GCAATGGGGT TCTTAAACCG TGAAGCAAAC 
TTGCAGGCCC TAATAGCAAC AGGAGGCGAC ATCAATGCAG CCATTGAAAG GCTGCTGGGC 
TCCCAGCCAT CGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038472.2
CDS	282..2156
Translation	MAENGESSGPPRPSRGPAAAQGSAAAPAEPKIIKVTVKTPKEKEEFAVPENSSVQQFKEAISKRFKSQTDQLVLIFAGKILKDQDTLIQHGIHDGLTVHLVIKSQNRPQGQSTQPSNAAGTNTTSASTPRSNSTPISTNSNPFGLGSLGGLAGLSSLGLSSTNFSELQSQMQQQLMASPEMMIQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHLLNNPDIMRQTLEIARNPAMMQEMMRNQDLALSNLESIPGGYNALRRMYTDIQEPMLNAAQEQFGGNPFASVGSSSSSGEGTQPSRTENRDPLPNPWAPPPATQSSATTSTTTSTGSGSGNSSSNATGNTVAAANYVASIFSTPGMQSLLQQITENPQLIQNMLSAPYMRSMMQSLSQNPDLAAQMMLNSPLFTANPQLQEQMRPQLPAFLQQMQNPDTLSAMSNPRAMQALMQIQQGLQTLATEAPGLIPSFTPGVGVGVLGTAIGPVGPVTPIGPIGPIVPFTPIGPIGPIGPTGPAAPPGSTGSGGPTGPTVSSAAPSETTSPTSESGPNQQFIQQMVQALAGANAPQLPNPEVRFQQQLEQLNAMGFLNREANLQALIATGGDINAAIERLLGSQPS

Target ORF information:

RefSeq Version	NM_013444.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquilin 2 (UBQLN2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013444.3

ORF Insert Sequence:

ATGGCTGAGA ATGGCGAGAG CAGCGGCCCC CCGCGCCCCT CCCGCGGCCC TGCTGCGGCC 
CAAGGCTCGG CTGCTGCCCC GGCTGAGCCT AAAATCATCA AAGTCACGGT GAAGACTCCC 
AAAGAGAAAG AGGAGTTCGC GGTGCCCGAG AACAGCTCGG TTCAGCAGTT TAAGGAAGCG 
ATTTCGAAAC GCTTCAAATC CCAAACCGAT CAGCTAGTGC TGATTTTTGC CGGAAAAATC 
TTAAAAGATC AAGATACCTT GATCCAGCAT GGCATCCATG ATGGGCTGAC TGTTCACCTT 
GTCATCAAAA GCCAGAACCG ACCTCAGGGC CAGTCCACGC AGCCTAGCAA TGCCGCGGGA 
ACTAACACTA CCTCGGCGTC GACTCCCAGG AGTAACTCCA CACCTATTTC CACAAATAGC 
AACCCGTTTG GGTTGGGGAG CCTGGGAGGA CTTGCAGGCC TTAGCAGCCT GGGCTTGAGC 
TCGACCAACT TCTCTGAGCT CCAGAGCCAG ATGCAGCAGC AGCTTATGGC CAGCCCTGAG 
ATGATGATCC AAATAATGGA AAATCCCTTT GTTCAGAGCA TGCTTTCGAA TCCCGATCTG 
ATGAGGCAGC TCATTATGGC TAATCCACAG ATGCAGCAAT TGATTCAGAG AAACCCAGAA 
ATCAGTCACC TGCTCAACAA CCCAGACATA ATGAGGCAGA CACTCGAAAT TGCCAGGAAT 
CCAGCCATGA TGCAAGAGAT GATGAGAAAT CAAGACCTGG CTCTTAGCAA TCTAGAAAGC 
ATCCCAGGTG GCTATAATGC TTTACGGCGC ATGTACACTG ACATTCAAGA GCCGATGCTG 
AATGCCGCAC AAGAGCAGTT TGGGGGTAAT CCATTTGCCT CCGTGGGGAG TAGTTCCTCC 
TCTGGGGAAG GTACGCAGCC TTCCCGCACA GAAAATCGCG ATCCACTACC CAATCCATGG 
GCACCACCGC CAGCTACCCA GAGTTCTGCA ACTACCAGCA CGACCACAAG CACTGGTAGT 
GGGTCTGGCA ATAGTTCCAG CAATGCTACT GGGAACACCG TTGCTGCCGC TAATTATGTC 
GCCAGCATCT TTAGTACCCC AGGCATGCAG AGCCTGCTGC AACAGATAAC TGAAAACCCC 
CAGCTGATTC AGAATATGCT GTCGGCGCCC TACATGAGAA GCATGATGCA GTCGCTGAGC 
CAGAATCCAG ATTTGGCTGC ACAGATGATG CTGAATAGCC CGCTGTTTAC TGCAAATCCT 
CAGCTGCAGG AGCAGATGCG GCCACAGCTC CCAGCCTTCC TGCAGCAGAT GCAGAATCCA 
GACACACTAT CAGCCATGTC AAACCCAAGA GCAATGCAGG CTTTAATGCA GATCCAGCAG 
GGGCTACAGA CATTAGCCAC TGAAGCACCT GGCCTGATTC CGAGCTTCAC TCCAGGTGTG 
GGGGTGGGGG TGCTGGGAAC CGCTATAGGC CCTGTAGGCC CAGTCACCCC CATAGGCCCC 
ATAGGCCCTA TAGTCCCTTT TACCCCCATA GGCCCCATTG GGCCCATAGG ACCCACTGGC 
CCTGCAGCCC CCCCTGGCTC CACCGGCTCT GGTGGCCCCA CGGGGCCTAC TGTGTCCAGC 
GCTGCACCTA GTGAAACCAC GAGTCCTACA TCAGAATCTG GACCCAACCA GCAGTTCATT 
CAGCAAATGG TGCAGGCCCT GGCTGGAGCA AATGCTCCAC AGCTGCCGAA TCCAGAAGTC 
AGATTTCAGC AACAACTGGA ACAGCTCAAC GCAATGGGGT TCTTAAACCG TGAAGCAAAC 
TTGCAGGCCC TAATAGCAAC AGGAGGCGAC ATCAATGCAG CCATTGAAAG GCTGCTGGGC 
TCCCAGCCAT CGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The MTM1-UBQLN2-HSP complex mediates degradation of misfolded intermediate filaments in skeletal muscle.
Nature cell biology(2018 Jan)
Gavriilidis C,Laredj L,Solinhac R,Messaddeq N,Viaud J,Laporte J,Sumara I,Hnia K

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UBQLN2 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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