Qrfpr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Qrfpr
Entrez Gene ID	310327
Full Name	pyroglutamylated RFamide peptide receptor
Synonyms	AQ27,Gpr103
General protein information	Preferred Names pyroglutamylated RFamide peptide receptor Names pyroglutamylated RFamide peptide receptor G-protein coupled receptor 103 QRFP receptor SP9155 orexigenic neuropeptide QRFP receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q25
Summary	orphan G protein-coupled receptor; has a role in regulating adrenal function [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_198199.1	NP_937842.1	pyroglutamylated RF-amide peptide receptor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	QRFPR	NP_001179610.1
Xenopus tropicalis (tropical clawed frog)	qrfpr	NP_001072295.1
Canis lupus familiaris (dog)	QRFPR	XP_540966.3
Rattus norvegicus (Norway rat)	Qrfpr	NP_937842.1
Gallus gallus (chicken)	QRFPR	NP_001120642.1
Homo sapiens (human)	QRFPR	NP_937822.2
Pan troglodytes (chimpanzee)	QRFPR	XP_001143462.1
Mus musculus (house mouse)	Qrfpr	NP_937835.1
Danio rerio (zebrafish)	LOC100149491	XP_001920042.3

Gene Ontology
Bibliography

Related articles in PubMed

QRFP-26 enhances insulin's effects on glucose uptake in rat skeletal muscle cells.
Allerton TD, Primeaux SD
Peptides6977-9(2015 Jul)

Expression profile of neurotransmitter receptor and regulatory genes in the prefrontal cortex of spontaneously hypertensive rats: relevance to neuropsychiatric disorders.
Santoro ML, Santos CM, Ota VK, Gadelha A, Stilhano RS, Diana MC, Silva PN, Sp?ndola LM, Melaragno MI, Bressan RA, Han SW, Ab?lio VC, Belangero SI
Psychiatry research219(3)674-9(2014 Nov)

Neuropeptide Y family receptors traffic via the Bardet-Biedl syndrome pathway to signal in neuronal primary cilia.
Loktev AV, Jackson PK
Cell reports5(5)1316-29(2013 Dec)

Distribution of 26RFa binding sites and GPR103 mRNA in the central nervous system of the rat.
Bruzzone F, Lectez B, Alexandre D, J?gou S, Mounien L, Tollemer H, Chatenet D, Leprince J, Vallarino M, Vaudry H, Chartrel N
The Journal of comparative neurology503(4)573-91(2007 Aug)

Effect of central administration of QRFP(26) peptide on energy balance and characterization of a second QRFP receptor in rat.
Kampe J, Wiedmer P, Pfluger PT, Castaneda TR, Burget L, Mondala H, Kerr J, Liaw C, Oldfield BJ, Tsch?p MH, Bagnol D
Brain research1119(1)133-49(2006 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

prepro-QRFP mRNA and GPR103a mRNA are expressed in L6 cells, though GPR103b mRNA was not detected. Using complementary assays, co-incubation with QRFP-26, increased insulin's ability to induce glycogen synthesis and 2-deoxyglucose uptake in L6 cells
Title: QRFP-26 enhances insulin's effects on glucose uptake in rat skeletal muscle cells.

Four genes were significantly downregulated in the PFC [prefrontal cortex ]of SHR[spontaneously hypertensive rat ] compared to Wistar rats (Gad2, Chrnb4, Slc5a7, and Qrfpr) and none in nucleus accumbens.
Title: Expression profile of neurotransmitter receptor and regulatory genes in the prefrontal cortex of spontaneously hypertensive rats: relevance to neuropsychiatric disorders.

the expression of GPR103 mRNA was more discrete, notably in the midbrain, the pons, and the medulla oblongata.
Title: Distribution of 26RFa binding sites and GPR103 mRNA in the central nervous system of the rat.

We found an additional receptor with high homology for GPR103 in rat. This receptor increases inositol triphosphate production in transfected cells in presence of QRFP(26) and its mRNA was particularly enriched in the brain.(GPR103 protein, rat)
Title: Effect of central administration of QRFP(26) peptide on energy balance and characterization of a second QRFP receptor in rat.

QRFP and GPR103A/B may regulate diverse neuroendocrine and behavioral functions and implicate this neuropeptide system in metabolic syndrome
Title: A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.

The following Qrfpr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Qrfpr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04776	NM_198199.1 Latest version!	Rattus norvegicus pyroglutamylated RFamide peptide receptor (Qrfpr), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Qrfpr ( NM_198199.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_937842.1 Rattus norvegicus pyroglutamylated RFamide peptide receptor (Qrfpr), mRNA.

Price & Availability↑

CloneID	ORa04776
Clone ID Related Accession (Same CDS sequence)	NM_198199.1
Accession Version	NM_198199.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1302bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Rattus norvegicus(Norway rat)
Product	pyroglutamylated RF-amide peptide receptor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB109630.1. On Dec 17, 2003 this sequence version replaced XM_227067.2. ##Evidence-Data-START## Transcript exon combination :: AB109630.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCAGGCGC TCAACATCAC CGCGGAGCAG TTCTCCCGGC TGCTGAGCGC GCACAACCTG 
ACTCGGGAGC AGTTCATTCA TCGCTATGGG CTGAGACCGC TGGTCTACAC TCCGGAGCTG 
CCCGCGCGTG CTAAAGTGGC CTTTGCGCTG GCAGGAGCAC TCATTTTTGC CCTGGCGCTC 
TTCGGCAACT CTCTGGTCAT CTATGTGGTG ACCCGCAGCA AGGCCATGCG CACCGTCACC 
AACATCTTCA TCTGCTCTCT GGCACTCAGT GATCTGCTCA TTGCCTTCTT CTGCATCCCC 
GTCACGATGC TCCAGAACAT CTCCGACAAG TGGCTGGGTG GTGCCTTCAT CTGCAAGATG 
GTACCCTTTG TCCAGTCCAC GGCCGTCGTG ACAGAAATCC TCACCATGAC CTGCATCGCT 
GTTGAGAGGC ACCAAGGACT TGTCCATCCT TTTAAAATGA AGTGGCAGTA CACCACCCGA 
AGGGCCTTCA CGATCTTGGG CGTGGTCTGG TTGGCGGCCA TCATCGTAGG ATCACCCATG 
TGGCACGTGC AACGCCTTGA GATTAAGTAT GACTTCCTCT ATGAAAAAGA ACACATCTGC 
TGCTTGGAAG AATGGGCCAG CCCCGTGCAC CAGAGAATCT ACAGCACCTT CATTCTCGTC 
ATCCTCTTCC TCCTGCCTCT TGTGGTAATG CTAGTCCTCT ATAGCAAGAT TGGCTATGAA 
CTGTGGATCA AGAAGAGAGT GGGAGACAGT TCAGCGCTTC AAACTATCCA CGGGAAAGAA 
ATGTCCAAAA TAGCCAGGAA GAAGAAGCGG GCTGTCATTA TGATGGTGAC TGTGGTGGCT 
CTCTTTGCTG CATGCTGGGC ACCTTTCCAC GTTGTTCACA TGATGGTTGA GTACAGTAAT 
TTTGAAAAAG AATATGATGA TGTCACAATC AAGATGGTCT TTGCTGTCGC GCAGACAATT 
GGCTTTTTCA ACTCCATCTG TAATCCCTTT GTGTATGCGT TTATGAATGA AAACTTCAAA 
AAGAATTTTC TGTCTGCTGT TTGTTATTGC ATAGTGAAAG AATCCTCCTC CCCAGCACGG 
AAGCCTGGGA ATTCTGGAAT ATCAATGATG CAGAAGAGAG CAAAGTTATC TCGACCACAG 
CGTCCAGTGG AAGAAACCAA AGGAGACACA TTCAGTGATG CCAGCATTGA TGTCAAATTG 
TGCGAGCAGC CGCGGGAGAA AAGACAACTC AAGAGACAGC TAGCCTTCTT CAGTTCTGAA 
CTTTCTGAAA ACTCTACTTT TGGTAGTGGC CATGAACTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_937842.1
CDS	1..1302
Translation	MQALNITAEQFSRLLSAHNLTREQFIHRYGLRPLVYTPELPARAKVAFALAGALIFALALFGNSLVIYVVTRSKAMRTVTNIFICSLALSDLLIAFFCIPVTMLQNISDKWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTTRRAFTILGVVWLAAIIVGSPMWHVQRLEIKYDFLYEKEHICCLEEWASPVHQRIYSTFILVILFLLPLVVMLVLYSKIGYELWIKKRVGDSSALQTIHGKEMSKIARKKKRAVIMMVTVVALFAACWAPFHVVHMMVEYSNFEKEYDDVTIKMVFAVAQTIGFFNSICNPFVYAFMNENFKKNFLSAVCYCIVKESSSPARKPGNSGISMMQKRAKLSRPQRPVEETKGDTFSDASIDVKLCEQPREKRQLKRQLAFFSSELSENSTFGSGHEL

Target ORF information:

RefSeq Version	NM_198199.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus pyroglutamylated RFamide peptide receptor (Qrfpr), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198199.1

ORF Insert Sequence:

ATGCAGGCGC TCAACATCAC CGCGGAGCAG TTCTCCCGGC TGCTGAGCGC GCACAACCTG 
ACTCGGGAGC AGTTCATTCA TCGCTATGGG CTGAGACCGC TGGTCTACAC TCCGGAGCTG 
CCCGCGCGTG CTAAAGTGGC CTTTGCGCTG GCAGGAGCAC TCATTTTTGC CCTGGCGCTC 
TTCGGCAACT CTCTGGTCAT CTATGTGGTG ACCCGCAGCA AGGCCATGCG CACCGTCACC 
AACATCTTCA TCTGCTCTCT GGCACTCAGT GATCTGCTCA TTGCCTTCTT CTGCATCCCC 
GTCACGATGC TCCAGAACAT CTCCGACAAG TGGCTGGGTG GTGCCTTCAT CTGCAAGATG 
GTACCCTTTG TCCAGTCCAC GGCCGTCGTG ACAGAAATCC TCACCATGAC CTGCATCGCT 
GTTGAGAGGC ACCAAGGACT TGTCCATCCT TTTAAAATGA AGTGGCAGTA CACCACCCGA 
AGGGCCTTCA CGATCTTGGG CGTGGTCTGG TTGGCGGCCA TCATCGTAGG ATCACCCATG 
TGGCACGTGC AACGCCTTGA GATTAAGTAT GACTTCCTCT ATGAAAAAGA ACACATCTGC 
TGCTTGGAAG AATGGGCCAG CCCCGTGCAC CAGAGAATCT ACAGCACCTT CATTCTCGTC 
ATCCTCTTCC TCCTGCCTCT TGTGGTAATG CTAGTCCTCT ATAGCAAGAT TGGCTATGAA 
CTGTGGATCA AGAAGAGAGT GGGAGACAGT TCAGCGCTTC AAACTATCCA CGGGAAAGAA 
ATGTCCAAAA TAGCCAGGAA GAAGAAGCGG GCTGTCATTA TGATGGTGAC TGTGGTGGCT 
CTCTTTGCTG CATGCTGGGC ACCTTTCCAC GTTGTTCACA TGATGGTTGA GTACAGTAAT 
TTTGAAAAAG AATATGATGA TGTCACAATC AAGATGGTCT TTGCTGTCGC GCAGACAATT 
GGCTTTTTCA ACTCCATCTG TAATCCCTTT GTGTATGCGT TTATGAATGA AAACTTCAAA 
AAGAATTTTC TGTCTGCTGT TTGTTATTGC ATAGTGAAAG AATCCTCCTC CCCAGCACGG 
AAGCCTGGGA ATTCTGGAAT ATCAATGATG CAGAAGAGAG CAAAGTTATC TCGACCACAG 
CGTCCAGTGG AAGAAACCAA AGGAGACACA TTCAGTGATG CCAGCATTGA TGTCAAATTG 
TGCGAGCAGC CGCGGGAGAA AAGACAACTC AAGAGACAGC TAGCCTTCTT CAGTTCTGAA 
CTTTCTGAAA ACTCTACTTT TGGTAGTGGC CATGAACTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

QRFP-26 enhances insulin's effects on glucose uptake in rat skeletal muscle cells.
Peptides6977-9(2015 Jul)
Allerton TD,Primeaux SD

Expression profile of neurotransmitter receptor and regulatory genes in the prefrontal cortex of spontaneously hypertensive rats: relevance to neuropsychiatric disorders.
Psychiatry research219(3)674-9(2014 Nov)
Santoro ML,Santos CM,Ota VK,Gadelha A,Stilhano RS,Diana MC,Silva PN,Sp?ndola LM,Melaragno MI,Bressan RA,Han SW,Ab?lio VC,Belangero SI

Neuropeptide Y family receptors traffic via the Bardet-Biedl syndrome pathway to signal in neuronal primary cilia.
Cell reports5(5)1316-29(2013 Dec)
Loktev AV,Jackson PK

Distribution of 26RFa binding sites and GPR103 mRNA in the central nervous system of the rat.
The Journal of comparative neurology503(4)573-91(2007 Aug)
Bruzzone F,Lectez B,Alexandre D,J?gou S,Mounien L,Tollemer H,Chatenet D,Leprince J,Vallarino M,Vaudry H,Chartrel N

Effect of central administration of QRFP(26) peptide on energy balance and characterization of a second QRFP receptor in rat.
Brain research1119(1)133-49(2006 Nov)
Kampe J,Wiedmer P,Pfluger PT,Castaneda TR,Burget L,Mondala H,Kerr J,Liaw C,Oldfield BJ,Tsch?p MH,Bagnol D

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Qrfpr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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