Diaph1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Diaph1
Entrez Gene ID	307483
Full Name	diaphanous-related formin 1
Synonyms	Diap1
General protein information	Preferred Names diaphanous-related formin 1 Names protein diaphanous homolog 1 diaphanous homolog 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18p11

mRNA and Protein(s)

mRNA	Protein	Name
NM_001107393.2	NP_001100863.2	protein diaphanous homolog 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	DIAPH1	NP_001073280.1
	DIAPH1	XP_001089232.2
Rattus norvegicus (Norway rat)	Diaph1	NP_001100863.2
Mus musculus (house mouse)	Diap1	NP_031884.1
Pan troglodytes (chimpanzee)	DIAPH1	XP_003310971.1
Drosophila melanogaster (fruit fly)	dia	NP_001246113.1
Canis lupus familiaris (dog)	DIAPH1	XP_005617363.1
Xenopus tropicalis (tropical clawed frog)	diaph1	XP_002940036.2

Gene Ontology
Bibliography

Related articles in PubMed

Stabilization of dynamic microtubules by mDia1 drives Tau-dependent A?
Qu X, Yuan FN, Corona C, Pasini S, Pero ME, Gundersen GG, Shelanski ML, Bartolini F
The Journal of cell biology216(10)3161-3178(2017 Oct)

A gain-of-function variant in DIAPH1 causes dominant macrothrombocytopenia and hearing loss.
Stritt S, Nurden P, Turro E, Greene D, Jansen SB, Westbury SK, Petersen R, Astle WJ, Marlin S, Bariana TK, Kostadima M, Lentaigne C, Maiwald S, Papadia S, Kelly AM, Stephens JC, Penkett CJ, Ashford S, Tuna S, Austin S, Bakchoul T, Collins P, Favier R, Lambert MP, Mathias M, Millar CM, Mapeta R, Perry DJ, Schulman S, Simeoni I, Thys C, , Gomez K, Erber WN, Stirrups K, Rendon A, Bradley JR, van Geet C, Raymond FL, Laffan MA, Nurden AT, Nieswandt B, Richardson S, Freson K, Ouwehand WH, Mumford AD
Blood127(23)2903-14(2016 06)

Homozygous loss of DIAPH1 is a novel cause of microcephaly in humans.
Ercan-Sencicek AG, Jambi S, Franjic D, Nishimura S, Li M, El-Fishawy P, Morgan TM, Sanders SJ, Bilguvar K, Suri M, Johnson MH, Gupta AR, Yuksel Z, Mane S, Grigorenko E, Picciotto M, Alberts AS, Gunel M, ?estan N, State MW
European journal of human genetics : EJHG23(2)165-72(2015 Feb)

Nuclear actin network assembly by formins regulates the SRF coactivator MAL.
Baarlink C, Wang H, Grosse R
Science (New York, N.Y.)340(6134)864-7(2013 May)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these results uncover a novel role for mDia1 in Abeta-mediated synaptotoxicity and demonstrate that inhibition of MT dynamics and accumulation of PTMs are driving factors for the induction of tau-mediated neuronal damage.
Title: Stabilization of dynamic microtubules by mDia1 drives Tau-dependent A?

mDia plays an important role in the development of force-induced transcriptional activation of SMA and myofibroblast differentiation
Title: Force-induced myofibroblast differentiation through collagen receptors is dependent on mammalian diaphanous (mDia).

mDia1 and mDia2 are indeed involved in the regulation of Sertoli cell and germ structure during mammalian spermatogenesis
Title: Expression of the diaphanous-related formin proteins mDia1 and mDia2 in the rat testis.

These data show that coordinate regulation between the WASP family and mDia proteins controls the balance between lamellar and lamellipodial protrusion activity.
Title: WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells.

These results indicate that RhoA-dependent signaling through mDia1/2 and the MRTFs is important for SMC-specific gene expression in smooth muscle cells.
Title: Diaphanous 1 and 2 regulate smooth muscle cell differentiation by activating the myocardin-related transcription factors.

The following Diaph1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Diaph1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05318	NM_001107393.2 Latest version!	Rattus norvegicus diaphanous-related formin 1 (Diaph1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	Quote Price

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Diaph1 ( NM_001107393.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100863.2 Rattus norvegicus diaphanous-related formin 1 (Diaph1), mRNA.

Price & Availability↑

CloneID	ORa05318
Clone ID Related Accession (Same CDS sequence)	NM_001107393.2
Accession Version	NM_001107393.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3798bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Rattus norvegicus(Norway rat)
Product	protein diaphanous homolog 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07031738.1, AABR07031737.1 and AABR07031736.1. On Sep 6, 2012 this sequence version replaced NM_001107393.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGAGCCGT CCGGCGGGGG CCTAGGGCCC GGCCGCGGGA CCCGGGACAA GAAGAAGGGT 
CGGAGCCCGG ATGAGCTGCC TGCGACGGGC GGCGACGGCG GCAAACATAA GAAATTTACT 
TTGAAGCGGC TCATGGCAGA CGAGCTGGAG AGATTTACCA GCATGAGGAT TAAGAAGGAG 
AAGGAAAAGC CCAATTCTGC TCATAGAAAC TCCTCTGCAT CGTATGGAGA TGACCCCACT 
GCTCAGTCAC TGCAGGACAT CTCAGATGAT CAAGTTCTTG TCCTCTTTGA GCAGATGCTG 
GTGGATATGA ACCTGAATGA GGAGAAACAG CAGCCTTTGC GAGAGAAGGA CATTGTCATC 
AAGAGGGAGA TGGTGTCCCA GTATCTGCAT ACTTCCAAAG CTGGCATGAA CCAGAAGGAG 
AGTTCCAGGT CTGCCATGAT GTACATTCAG GAGCTGAGGT CAGGCTTGCG GGATATGCAC 
CTGCTTAGCT GCCTGGAGTC CCTTCGAGTC TCTCTCAACA ATAACCCTGT CAGTTGGGTG 
CAGACATTTG GTGCTGAGGG CCTAGCCTCC TTATTGGACA TCCTCAAACG ACTCCATGAT 
GAGAAAGAGG AGACTTCTGG AAACTACGAC AGCCGGAACC AGCATGAGAT TATCCGCTGT 
TTGAAAGCTT TCATGAACAA CAAGTTTGGA ATCAAAACCA TGTTGGAGAC GGAAGAAGGA 
ATCCTACTGC TGGTCAGAGC CATGGATCCT GCTGTTCCCA ATATGATGAT TGATGCAGCA 
AAGCTGCTGT CTGCCCTCTG TATCCTACCG CAGCCAGAGG ACATGAATGA ACGAGTTTTA 
GAGGCTATGA CAGAGAGAGC TGAAATGGAA GAGGTTGAAC GCTTCCAGCC ACTGCTGGAT 
GGGTTAAAAA GTGGGACGTC TATTGCACTC AAAGTGGGAT GCCTACAGCT GATCAATGCT 
CTCATCACTC CCGCTGAGGA ACTTGACTTC CGGGTTCACA TCCGAAGTGA GCTGATGCGC 
TTGGGACTGC ATCAAGTGTT GCAGGAGCTT CGAGAGATTG ACAATGATGA TATGCGAGTA 
CAGCTCAATG TGTTTGATGA ACAAGGGGAT GAAGATTTCT TCGATCTGAA GGGACGACTG 
GATGATATCC GCATGGAGAT GGATGACTTT GGTGAAGTTT TCCAGATTAT TTTAAACACA 
GTGAAAGATT CCAAGGCAGA ACCACACTTC CTGTCTATCT TGCAGCATCT CCTGTTGGTC 
CGAAATGATT ATGAAGCTAG GCCGCAGTAC TATAAATTGA TTGAAGAATG TGTTTCTCAG 
ATAGTTCTAC ACAAAAATGG AACTGATCCT GACTTCAAGT GCCGGCACCT GCAGATTGAT 
ATTGAGGGGT TGGTTGATCA AATGATTGAT AAAACGAAGG TGGAAAAATC TGAGGCCAAA 
GCTACAGAGC TGGAAAAAAA GTTGGACTCA GAATTAACAG CCCGGCATGA GTTACAAGTA 
GAAATGAAAA AGATGGAAAA TGACTTTGAG CAGAAACTTC AGGATCTTCA AGGAGAAAAG 
GATGCCTTGG ATTCTGAAAA GCAGCAGATC ACTACACAAA AACAAGACCT GGAAGCAGAG 
GTGTCCAAGC TGACAGGAGA GGTTGCCAAG CTGTCAAAAG AACTAGAAGA TGCCAAGAAG 
GAAATGGCTT CTCTCTCTGC TGTGGCTGTT GCACCTTCAG TTTCTAGTAG TGCTGCTGTT 
CCCCAAGCCC CTCCTCTGCC TGGCACTTCA GGCACTGTTA TTCCACCTCC CCCACCACCC 
CCTCTCCCTG GAGGTGCCGT CCCACCCCCT CCTCCTCCTC CTCTGCCTGC AGGTACTGGT 
ATCCCTCCAC CTCCTCCTTT ACCTGGAGGT GCTTGTATAT CCTCTTCCCC ACAGTTGTTT 
GGCAGTACTG CCATTCCCCC ACCTCCTCCT TTGCCTGGAG CTACTGCCAT CCCCCCACCT 
CCCCCTTTGC CTGGAGATAC TGCCATCCCC CCACCTCCCC CTTTGCCTGG AGNTACTGCC 
ATCCCCCCTC CTCCTCCTTT GCCTGGAGCT ACTGGTGTAC CACCACCTCC TCCCCCTTTA 
CCTGGAAGTG TTGGTGTTCC CCCACCCCCT CCCTTGCCTG GAGGACCAGG ACTGCCTCCT 
CCTCCTCCCC CCTTTCCTGG AGCACCTGGC ATTCCCCCCC CACCGCCTGG TATGGGCGTG 
CCTCCACCTC CCCCCTTTGG ATTTGGGATT CCTGCAGCCC CAGTTCTGCC ATTTGGATTA 
ACCCCCAAAA AAGTTTATAA GCCAGAGGTG CAACTCCGGA GGCCAAACTG GTCCAAGTTC 
GTGGCTGAGG ACCTTTCCCA GGACTGCTTC TGGACAAAGG TGAAGGAGGA CCGCTTTGAG 
AACAATGAAC TATTTGCCAA ACTTACCCTT GCCTTCTCTG CCCAGACCAA GACTTCTAAA 
GCCAAGAAGG ATCAAGAAGG TGGAGAAGAA AAGAAATCTG TTCAAAAGAA GAAAGTAAAA 
GAGCTGAAAG TGCTGGATTC AAAGACAGCC CAGAATCTCT CAATCTTTTT GGGTTCATTC 
CGTATGCCCT ATCAAGAGAT TAAGAACGTT ATCCTGGAGG TGAATGAGGC TGTTCTCACG 
GAGTCTATGA TCCAGAACCT CATTAAGCAG ATGCCAGAAC CAGAGCAGTT AAAAATGCTT 
TCTGAACTGA AGGAGGAGTA CGATGATCTG GCTGAGTCAG AGCAGTTCGG CGTGGTGATG 
GGCACGGTTC CCCGTCTTCG GCCTCGCCTC AATGCCATCC TTTTCAAGCT ACAGTTCAGT 
GAGCAAGTTG AGAATATCAA GCCAGAGATT GTATCTGTCA CTGCGGCATG TGAGGAGCTG 
CGTAAGAGTG AGAACTTCTC TAGCCTCCTG GAGCTCACAC TGCTCGTTGG AAACTATATG 
AATGCGGGCT CCAGGAATGC TGGAGCTTTT GGCTTCAATA TCAGCTTCCT TTGTAAGCTT 
CGAGACACCA AGTCTGCAGA TCAGAAGATG ACTCTGTTGC ATTTCTTGGC TGAGTTATGT 
GAGACTGACC ACCCCGATGT CCTCAAGTTT CCTGATGAGC TTGCCCATGT AGAGAAAGCC 
AGCAGAGTTT CTGCTGAGAA CTTGCAGAAG AATTTAGATC AGATGAAGAA ACAGATTGCT 
GATGTGGAAC GCGATGTTCA AAATTTCCCA GCTGCCACAG ACGAAAAAGA CAAGTTTGTT 
GAGAAGATGA CTAGCTTTGT GAAGGATGCA CAGGAACAGT ATAACAAGCT ACGGATGATG 
CACTCCAACA TGGAGACTCT CTATAAGGAG CTAGGCGACT ACTTCGTCTT TGACCCTAAG 
AAGTTGTCTG TAGAAGAATT TTTTATGGAT CTGCACAACT TTAGGAATAT GTTTTTGCAA 
GCAGTCAAGG AGAACCAGAA GCGCCGGGAA ACAGAAGAAA AGATGAGGAG AGCAAAACTA 
GCCAAGGAAA AGGCGGAAAA AGAGCGACTG GAGAAGCAGC AGAAGCGAGA GCAGCTCATA 
GACATGAATG CAGAGGGGGA TGAGACAGGT GTGATGGACA GTCTTCTAGA AGCTCTGCAG 
TCAGGAGCAG CATTCCGACG GAAGAGAGGG CCCCGGCAGG TCAACAGGAA AGCTGGGTGT 
GCAGTCACAT CTCTGCTAGC CTCGGAGCTG ACCAAGGATG ATGCCGTGGC TGCTAGTTCT 
GCTAAGGTGC CCAAGAAAAG TGAAGGAGTC ACCACAATCC TTGAAGAAGC CAAGGAACTG 
GTTGGCCGTG CAAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100863.2
CDS	69..3866
Translation	MEPSGGGLGPGRGTRDKKKGRSPDELPATGGDGGKHKKFTLKRLMADELERFTSMRIKKEKEKPNSAHRNSSASYGDDPTAQSLQDISDDQVLVLFEQMLVDMNLNEEKQQPLREKDIVIKREMVSQYLHTSKAGMNQKESSRSAMMYIQELRSGLRDMHLLSCLESLRVSLNNNPVSWVQTFGAEGLASLLDILKRLHDEKEETSGNYDSRNQHEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMEEVERFQPLLDGLKSGTSIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQELREIDNDDMRVQLNVFDEQGDEDFFDLKGRLDDIRMEMDDFGEVFQIILNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECVSQIVLHKNGTDPDFKCRHLQIDIEGLVDQMIDKTKVEKSEAKATELEKKLDSELTARHELQVEMKKMENDFEQKLQDLQGEKDALDSEKQQITTQKQDLEAEVSKLTGEVAKLSKELEDAKKEMASLSAVAVAPSVSSSAAVPQAPPLPGTSGTVIPPPPPPPLPGGAVPPPPPPPLPAGTGIPPPPPLPGGACISSSPQLFGSTAIPPPPPLPGATAIPPPPPLPGDTAIPPPPPLPGnullTAIPPPPPLPGATGVPPPPPPLPGSVGVPPPPPLPGGPGLPPPPPPFPGAPGIPPPPPGMGVPPPPPFGFGIPAAPVLPFGLTPKKVYKPEVQLRRPNWSKFVAEDLSQDCFWTKVKEDRFENNELFAKLTLAFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKEEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSENFSSLLELTLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSADQKMTLLHFLAELCETDHPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQIADVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGDYFVFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFRRKRGPRQVNRKAGCAVTSLLASELTKDDAVAASSAKVPKKSEGVTTILEEAKELVGRAS

Target ORF information:

RefSeq Version	NM_001107393.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus diaphanous-related formin 1 (Diaph1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107393.2

ORF Insert Sequence:

ATGGAGCCGT CCGGCGGGGG CCTAGGGCCC GGCCGCGGGA CCCGGGACAA GAAGAAGGGT 
CGGAGCCCGG ATGAGCTGCC TGCGACGGGC GGCGACGGCG GCAAACATAA GAAATTTACT 
TTGAAGCGGC TCATGGCAGA CGAGCTGGAG AGATTTACCA GCATGAGGAT TAAGAAGGAG 
AAGGAAAAGC CCAATTCTGC TCATAGAAAC TCCTCTGCAT CGTATGGAGA TGACCCCACT 
GCTCAGTCAC TGCAGGACAT CTCAGATGAT CAAGTTCTTG TCCTCTTTGA GCAGATGCTG 
GTGGATATGA ACCTGAATGA GGAGAAACAG CAGCCTTTGC GAGAGAAGGA CATTGTCATC 
AAGAGGGAGA TGGTGTCCCA GTATCTGCAT ACTTCCAAAG CTGGCATGAA CCAGAAGGAG 
AGTTCCAGGT CTGCCATGAT GTACATTCAG GAGCTGAGGT CAGGCTTGCG GGATATGCAC 
CTGCTTAGCT GCCTGGAGTC CCTTCGAGTC TCTCTCAACA ATAACCCTGT CAGTTGGGTG 
CAGACATTTG GTGCTGAGGG CCTAGCCTCC TTATTGGACA TCCTCAAACG ACTCCATGAT 
GAGAAAGAGG AGACTTCTGG AAACTACGAC AGCCGGAACC AGCATGAGAT TATCCGCTGT 
TTGAAAGCTT TCATGAACAA CAAGTTTGGA ATCAAAACCA TGTTGGAGAC GGAAGAAGGA 
ATCCTACTGC TGGTCAGAGC CATGGATCCT GCTGTTCCCA ATATGATGAT TGATGCAGCA 
AAGCTGCTGT CTGCCCTCTG TATCCTACCG CAGCCAGAGG ACATGAATGA ACGAGTTTTA 
GAGGCTATGA CAGAGAGAGC TGAAATGGAA GAGGTTGAAC GCTTCCAGCC ACTGCTGGAT 
GGGTTAAAAA GTGGGACGTC TATTGCACTC AAAGTGGGAT GCCTACAGCT GATCAATGCT 
CTCATCACTC CCGCTGAGGA ACTTGACTTC CGGGTTCACA TCCGAAGTGA GCTGATGCGC 
TTGGGACTGC ATCAAGTGTT GCAGGAGCTT CGAGAGATTG ACAATGATGA TATGCGAGTA 
CAGCTCAATG TGTTTGATGA ACAAGGGGAT GAAGATTTCT TCGATCTGAA GGGACGACTG 
GATGATATCC GCATGGAGAT GGATGACTTT GGTGAAGTTT TCCAGATTAT TTTAAACACA 
GTGAAAGATT CCAAGGCAGA ACCACACTTC CTGTCTATCT TGCAGCATCT CCTGTTGGTC 
CGAAATGATT ATGAAGCTAG GCCGCAGTAC TATAAATTGA TTGAAGAATG TGTTTCTCAG 
ATAGTTCTAC ACAAAAATGG AACTGATCCT GACTTCAAGT GCCGGCACCT GCAGATTGAT 
ATTGAGGGGT TGGTTGATCA AATGATTGAT AAAACGAAGG TGGAAAAATC TGAGGCCAAA 
GCTACAGAGC TGGAAAAAAA GTTGGACTCA GAATTAACAG CCCGGCATGA GTTACAAGTA 
GAAATGAAAA AGATGGAAAA TGACTTTGAG CAGAAACTTC AGGATCTTCA AGGAGAAAAG 
GATGCCTTGG ATTCTGAAAA GCAGCAGATC ACTACACAAA AACAAGACCT GGAAGCAGAG 
GTGTCCAAGC TGACAGGAGA GGTTGCCAAG CTGTCAAAAG AACTAGAAGA TGCCAAGAAG 
GAAATGGCTT CTCTCTCTGC TGTGGCTGTT GCACCTTCAG TTTCTAGTAG TGCTGCTGTT 
CCCCAAGCCC CTCCTCTGCC TGGCACTTCA GGCACTGTTA TTCCACCTCC CCCACCACCC 
CCTCTCCCTG GAGGTGCCGT CCCACCCCCT CCTCCTCCTC CTCTGCCTGC AGGTACTGGT 
ATCCCTCCAC CTCCTCCTTT ACCTGGAGGT GCTTGTATAT CCTCTTCCCC ACAGTTGTTT 
GGCAGTACTG CCATTCCCCC ACCTCCTCCT TTGCCTGGAG CTACTGCCAT CCCCCCACCT 
CCCCCTTTGC CTGGAGATAC TGCCATCCCC CCACCTCCCC CTTTGCCTGG AGNTACTGCC 
ATCCCCCCTC CTCCTCCTTT GCCTGGAGCT ACTGGTGTAC CACCACCTCC TCCCCCTTTA 
CCTGGAAGTG TTGGTGTTCC CCCACCCCCT CCCTTGCCTG GAGGACCAGG ACTGCCTCCT 
CCTCCTCCCC CCTTTCCTGG AGCACCTGGC ATTCCCCCCC CACCGCCTGG TATGGGCGTG 
CCTCCACCTC CCCCCTTTGG ATTTGGGATT CCTGCAGCCC CAGTTCTGCC ATTTGGATTA 
ACCCCCAAAA AAGTTTATAA GCCAGAGGTG CAACTCCGGA GGCCAAACTG GTCCAAGTTC 
GTGGCTGAGG ACCTTTCCCA GGACTGCTTC TGGACAAAGG TGAAGGAGGA CCGCTTTGAG 
AACAATGAAC TATTTGCCAA ACTTACCCTT GCCTTCTCTG CCCAGACCAA GACTTCTAAA 
GCCAAGAAGG ATCAAGAAGG TGGAGAAGAA AAGAAATCTG TTCAAAAGAA GAAAGTAAAA 
GAGCTGAAAG TGCTGGATTC AAAGACAGCC CAGAATCTCT CAATCTTTTT GGGTTCATTC 
CGTATGCCCT ATCAAGAGAT TAAGAACGTT ATCCTGGAGG TGAATGAGGC TGTTCTCACG 
GAGTCTATGA TCCAGAACCT CATTAAGCAG ATGCCAGAAC CAGAGCAGTT AAAAATGCTT 
TCTGAACTGA AGGAGGAGTA CGATGATCTG GCTGAGTCAG AGCAGTTCGG CGTGGTGATG 
GGCACGGTTC CCCGTCTTCG GCCTCGCCTC AATGCCATCC TTTTCAAGCT ACAGTTCAGT 
GAGCAAGTTG AGAATATCAA GCCAGAGATT GTATCTGTCA CTGCGGCATG TGAGGAGCTG 
CGTAAGAGTG AGAACTTCTC TAGCCTCCTG GAGCTCACAC TGCTCGTTGG AAACTATATG 
AATGCGGGCT CCAGGAATGC TGGAGCTTTT GGCTTCAATA TCAGCTTCCT TTGTAAGCTT 
CGAGACACCA AGTCTGCAGA TCAGAAGATG ACTCTGTTGC ATTTCTTGGC TGAGTTATGT 
GAGACTGACC ACCCCGATGT CCTCAAGTTT CCTGATGAGC TTGCCCATGT AGAGAAAGCC 
AGCAGAGTTT CTGCTGAGAA CTTGCAGAAG AATTTAGATC AGATGAAGAA ACAGATTGCT 
GATGTGGAAC GCGATGTTCA AAATTTCCCA GCTGCCACAG ACGAAAAAGA CAAGTTTGTT 
GAGAAGATGA CTAGCTTTGT GAAGGATGCA CAGGAACAGT ATAACAAGCT ACGGATGATG 
CACTCCAACA TGGAGACTCT CTATAAGGAG CTAGGCGACT ACTTCGTCTT TGACCCTAAG 
AAGTTGTCTG TAGAAGAATT TTTTATGGAT CTGCACAACT TTAGGAATAT GTTTTTGCAA 
GCAGTCAAGG AGAACCAGAA GCGCCGGGAA ACAGAAGAAA AGATGAGGAG AGCAAAACTA 
GCCAAGGAAA AGGCGGAAAA AGAGCGACTG GAGAAGCAGC AGAAGCGAGA GCAGCTCATA 
GACATGAATG CAGAGGGGGA TGAGACAGGT GTGATGGACA GTCTTCTAGA AGCTCTGCAG 
TCAGGAGCAG CATTCCGACG GAAGAGAGGG CCCCGGCAGG TCAACAGGAA AGCTGGGTGT 
GCAGTCACAT CTCTGCTAGC CTCGGAGCTG ACCAAGGATG ATGCCGTGGC TGCTAGTTCT 
GCTAAGGTGC CCAAGAAAAG TGAAGGAGTC ACCACAATCC TTGAAGAAGC CAAGGAACTG 
GTTGGCCGTG CAAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Stabilization of dynamic microtubules by mDia1 drives Tau-dependent A?
The Journal of cell biology216(10)3161-3178(2017 Oct)
Qu X,Yuan FN,Corona C,Pasini S,Pero ME,Gundersen GG,Shelanski ML,Bartolini F

A gain-of-function variant in DIAPH1 causes dominant macrothrombocytopenia and hearing loss.
Blood127(23)2903-14(2016 06)
Stritt S,Nurden P,Turro E,Greene D,Jansen SB,Westbury SK,Petersen R,Astle WJ,Marlin S,Bariana TK,Kostadima M,Lentaigne C,Maiwald S,Papadia S,Kelly AM,Stephens JC,Penkett CJ,Ashford S,Tuna S,Austin S,Bakchoul T,Collins P,Favier R,Lambert MP,Mathias M,Millar CM,Mapeta R,Perry DJ,Schulman S,Simeoni I,Thys C,,Gomez K,Erber WN,Stirrups K,Rendon A,Bradley JR,van Geet C,Raymond FL,Laffan MA,Nurden AT,Nieswandt B,Richardson S,Freson K,Ouwehand WH,Mumford AD

Homozygous loss of DIAPH1 is a novel cause of microcephaly in humans.
European journal of human genetics : EJHG23(2)165-72(2015 Feb)
Ercan-Sencicek AG,Jambi S,Franjic D,Nishimura S,Li M,El-Fishawy P,Morgan TM,Sanders SJ,Bilguvar K,Suri M,Johnson MH,Gupta AR,Yuksel Z,Mane S,Grigorenko E,Picciotto M,Alberts AS,Gunel M,?estan N,State MW

Nuclear actin network assembly by formins regulates the SRF coactivator MAL.
Science (New York, N.Y.)340(6134)864-7(2013 May)
Baarlink C,Wang H,Grosse R

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

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Diaph1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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