Nek4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nek4
Entrez Gene ID	306252
Full Name	NIMA-related kinase 4
General protein information	Preferred Names NIMA-related kinase 4 Names serine/threonine-protein kinase Nek4 NIMA (never in mitosis gene a)-related expressed kinase 4 NIMA (never in mitosis gene a)-related kinase 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16p16

mRNA and Protein(s)

mRNA	Protein	Name
NM_001013134.2	NP_001013152.2	serine/threonine-protein kinase Nek4
XM_008770996.2	XP_008769218.1	serine/threonine-protein kinase Nek4 isoform X1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	NEK4	XP_414252.2
Danio rerio (zebrafish)	nek4	NP_957306.1
Xenopus tropicalis (tropical clawed frog)	nek4	NP_001072768.1
Homo sapiens (human)	NEK4	NP_003148.2
Pan troglodytes (chimpanzee)	NEK4	XP_516519.4
Canis lupus familiaris (dog)	NEK4	XP_005632492.1
Bos taurus (cattle)	NEK4	NP_001095414.1
Mus musculus (house mouse)	Nek4	NP_035979.1
Rattus norvegicus (Norway rat)	Nek4	NP_001013152.2
	NEK4	XP_002802834.1

Gene Ontology
Bibliography

Related articles in PubMed

Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts.
Nguyen CL, Possemato R, Bauerlein EL, Xie A, Scully R, Hahn WC
Molecular and cellular biology32(19)3963-77(2012 Oct)

The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase.
Coene KL, Mans DA, Boldt K, Gloeckner CJ, van Reeuwijk J, Bolat E, Roosing S, Letteboer SJ, Peters TA, Cremers FP, Ueffing M, Roepman R
Human molecular genetics20(18)3592-605(2011 Sep)

Activity and substrate specificity of the murine STK2 Serine/Threonine kinase that is structurally related to the mitotic regulator protein NIMA of Aspergillus nidulans.
Hayashi K, Igarashi H, Ogawa M, Sakaguchi N
Biochemical and biophysical research communications264(2)449-56(1999 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Nek4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nek4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03497	NM_001013134.2 Latest version!	Rattus norvegicus NIMA-related kinase 4 (Nek4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
ORa46390	XM_008770996.2 Latest version!	Rattus norvegicus NIMA-related kinase 4 (Nek4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nek4 ( NM_001013134.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001013152.2 Rattus norvegicus NIMA-related kinase 4 (Nek4), mRNA.

Price & Availability↑

CloneID	ORa03497
Clone ID Related Accession (Same CDS sequence)	NM_001013134.2
Accession Version	NM_001013134.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2382bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	serine/threonine-protein kinase Nek4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474046.1. On or before Sep 11, 2008 this sequence version replaced XM_001060068.1, XM_001060008.1, XM_224610.4, NM_001013134.1. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCCCAAG CCGCATACTG TTACTTGCGG GTCGTGGGCA GGGGTAGTTA CGGGGAGGTG 
ACGCTCGTGA AGCATCGGCG GGACGGCAAG CAGTATGTCA TCAAAAAGCT GAACCTCCGG 
AATGCCTCCA GCCGGGAGCG TCGAGCGGCA GAGCAGGAGG CTCAGCTCCT GTCTCAGTTG 
AAGCACCCCA ACATTGTCAC CTACAAAGAG TCATGGGAGG GCGGAGACGG TCTGCTCTAC 
ATCGTCATGG GCTTCTGCGA AGGAGGCGAT CTGTACCGGA AGCTCAAGGA GCAGAAGGGG 
CAGCTTCTGC CTGAGAGTCA GGTGGTGGAG TGGTTTGTCC AGATCGCCAT GGCCTTGCAG 
TACTTACATG AGAAGCACAT CCTTCATCGA GATCTGAAAA CTCAGAATGT CTTCCTAACA 
AGAACAAACA TCATCAAAGT AGGTGACCTA GGCATTGCCC GAGTGTTGGA GAATCACAGT 
GACATGGCGA GCACCCTCAT TGGCACACCC TATTACATGA GTCCTGAGCT GTTCTCCAAC 
AAACCCTACA ACTATAAGTC GGATGTTTGG GCTTTGGGAT GCTGCGTGTA TGAAATGGCC 
ACCCTGAAGC ATGCTTTTAA TGCAAAAGAC ATGAATTCTT TAGTTTATCG GATTATTGAA 
GGAAAGTTGC CACCAATGCC AAAAGTTTAC AGTGCGGAGC TGGCAGAGCT GATAAGAACC 
ATGTTGAGCA GGAGACCTGA GGAGAGGCCC TCTGTGCGGA GCATCCTGCG GCAGCCCTAC 
ATAAAACACC ACATCTCCTT GTTCTTGGAG GCCACCAAGG CGAAAACTTC CAAAAATAAT 
GTTAAAAACT GTGACTCCAG AGCCAAACCC GTTGCTGCTG TAGTTTCCAG AAAGGAAGAA 
CCAAATCATG AAATGATTCC CTACCAGCCA CGCTCTTCTG AGGGCTCCGC TGTACATGCC 
ACGGGTGAAG ATAAATGTCT GTCCCAAGAA AAACCAGTGG ACATTGGTCC CTTGAAATCA 
CCTGCTAGTC TCGAAGGCCA CACTGGCAAA CAAGACATGA ACAGGACTGC AGAGTCGTGT 
GCCACAGTCA GTAGGATAAA TATCGATATC TTACCTGCAG AAAGGAGGGA CTCAGCAAAA 
GATGGCACAG TTGAGGAGGG CCGACCACAG CACGTGGATG CTTCTAATGA AGTAGACCGT 
CAATGCAGTA TTTCTCAAGA GAAGGAGAGG CTACAGGGCA ACAGCAAGTC TAGTGATCAG 
CCGGAAAATC TCCTTCCCAG ATGGTCCTCT GGTGGTGGTG ATGGGGAAGG GAATGAACTG 
GTGAAGCTGT TGTACTCCTC GGGTAAAGAC CAAAAGCCAC AGCAGGATCA AGTTACTAGC 
GGGTGTATTC TAGAAGATCA GGACAGCATC CACCCAAGAC TGCAGCCGCA CAGCTCTGTA 
TCTGAACCTT CTTTGTCCCG GCAGCGAAGG CAGAGAAAAA GGGAACAGAC GAACCACGGT 
CGGGCAAAGA GCCAGCTCCA AGAATCACCC CCTCGTCTTG TGCCTTCTCA CCCTGATACT 
GGGAAAGCAG ATATCATAAG TACACAGCAA AGTGATGGAA ACCAAAGTGG ACCTGTGGCT 
AGGTCTGTGA ATGGTTCAAG GTCTAGTTCG ACAGCGTCAT CAAAGGATCG GCCATTATCA 
GCCAGAGAGA GGAGACGACT AAAGCAGTCG CAGGAAGAGA TGCTCCCCTC AGGCCCTGCA 
GTTCAGAGAA CTCCAAGTTC AGTAGAGCCA GTGAAACCAC AGGAAGAAGA CCAACCCATC 
CCTGCCCAAC GATTCTCTTC TGACTGCAAC ATCACTCAGG TGAATCCCAC ACTCCTGAGG 
GAAAAGAAGA GACTGATCCA TGGACTGTCT GAGGATGAGT TAAGTTCTTC CACAAGCTCA 
ACTGATAAAT CAGATGGGGA TTCCAGGGAG GGGAAAAGTC ATACAAATGA AATGAGAGAC 
TTGGTGCAGC TGATGACTCA GACTCTGAGG CTGGAAGCTA AAGAGAGCTG TGAAGATCTT 
CATGTACCAA ACCCAGGGTC AGAGTTCAGA CTTCATCGCA AGTATCGAGA CACGCTGGTG 
CTCCACGGCA AGGCTGCGGA AGAGGGGGAG CCCCCCTGTG TGGAGTTACC TCCAGGTATC 
ACACCAGGTT CTGAAAAGAT CAGGAGAATA GTTGAAGTCT TAAGAGCTGA TGTGATCCAG 
GGCCTGGGGG TTCAGCTTTT AGAGCAGGTG TATGATCTTT TGGAGGAGGA AGATGAGTTG 
GAGAGAGAGG CACGATTACA GGAGCACATG GGAGACAAGT ATACAACTTA CAGTGTGAAA 
GCTCGCCAGT TGAAGTTTTT TGAAGAAAAT GTGAGTTTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001013152.2
CDS	139..2520
Translation	MPQAAYCYLRVVGRGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPESQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHSDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPKVYSAELAELIRTMLSRRPEERPSVRSILRQPYIKHHISLFLEATKAKTSKNNVKNCDSRAKPVAAVVSRKEEPNHEMIPYQPRSSEGSAVHATGEDKCLSQEKPVDIGPLKSPASLEGHTGKQDMNRTAESCATVSRINIDILPAERRDSAKDGTVEEGRPQHVDASNEVDRQCSISQEKERLQGNSKSSDQPENLLPRWSSGGGDGEGNELVKLLYSSGKDQKPQQDQVTSGCILEDQDSIHPRLQPHSSVSEPSLSRQRRQRKREQTNHGRAKSQLQESPPRLVPSHPDTGKADIISTQQSDGNQSGPVARSVNGSRSSSTASSKDRPLSARERRRLKQSQEEMLPSGPAVQRTPSSVEPVKPQEEDQPIPAQRFSSDCNITQVNPTLLREKKRLIHGLSEDELSSSTSSTDKSDGDSREGKSHTNEMRDLVQLMTQTLRLEAKESCEDLHVPNPGSEFRLHRKYRDTLVLHGKAAEEGEPPCVELPPGITPGSEKIRRIVEVLRADVIQGLGVQLLEQVYDLLEEEDELEREARLQEHMGDKYTTYSVKARQLKFFEENVSF

Target ORF information:

RefSeq Version	NM_001013134.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus NIMA-related kinase 4 (Nek4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013134.2

ORF Insert Sequence:

ATGCCCCAAG CCGCATACTG TTACTTGCGG GTCGTGGGCA GGGGTAGTTA CGGGGAGGTG 
ACGCTCGTGA AGCATCGGCG GGACGGCAAG CAGTATGTCA TCAAAAAGCT GAACCTCCGG 
AATGCCTCCA GCCGGGAGCG TCGAGCGGCA GAGCAGGAGG CTCAGCTCCT GTCTCAGTTG 
AAGCACCCCA ACATTGTCAC CTACAAAGAG TCATGGGAGG GCGGAGACGG TCTGCTCTAC 
ATCGTCATGG GCTTCTGCGA AGGAGGCGAT CTGTACCGGA AGCTCAAGGA GCAGAAGGGG 
CAGCTTCTGC CTGAGAGTCA GGTGGTGGAG TGGTTTGTCC AGATCGCCAT GGCCTTGCAG 
TACTTACATG AGAAGCACAT CCTTCATCGA GATCTGAAAA CTCAGAATGT CTTCCTAACA 
AGAACAAACA TCATCAAAGT AGGTGACCTA GGCATTGCCC GAGTGTTGGA GAATCACAGT 
GACATGGCGA GCACCCTCAT TGGCACACCC TATTACATGA GTCCTGAGCT GTTCTCCAAC 
AAACCCTACA ACTATAAGTC GGATGTTTGG GCTTTGGGAT GCTGCGTGTA TGAAATGGCC 
ACCCTGAAGC ATGCTTTTAA TGCAAAAGAC ATGAATTCTT TAGTTTATCG GATTATTGAA 
GGAAAGTTGC CACCAATGCC AAAAGTTTAC AGTGCGGAGC TGGCAGAGCT GATAAGAACC 
ATGTTGAGCA GGAGACCTGA GGAGAGGCCC TCTGTGCGGA GCATCCTGCG GCAGCCCTAC 
ATAAAACACC ACATCTCCTT GTTCTTGGAG GCCACCAAGG CGAAAACTTC CAAAAATAAT 
GTTAAAAACT GTGACTCCAG AGCCAAACCC GTTGCTGCTG TAGTTTCCAG AAAGGAAGAA 
CCAAATCATG AAATGATTCC CTACCAGCCA CGCTCTTCTG AGGGCTCCGC TGTACATGCC 
ACGGGTGAAG ATAAATGTCT GTCCCAAGAA AAACCAGTGG ACATTGGTCC CTTGAAATCA 
CCTGCTAGTC TCGAAGGCCA CACTGGCAAA CAAGACATGA ACAGGACTGC AGAGTCGTGT 
GCCACAGTCA GTAGGATAAA TATCGATATC TTACCTGCAG AAAGGAGGGA CTCAGCAAAA 
GATGGCACAG TTGAGGAGGG CCGACCACAG CACGTGGATG CTTCTAATGA AGTAGACCGT 
CAATGCAGTA TTTCTCAAGA GAAGGAGAGG CTACAGGGCA ACAGCAAGTC TAGTGATCAG 
CCGGAAAATC TCCTTCCCAG ATGGTCCTCT GGTGGTGGTG ATGGGGAAGG GAATGAACTG 
GTGAAGCTGT TGTACTCCTC GGGTAAAGAC CAAAAGCCAC AGCAGGATCA AGTTACTAGC 
GGGTGTATTC TAGAAGATCA GGACAGCATC CACCCAAGAC TGCAGCCGCA CAGCTCTGTA 
TCTGAACCTT CTTTGTCCCG GCAGCGAAGG CAGAGAAAAA GGGAACAGAC GAACCACGGT 
CGGGCAAAGA GCCAGCTCCA AGAATCACCC CCTCGTCTTG TGCCTTCTCA CCCTGATACT 
GGGAAAGCAG ATATCATAAG TACACAGCAA AGTGATGGAA ACCAAAGTGG ACCTGTGGCT 
AGGTCTGTGA ATGGTTCAAG GTCTAGTTCG ACAGCGTCAT CAAAGGATCG GCCATTATCA 
GCCAGAGAGA GGAGACGACT AAAGCAGTCG CAGGAAGAGA TGCTCCCCTC AGGCCCTGCA 
GTTCAGAGAA CTCCAAGTTC AGTAGAGCCA GTGAAACCAC AGGAAGAAGA CCAACCCATC 
CCTGCCCAAC GATTCTCTTC TGACTGCAAC ATCACTCAGG TGAATCCCAC ACTCCTGAGG 
GAAAAGAAGA GACTGATCCA TGGACTGTCT GAGGATGAGT TAAGTTCTTC CACAAGCTCA 
ACTGATAAAT CAGATGGGGA TTCCAGGGAG GGGAAAAGTC ATACAAATGA AATGAGAGAC 
TTGGTGCAGC TGATGACTCA GACTCTGAGG CTGGAAGCTA AAGAGAGCTG TGAAGATCTT 
CATGTACCAA ACCCAGGGTC AGAGTTCAGA CTTCATCGCA AGTATCGAGA CACGCTGGTG 
CTCCACGGCA AGGCTGCGGA AGAGGGGGAG CCCCCCTGTG TGGAGTTACC TCCAGGTATC 
ACACCAGGTT CTGAAAAGAT CAGGAGAATA GTTGAAGTCT TAAGAGCTGA TGTGATCCAG 
GGCCTGGGGG TTCAGCTTTT AGAGCAGGTG TATGATCTTT TGGAGGAGGA AGATGAGTTG 
GAGAGAGAGG CACGATTACA GGAGCACATG GGAGACAAGT ATACAACTTA CAGTGTGAAA 
GCTCGCCAGT TGAAGTTTTT TGAAGAAAAT GTGAGTTTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nek4 ( XM_008770996.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008769218.1 Rattus norvegicus NIMA-related kinase 4 (Nek4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa46390
Clone ID Related Accession (Same CDS sequence)	XM_008770996.2
Accession Version	XM_008770996.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2517bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	serine/threonine-protein kinase Nek4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005115.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008770996.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCCAAG CCGCATACTG TTACTTGCGG GTCGTGGGCA GGGGTAGTTA CGGGGAGGTG 
ACGCTCGTGA AGCATCGGCG GGACGGCAAG CAGTATGTCA TCAAAAAGCT GAACCTCCGG 
AATGCCTCCA GCCGGGAGCG TCGAGCGGCA GAGCAGGAGG CTCAGCTCCT GTCTCAGTTG 
AAGCACCCCA ACATTGTCAC CTACAAAGAG TCATGGGAGG GCGGAGACGG TCTGCTCTAC 
ATCGTCATGG GCTTCTGCGA AGGAGGCGAT CTGTACCGGA AGCTCAAGGA GCAGAAGGGG 
CAGCTTCTGC CTGAGAGTCA GGTGGTGGAG TGGTTTGTCC AGATCGCCAT GGCCTTGCAG 
TACTTACATG AGAAGCACAT CCTTCATCGA GATCTGAAAA CTCAGAATGT CTTCCTAACA 
AGAACAAACA TCATCAAAGT AGGTGACCTA GGCATTGCCC GAGTGTTGGA GAATCACAGT 
GACATGGCGA GCACCCTCAT TGGCACACCC TATTACATGA GTCCTGAGCT GTTCTCCAAC 
AAACCCTACA ACTATAAGTC GGATGTTTGG GCTTTGGGAT GCTGCGTGTA TGAAATGGCC 
ACCCTGAAGC ATGCTTTTAA TGCAAAAGAC ATGAATTCTT TAGTTTATCG GATTATTGAA 
GGAAAGTTGC CACCAATGCC AAAAGTTTAC AGTGCGGAGC TGGCAGAGCT GATAAGAACC 
ATGTTGAGCA GGAGACCTGA GGAGAGGCCC TCTGTGCGGA GCATCCTGCG GCAGCCCTAC 
ATAAAACACC ACATCTCCTT GTTCTTGGAG GCCACCAAGG CGAAAACTTC CAAAAATAAT 
GTTAAAAACT GTGACTCCAG AGCCAAACCC GTTGCTGCTG TAGTTTCCAG AAAGGAAGAA 
CCAAATCATG AAATGATTCC CTACCAGCCA CGCTCTTCTG AGGGCTCCGC TGTACATGCC 
ACGGGTGAAG ATAAATGTCT GTCCCAAGAA AAACCAGTGG ACATTGGTCC CTTGAAATCA 
CCTGCTAGTC TCGAAGGCCA CACTGGCAAA CAAGACATGA ACAGGACTGC AGAGTCGTGT 
GCCACAGTCA GTAGGATAAA TATCGATATC TTACCTGCAG AAAGGAGGGA CTCAGCAAAA 
GATGGCACAG TTGAGGAGGG CCGACCACAG CACGTGGATG CTTCTAATGA AGTAGACCGT 
CAATGCAGTA TTTCTCAAGA GAAGGAGAGG CTACAGGGCA ACAGCAAGTC TAGTGATCAG 
CCGGAAAATC TCCTTCCCAG ATGGTCCTCT GGTGGTGGTG ATGGGGAAGG GAATGAACTG 
GTGAAGCTGT TGTACTCCTC GGGTAAAGAC CAAAAGCCAC AGCAGGATCA AGTTACTAGC 
GGGTGTATTC TAGAAGATCA GGACAGCATC CACCCAAGAC TGCAGCCGCA CAGCTCTGTA 
TCTGAACCTT CTTTGTCCCG GCAGCGAAGG CAGAGAAAAA GGGAACAGAC GAACCACGGT 
CGGGCAAAGA GCCAGCTCCA AGAATCACCC CCTCGTCTTG TGCCTTCTCA CCCTGATACT 
GGGAAAGCAG ATATCATAAG TACACAGCAA AGTGATGGAA ACCAAAGTGG ACCTGTGGCT 
AGGTCTGTGA ATGGTTCAAG GTCTAGTTCG ACAGCGTCAT CAAAGGATCG GCCATTATCA 
GCCAGAGAGA GGAGACGACT AAAGCAGTCG CAGGAAGAGA TGCTCCCCTC AGGCCCTGCA 
GTTCAGAGAA CTCCAAGTTC AGTAGAGCCA GTGAAACCAC AGGAAGAAGA CCAACCCATC 
CCTGCCCAAC GATTCTCTTC TGACTGCAAC ATCACTCAGG TGAATCCCAC ACTCCTGAGG 
GAAAAGAAGA GACTGATCCA TGGACTGTCT GAGGATGAGT TAAGTTCTTC CACAAGCTCA 
ACTGATAAAT CAGATGGGGA TTCCAGGGAG GGGAAAAGTC ATACAAATGA AATGAGAGAC 
TTGGTGCAGC TGATGACTCA GACTCTGAGG CTGGAAGCTA AAGAGAGCTG TGAAGATCTT 
CATGTACCAA ACCCAGGGTC AGAGTTCAGA CTTCATCGCA AGTATCGAGA CACGCTGGTG 
CTCCACGGCA AGGCTGCGGA AGAGGGGGAG CCCCCCTGTG TGGAGTTACC TCCAGGTATC 
ACACCAGGTT CTGAAAAGAT CAGGAGAATA GTTGAAGTCT TAAGAGCTGA TGTGATCCAG 
GGCCTGGGGG TTCAGCTTTT AGAGCAGGTG TATGATCTTT TGGAGGAGGA AGATGAGTTG 
GAGAGAGAGG CACGATTACA GGAGCACATG GGAGACAAGT ATACAACTTA CAGTGTGAAA 
GCTCGCCAGT TGAAGTTTTT TGAAGAAAAT TCATTTGGAA ATATTAAAAG GAATGTCAAG 
ATTTACAGTG ACTCCCTTCA AGCACATGTT CAAGTACATG CTCTTGTTCC AGAGGTGCCA 
AGCACTGTTT TACCACAGGT TCACATTGGT AAGTTTCTCG GAAGTGTTTG CTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008769218.1
CDS	240..2756
Translation	MPQAAYCYLRVVGRGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPESQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHSDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPKVYSAELAELIRTMLSRRPEERPSVRSILRQPYIKHHISLFLEATKAKTSKNNVKNCDSRAKPVAAVVSRKEEPNHEMIPYQPRSSEGSAVHATGEDKCLSQEKPVDIGPLKSPASLEGHTGKQDMNRTAESCATVSRINIDILPAERRDSAKDGTVEEGRPQHVDASNEVDRQCSISQEKERLQGNSKSSDQPENLLPRWSSGGGDGEGNELVKLLYSSGKDQKPQQDQVTSGCILEDQDSIHPRLQPHSSVSEPSLSRQRRQRKREQTNHGRAKSQLQESPPRLVPSHPDTGKADIISTQQSDGNQSGPVARSVNGSRSSSTASSKDRPLSARERRRLKQSQEEMLPSGPAVQRTPSSVEPVKPQEEDQPIPAQRFSSDCNITQVNPTLLREKKRLIHGLSEDELSSSTSSTDKSDGDSREGKSHTNEMRDLVQLMTQTLRLEAKESCEDLHVPNPGSEFRLHRKYRDTLVLHGKAAEEGEPPCVELPPGITPGSEKIRRIVEVLRADVIQGLGVQLLEQVYDLLEEEDELEREARLQEHMGDKYTTYSVKARQLKFFEENSFGNIKRNVKIYSDSLQAHVQVHALVPEVPSTVLPQVHIGKFLGSVCY

Target ORF information:

RefSeq Version	XM_008770996.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus NIMA-related kinase 4 (Nek4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008770996.2

ORF Insert Sequence:

ATGCCCCAAG CCGCATACTG TTACTTGCGG GTCGTGGGCA GGGGTAGTTA CGGGGAGGTG 
ACGCTCGTGA AGCATCGGCG GGACGGCAAG CAGTATGTCA TCAAAAAGCT GAACCTCCGG 
AATGCCTCCA GCCGGGAGCG TCGAGCGGCA GAGCAGGAGG CTCAGCTCCT GTCTCAGTTG 
AAGCACCCCA ACATTGTCAC CTACAAAGAG TCATGGGAGG GCGGAGACGG TCTGCTCTAC 
ATCGTCATGG GCTTCTGCGA AGGAGGCGAT CTGTACCGGA AGCTCAAGGA GCAGAAGGGG 
CAGCTTCTGC CTGAGAGTCA GGTGGTGGAG TGGTTTGTCC AGATCGCCAT GGCCTTGCAG 
TACTTACATG AGAAGCACAT CCTTCATCGA GATCTGAAAA CTCAGAATGT CTTCCTAACA 
AGAACAAACA TCATCAAAGT AGGTGACCTA GGCATTGCCC GAGTGTTGGA GAATCACAGT 
GACATGGCGA GCACCCTCAT TGGCACACCC TATTACATGA GTCCTGAGCT GTTCTCCAAC 
AAACCCTACA ACTATAAGTC GGATGTTTGG GCTTTGGGAT GCTGCGTGTA TGAAATGGCC 
ACCCTGAAGC ATGCTTTTAA TGCAAAAGAC ATGAATTCTT TAGTTTATCG GATTATTGAA 
GGAAAGTTGC CACCAATGCC AAAAGTTTAC AGTGCGGAGC TGGCAGAGCT GATAAGAACC 
ATGTTGAGCA GGAGACCTGA GGAGAGGCCC TCTGTGCGGA GCATCCTGCG GCAGCCCTAC 
ATAAAACACC ACATCTCCTT GTTCTTGGAG GCCACCAAGG CGAAAACTTC CAAAAATAAT 
GTTAAAAACT GTGACTCCAG AGCCAAACCC GTTGCTGCTG TAGTTTCCAG AAAGGAAGAA 
CCAAATCATG AAATGATTCC CTACCAGCCA CGCTCTTCTG AGGGCTCCGC TGTACATGCC 
ACGGGTGAAG ATAAATGTCT GTCCCAAGAA AAACCAGTGG ACATTGGTCC CTTGAAATCA 
CCTGCTAGTC TCGAAGGCCA CACTGGCAAA CAAGACATGA ACAGGACTGC AGAGTCGTGT 
GCCACAGTCA GTAGGATAAA TATCGATATC TTACCTGCAG AAAGGAGGGA CTCAGCAAAA 
GATGGCACAG TTGAGGAGGG CCGACCACAG CACGTGGATG CTTCTAATGA AGTAGACCGT 
CAATGCAGTA TTTCTCAAGA GAAGGAGAGG CTACAGGGCA ACAGCAAGTC TAGTGATCAG 
CCGGAAAATC TCCTTCCCAG ATGGTCCTCT GGTGGTGGTG ATGGGGAAGG GAATGAACTG 
GTGAAGCTGT TGTACTCCTC GGGTAAAGAC CAAAAGCCAC AGCAGGATCA AGTTACTAGC 
GGGTGTATTC TAGAAGATCA GGACAGCATC CACCCAAGAC TGCAGCCGCA CAGCTCTGTA 
TCTGAACCTT CTTTGTCCCG GCAGCGAAGG CAGAGAAAAA GGGAACAGAC GAACCACGGT 
CGGGCAAAGA GCCAGCTCCA AGAATCACCC CCTCGTCTTG TGCCTTCTCA CCCTGATACT 
GGGAAAGCAG ATATCATAAG TACACAGCAA AGTGATGGAA ACCAAAGTGG ACCTGTGGCT 
AGGTCTGTGA ATGGTTCAAG GTCTAGTTCG ACAGCGTCAT CAAAGGATCG GCCATTATCA 
GCCAGAGAGA GGAGACGACT AAAGCAGTCG CAGGAAGAGA TGCTCCCCTC AGGCCCTGCA 
GTTCAGAGAA CTCCAAGTTC AGTAGAGCCA GTGAAACCAC AGGAAGAAGA CCAACCCATC 
CCTGCCCAAC GATTCTCTTC TGACTGCAAC ATCACTCAGG TGAATCCCAC ACTCCTGAGG 
GAAAAGAAGA GACTGATCCA TGGACTGTCT GAGGATGAGT TAAGTTCTTC CACAAGCTCA 
ACTGATAAAT CAGATGGGGA TTCCAGGGAG GGGAAAAGTC ATACAAATGA AATGAGAGAC 
TTGGTGCAGC TGATGACTCA GACTCTGAGG CTGGAAGCTA AAGAGAGCTG TGAAGATCTT 
CATGTACCAA ACCCAGGGTC AGAGTTCAGA CTTCATCGCA AGTATCGAGA CACGCTGGTG 
CTCCACGGCA AGGCTGCGGA AGAGGGGGAG CCCCCCTGTG TGGAGTTACC TCCAGGTATC 
ACACCAGGTT CTGAAAAGAT CAGGAGAATA GTTGAAGTCT TAAGAGCTGA TGTGATCCAG 
GGCCTGGGGG TTCAGCTTTT AGAGCAGGTG TATGATCTTT TGGAGGAGGA AGATGAGTTG 
GAGAGAGAGG CACGATTACA GGAGCACATG GGAGACAAGT ATACAACTTA CAGTGTGAAA 
GCTCGCCAGT TGAAGTTTTT TGAAGAAAAT TCATTTGGAA ATATTAAAAG GAATGTCAAG 
ATTTACAGTG ACTCCCTTCA AGCACATGTT CAAGTACATG CTCTTGTTCC AGAGGTGCCA 
AGCACTGTTT TACCACAGGT TCACATTGGT AAGTTTCTCG GAAGTGTTTG CTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts.
Molecular and cellular biology32(19)3963-77(2012 Oct)
Nguyen CL,Possemato R,Bauerlein EL,Xie A,Scully R,Hahn WC

The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase.
Human molecular genetics20(18)3592-605(2011 Sep)
Coene KL,Mans DA,Boldt K,Gloeckner CJ,van Reeuwijk J,Bolat E,Roosing S,Letteboer SJ,Peters TA,Cremers FP,Ueffing M,Roepman R

Activity and substrate specificity of the murine STK2 Serine/Threonine kinase that is structurally related to the mitotic regulator protein NIMA of Aspergillus nidulans.
Biochemical and biophysical research communications264(2)449-56(1999 Oct)
Hayashi K,Igarashi H,Ogawa M,Sakaguchi N

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Nek4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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