Tlr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tlr1
Entrez Gene ID	305354
Full Name	toll-like receptor 1
General protein information	Preferred Names toll-like receptor 1 Names toll-like receptor 1 rCG56938-like
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14p11

mRNA and Protein(s)

mRNA	Protein	Name
NM_001172120.2	NP_001165591.1	toll-like receptor 1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TLR1	NP_001123937.1
Canis lupus familiaris (dog)	TLR1	NP_001139615.1
Rattus norvegicus (Norway rat)	Tlr1	NP_001165591.1
	TLR1	NP_001123896.1
Mus musculus (house mouse)	Tlr1	NP_001263374.1
Danio rerio (zebrafish)	tlr1	NP_001124065.1
Xenopus tropicalis (tropical clawed frog)	tlr1	XP_002938702.2
Xenopus tropicalis (tropical clawed frog)	LOC100495326	XP_002938703.2
Homo sapiens (human)	TLR1	NP_003254.2

Gene Ontology
Bibliography

Related articles in PubMed

Diabetes increases the susceptibility to acute kidney injury after myocardial infarction through augmented activation of renal Toll-like receptors in rats.
Ohno K, Kuno A, Murase H, Muratsubaki S, Miki T, Tanno M, Yano T, Ishikawa S, Yamashita T, Miura T
American journal of physiology. Heart and circulatory physiology313(6)H1130-H1142(2017 Dec)

Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors.
Aplin AC, Ligresti G, Fogel E, Zorzi P, Smith K, Nicosia RF
Angiogenesis17(1)147-61(2014 Jan)

TLR2 is a primary receptor for Alzheimer's amyloid ? peptide to trigger neuroinflammatory activation.
Liu S, Liu Y, Hao W, Wolf L, Kiliaan AJ, Penke B, R?be CE, Walter J, Heneka MT, Hartmann T, Menger MD, Fassbender K
Journal of immunology (Baltimore, Md. : 1950)188(3)1098-107(2012 Feb)

Isolated Toll-like receptor transmembrane domains are capable of oligomerization.
Godfroy JI 3rd, Roostan M, Moroz YS, Korendovych IV, Yin H
PloS one7(11)e48875(2012)

Modulation of inflammatory responses by a cannabinoid-2-selective agonist after spinal cord injury.
Adhikary S, Li H, Heller J, Skarica M, Zhang M, Ganea D, Tuma RF
Journal of neurotrauma28(12)2417-27(2011 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Diabetes mellitus increases the susceptibility to acute kidney injury after acute myocardial infarction by augmented activation of renal TLR1/TLR2-mediated signaling.
Title: Diabetes increases the susceptibility to acute kidney injury after myocardial infarction through augmented activation of renal Toll-like receptors in rats.

aortic angiogenesis is preceded by an immune reaction with overexpression of Toll-like receptors (TLRs) and TLR-inducible genes.
Title: Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors.

toll-like receptors and nucleotide-binding oligomerization domain 2 combinations are contributors to the signaling cascades resulting in purinergic microglial activation
Title: Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression.

The following Tlr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tlr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42274	NM_001172120.2 Latest version!	Rattus norvegicus toll-like receptor 1 (Tlr1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tlr1 ( NM_001172120.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001165591.1 Rattus norvegicus toll-like receptor 1 (Tlr1), mRNA.

Price & Availability↑

CloneID	ORa42274
Clone ID Related Accession (Same CDS sequence)	NM_001172120.2
Accession Version	NM_001172120.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2388bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	toll-like receptor 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AAHX01079541.1. On Feb 16, 2013 this sequence version replaced NM_001172120.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGACTAAAA CACAGTCCAC CATCTTCTAT TGTATTGTTG TCTTAGGGCT GATACTTATC 
AAAATCCAGT TATCTGAGGA AAGTGAGTTG ATCATTAAGA GGCCAAATGC AAACCTTACC 
AGAGTGCCCA AGGACCTACC CTTGCAAACA ACTACTTTAG ATGTATCACA AAACAATATA 
TCTGAGCTTC AGACTTCTGA CATACTCTTG TTGTCCAAAC TGAGGGTCTT CATTATGTCC 
TACAACAGAC TCCAGTATCT TAATATCAGT GTTTTCAAAT TCAACACGGA ACTGGAATAT 
TTGGATTTGT CCCACAATGA GTTAAGGCTG ATCTCTTGCC ACGCAACAGC CGACCTCAAA 
CATTTAGACC TCTCCTTTAA TGCATTTGAT GCCCTGCCCA TATGCAAAGA GTTTGGCAAC 
CTGTCCCAAC TACAGTTTCT GGGATTGAGC GGTTCTCAGA TACAAAATTC AAGTGTGCAG 
CTGATTGCTC ATCTGAACAT CAGTAAGGTT TTGCTGGTGT TAGGAGACAC TTATGGGGAA 
AAAGAAGATC CCAAGTGTCT TCAGCACATT AGCACTGAGA CTCTGCATAT CGTTTTCCCT 
TCCAAAAGAG AATTCCATTT TCTTCTGGAC ATGTCTGTCA GCACGGCCAT CAGTTTGGAA 
CTGTCTAACA TCAAGTGTGT GCTTGAGGAC AAGAACTGCT CTTACTTCCT AGGTACCTTA 
GAAAGACTTA GAAAGACTCA GAGGCTCTCA AATCTTACCC TGAACAACGT GGACACAACA 
TGGAATTCCT TCATTAACAT CCTTCAGCTG GTTTGGCATA CACCAGTCAA GTCTTTCTCA 
ATTTCAAACG TGAAACTAAA AGGTCATTTT AACTTCAGAA GATTCCATTA TTCTGACACT 
TCTCTGAGGG CTTTGTCGAT ACATCAAGTT GTCACTGATG TGTTCAGCTT CCCCCAAAGT 
AACATATACA GCATCTTCTC CAATATGAAC ATCCAAAGTT TTACAGTATC TGGAACACGC 
ATGGTCCACA TGCTTTGCCC AGACCAAATT AGCCCATTTC TGTATTTGGA CTTTACAGAT 
AACCTTTTAA CAGACATAGT TTTTGAAGAC TGTAGAAATT TAATTAGATT GAAAACACTT 
AGTTTACAAA AGAATCAGTT AAAAACACTT GAAAATATAA TTCTTATGTC TATGGAGATG 
ACATCCCTAC AAAAACTAGA CATTAGCCAG AATTCTCTAA GGTACAGTGA TGCGGGAAGC 
CCATGCTCCT GGACCCAGAG TTTGTTAGTT TTAAATTTGT CTTCAAACAT GCTTACGGAC 
TCTGTCTTCA GGTGCTTACC TCCCAAGGTC AAGGTCCTTG ACCTTCACAA CAACAGGATA 
GTGAGCATCT CTAAAGATGT CACCCACCTG CAAGCTTTGC AGGAACTCAA TGTCGCATCC 
AATTTTTTAA CTGACCTTCC TGGATGTGGA GCCTTCAGTA GCCTTTCTGT GCTGGTCATC 
GACCATAACT CAGTTTCCCA CCCCTCCTCT GATTTCTTCC AGAGCTGTCA GAATATCAGG 
TCCATAACAG CGGGGAACAA CCCATTCCGA TGCACATGTG AGCTGAGGGA GTTTGTCAAA 
AACATAGGTC AGGCATCAAG AGAAGTGGTG GAGGGCTGGC CTGACTCTTA CAGGTGTGAT 
TACCCAGACA GCATTAAGGG AACCCCACTG CAGGACTTCC ACATGTCTCC ACTGTCCTGC 
GATACAATTC TACTGACTGT CACCATTGGG GCCACTCTGC TGCTGCTGGC TGCCATTGGG 
GCTTCCCTCT GTCTCTACTT TGATCTGCCC TGGTATCTCA GGATGCTATG GCAGTGGACA 
CAGACCAGGC ACAGGGCCCG GAACATCCCC TTAGAGGAAC TGCAGAGGAA CCTCCAGTTC 
CATGCTTTTG TCTCATACAG TGGGCATGAT TCTGCCTGGG TGAAGAATGA ATTACTACCA 
AACCTAGAGA AAGATGACAT TCGGGTTTGC CTCCATGAGA GAAACTTTGT CCCTGGCAAG 
AGCATTGTGG AGAACATCAT ACACTTCATT GAGAAGAGTT ACAAGTCCAT CTTTGTGCTG 
TCTCCCCACT TCATCCAGAG TGAGTGGTGC CATTATGAAC TCTACTTTGC CCATCACAAT 
CTCTTCCACG AAGGGTCTGA TAACTTAATC CTGATCTTGC TGGAACCAAT TCCACAGTAC 
TCCATCCCTA CCAATTACCA CAAGCTCAAA ACTCTCATGG CACGGAGGAC CTATTTGGAA 
TGGCCCACAG AAAAGAGCAA GCATGGACTC TTTTGGGCAA ATCTAAGAGC ATCCATTAAT 
GTTAAGCTGG TCAACCAGGC AGAAGCAACA TGTTACACAC AGCAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001165591.1
CDS	1..2388
Translation	MTKTQSTIFYCIVVLGLILIKIQLSEESELIIKRPNANLTRVPKDLPLQTTTLDVSQNNISELQTSDILLLSKLRVFIMSYNRLQYLNISVFKFNTELEYLDLSHNELRLISCHATADLKHLDLSFNAFDALPICKEFGNLSQLQFLGLSGSQIQNSSVQLIAHLNISKVLLVLGDTYGEKEDPKCLQHISTETLHIVFPSKREFHFLLDMSVSTAISLELSNIKCVLEDKNCSYFLGTLERLRKTQRLSNLTLNNVDTTWNSFINILQLVWHTPVKSFSISNVKLKGHFNFRRFHYSDTSLRALSIHQVVTDVFSFPQSNIYSIFSNMNIQSFTVSGTRMVHMLCPDQISPFLYLDFTDNLLTDIVFEDCRNLIRLKTLSLQKNQLKTLENIILMSMEMTSLQKLDISQNSLRYSDAGSPCSWTQSLLVLNLSSNMLTDSVFRCLPPKVKVLDLHNNRIVSISKDVTHLQALQELNVASNFLTDLPGCGAFSSLSVLVIDHNSVSHPSSDFFQSCQNIRSITAGNNPFRCTCELREFVKNIGQASREVVEGWPDSYRCDYPDSIKGTPLQDFHMSPLSCDTILLTVTIGATLLLLAAIGASLCLYFDLPWYLRMLWQWTQTRHRARNIPLEELQRNLQFHAFVSYSGHDSAWVKNELLPNLEKDDIRVCLHERNFVPGKSIVENIIHFIEKSYKSIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILILLEPIPQYSIPTNYHKLKTLMARRTYLEWPTEKSKHGLFWANLRASINVKLVNQAEATCYTQQ

Target ORF information:

RefSeq Version	NM_001172120.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus toll-like receptor 1 (Tlr1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001172120.2

ORF Insert Sequence:

ATGACTAAAA CACAGTCCAC CATCTTCTAT TGTATTGTTG TCTTAGGGCT GATACTTATC 
AAAATCCAGT TATCTGAGGA AAGTGAGTTG ATCATTAAGA GGCCAAATGC AAACCTTACC 
AGAGTGCCCA AGGACCTACC CTTGCAAACA ACTACTTTAG ATGTATCACA AAACAATATA 
TCTGAGCTTC AGACTTCTGA CATACTCTTG TTGTCCAAAC TGAGGGTCTT CATTATGTCC 
TACAACAGAC TCCAGTATCT TAATATCAGT GTTTTCAAAT TCAACACGGA ACTGGAATAT 
TTGGATTTGT CCCACAATGA GTTAAGGCTG ATCTCTTGCC ACGCAACAGC CGACCTCAAA 
CATTTAGACC TCTCCTTTAA TGCATTTGAT GCCCTGCCCA TATGCAAAGA GTTTGGCAAC 
CTGTCCCAAC TACAGTTTCT GGGATTGAGC GGTTCTCAGA TACAAAATTC AAGTGTGCAG 
CTGATTGCTC ATCTGAACAT CAGTAAGGTT TTGCTGGTGT TAGGAGACAC TTATGGGGAA 
AAAGAAGATC CCAAGTGTCT TCAGCACATT AGCACTGAGA CTCTGCATAT CGTTTTCCCT 
TCCAAAAGAG AATTCCATTT TCTTCTGGAC ATGTCTGTCA GCACGGCCAT CAGTTTGGAA 
CTGTCTAACA TCAAGTGTGT GCTTGAGGAC AAGAACTGCT CTTACTTCCT AGGTACCTTA 
GAAAGACTTA GAAAGACTCA GAGGCTCTCA AATCTTACCC TGAACAACGT GGACACAACA 
TGGAATTCCT TCATTAACAT CCTTCAGCTG GTTTGGCATA CACCAGTCAA GTCTTTCTCA 
ATTTCAAACG TGAAACTAAA AGGTCATTTT AACTTCAGAA GATTCCATTA TTCTGACACT 
TCTCTGAGGG CTTTGTCGAT ACATCAAGTT GTCACTGATG TGTTCAGCTT CCCCCAAAGT 
AACATATACA GCATCTTCTC CAATATGAAC ATCCAAAGTT TTACAGTATC TGGAACACGC 
ATGGTCCACA TGCTTTGCCC AGACCAAATT AGCCCATTTC TGTATTTGGA CTTTACAGAT 
AACCTTTTAA CAGACATAGT TTTTGAAGAC TGTAGAAATT TAATTAGATT GAAAACACTT 
AGTTTACAAA AGAATCAGTT AAAAACACTT GAAAATATAA TTCTTATGTC TATGGAGATG 
ACATCCCTAC AAAAACTAGA CATTAGCCAG AATTCTCTAA GGTACAGTGA TGCGGGAAGC 
CCATGCTCCT GGACCCAGAG TTTGTTAGTT TTAAATTTGT CTTCAAACAT GCTTACGGAC 
TCTGTCTTCA GGTGCTTACC TCCCAAGGTC AAGGTCCTTG ACCTTCACAA CAACAGGATA 
GTGAGCATCT CTAAAGATGT CACCCACCTG CAAGCTTTGC AGGAACTCAA TGTCGCATCC 
AATTTTTTAA CTGACCTTCC TGGATGTGGA GCCTTCAGTA GCCTTTCTGT GCTGGTCATC 
GACCATAACT CAGTTTCCCA CCCCTCCTCT GATTTCTTCC AGAGCTGTCA GAATATCAGG 
TCCATAACAG CGGGGAACAA CCCATTCCGA TGCACATGTG AGCTGAGGGA GTTTGTCAAA 
AACATAGGTC AGGCATCAAG AGAAGTGGTG GAGGGCTGGC CTGACTCTTA CAGGTGTGAT 
TACCCAGACA GCATTAAGGG AACCCCACTG CAGGACTTCC ACATGTCTCC ACTGTCCTGC 
GATACAATTC TACTGACTGT CACCATTGGG GCCACTCTGC TGCTGCTGGC TGCCATTGGG 
GCTTCCCTCT GTCTCTACTT TGATCTGCCC TGGTATCTCA GGATGCTATG GCAGTGGACA 
CAGACCAGGC ACAGGGCCCG GAACATCCCC TTAGAGGAAC TGCAGAGGAA CCTCCAGTTC 
CATGCTTTTG TCTCATACAG TGGGCATGAT TCTGCCTGGG TGAAGAATGA ATTACTACCA 
AACCTAGAGA AAGATGACAT TCGGGTTTGC CTCCATGAGA GAAACTTTGT CCCTGGCAAG 
AGCATTGTGG AGAACATCAT ACACTTCATT GAGAAGAGTT ACAAGTCCAT CTTTGTGCTG 
TCTCCCCACT TCATCCAGAG TGAGTGGTGC CATTATGAAC TCTACTTTGC CCATCACAAT 
CTCTTCCACG AAGGGTCTGA TAACTTAATC CTGATCTTGC TGGAACCAAT TCCACAGTAC 
TCCATCCCTA CCAATTACCA CAAGCTCAAA ACTCTCATGG CACGGAGGAC CTATTTGGAA 
TGGCCCACAG AAAAGAGCAA GCATGGACTC TTTTGGGCAA ATCTAAGAGC ATCCATTAAT 
GTTAAGCTGG TCAACCAGGC AGAAGCAACA TGTTACACAC AGCAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Diabetes increases the susceptibility to acute kidney injury after myocardial infarction through augmented activation of renal Toll-like receptors in rats.
American journal of physiology. Heart and circulatory physiology313(6)H1130-H1142(2017 Dec)
Ohno K,Kuno A,Murase H,Muratsubaki S,Miki T,Tanno M,Yano T,Ishikawa S,Yamashita T,Miura T

Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors.
Angiogenesis17(1)147-61(2014 Jan)
Aplin AC,Ligresti G,Fogel E,Zorzi P,Smith K,Nicosia RF

TLR2 is a primary receptor for Alzheimer's amyloid ? peptide to trigger neuroinflammatory activation.
Journal of immunology (Baltimore, Md. : 1950)188(3)1098-107(2012 Feb)
Liu S,Liu Y,Hao W,Wolf L,Kiliaan AJ,Penke B,R?be CE,Walter J,Heneka MT,Hartmann T,Menger MD,Fassbender K

Isolated Toll-like receptor transmembrane domains are capable of oligomerization.
PloS one7(11)e48875(2012)
Godfroy JI 3rd,Roostan M,Moroz YS,Korendovych IV,Yin H

Modulation of inflammatory responses by a cannabinoid-2-selective agonist after spinal cord injury.
Journal of neurotrauma28(12)2417-27(2011 Dec)
Adhikary S,Li H,Heller J,Skarica M,Zhang M,Ganea D,Tuma RF

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Tlr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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