Kat2a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kat2a
Entrez Gene ID	303539
Full Name	lysine acetyltransferase 2A
Synonyms	Gcn5,Gcn5l2
General protein information	Preferred Names lysine acetyltransferase 2A Names histone acetyltransferase KAT2A GCN5 general control of amino acid synthesis-like 2 K(lysine) acetyltransferase 2A general control of amino acid synthesis 5-like 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q31

mRNA and Protein(s)

mRNA	Protein	Name
XM_006247317.3	XP_006247379.1	histone acetyltransferase KAT2A isoform X1
NM_001107050.1	NP_001100520.1	histone acetyltransferase KAT2A

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	KAT2A	XP_548094.3
Rattus norvegicus (Norway rat)	Kat2a	NP_001100520.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004434	XP_313721.3
Gallus gallus (chicken)	KAT2A	XP_004948702.1
Bos taurus (cattle)	KAT2A	XP_003587495.2
Pan troglodytes (chimpanzee)	KAT2A	XP_511500.2
Danio rerio (zebrafish)	kat2a	XP_001922732.1
Drosophila melanogaster (fruit fly)	Pcaf	NP_648586.2
Magnaporthe oryzae (rice blast fungus)	MGG_11716	XP_003710047.1
Homo sapiens (human)	KAT2A	NP_066564.2
Mus musculus (house mouse)	Kat2a	NP_001033099.1
Xenopus tropicalis (tropical clawed frog)	kat2a	XP_002939088.2

Gene Ontology
Bibliography

Related articles in PubMed

KAT2A coupled with the ?-KGDH complex acts as a histone H3 succinyltransferase.
Wang Y, Guo YR, Liu K, Yin Z, Liu R, Xia Y, Tan L, Yang P, Lee JH, Li XJ, Hawke D, Zheng Y, Qian X, Lyu J, He J, Xing D, Tao YJ, Lu Z
Nature552(7684)273-277(2017 Dec)

Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development.
Ghosh TK, Aparicio-S?nchez JJ, Buxton S, Ketley A, Mohamed T, Rutland CS, Loughna S, Brook JD
Journal of molecular and cellular cardiology114185-198(2017 Nov)

The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation.
Gao B, Kong Q, Zhang Y, Yun C, Dent SYR, Song J, Zhang DD, Wang Y, Li X, Fang D
Journal of immunology (Baltimore, Md. : 1950)198(10)3927-3938(2017 May)

Loss of GCN5 leads to increased neuronal apoptosis by upregulating E2F1- and Egr-1-dependent BH3-only protein Bim.
Wu Y, Ma S, Xia Y, Lu Y, Xiao S, Cao Y, Zhuang S, Tan X, Fu Q, Xie L, Li Z, Yuan Z
Cell death & disease8(1)e2570(2017 Jan)

KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification.
Fournier M, Orpinell M, Grauffel C, Scheer E, Garnier JM, Ye T, Chavant V, Joint M, Esashi F, Dejaegere A, G?nczy P, Tora L
Nature communications713227(2016 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the loss of GCN5 activity and the induction of Egr-1, E2F1 and Bim are involved in the early brain injury (EBI) following subarachnoid haemorrhage (SAH) in rats.
Title: Loss of GCN5 leads to increased neuronal apoptosis by upregulating E2F1- and Egr-1-dependent BH3-only protein Bim.

Gcn5, possessing acetyltransferase activity, is involved in regulating chromatin configuration in cardiomyocyte differentiation of rat mesenchymal stem cells by changing the level of histone acetylation
Title: A role for Gcn5 in cardiomyocyte differentiation of rat mesenchymal stem cells.

Ang II stimulates Akt-dependent PGC-1 alpha serine 570 phosphorylation, which is required for the binding of the histone acetyltransferase GCN5 (general control nonderepressible 5) to PGC-1 alpha and for its lysine acetylation
Title: PGC-1 alpha serine 570 phosphorylation and GCN5-mediated acetylation by angiotensin II drive catalase down-regulation and vascular hypertrophy.

The following Kat2a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kat2a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02785	NM_001107050.1 Latest version!	Rattus norvegicus lysine acetyltransferase 2A (Kat2a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
ORa33692	XM_006247317.3 Latest version!	Rattus norvegicus lysine acetyltransferase 2A (Kat2a), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kat2a ( NM_001107050.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100520.1 Rattus norvegicus lysine acetyltransferase 2A (Kat2a), mRNA.

Price & Availability↑

CloneID	ORa02785
Clone ID Related Accession (Same CDS sequence)	NM_001107050.1
Accession Version	NM_001107050.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2499bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	histone acetyltransferase KAT2A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473948.1. On or before Oct 4, 2007 this sequence version replaced XM_239340.4, XM_001081432.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGAAC CTTCCCAGGC CCCAAACCCG GCCCCGGCAG CGCAGCCCCG GCCCCTTCAG 
TCCCCGGCCC CTGCCCCAAC TTCGACTCCT GCGCCCAGTC CGGCTTCAGC CCCCACTCCG 
GCTCCTACTC CGGCACCAGC TCCTGCCCCA GCTGCAGCCC CAGCCGGGAG CACAGGGACT 
GGGGGGGCCG GGGTAGGAAG TGGAGGGGAT CCGGCTCGAC CTGGCCTGAG CCAGCAGCAG 
CGCGCTAGCC AGAGAAAGGC GCAAGTCCGG GGGCTGCCGC GTGCCAAGAA GCTTGAGAAA 
CTAGGGGTCT TCTCAGCTTG CAAGGCCAAT GAAACCTGCA AGTGTAATGG CTGGAAAAAC 
CCCAAGCCCC CCACTGCACC CCGCATGGAC CTACAGCAGC CAGCTGCTAA CCTGAGCGAG 
TTGTGCCGCA GCTGTGAGCA CCCCTTGGCG GACCATGTGT CCCACCTGGA GAATGTGTCA 
GAGGATGAGA TTAACCGGCT CTTGGGAATG GTAGTGGATG TAGAAAATCT GTTCATGTCT 
GTTCACAAGG AAGAGGACAC GGACACCAAG CAGGTCTATT TCTACCTCTT CAAGCTCCTG 
CGGAAATGCA TCCTGCAAAT GACACGACCA GTGGTGGAGG GATCCCTAGG CAGCCCGCCA 
TTTGAGAAGC CTAACATCGA GCAGGGTGTT CTGAACTTTG TGCAGTACAA ATTTAGCCAC 
CTGGCCCCCC GGGAGCGGCA GACAATGTTC GAGCTCTCAA AGATGTTCCT GCTCTGCCTT 
AACTACTGGA AGCTGGAGAC CCCTGCTCAA TTCCGGCAGC GATCCCAGTC TGAGGATGTT 
GCTACCTATA AGGTCAATTA TACCAGATGG CTCTGTTACT GCCACGTGCC TCAGAGCTGC 
GACAGCCTCC CCCGATATGA GACCACCCAT GTGTTTGGCC GAAGCCTTCT GCGGTCCATT 
TTTACTGTCA CCCGCCGGCA GCTACTGGAA AAATTTCGGG TGGAGAAGGA CAAACTGGTG 
CCCGAGAAGA GGACCCTCAT CCTCACTCAC TTCCCCAAGT TCCTGTCCAT GCTTGAGGAA 
GAGATCTACG GGGCGAATTC CCCCATCTGG GAGTCAGGCT TCACCATGCC ACCTTCGGAG 
GGGACACAGC TGGTGCCCCG GCCAGCGACT GTCAGTGCAA CAGTTGTACC CAGCACTCCC 
ATCTTCAGTC CTTCCATGGG CGGAGGCAGC AACAGCTCCC TGAGCCTAGA TTCCACAGGG 
ACAGAGCCCA TGCCAGGAGA GAAGAGGAAG CTTCCTGAGA ACCTGACTCT GGAGGATGCT 
AAGCGGCTCC GAGTGATGGG CGACATTCCC ATGGAGCTGG TCAACGAGGT CATGCTGACC 
ATCACCGACC CTGCTGCCAT GCTGGGGCCC GAGACGAGCC TGCTTTCAGC CAACGCAGCT 
CGAGATGAAA CAGCTCGCCT GGAAGAGCGT CGAGGGATCA TCGAATTCCA CGTCATTGGC 
AACTCTCTGA CGCCCAAGGC CAACCGGCGT GTGCTGCTGT GGCTTGTGGG GCTGCAGAAC 
GTCTTCTCCC ACCAGCTGCC ACGAATGCCC AAGGAATATA TTGCCCGCCT CGTCTTTGAC 
CCGAAGCATA AGACCCTGGC CTTGATCAAG GATGGGCGGG TCATCGGTGG GATTTGCTTC 
CGCATGTTTC CCACCCAGGG CTTCACGGAA ATCGTCTTCT GTGCTGTCAC CTCAAATGAG 
CAGGTCAAGG GCTATGGCAC CCACCTGATG AATCACCTGA AGGAGTACCA CATCAAACAC 
AGCATCCTGT ACTTCCTCAC CTACGCCGAC GAGTACGCCA TCGGCTACTT CAAGAAGCAG 
GGCTTCTCCA AGGACATCAA GGTGCCCAAG AGCCGATATC TGGGCTACAT CAAGGACTAT 
GAGGGAGCGA CCCTGATGGA GTGTGAGCTG AACCCCCGCA TCCCCTACAC AGAGCTGTCC 
CACATCATCA AGAAGCAGAA GGAGATCATC AAGAAGTTGA TTGAGCGCAA ACAGGCACAG 
ATCCGAAAGG TTTACCCTGG ACTCAGCTGC TTCAAAGAAG GAGTGAGGCA GATCCCTGTG 
GAGAGCGTCC CTGGCATTCG AGAGACAGGC TGGAAGCCAC TGGGAAAGGA GAAGGGCAAG 
GAGCTGAAGG ACCCTGACCA GCTGTATACG ACCCTCAAAA ACCTGCTGGC TCAGATCAAG 
TCACACCCCA GTGCCTGGCC CTTCATGGAA CCTGTGAAGA AGTCGGAGGC CCCTGACTAC 
TACGAGGTTA TCCGCTTCCC CATTGACCTG AAGACCATGA CAGAACGGTT GCGCAGCCGC 
TACTATGTGA CCCGGAAGCT CTTTGTAGCC GACCTGCAGC GGGTCATCGC CAACTGCCGG 
GAGTACAATC CCCCAGACAG CGAATATTGT CGCTGCGCCA GTGCCCTGGA GAAGTTCTTC 
TACTTCAAGC TCAAAGAAGG AGGGCTCATT GACAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100520.1
CDS	55..2553
Translation	MAEPSQAPNPAPAAQPRPLQSPAPAPTSTPAPSPASAPTPAPTPAPAPAPAAAPAGSTGTGGAGVGSGGDPARPGLSQQQRASQRKAQVRGLPRAKKLEKLGVFSACKANETCKCNGWKNPKPPTAPRMDLQQPAANLSELCRSCEHPLADHVSHLENVSEDEINRLLGMVVDVENLFMSVHKEEDTDTKQVYFYLFKLLRKCILQMTRPVVEGSLGSPPFEKPNIEQGVLNFVQYKFSHLAPRERQTMFELSKMFLLCLNYWKLETPAQFRQRSQSEDVATYKVNYTRWLCYCHVPQSCDSLPRYETTHVFGRSLLRSIFTVTRRQLLEKFRVEKDKLVPEKRTLILTHFPKFLSMLEEEIYGANSPIWESGFTMPPSEGTQLVPRPATVSATVVPSTPIFSPSMGGGSNSSLSLDSTGTEPMPGEKRKLPENLTLEDAKRLRVMGDIPMELVNEVMLTITDPAAMLGPETSLLSANAARDETARLEERRGIIEFHVIGNSLTPKANRRVLLWLVGLQNVFSHQLPRMPKEYIARLVFDPKHKTLALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHSILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDYEGATLMECELNPRIPYTELSHIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKEGVRQIPVESVPGIRETGWKPLGKEKGKELKDPDQLYTTLKNLLAQIKSHPSAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTERLRSRYYVTRKLFVADLQRVIANCREYNPPDSEYCRCASALEKFFYFKLKEGGLIDK

Target ORF information:

RefSeq Version	NM_001107050.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus lysine acetyltransferase 2A (Kat2a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107050.1

ORF Insert Sequence:

ATGGCGGAAC CTTCCCAGGC CCCAAACCCG GCCCCGGCAG CGCAGCCCCG GCCCCTTCAG 
TCCCCGGCCC CTGCCCCAAC TTCGACTCCT GCGCCCAGTC CGGCTTCAGC CCCCACTCCG 
GCTCCTACTC CGGCACCAGC TCCTGCCCCA GCTGCAGCCC CAGCCGGGAG CACAGGGACT 
GGGGGGGCCG GGGTAGGAAG TGGAGGGGAT CCGGCTCGAC CTGGCCTGAG CCAGCAGCAG 
CGCGCTAGCC AGAGAAAGGC GCAAGTCCGG GGGCTGCCGC GTGCCAAGAA GCTTGAGAAA 
CTAGGGGTCT TCTCAGCTTG CAAGGCCAAT GAAACCTGCA AGTGTAATGG CTGGAAAAAC 
CCCAAGCCCC CCACTGCACC CCGCATGGAC CTACAGCAGC CAGCTGCTAA CCTGAGCGAG 
TTGTGCCGCA GCTGTGAGCA CCCCTTGGCG GACCATGTGT CCCACCTGGA GAATGTGTCA 
GAGGATGAGA TTAACCGGCT CTTGGGAATG GTAGTGGATG TAGAAAATCT GTTCATGTCT 
GTTCACAAGG AAGAGGACAC GGACACCAAG CAGGTCTATT TCTACCTCTT CAAGCTCCTG 
CGGAAATGCA TCCTGCAAAT GACACGACCA GTGGTGGAGG GATCCCTAGG CAGCCCGCCA 
TTTGAGAAGC CTAACATCGA GCAGGGTGTT CTGAACTTTG TGCAGTACAA ATTTAGCCAC 
CTGGCCCCCC GGGAGCGGCA GACAATGTTC GAGCTCTCAA AGATGTTCCT GCTCTGCCTT 
AACTACTGGA AGCTGGAGAC CCCTGCTCAA TTCCGGCAGC GATCCCAGTC TGAGGATGTT 
GCTACCTATA AGGTCAATTA TACCAGATGG CTCTGTTACT GCCACGTGCC TCAGAGCTGC 
GACAGCCTCC CCCGATATGA GACCACCCAT GTGTTTGGCC GAAGCCTTCT GCGGTCCATT 
TTTACTGTCA CCCGCCGGCA GCTACTGGAA AAATTTCGGG TGGAGAAGGA CAAACTGGTG 
CCCGAGAAGA GGACCCTCAT CCTCACTCAC TTCCCCAAGT TCCTGTCCAT GCTTGAGGAA 
GAGATCTACG GGGCGAATTC CCCCATCTGG GAGTCAGGCT TCACCATGCC ACCTTCGGAG 
GGGACACAGC TGGTGCCCCG GCCAGCGACT GTCAGTGCAA CAGTTGTACC CAGCACTCCC 
ATCTTCAGTC CTTCCATGGG CGGAGGCAGC AACAGCTCCC TGAGCCTAGA TTCCACAGGG 
ACAGAGCCCA TGCCAGGAGA GAAGAGGAAG CTTCCTGAGA ACCTGACTCT GGAGGATGCT 
AAGCGGCTCC GAGTGATGGG CGACATTCCC ATGGAGCTGG TCAACGAGGT CATGCTGACC 
ATCACCGACC CTGCTGCCAT GCTGGGGCCC GAGACGAGCC TGCTTTCAGC CAACGCAGCT 
CGAGATGAAA CAGCTCGCCT GGAAGAGCGT CGAGGGATCA TCGAATTCCA CGTCATTGGC 
AACTCTCTGA CGCCCAAGGC CAACCGGCGT GTGCTGCTGT GGCTTGTGGG GCTGCAGAAC 
GTCTTCTCCC ACCAGCTGCC ACGAATGCCC AAGGAATATA TTGCCCGCCT CGTCTTTGAC 
CCGAAGCATA AGACCCTGGC CTTGATCAAG GATGGGCGGG TCATCGGTGG GATTTGCTTC 
CGCATGTTTC CCACCCAGGG CTTCACGGAA ATCGTCTTCT GTGCTGTCAC CTCAAATGAG 
CAGGTCAAGG GCTATGGCAC CCACCTGATG AATCACCTGA AGGAGTACCA CATCAAACAC 
AGCATCCTGT ACTTCCTCAC CTACGCCGAC GAGTACGCCA TCGGCTACTT CAAGAAGCAG 
GGCTTCTCCA AGGACATCAA GGTGCCCAAG AGCCGATATC TGGGCTACAT CAAGGACTAT 
GAGGGAGCGA CCCTGATGGA GTGTGAGCTG AACCCCCGCA TCCCCTACAC AGAGCTGTCC 
CACATCATCA AGAAGCAGAA GGAGATCATC AAGAAGTTGA TTGAGCGCAA ACAGGCACAG 
ATCCGAAAGG TTTACCCTGG ACTCAGCTGC TTCAAAGAAG GAGTGAGGCA GATCCCTGTG 
GAGAGCGTCC CTGGCATTCG AGAGACAGGC TGGAAGCCAC TGGGAAAGGA GAAGGGCAAG 
GAGCTGAAGG ACCCTGACCA GCTGTATACG ACCCTCAAAA ACCTGCTGGC TCAGATCAAG 
TCACACCCCA GTGCCTGGCC CTTCATGGAA CCTGTGAAGA AGTCGGAGGC CCCTGACTAC 
TACGAGGTTA TCCGCTTCCC CATTGACCTG AAGACCATGA CAGAACGGTT GCGCAGCCGC 
TACTATGTGA CCCGGAAGCT CTTTGTAGCC GACCTGCAGC GGGTCATCGC CAACTGCCGG 
GAGTACAATC CCCCAGACAG CGAATATTGT CGCTGCGCCA GTGCCCTGGA GAAGTTCTTC 
TACTTCAAGC TCAAAGAAGG AGGGCTCATT GACAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kat2a ( XM_006247317.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006247379.1 Rattus norvegicus lysine acetyltransferase 2A (Kat2a), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa33692
Clone ID Related Accession (Same CDS sequence)	XM_006247317.3
Accession Version	XM_006247317.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2502bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	histone acetyltransferase KAT2A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006247317.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGAAC CTTCCCAGGC CCCAAACCCG GCCCCGGCAG CGCAGCCCCG GCCCCTTCAG 
TCCCCGGCCC CTGCCCCAAC TTCGACTCCT GCGCCCAGTC CGGCTTCAGC CCCCACTCCG 
GCTCCTACTC CGGCACCAGC TCCTGCCCCA GCTGCAGCCC CAGCCGGGAG CACAGGGACT 
GGGGGGGCCG GGGTAGGAAG TGGAGGGGAT CCGGCTCGAC CTGGCCTGAG CCAGCAGCAG 
CGCGCTAGCC AGAGAAAGGC GCAAGTCCGG GGGCTGCCGC GTGCCAAGAA GCTTGAGAAA 
CTAGGGGTCT TCTCAGCTTG CAAGGCCAAT GAAACCTGCA AGTGTAATGG CTGGAAAAAC 
CCCAAGCCCC CCACTGCACC CCGCATGGAC CTACAGCAGC CAGCTGCTAA CCTGAGCGAG 
TTGTGCCGCA GCTGTGAGCA CCCCTTGGCG GACCATGTGT CCCACCTGGA GAATGTGTCA 
GAGGATGAGA TTAACCGGCT CTTGGGAATG GTAGTGGATG TAGAAAATCT GTTCATGTCT 
GTTCACAAGG AAGAGGACAC GGACACCAAG CAGGTCTATT TCTACCTCTT CAAGCTCCTG 
CGGAAATGCA TCCTGCAAAT GACACGACCA GTGGTGGAGG GATCCCTAGG CAGCCCGCCA 
TTTGAGAAGC CTAACATCGA GCAGGGTGTT CTGAACTTTG TGCAGTACAA ATTTAGCCAC 
CTGGCCCCCC GGGAGCGGCA GACAATGTTC GAGCTCTCAA AGATGTTCCT GCTCTGCCTT 
AACTACTGGA AGCTGGAGAC CCCTGCTCAA TTCCGGCAGC GATCCCAGTC TGAGGATGTT 
GCTACCTATA AGGTCAATTA TACCAGATGG CTCTGTTACT GCCACGTGCC TCAGAGCTGC 
GACAGCCTCC CCCGATATGA GACCACCCAT GTGTTTGGCC GAAGCCTTCT GCGGTCCATT 
TTTACTGTCA CCCGCCGGCA GCTACTGGAA AAATTTCGGG TGGAGAAGGA CAAACTGGTG 
CCCGAGAAGA GGACCCTCAT CCTCACTCAC TTCCCCAAGT TCCTGTCCAT GCTTGAGGAA 
GAGATCTACG GGGCGAATTC CCCCATCTGG GAGTCAGGCT TCACCATGCC ACCTTCGGAG 
GGGACACAGC TGGTGCCCCG GCCAGCGACT GTCAGTGCAA CAGTTGTACC CAGCACTCCC 
ATCTTCAGTC CTTCCATGGG CGGAGGCAGC AACAGCTCCC TGAGCCTAGA TTCCACAGGG 
ACAGAGCCCA TGCCAGCAGG AGAGAAGAGG AAGCTTCCTG AGAACCTGAC TCTGGAGGAT 
GCTAAGCGGC TCCGAGTGAT GGGCGACATT CCCATGGAGC TGGTCAACGA GGTCATGCTG 
ACCATCACCG ACCCTGCTGC CATGCTGGGG CCCGAGACGA GCCTGCTTTC AGCCAACGCA 
GCTCGAGATG AAACAGCTCG CCTGGAAGAG CGTCGAGGGA TCATCGAATT CCACGTCATT 
GGCAACTCTC TGACGCCCAA GGCCAACCGG CGTGTGCTGC TGTGGCTTGT GGGGCTGCAG 
AACGTCTTCT CCCACCAGCT GCCACGAATG CCCAAGGAAT ATATTGCCCG CCTCGTCTTT 
GACCCGAAGC ATAAGACCCT GGCCTTGATC AAGGATGGGC GGGTCATCGG TGGGATTTGC 
TTCCGCATGT TTCCCACCCA GGGCTTCACG GAAATCGTCT TCTGTGCTGT CACCTCAAAT 
GAGCAGGTCA AGGGCTATGG CACCCACCTG ATGAATCACC TGAAGGAGTA CCACATCAAA 
CACAGCATCC TGTACTTCCT CACCTACGCC GACGAGTACG CCATCGGCTA CTTCAAGAAG 
CAGGGCTTCT CCAAGGACAT CAAGGTGCCC AAGAGCCGAT ATCTGGGCTA CATCAAGGAC 
TATGAGGGAG CGACCCTGAT GGAGTGTGAG CTGAACCCCC GCATCCCCTA CACAGAGCTG 
TCCCACATCA TCAAGAAGCA GAAGGAGATC ATCAAGAAGT TGATTGAGCG CAAACAGGCA 
CAGATCCGAA AGGTTTACCC TGGACTCAGC TGCTTCAAAG AAGGAGTGAG GCAGATCCCT 
GTGGAGAGCG TCCCTGGCAT TCGAGAGACA GGCTGGAAGC CACTGGGAAA GGAGAAGGGC 
AAGGAGCTGA AGGACCCTGA CCAGCTGTAT ACGACCCTCA AAAACCTGCT GGCTCAGATC 
AAGTCACACC CCAGTGCCTG GCCCTTCATG GAACCTGTGA AGAAGTCGGA GGCCCCTGAC 
TACTACGAGG TTATCCGCTT CCCCATTGAC CTGAAGACCA TGACAGAACG GTTGCGCAGC 
CGCTACTATG TGACCCGGAA GCTCTTTGTA GCCGACCTGC AGCGGGTCAT CGCCAACTGC 
CGGGAGTACA ATCCCCCAGA CAGCGAATAT TGTCGCTGCG CCAGTGCCCT GGAGAAGTTC 
TTCTACTTCA AGCTCAAAGA AGGAGGGCTC ATTGACAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006247379.1
CDS	76..2577
Translation	MAEPSQAPNPAPAAQPRPLQSPAPAPTSTPAPSPASAPTPAPTPAPAPAPAAAPAGSTGTGGAGVGSGGDPARPGLSQQQRASQRKAQVRGLPRAKKLEKLGVFSACKANETCKCNGWKNPKPPTAPRMDLQQPAANLSELCRSCEHPLADHVSHLENVSEDEINRLLGMVVDVENLFMSVHKEEDTDTKQVYFYLFKLLRKCILQMTRPVVEGSLGSPPFEKPNIEQGVLNFVQYKFSHLAPRERQTMFELSKMFLLCLNYWKLETPAQFRQRSQSEDVATYKVNYTRWLCYCHVPQSCDSLPRYETTHVFGRSLLRSIFTVTRRQLLEKFRVEKDKLVPEKRTLILTHFPKFLSMLEEEIYGANSPIWESGFTMPPSEGTQLVPRPATVSATVVPSTPIFSPSMGGGSNSSLSLDSTGTEPMPAGEKRKLPENLTLEDAKRLRVMGDIPMELVNEVMLTITDPAAMLGPETSLLSANAARDETARLEERRGIIEFHVIGNSLTPKANRRVLLWLVGLQNVFSHQLPRMPKEYIARLVFDPKHKTLALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHSILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDYEGATLMECELNPRIPYTELSHIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKEGVRQIPVESVPGIRETGWKPLGKEKGKELKDPDQLYTTLKNLLAQIKSHPSAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTERLRSRYYVTRKLFVADLQRVIANCREYNPPDSEYCRCASALEKFFYFKLKEGGLIDK

Target ORF information:

RefSeq Version	XM_006247317.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus lysine acetyltransferase 2A (Kat2a), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006247317.3

ORF Insert Sequence:

ATGGCGGAAC CTTCCCAGGC CCCAAACCCG GCCCCGGCAG CGCAGCCCCG GCCCCTTCAG 
TCCCCGGCCC CTGCCCCAAC TTCGACTCCT GCGCCCAGTC CGGCTTCAGC CCCCACTCCG 
GCTCCTACTC CGGCACCAGC TCCTGCCCCA GCTGCAGCCC CAGCCGGGAG CACAGGGACT 
GGGGGGGCCG GGGTAGGAAG TGGAGGGGAT CCGGCTCGAC CTGGCCTGAG CCAGCAGCAG 
CGCGCTAGCC AGAGAAAGGC GCAAGTCCGG GGGCTGCCGC GTGCCAAGAA GCTTGAGAAA 
CTAGGGGTCT TCTCAGCTTG CAAGGCCAAT GAAACCTGCA AGTGTAATGG CTGGAAAAAC 
CCCAAGCCCC CCACTGCACC CCGCATGGAC CTACAGCAGC CAGCTGCTAA CCTGAGCGAG 
TTGTGCCGCA GCTGTGAGCA CCCCTTGGCG GACCATGTGT CCCACCTGGA GAATGTGTCA 
GAGGATGAGA TTAACCGGCT CTTGGGAATG GTAGTGGATG TAGAAAATCT GTTCATGTCT 
GTTCACAAGG AAGAGGACAC GGACACCAAG CAGGTCTATT TCTACCTCTT CAAGCTCCTG 
CGGAAATGCA TCCTGCAAAT GACACGACCA GTGGTGGAGG GATCCCTAGG CAGCCCGCCA 
TTTGAGAAGC CTAACATCGA GCAGGGTGTT CTGAACTTTG TGCAGTACAA ATTTAGCCAC 
CTGGCCCCCC GGGAGCGGCA GACAATGTTC GAGCTCTCAA AGATGTTCCT GCTCTGCCTT 
AACTACTGGA AGCTGGAGAC CCCTGCTCAA TTCCGGCAGC GATCCCAGTC TGAGGATGTT 
GCTACCTATA AGGTCAATTA TACCAGATGG CTCTGTTACT GCCACGTGCC TCAGAGCTGC 
GACAGCCTCC CCCGATATGA GACCACCCAT GTGTTTGGCC GAAGCCTTCT GCGGTCCATT 
TTTACTGTCA CCCGCCGGCA GCTACTGGAA AAATTTCGGG TGGAGAAGGA CAAACTGGTG 
CCCGAGAAGA GGACCCTCAT CCTCACTCAC TTCCCCAAGT TCCTGTCCAT GCTTGAGGAA 
GAGATCTACG GGGCGAATTC CCCCATCTGG GAGTCAGGCT TCACCATGCC ACCTTCGGAG 
GGGACACAGC TGGTGCCCCG GCCAGCGACT GTCAGTGCAA CAGTTGTACC CAGCACTCCC 
ATCTTCAGTC CTTCCATGGG CGGAGGCAGC AACAGCTCCC TGAGCCTAGA TTCCACAGGG 
ACAGAGCCCA TGCCAGCAGG AGAGAAGAGG AAGCTTCCTG AGAACCTGAC TCTGGAGGAT 
GCTAAGCGGC TCCGAGTGAT GGGCGACATT CCCATGGAGC TGGTCAACGA GGTCATGCTG 
ACCATCACCG ACCCTGCTGC CATGCTGGGG CCCGAGACGA GCCTGCTTTC AGCCAACGCA 
GCTCGAGATG AAACAGCTCG CCTGGAAGAG CGTCGAGGGA TCATCGAATT CCACGTCATT 
GGCAACTCTC TGACGCCCAA GGCCAACCGG CGTGTGCTGC TGTGGCTTGT GGGGCTGCAG 
AACGTCTTCT CCCACCAGCT GCCACGAATG CCCAAGGAAT ATATTGCCCG CCTCGTCTTT 
GACCCGAAGC ATAAGACCCT GGCCTTGATC AAGGATGGGC GGGTCATCGG TGGGATTTGC 
TTCCGCATGT TTCCCACCCA GGGCTTCACG GAAATCGTCT TCTGTGCTGT CACCTCAAAT 
GAGCAGGTCA AGGGCTATGG CACCCACCTG ATGAATCACC TGAAGGAGTA CCACATCAAA 
CACAGCATCC TGTACTTCCT CACCTACGCC GACGAGTACG CCATCGGCTA CTTCAAGAAG 
CAGGGCTTCT CCAAGGACAT CAAGGTGCCC AAGAGCCGAT ATCTGGGCTA CATCAAGGAC 
TATGAGGGAG CGACCCTGAT GGAGTGTGAG CTGAACCCCC GCATCCCCTA CACAGAGCTG 
TCCCACATCA TCAAGAAGCA GAAGGAGATC ATCAAGAAGT TGATTGAGCG CAAACAGGCA 
CAGATCCGAA AGGTTTACCC TGGACTCAGC TGCTTCAAAG AAGGAGTGAG GCAGATCCCT 
GTGGAGAGCG TCCCTGGCAT TCGAGAGACA GGCTGGAAGC CACTGGGAAA GGAGAAGGGC 
AAGGAGCTGA AGGACCCTGA CCAGCTGTAT ACGACCCTCA AAAACCTGCT GGCTCAGATC 
AAGTCACACC CCAGTGCCTG GCCCTTCATG GAACCTGTGA AGAAGTCGGA GGCCCCTGAC 
TACTACGAGG TTATCCGCTT CCCCATTGAC CTGAAGACCA TGACAGAACG GTTGCGCAGC 
CGCTACTATG TGACCCGGAA GCTCTTTGTA GCCGACCTGC AGCGGGTCAT CGCCAACTGC 
CGGGAGTACA ATCCCCCAGA CAGCGAATAT TGTCGCTGCG CCAGTGCCCT GGAGAAGTTC 
TTCTACTTCA AGCTCAAAGA AGGAGGGCTC ATTGACAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

KAT2A coupled with the ?-KGDH complex acts as a histone H3 succinyltransferase.
Nature552(7684)273-277(2017 Dec)
Wang Y,Guo YR,Liu K,Yin Z,Liu R,Xia Y,Tan L,Yang P,Lee JH,Li XJ,Hawke D,Zheng Y,Qian X,Lyu J,He J,Xing D,Tao YJ,Lu Z

Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development.
Journal of molecular and cellular cardiology114185-198(2017 Nov)
Ghosh TK,Aparicio-S?nchez JJ,Buxton S,Ketley A,Mohamed T,Rutland CS,Loughna S,Brook JD

The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation.
Journal of immunology (Baltimore, Md. : 1950)198(10)3927-3938(2017 May)
Gao B,Kong Q,Zhang Y,Yun C,Dent SYR,Song J,Zhang DD,Wang Y,Li X,Fang D

Loss of GCN5 leads to increased neuronal apoptosis by upregulating E2F1- and Egr-1-dependent BH3-only protein Bim.
Cell death & disease8(1)e2570(2017 Jan)
Wu Y,Ma S,Xia Y,Lu Y,Xiao S,Cao Y,Zhuang S,Tan X,Fu Q,Xie L,Li Z,Yuan Z

KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification.
Nature communications713227(2016 Oct)
Fournier M,Orpinell M,Grauffel C,Scheer E,Garnier JM,Ye T,Chavant V,Joint M,Esashi F,Dejaegere A,G?nczy P,Tora L

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Kat2a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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