Grhl2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Grhl2
Entrez Gene ID	299979
Full Name	grainyhead-like transcription factor 2
Synonyms	RGD1561191
General protein information	Preferred Names grainyhead-like transcription factor 2 Names grainyhead-like protein 2 homolog grainyhead-like 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q22

mRNA and Protein(s)

mRNA	Protein	Name
NM_001134527.1	NP_001127999.1	grainyhead-like protein 2 homolog
XM_006241552.2	XP_006241614.1	grainyhead-like protein 2 homolog isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	GRHL2	NP_079191.2
	GRHL2	XP_001098439.2
Canis lupus familiaris (dog)	GRHL2	XP_005627890.1
Gallus gallus (chicken)	GRHL2	XP_004940038.1
Xenopus tropicalis (tropical clawed frog)	grhl2	NP_001011338.1
Pan troglodytes (chimpanzee)	GRHL2	XP_519890.3
Mus musculus (house mouse)	Grhl2	NP_080772.2
Bos taurus (cattle)	GRHL2	XP_002692840.1
Rattus norvegicus (Norway rat)	Grhl2	NP_001127999.1
Danio rerio (zebrafish)	grhl2b	NP_001076541.1

Gene Ontology
Bibliography

Related articles in PubMed

Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.
Ming Q, Roske Y, Schuetz A, Walentin K, Ibraimi I, Schmidt-Ott KM, Heinemann U
Nucleic acids research(2018 Jan)

A Grhl2-dependent gene network controls trophoblast branching morphogenesis.
Walentin K, Hinze C, Werth M, Haase N, Varma S, Morell R, Aue A, P?tschke E, Warburton D, Qiu A, Barasch J, Purf?rst B, Dieterich C, Popova E, Bader M, Dechend R, Staff AC, Yurtdas ZY, Kilic E, Schmidt-Ott KM
Development (Cambridge, England)142(6)1125-36(2015 Mar)

Mutations in GRHL2 result in an autosomal-recessive ectodermal Dysplasia syndrome.
Petrof G, Nanda A, Howden J, Takeichi T, McMillan JR, Aristodemou S, Ozoemena L, Liu L, South AP, Pourreyron C, Dafou D, Proudfoot LE, Al-Ajmi H, Akiyama M, McLean WH, Simpson MA, Parsons M, McGrath JA
American journal of human genetics95(3)308-14(2014 Sep)

Dual roles of the transcription factor grainyhead-like 2 (GRHL2) in breast cancer.
Werner S, Frey S, Riethdorf S, Schulze C, Alawi M, Kling L, Vafaizadeh V, Sauter G, Terracciano L, Schumacher U, Pantel K, Assmann V
The Journal of biological chemistry288(32)22993-3008(2013 Aug)

Grainyhead-like 2 (GRHL2) inhibits keratinocyte differentiation through epigenetic mechanism.
Chen W, Xiao Liu Z, Oh JE, Shin KH, Kim RH, Jiang M, Park NH, Kang MK
Cell death & disease3e450(2012 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Grhl2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Grhl2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02733	NM_001134527.1 Latest version!	Rattus norvegicus grainyhead-like transcription factor 2 (Grhl2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
ORa30307	XM_006241552.2 Latest version!	Rattus norvegicus grainyhead-like transcription factor 2 (Grhl2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Grhl2 ( NM_001134527.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001127999.1 Rattus norvegicus grainyhead-like transcription factor 2 (Grhl2), mRNA.

Price & Availability↑

CloneID	ORa02733
Clone ID Related Accession (Same CDS sequence)	NM_001134527.1
Accession Version	NM_001134527.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1881bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Rattus norvegicus(Norway rat)
Product	grainyhead-like protein 2 homolog
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC168688.1. On or before Sep 4, 2008 this sequence version replaced XM_238505.4, XM_001060905.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC168688.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689597, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGTCACAAG AGTCGGACAA TAATAAAAGA CTAGTGGCCT TGGTGCCCAT GCCCAGTGAC 
CCTCCCTTCA ACACCCGAAG AGCCTACACA AGTGAGGATG AGGCCTGGAA GTCGTATCTG 
GAGAACCCCC TGACGGCAGC CACCAAGGCA ATGATGAGCA TCAATGGGGA TGAGGACAGT 
GCTGCTGCCC TGGGCCTTCT CTATGACTAC TACAAGGTTC CTCGAGACAA GAGACTTCTG 
TCTGTGAGCA AAGCAAGCGA CAGCCAAGAA GACGAGGAAA AAAGAAACTG TCTTGGCACC 
AGCGAAGCCC AGATCAACTT GAGCGGAGGC GAGAACCGAG TGCAGGTTCT GAAGACCGTC 
CCTGTGAACC TCTGCCTGAG TCAAGACCAC ATGGAGAATT CGAAGCGTGA GCAGTACAGC 
GTGTCCATCA CTGAGAGCCC CGCCGTCATC CCCGTGTCGG GCATCACGGT GGTGAAAGCT 
GAGGATTTCA CGCCCGTGTT CATGGCGCCC CCGGTGCACT ATCCCCGCGC GGACGGTGGC 
GAGGAGCAGC GCGTGGTTAT CTTTGAACAG ACTCAGTATG ACCTGCCCTC CATAGCCAGC 
CACAGCTCCT ATCTAAAGGA CGACCAGCGC AGCACGCCCG ACAGCACCTA CAGCGAGAGC 
TTCAAGGACG GCGCCCCGGA GAAATTTCGG AGTACTTCTG TTGGTGCTGA TGAGTATACA 
TATGACCAGA CGGGGAGTGG TACATTTCAG TACACCCTGG AAGCCACCAA ATCTCTCCGG 
CAGAAGCAGG GGGAGGGCCC CATGACCTAC CTCAACAAAG GACAATTCTA TGCCATAACA 
CTCAGTGAGA CTGGAGACAA CAAATGCTTC CGACACCCCA TCAGCAAAGT CAGGAGTGTA 
GTGATGGTGG TCTTTAGTGA AGACAAAAAC CGAGACGAAC AGCTGAAGTA CTGGAAGTAC 
TGGCACTCCC GGCAGCACAC TGCTAAGCAG AGGGTCCTTG ACATTGCTGA TTACAAGGAA 
AGCTTCAACA CCATCGGGAA CATTGAAGAG ATCGCATACA ATGCCGTTTC CTTCACCTGG 
GATGTGAATG AGGAGGCGAA GATCTTCATC ACCGTGAACT GCTTGAGTAC AGATTTCTCC 
TCCCAGAAGG GTGTGAAAGG ACTTCCTCTG ATGATTCAGA TCGACACGTA CAGCTATAAC 
AACCGCAGCA ATAAACCCAT CCACAGAGCG TACTGCCAGA TCAAGGTCTT CTGCGACAAG 
GGAGCAGAAA GAAAAATCCG GGATGAAGAG AGGAAGCAGA ACAGGAAGAA AGGGAAGGGC 
CAGGCCTCCC AAACCCAGTG CAGCAATTCC TCTGATGGGA AGATGGCCGC CATACCGTTA 
CAGAAGAAGA GTGACATCAC GTACTTCAAA ACCATGCCCG ACCTGCACTC ACAGCCTGTG 
CTCTTCATAC CAGATGTTCA CTTTGCCAAC CTGCAGAGGA CTGGACAGGT CTATTACAAC 
ACCGATGATG AGCGAGAAGG CAGCAGTGTC CTCGTTAAAC GGATGTTCAG GCCCATGGAA 
GAGGAATTTG GTCCAACACC GTCTAAGCAG ATTAAAGAAG AAAACGTAAA GCGAGTGCTT 
TTATACGTGA GGAAGGAGAA CGATGACGTG TTCGATGCTC TGATGCTGAA ATCGCCCACA 
GTGAAGGGCC TGATGGAAGC GCTGTCTGAG AAGTACGGGC TGCCGGTGGA GAAGATCACA 
AAGCTTTATA AGAAGAGCAA AAAGGGAATC CTGGTCAACA TGGACGACAA CATCATTGAG 
CACTATTCAA ATGAGGACAC CTTCATTCTC AACATGGAGA GCATGGTGGA AGGCTTCAAG 
ATCACATTGA TGGAGATCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001127999.1
CDS	134..2014
Translation	MSQESDNNKRLVALVPMPSDPPFNTRRAYTSEDEAWKSYLENPLTAATKAMMSINGDEDSAAALGLLYDYYKVPRDKRLLSVSKASDSQEDEEKRNCLGTSEAQINLSGGENRVQVLKTVPVNLCLSQDHMENSKREQYSVSITESPAVIPVSGITVVKAEDFTPVFMAPPVHYPRADGGEEQRVVIFEQTQYDLPSIASHSSYLKDDQRSTPDSTYSESFKDGAPEKFRSTSVGADEYTYDQTGSGTFQYTLEATKSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTAKQRVLDIADYKESFNTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFCDKGAERKIRDEERKQNRKKGKGQASQTQCSNSSDGKMAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGSSVLVKRMFRPMEEEFGPTPSKQIKEENVKRVLLYVRKENDDVFDALMLKSPTVKGLMEALSEKYGLPVEKITKLYKKSKKGILVNMDDNIIEHYSNEDTFILNMESMVEGFKITLMEI

Target ORF information:

RefSeq Version	NM_001134527.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus grainyhead-like transcription factor 2 (Grhl2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001134527.1

ORF Insert Sequence:

ATGTCACAAG AGTCGGACAA TAATAAAAGA CTAGTGGCCT TGGTGCCCAT GCCCAGTGAC 
CCTCCCTTCA ACACCCGAAG AGCCTACACA AGTGAGGATG AGGCCTGGAA GTCGTATCTG 
GAGAACCCCC TGACGGCAGC CACCAAGGCA ATGATGAGCA TCAATGGGGA TGAGGACAGT 
GCTGCTGCCC TGGGCCTTCT CTATGACTAC TACAAGGTTC CTCGAGACAA GAGACTTCTG 
TCTGTGAGCA AAGCAAGCGA CAGCCAAGAA GACGAGGAAA AAAGAAACTG TCTTGGCACC 
AGCGAAGCCC AGATCAACTT GAGCGGAGGC GAGAACCGAG TGCAGGTTCT GAAGACCGTC 
CCTGTGAACC TCTGCCTGAG TCAAGACCAC ATGGAGAATT CGAAGCGTGA GCAGTACAGC 
GTGTCCATCA CTGAGAGCCC CGCCGTCATC CCCGTGTCGG GCATCACGGT GGTGAAAGCT 
GAGGATTTCA CGCCCGTGTT CATGGCGCCC CCGGTGCACT ATCCCCGCGC GGACGGTGGC 
GAGGAGCAGC GCGTGGTTAT CTTTGAACAG ACTCAGTATG ACCTGCCCTC CATAGCCAGC 
CACAGCTCCT ATCTAAAGGA CGACCAGCGC AGCACGCCCG ACAGCACCTA CAGCGAGAGC 
TTCAAGGACG GCGCCCCGGA GAAATTTCGG AGTACTTCTG TTGGTGCTGA TGAGTATACA 
TATGACCAGA CGGGGAGTGG TACATTTCAG TACACCCTGG AAGCCACCAA ATCTCTCCGG 
CAGAAGCAGG GGGAGGGCCC CATGACCTAC CTCAACAAAG GACAATTCTA TGCCATAACA 
CTCAGTGAGA CTGGAGACAA CAAATGCTTC CGACACCCCA TCAGCAAAGT CAGGAGTGTA 
GTGATGGTGG TCTTTAGTGA AGACAAAAAC CGAGACGAAC AGCTGAAGTA CTGGAAGTAC 
TGGCACTCCC GGCAGCACAC TGCTAAGCAG AGGGTCCTTG ACATTGCTGA TTACAAGGAA 
AGCTTCAACA CCATCGGGAA CATTGAAGAG ATCGCATACA ATGCCGTTTC CTTCACCTGG 
GATGTGAATG AGGAGGCGAA GATCTTCATC ACCGTGAACT GCTTGAGTAC AGATTTCTCC 
TCCCAGAAGG GTGTGAAAGG ACTTCCTCTG ATGATTCAGA TCGACACGTA CAGCTATAAC 
AACCGCAGCA ATAAACCCAT CCACAGAGCG TACTGCCAGA TCAAGGTCTT CTGCGACAAG 
GGAGCAGAAA GAAAAATCCG GGATGAAGAG AGGAAGCAGA ACAGGAAGAA AGGGAAGGGC 
CAGGCCTCCC AAACCCAGTG CAGCAATTCC TCTGATGGGA AGATGGCCGC CATACCGTTA 
CAGAAGAAGA GTGACATCAC GTACTTCAAA ACCATGCCCG ACCTGCACTC ACAGCCTGTG 
CTCTTCATAC CAGATGTTCA CTTTGCCAAC CTGCAGAGGA CTGGACAGGT CTATTACAAC 
ACCGATGATG AGCGAGAAGG CAGCAGTGTC CTCGTTAAAC GGATGTTCAG GCCCATGGAA 
GAGGAATTTG GTCCAACACC GTCTAAGCAG ATTAAAGAAG AAAACGTAAA GCGAGTGCTT 
TTATACGTGA GGAAGGAGAA CGATGACGTG TTCGATGCTC TGATGCTGAA ATCGCCCACA 
GTGAAGGGCC TGATGGAAGC GCTGTCTGAG AAGTACGGGC TGCCGGTGGA GAAGATCACA 
AAGCTTTATA AGAAGAGCAA AAAGGGAATC CTGGTCAACA TGGACGACAA CATCATTGAG 
CACTATTCAA ATGAGGACAC CTTCATTCTC AACATGGAGA GCATGGTGGA AGGCTTCAAG 
ATCACATTGA TGGAGATCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Grhl2 ( XM_006241552.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006241614.1 Rattus norvegicus grainyhead-like transcription factor 2 (Grhl2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa30307
Clone ID Related Accession (Same CDS sequence)	XM_006241552.2
Accession Version	XM_006241552.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1878bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	grainyhead-like protein 2 homolog isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005106.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006241552.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCACAAG AGTCGGACAA TAATAAAAGA CTAGTGGCCT TGGTGCCCAT GCCCAGTGAC 
CCTCCCTTCA ACACCCGAAG AGCCTACACA AGTGAGGATG AGGCCTGGAA GTCGTATCTG 
GAGAACCCCC TGACGGCAGC CACCAAGGCA ATGATGAGCA TCAATGGGGA TGAGGACAGT 
GCTGCTGCCC TGGGCCTTCT CTATGACTAC TACAAGGTTC CTCGAGACAA GAGACTTCTG 
TCTGTGAGCA AAGCAAGCGA CAGCCAAGAA GACGAGGAAA AAAGAAACTG TCTTGGCACC 
AGCGAAGCCC AGATCAACTT GAGCGGAGGC GAGAACCGAG TGCAGGTTCT GAAGACCGTC 
CCTGTGAACC TCTGCCTGAG TCAAGACCAC ATGGAGAATT CGAAGCGTGA GCAGTACAGC 
GTGTCCATCA CTGAGAGCCC CGCCGTCATC CCCGTGTCGG GCATCACGGT GGTGAAAGCT 
GAGGATTTCA CGCCCGTGTT CATGGCGCCC CCGGTGCACT ATCCCCGCGC GGACGGTGGC 
GAGGAGCAGC GCGTGGTTAT CTTTGAACAG ACTCAGTATG ACCTGCCCTC CATAGCCAGC 
CACAGCTCCT ATCTAAAGGA CGACCAGCGC AGCACGCCCG ACAGCACCTA CAGCGAGAGC 
TTCAAGGACG GCGCCCCGGA GAAATTTCGG AGTACTTCTG TTGGTGCTGA TGAGTATACA 
TATGACCAGA CGGGGAGTGG TACATTTCAG TACACCCTGG AAGCCACCAA ATCTCTCCGG 
CAGAAGCAGG GGGAGGGCCC CATGACCTAC CTCAACAAAG GACAATTCTA TGCCATAACA 
CTCAGTGAGA CTGGAGACAA CAAATGCTTC CGACACCCCA TCAGCAAAGT CAGGAGTGTA 
GTGATGGTGG TCTTTAGTGA AGACAAAAAC CGAGACGAAC AGCTGAAGTA CTGGAAGTAC 
TGGCACTCCC GGCAGCACAC TGCTAAGCAG AGGGTCCTTG ACATTGCTGA TTACAAGGAA 
AGCTTCAACA CCATCGGGAA CATTGAAGAG ATCGCATACA ATGCCGTTTC CTTCACCTGG 
GATGTGAATG AGGAGGCGAA GATCTTCATC ACCGTGAACT GCTTGAGTAC AGATTTCTCC 
TCCCAGAAGG GTGTGAAAGG ACTTCCTCTG ATGATTCAGA TCGACACGTA CAGCTATAAC 
AACCGCAGCA ATAAACCCAT CCACAGAGCG TACTGCCAGA TCAAGGTCTT CTGCGACAAG 
GGAGCAGAAA GAAAAATCCG GGATGAAGAG AGGAAGCAGA ACAGGAAGAA AGGGAAGGGC 
CAGGCCTCCC AAACCCAGTG CAGCAATTCC TCTGATGGGA AGATGGCCGC CATACCGTTA 
CAGAAGAAGA GTGACATCAC GTACTTCAAA ACCATGCCCG ACCTGCACTC ACAGCCTGTG 
CTCTTCATAC CAGATGTTCA CTTTGCCAAC CTGCAGAGGA CTGGACAGGT CTATTACAAC 
ACCGATGATG AGCGAGAAGG CAGTGTCCTC GTTAAACGGA TGTTCAGGCC CATGGAAGAG 
GAATTTGGTC CAACACCGTC TAAGCAGATT AAAGAAGAAA ACGTAAAGCG AGTGCTTTTA 
TACGTGAGGA AGGAGAACGA TGACGTGTTC GATGCTCTGA TGCTGAAATC GCCCACAGTG 
AAGGGCCTGA TGGAAGCGCT GTCTGAGAAG TACGGGCTGC CGGTGGAGAA GATCACAAAG 
CTTTATAAGA AGAGCAAAAA GGGAATCCTG GTCAACATGG ACGACAACAT CATTGAGCAC 
TATTCAAATG AGGACACCTT CATTCTCAAC ATGGAGAGCA TGGTGGAAGG CTTCAAGATC 
ACATTGATGG AGATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006241614.1
CDS	962..2839
Translation	MSQESDNNKRLVALVPMPSDPPFNTRRAYTSEDEAWKSYLENPLTAATKAMMSINGDEDSAAALGLLYDYYKVPRDKRLLSVSKASDSQEDEEKRNCLGTSEAQINLSGGENRVQVLKTVPVNLCLSQDHMENSKREQYSVSITESPAVIPVSGITVVKAEDFTPVFMAPPVHYPRADGGEEQRVVIFEQTQYDLPSIASHSSYLKDDQRSTPDSTYSESFKDGAPEKFRSTSVGADEYTYDQTGSGTFQYTLEATKSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTAKQRVLDIADYKESFNTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFCDKGAERKIRDEERKQNRKKGKGQASQTQCSNSSDGKMAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGSVLVKRMFRPMEEEFGPTPSKQIKEENVKRVLLYVRKENDDVFDALMLKSPTVKGLMEALSEKYGLPVEKITKLYKKSKKGILVNMDDNIIEHYSNEDTFILNMESMVEGFKITLMEI

Target ORF information:

RefSeq Version	XM_006241552.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus grainyhead-like transcription factor 2 (Grhl2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006241552.2

ORF Insert Sequence:

ATGTCACAAG AGTCGGACAA TAATAAAAGA CTAGTGGCCT TGGTGCCCAT GCCCAGTGAC 
CCTCCCTTCA ACACCCGAAG AGCCTACACA AGTGAGGATG AGGCCTGGAA GTCGTATCTG 
GAGAACCCCC TGACGGCAGC CACCAAGGCA ATGATGAGCA TCAATGGGGA TGAGGACAGT 
GCTGCTGCCC TGGGCCTTCT CTATGACTAC TACAAGGTTC CTCGAGACAA GAGACTTCTG 
TCTGTGAGCA AAGCAAGCGA CAGCCAAGAA GACGAGGAAA AAAGAAACTG TCTTGGCACC 
AGCGAAGCCC AGATCAACTT GAGCGGAGGC GAGAACCGAG TGCAGGTTCT GAAGACCGTC 
CCTGTGAACC TCTGCCTGAG TCAAGACCAC ATGGAGAATT CGAAGCGTGA GCAGTACAGC 
GTGTCCATCA CTGAGAGCCC CGCCGTCATC CCCGTGTCGG GCATCACGGT GGTGAAAGCT 
GAGGATTTCA CGCCCGTGTT CATGGCGCCC CCGGTGCACT ATCCCCGCGC GGACGGTGGC 
GAGGAGCAGC GCGTGGTTAT CTTTGAACAG ACTCAGTATG ACCTGCCCTC CATAGCCAGC 
CACAGCTCCT ATCTAAAGGA CGACCAGCGC AGCACGCCCG ACAGCACCTA CAGCGAGAGC 
TTCAAGGACG GCGCCCCGGA GAAATTTCGG AGTACTTCTG TTGGTGCTGA TGAGTATACA 
TATGACCAGA CGGGGAGTGG TACATTTCAG TACACCCTGG AAGCCACCAA ATCTCTCCGG 
CAGAAGCAGG GGGAGGGCCC CATGACCTAC CTCAACAAAG GACAATTCTA TGCCATAACA 
CTCAGTGAGA CTGGAGACAA CAAATGCTTC CGACACCCCA TCAGCAAAGT CAGGAGTGTA 
GTGATGGTGG TCTTTAGTGA AGACAAAAAC CGAGACGAAC AGCTGAAGTA CTGGAAGTAC 
TGGCACTCCC GGCAGCACAC TGCTAAGCAG AGGGTCCTTG ACATTGCTGA TTACAAGGAA 
AGCTTCAACA CCATCGGGAA CATTGAAGAG ATCGCATACA ATGCCGTTTC CTTCACCTGG 
GATGTGAATG AGGAGGCGAA GATCTTCATC ACCGTGAACT GCTTGAGTAC AGATTTCTCC 
TCCCAGAAGG GTGTGAAAGG ACTTCCTCTG ATGATTCAGA TCGACACGTA CAGCTATAAC 
AACCGCAGCA ATAAACCCAT CCACAGAGCG TACTGCCAGA TCAAGGTCTT CTGCGACAAG 
GGAGCAGAAA GAAAAATCCG GGATGAAGAG AGGAAGCAGA ACAGGAAGAA AGGGAAGGGC 
CAGGCCTCCC AAACCCAGTG CAGCAATTCC TCTGATGGGA AGATGGCCGC CATACCGTTA 
CAGAAGAAGA GTGACATCAC GTACTTCAAA ACCATGCCCG ACCTGCACTC ACAGCCTGTG 
CTCTTCATAC CAGATGTTCA CTTTGCCAAC CTGCAGAGGA CTGGACAGGT CTATTACAAC 
ACCGATGATG AGCGAGAAGG CAGTGTCCTC GTTAAACGGA TGTTCAGGCC CATGGAAGAG 
GAATTTGGTC CAACACCGTC TAAGCAGATT AAAGAAGAAA ACGTAAAGCG AGTGCTTTTA 
TACGTGAGGA AGGAGAACGA TGACGTGTTC GATGCTCTGA TGCTGAAATC GCCCACAGTG 
AAGGGCCTGA TGGAAGCGCT GTCTGAGAAG TACGGGCTGC CGGTGGAGAA GATCACAAAG 
CTTTATAAGA AGAGCAAAAA GGGAATCCTG GTCAACATGG ACGACAACAT CATTGAGCAC 
TATTCAAATG AGGACACCTT CATTCTCAAC ATGGAGAGCA TGGTGGAAGG CTTCAAGATC 
ACATTGATGG AGATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.
Nucleic acids research(2018 Jan)
Ming Q,Roske Y,Schuetz A,Walentin K,Ibraimi I,Schmidt-Ott KM,Heinemann U

A Grhl2-dependent gene network controls trophoblast branching morphogenesis.
Development (Cambridge, England)142(6)1125-36(2015 Mar)
Walentin K,Hinze C,Werth M,Haase N,Varma S,Morell R,Aue A,P?tschke E,Warburton D,Qiu A,Barasch J,Purf?rst B,Dieterich C,Popova E,Bader M,Dechend R,Staff AC,Yurtdas ZY,Kilic E,Schmidt-Ott KM

Mutations in GRHL2 result in an autosomal-recessive ectodermal Dysplasia syndrome.
American journal of human genetics95(3)308-14(2014 Sep)
Petrof G,Nanda A,Howden J,Takeichi T,McMillan JR,Aristodemou S,Ozoemena L,Liu L,South AP,Pourreyron C,Dafou D,Proudfoot LE,Al-Ajmi H,Akiyama M,McLean WH,Simpson MA,Parsons M,McGrath JA

Dual roles of the transcription factor grainyhead-like 2 (GRHL2) in breast cancer.
The Journal of biological chemistry288(32)22993-3008(2013 Aug)
Werner S,Frey S,Riethdorf S,Schulze C,Alawi M,Kling L,Vafaizadeh V,Sauter G,Terracciano L,Schumacher U,Pantel K,Assmann V

Grainyhead-like 2 (GRHL2) inhibits keratinocyte differentiation through epigenetic mechanism.
Cell death & disease3e450(2012 Dec)
Chen W,Xiao Liu Z,Oh JE,Shin KH,Kim RH,Jiang M,Park NH,Kang MK

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Grhl2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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