Prps1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Prps1
Entrez Gene ID	29562
Full Name	phosphoribosyl pyrophosphate synthetase 1
General protein information	Preferred Names phosphoribosyl pyrophosphate synthetase 1 Names ribose-phosphate pyrophosphokinase 1 PRS-I phosphoribosyl pyrophosphate synthase I phosphoribosyl pyrophosphate synthetase I
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq32
Summary	may phosphorylate ribose [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017243.2	NP_058939.1	ribose-phosphate pyrophosphokinase 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PRPS1	XP_001144504.1
	PRPS1	XP_001095604.1
Gallus gallus (chicken)	PRPS1	XP_004940671.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004890	XP_001688552.1
Oryza sativa (rice)	Os02g0127700	NP_001045763.1
Danio rerio (zebrafish)	prps1b	NP_001070036.1
Arabidopsis thaliana (thale cress)	AT2G35390	NP_850244.1
Canis lupus familiaris (dog)	PRPS1	XP_005641702.1
Bos taurus (cattle)	PRPS1	NP_001039654.1
Rattus norvegicus (Norway rat)	Prps1	NP_058939.1
Drosophila melanogaster (fruit fly)	CG6767	NP_729528.2
Arabidopsis thaliana (thale cress)	PRS2	NP_174516.1
Mus musculus (house mouse)	Prps1	NP_067438.1
Arabidopsis thaliana (thale cress)	AT2G44530	NP_181981.2
Homo sapiens (human)	PRPS1	NP_002755.1

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in PRPS1 causing syndromic or nonsyndromic hearing impairment: intrafamilial phenotypic variation complicates genetic counseling.
Gand?a M, Fern?ndez-Toral J, Solanellas J, Dom?nguez-Ruiz M, G?mez-Rosas E, Del Castillo FJ, Villamar M, Moreno-Pelayo MA, Del Castillo I
Pediatric research78(1)97-102(2015 Jul)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

Expanding the phenotype of PRPS1 syndromes in females: neuropathy, hearing loss and retinopathy.
Almoguera B, He S, Corton M, Fernandez-San Jose P, Blanco-Kelly F, L?pez-Molina MI, Garc?a-Sandoval B, Del Val J, Guo Y, Tian L, Liu X, Guan L, Torres RJ, Puig JG, Hakonarson H, Xu X, Keating B, Ayuso C
Orphanet journal of rare diseases9190(2014 Dec)

Pediatric neurological syndromes and inborn errors of purine metabolism.
Camici M, Micheli V, Ipata PL, Tozzi MG
Neurochemistry international56(3)367-78(2010 Feb)

Mutations in PRPS1, which encodes the phosphoribosyl pyrophosphate synthetase enzyme critical for nucleotide biosynthesis, cause hereditary peripheral neuropathy with hearing loss and optic neuropathy (cmtx5).
Kim HJ, Sohn KM, Shy ME, Krajewski KM, Hwang M, Park JH, Jang SY, Won HH, Choi BO, Hong SH, Kim BJ, Suh YL, Ki CS, Lee SY, Kim SH, Kim JW
American journal of human genetics81(3)552-8(2007 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Prps1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Prps1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03362	NM_017243.2 Latest version!	Rattus norvegicus phosphoribosyl pyrophosphate synthetase 1 (Prps1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Prps1 ( NM_017243.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058939.1 Rattus norvegicus phosphoribosyl pyrophosphate synthetase 1 (Prps1), mRNA.

Price & Availability↑

CloneID	ORa03362
Clone ID Related Accession (Same CDS sequence)	NM_017243.2
Accession Version	NM_017243.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	ribose-phosphate pyrophosphokinase 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB702494.1, X16554.1, CO405720.1 and CK841243.1. On Apr 25, 2008 this sequence version replaced NM_017243.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X16554.1, M17258.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCGAATA TCAAAATCTT CAGCGGGAGC TCCCACCAGG ACTTATCCCA GAAAATTGCT 
GACCGCCTGG GCCTGGAGCT AGGCAAGGTG GTGACTAAGA AATTCAGCAA CCAGGAGACC 
TGTGTGGAAA TTGGGGAGAG TGTTCGTGGA GAGGATGTCT ACATTGTTCA GAGTGGCTGC 
GGTGAGATAA ATGACAATCT AATGGAGCTT TTGATCATGA TCAATGCTTG CAAGATCGCT 
TCTGCCAGCC GGGTTACTGC GGTCATCCCA TGCTTCCCTT ATGCCCGGCA GGATAAGAAG 
GATAAGAGCC GGGCTCCAAT CTCAGCTAAG CTTGTTGCAA ATATGCTATC TGTAGCAGGT 
GCGGATCATA TTATCACCAT GGATCTACAT GCATCTCAGA TTCAGGGCTT CTTTGATATC 
CCAGTGGACA ATTTATACGC AGAGCCAGCT GTCCTGAAGT GGATTCGGGA GAACATATCT 
GAGTGGAGAA ACTGTACTAT TGTCTCACCT GACGCTGGCG GAGCCAAGAG AGTGACCTCC 
ATTGCAGACC GATTGAATGT GGATTTTGCT TTGATTCACA AAGAACGGAA GAAGGCCAAT 
GAAGTGGACC GCATGGTACT AGTAGGAGAT GTGAAGGATC GTGTGGCTAT ACTTGTGGAT 
GACATGGCTG ACACTTGTGG TACAATTTGT CATGCTGCTG ACAAACTTCT CTCAGCTGGA 
GCTACCAGAG TTTATGCCAT TTTGACGCAT GGGATCTTTT CTGGCCCAGC CATTTCTCGC 
ATCAACAATG CATGCTTTGA AGCAGTAGTA GTTACCAATA CCATACCTCA GGAGGACAAG 
ATGAAACACT GCTCCAAAAT CCAGGTGATC GACATCTCTA TGATCCTTGC AGAAGCCATC 
AGGAGAACCC ACAATGGAGA ATCTGTCTCC TACCTGTTCA GCCATGTTCC TCTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058939.1
CDS	115..1071
Translation	MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL

Target ORF information:

RefSeq Version	NM_017243.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus phosphoribosyl pyrophosphate synthetase 1 (Prps1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017243.2

ORF Insert Sequence:

ATGCCGAATA TCAAAATCTT CAGCGGGAGC TCCCACCAGG ACTTATCCCA GAAAATTGCT 
GACCGCCTGG GCCTGGAGCT AGGCAAGGTG GTGACTAAGA AATTCAGCAA CCAGGAGACC 
TGTGTGGAAA TTGGGGAGAG TGTTCGTGGA GAGGATGTCT ACATTGTTCA GAGTGGCTGC 
GGTGAGATAA ATGACAATCT AATGGAGCTT TTGATCATGA TCAATGCTTG CAAGATCGCT 
TCTGCCAGCC GGGTTACTGC GGTCATCCCA TGCTTCCCTT ATGCCCGGCA GGATAAGAAG 
GATAAGAGCC GGGCTCCAAT CTCAGCTAAG CTTGTTGCAA ATATGCTATC TGTAGCAGGT 
GCGGATCATA TTATCACCAT GGATCTACAT GCATCTCAGA TTCAGGGCTT CTTTGATATC 
CCAGTGGACA ATTTATACGC AGAGCCAGCT GTCCTGAAGT GGATTCGGGA GAACATATCT 
GAGTGGAGAA ACTGTACTAT TGTCTCACCT GACGCTGGCG GAGCCAAGAG AGTGACCTCC 
ATTGCAGACC GATTGAATGT GGATTTTGCT TTGATTCACA AAGAACGGAA GAAGGCCAAT 
GAAGTGGACC GCATGGTACT AGTAGGAGAT GTGAAGGATC GTGTGGCTAT ACTTGTGGAT 
GACATGGCTG ACACTTGTGG TACAATTTGT CATGCTGCTG ACAAACTTCT CTCAGCTGGA 
GCTACCAGAG TTTATGCCAT TTTGACGCAT GGGATCTTTT CTGGCCCAGC CATTTCTCGC 
ATCAACAATG CATGCTTTGA AGCAGTAGTA GTTACCAATA CCATACCTCA GGAGGACAAG 
ATGAAACACT GCTCCAAAAT CCAGGTGATC GACATCTCTA TGATCCTTGC AGAAGCCATC 
AGGAGAACCC ACAATGGAGA ATCTGTCTCC TACCTGTTCA GCCATGTTCC TCTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in PRPS1 causing syndromic or nonsyndromic hearing impairment: intrafamilial phenotypic variation complicates genetic counseling.
Pediatric research78(1)97-102(2015 Jul)
Gand?a M,Fern?ndez-Toral J,Solanellas J,Dom?nguez-Ruiz M,G?mez-Rosas E,Del Castillo FJ,Villamar M,Moreno-Pelayo MA,Del Castillo I

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

Expanding the phenotype of PRPS1 syndromes in females: neuropathy, hearing loss and retinopathy.
Orphanet journal of rare diseases9190(2014 Dec)
Almoguera B,He S,Corton M,Fernandez-San Jose P,Blanco-Kelly F,L?pez-Molina MI,Garc?a-Sandoval B,Del Val J,Guo Y,Tian L,Liu X,Guan L,Torres RJ,Puig JG,Hakonarson H,Xu X,Keating B,Ayuso C

Pediatric neurological syndromes and inborn errors of purine metabolism.
Neurochemistry international56(3)367-78(2010 Feb)
Camici M,Micheli V,Ipata PL,Tozzi MG

Mutations in PRPS1, which encodes the phosphoribosyl pyrophosphate synthetase enzyme critical for nucleotide biosynthesis, cause hereditary peripheral neuropathy with hearing loss and optic neuropathy (cmtx5).
American journal of human genetics81(3)552-8(2007 Sep)
Kim HJ,Sohn KM,Shy ME,Krajewski KM,Hwang M,Park JH,Jang SY,Won HH,Choi BO,Hong SH,Kim BJ,Suh YL,Ki CS,Lee SY,Kim SH,Kim JW

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Prps1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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