Numbl cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Numbl
Entrez Gene ID	292732
Full Name	NUMB-like, endocytic adaptor protein
General protein information	Preferred Names NUMB-like, endocytic adaptor protein Names numb-like protein numb homolog-like
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q21

mRNA and Protein(s)

mRNA	Protein	Name
NM_001033888.1	NP_001029060.1	numb-like protein
XM_006228566.3	XP_006228628.1	numb-like protein isoform X2
XM_006228567.3	XP_006228629.1	numb-like protein isoform X3
XM_006228565.3	XP_006228627.1	numb-like protein isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	NUMBL	XP_855314.2
Xenopus tropicalis (tropical clawed frog)	numbl	XP_002938862.2
Homo sapiens (human)	NUMBL	NP_004747.1
Mus musculus (house mouse)	Numbl	NP_035080.2
Pan troglodytes (chimpanzee)	NUMBL	XP_524270.4
Rattus norvegicus (Norway rat)	Numbl	NP_001029060.1
Danio rerio (zebrafish)	numbl	NP_001012375.3
Bos taurus (cattle)	NUMBL	NP_001070302.1

Gene Ontology
Bibliography

Related articles in PubMed

Dynamic change of Numbl expression after sciatic nerve crush and its role in Schwann cell differentiation.
Zhu L, Yan Y, Ke K, Wu X, Gao Y, Shen A, Li J, Kang L, Zhang G, Wu Q, Yang H
Journal of neuroscience research90(8)1557-65(2012 Aug)

Expression of Numb and Numb-like in the development of mammalian auditory sensory epithelium.
Gao Z, Chi FL, Huang YB, Yang JM, Cong N, Li W
Neuroreport22(2)49-54(2011 Jan)

NUMBL interacts with TRAF6 and promotes the degradation of TRAF6.
Zhou L, Ma Q, Shi H, Huo K
Biochemical and biophysical research communications392(3)409-14(2010 Feb)

NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation.
Ma Q, Zhou L, Shi H, Huo K
Cellular signalling20(6)1044-51(2008 Jun)

Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors.
Rasin MR, Gazula VR, Breunig JJ, Kwan KY, Johnson MB, Liu-Chen S, Li HS, Jan LY, Jan YN, Rakic P, Sestan N
Nature neuroscience10(7)819-27(2007 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

peripheral nerve injury induced a downregulation of Numbl in the sciatic nerve, which was associated with Schwann cell differentiation.
Title: Dynamic change of Numbl expression after sciatic nerve crush and its role in Schwann cell differentiation.

We show that NUMBL is expressed in the rat auditory sensory epithelium during cochlear development
Title: Expression of Numb and Numb-like in the development of mammalian auditory sensory epithelium.

Numb and Numbl may be intracellular targets for CaM-Ks, and they may also be regulated by phosphorylation-dependent interaction with 14-3-3 protein
Title: Phosphorylation of Numb family proteins. Possible involvement of Ca2+/calmodulin-dependent protein kinases.

The following Numbl gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Numbl cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa08693	NM_001033888.1 Latest version!	Rattus norvegicus NUMB-like, endocytic adaptor protein (Numbl), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$363.30 $519.00
ORa22474	XM_006228565.3 Latest version!	Rattus norvegicus NUMB-like, endocytic adaptor protein (Numbl), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
ORa22475	XM_006228566.3 Latest version!	Rattus norvegicus NUMB-like, endocytic adaptor protein (Numbl), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
ORa22476	XM_006228567.3 Latest version!	Rattus norvegicus NUMB-like, endocytic adaptor protein (Numbl), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Numbl ( NM_001033888.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001029060.1 Rattus norvegicus NUMB-like, endocytic adaptor protein (Numbl), mRNA.

Price & Availability↑

CloneID	ORa08693
Clone ID Related Accession (Same CDS sequence)	NM_001033888.1
Accession Version	NM_001033888.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1854bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Rattus norvegicus(Norway rat)
Product	numb-like protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB210107.1. On Sep 30, 2005 this sequence version replaced XM_218360.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB210107.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTCCCGCA GCGCGGCGGC CAGCGGCGGA CCCAGGAGAC CTGATCAGCA TTTGCCCCCA 
GCCCCCTGTG GGGCCTCGGG GCCCCCTGAA ACCTTCAGGA CGGAGTCAGA CGGGGCGGGC 
ACCATGAACA AGTTACGGCA GAGTCTGCGG CGGAGGAAGC CAGCCTATGT GCCTGAGGCG 
TCACGCCCAC ACCAGTGGCA GGCAGATGAG GATGCGGTGC GGAAGGGCAC ATGCAGCTTC 
CCCGTTAGGT ACCTGGGCCA CGTGGAAGTG GAGGAGTCCC GGGGGATGCA CGTTTGTGAA 
GACGCGGTGA AGAAGCTGAA GGCGATGGGC CGGAAGTCCG TGAAGTCTGT CCTGTGGGTG 
TCGGCTGATG GGCTCCGAGT GGTGGATGAC AAGACCAAGG ACCTGCTGGT AGACCAGACC 
ATCGAGAAGG TGTCCTTCTG TGCTCCTGAC CGCAACCTGG ACAAGGCATT CTCCTACATA 
TGCCGTGATG GCACCACACG CCGCTGGATC TGCCACTGTT TCCTGGCCCT CAAGGACTCT 
GGTGAGAGGC TGAGCCACGC TGTGGGCTGC GCGTTCGCTG CCTGCCTGGA GAGGAAGCAG 
CGACGGGAGA AGGAGTGCGG AGTCACCGCC GCCTTCGATG CCAGTCGCAC CAGCTTTGCC 
CGCGAGGGCT CCTTCCGCCT GTCCGGTGGC GGGCGGCCTG CGGAGCGCGA GGCTGGGGAC 
AAGAAGAAAG AAGCAGCAGC TGCTCCTGCT GTGGCTCCTG GCCCTGCCCA GCCTGGGCAC 
GTTTCTCCGA CACCGGCCAC TACATCCCCT GGTGAGAAGG GAGAGGCGGG TACCCCAGTG 
GCTGCAGGCA CCACTGCTGC TGCCATTCCC CGGCGCCATG CACCTCTGGA ACAGCTGGTT 
CGCCAGGGCT CCTTTCGTGG GTTTCCTGCC CTCAGCCAGA AGAACTCACC TTTCAAACGT 
CAGCTGAGTC TACGGTTGAA TGAGCTGCCA TCCACACTGC AGCGCCGTAC AGACTTCCAG 
GTGAAGGGCA CAGTGCCTGA GATGGAGCCT CCTGGTACTG GTGACAGCGA CGGCATCAGT 
GCCCTGTGTA CACAAATCAG CTCGTCTTTC GCCAGTGCCG GAGCACCAGT GCCAGGGCCA 
CCGTCTGCCA CCACAGGGAC GTCTGCCTGG GGTGAGCCCT CTGTACCTGC TGCAACTGCC 
TTCCAGCCCG GGCACAAGCG GACACCGTCG GAGGCTGAGC GATGGTTGGA GGAAGTGTCC 
CAGGTGGCTA AGGCCCAACA ACAGCAGCAG CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG 
CAGCAGCAGC AGCAGCAGCA GCAGCAACAA CAACAGCAAC AAGCCACCTC CGTGCCACCA 
ATGCCCACCA TGGCCCCCAC CCTTCAACCC TTCTCCGCCC CAGTGGGGCC CTTTGACACT 
GCAGCTGCCC AGGTGGCTGT GTTCCTGCCA CCCACACACA TGCAGCCTCC ATTTGTGCCC 
GCCTACCCAG GCCTGGGTTA CCCACCCATG CCCCGGGTGC CAGTGGTGGG CATCACACCT 
TCACAGATGG TGGCCAACGC CTTCTGCTCA GCTGCTCAGC TCCAGCCCCA ACCTGCCACA 
CTGCTTGGAA AAGCCGGGGC CTTCCCCCCA CCTACCGCAC CCAGTGCCCC TGGGGGCCAG 
GCCCGTCCAC GCCCTAATGG GGCTCCCTGG CCCCCAGAGC CAGCGCCTGC CCCTGCCCCT 
GAGTTGGACC CCTTTGAGGC CCAGTGGGCA GCTTTAGAAG GCAAGCCCGC CGTGGAGAAA 
CCCTCCAACC CCTTCTCTGG TGACTTGCAG AAGACCTTCG AGATTGAACT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001029060.1
CDS	1..1854
Translation	MSRSAAASGGPRRPDQHLPPAPCGASGPPETFRTESDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAGDKKKEAAAAPAVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGTGDSDGISALCTQISSSFASAGAPVPGPPSATTGTSAWGEPSVPAATAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQQQQQQQQQQATSVPPMPTMAPTLQPFSAPVGPFDTAAAQVAVFLPPTHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPTAPSAPGGQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKPAVEKPSNPFSGDLQKTFEIEL

Target ORF information:

RefSeq Version	NM_001033888.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus NUMB-like, endocytic adaptor protein (Numbl), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033888.1

ORF Insert Sequence:

ATGTCCCGCA GCGCGGCGGC CAGCGGCGGA CCCAGGAGAC CTGATCAGCA TTTGCCCCCA 
GCCCCCTGTG GGGCCTCGGG GCCCCCTGAA ACCTTCAGGA CGGAGTCAGA CGGGGCGGGC 
ACCATGAACA AGTTACGGCA GAGTCTGCGG CGGAGGAAGC CAGCCTATGT GCCTGAGGCG 
TCACGCCCAC ACCAGTGGCA GGCAGATGAG GATGCGGTGC GGAAGGGCAC ATGCAGCTTC 
CCCGTTAGGT ACCTGGGCCA CGTGGAAGTG GAGGAGTCCC GGGGGATGCA CGTTTGTGAA 
GACGCGGTGA AGAAGCTGAA GGCGATGGGC CGGAAGTCCG TGAAGTCTGT CCTGTGGGTG 
TCGGCTGATG GGCTCCGAGT GGTGGATGAC AAGACCAAGG ACCTGCTGGT AGACCAGACC 
ATCGAGAAGG TGTCCTTCTG TGCTCCTGAC CGCAACCTGG ACAAGGCATT CTCCTACATA 
TGCCGTGATG GCACCACACG CCGCTGGATC TGCCACTGTT TCCTGGCCCT CAAGGACTCT 
GGTGAGAGGC TGAGCCACGC TGTGGGCTGC GCGTTCGCTG CCTGCCTGGA GAGGAAGCAG 
CGACGGGAGA AGGAGTGCGG AGTCACCGCC GCCTTCGATG CCAGTCGCAC CAGCTTTGCC 
CGCGAGGGCT CCTTCCGCCT GTCCGGTGGC GGGCGGCCTG CGGAGCGCGA GGCTGGGGAC 
AAGAAGAAAG AAGCAGCAGC TGCTCCTGCT GTGGCTCCTG GCCCTGCCCA GCCTGGGCAC 
GTTTCTCCGA CACCGGCCAC TACATCCCCT GGTGAGAAGG GAGAGGCGGG TACCCCAGTG 
GCTGCAGGCA CCACTGCTGC TGCCATTCCC CGGCGCCATG CACCTCTGGA ACAGCTGGTT 
CGCCAGGGCT CCTTTCGTGG GTTTCCTGCC CTCAGCCAGA AGAACTCACC TTTCAAACGT 
CAGCTGAGTC TACGGTTGAA TGAGCTGCCA TCCACACTGC AGCGCCGTAC AGACTTCCAG 
GTGAAGGGCA CAGTGCCTGA GATGGAGCCT CCTGGTACTG GTGACAGCGA CGGCATCAGT 
GCCCTGTGTA CACAAATCAG CTCGTCTTTC GCCAGTGCCG GAGCACCAGT GCCAGGGCCA 
CCGTCTGCCA CCACAGGGAC GTCTGCCTGG GGTGAGCCCT CTGTACCTGC TGCAACTGCC 
TTCCAGCCCG GGCACAAGCG GACACCGTCG GAGGCTGAGC GATGGTTGGA GGAAGTGTCC 
CAGGTGGCTA AGGCCCAACA ACAGCAGCAG CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG 
CAGCAGCAGC AGCAGCAGCA GCAGCAACAA CAACAGCAAC AAGCCACCTC CGTGCCACCA 
ATGCCCACCA TGGCCCCCAC CCTTCAACCC TTCTCCGCCC CAGTGGGGCC CTTTGACACT 
GCAGCTGCCC AGGTGGCTGT GTTCCTGCCA CCCACACACA TGCAGCCTCC ATTTGTGCCC 
GCCTACCCAG GCCTGGGTTA CCCACCCATG CCCCGGGTGC CAGTGGTGGG CATCACACCT 
TCACAGATGG TGGCCAACGC CTTCTGCTCA GCTGCTCAGC TCCAGCCCCA ACCTGCCACA 
CTGCTTGGAA AAGCCGGGGC CTTCCCCCCA CCTACCGCAC CCAGTGCCCC TGGGGGCCAG 
GCCCGTCCAC GCCCTAATGG GGCTCCCTGG CCCCCAGAGC CAGCGCCTGC CCCTGCCCCT 
GAGTTGGACC CCTTTGAGGC CCAGTGGGCA GCTTTAGAAG GCAAGCCCGC CGTGGAGAAA 
CCCTCCAACC CCTTCTCTGG TGACTTGCAG AAGACCTTCG AGATTGAACT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Numbl ( XM_006228565.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006228627.1 Rattus norvegicus NUMB-like, endocytic adaptor protein (Numbl), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa22474
Clone ID Related Accession (Same CDS sequence)	XM_006228565.3
Accession Version	XM_006228565.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1926bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	numb-like protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006228565.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACTACCA GGTTTCCTAC TAGGGAGCCT GAGATGGAGG GGGCTGAAGA GGGGACCAAA 
TCCCCTGCCC CAACAAACTT CTCATTGTCT CACTCCCTTG AGCAGGGCGG ACCCAGGAGA 
CCTGATCAGC ATTTGCCCCC AGCCCCCTGT GGGGCCTCGG GGCCCCCTGA AACCTTCAGG 
ACGGAGTCAG ACGGGGCGGG CACCATGAAC AAGTTACGGC AGAGTCTGCG GCGGAGGAAG 
CCAGCCTATG TGCCTGAGGC GTCACGCCCA CACCAGTGGC AGGCAGATGA GGATGCGGTG 
CGGAAGGGCA CATGCAGCTT CCCCGTTAGG TACCTGGGCC ACGTGGAAGT GGAGGAGTCC 
CGGGGGATGC ACGTTTGTGA AGACGCGGTG AAGAAGCTGA AGGCGATGGG CCGGAAGTCC 
GTGAAGTCTG TCCTGTGGGT GTCGGCTGAT GGGCTCCGAG TGGTGGATGA CAAGACCAAG 
GACCTGCTGG TAGACCAGAC CATCGAGAAG GTGTCCTTCT GTGCTCCTGA CCGCAACCTG 
GACAAGGCAT TCTCCTACAT ATGCCGTGAT GGCACCACAC GCCGCTGGAT CTGCCACTGT 
TTCCTGGCCC TCAAGGACTC TGGTGAGAGG CTGAGCCACG CTGTGGGCTG CGCGTTCGCT 
GCCTGCCTGG AGAGGAAGCA GCGACGGGAG AAGGAGTGCG GAGTCACCGC CGCCTTCGAT 
GCCAGTCGCA CCAGCTTTGC CCGCGAGGGC TCCTTCCGCC TGTCCGGTGG CGGGCGGCCT 
GCGGAGCGCG AGGCTGGGGA CAAGAAGAAA GCAGAAGCAG CAGCTGCTCC TGCTGTGGCT 
CCTGGCCCTG CCCAGCCTGG GCACGTTTCT CCGACACCGG CCACTACATC CCCTGGTGAG 
AAGGGAGAGG CGGGTACCCC AGTGGCTGCA GGCACCACTG CTGCTGCCAT TCCCCGGCGC 
CATGCACCTC TGGAACAGCT GGTTCGCCAG GGCTCCTTTC GTGGGTTTCC TGCCCTCAGC 
CAGAAGAACT CACCTTTCAA ACGTCAGCTG AGTCTACGGT TGAATGAGCT GCCATCCACA 
CTGCAGCGCC GTACAGACTT CCAGGTGAAG GGCACAGTGC CTGAGATGGA GCCTCCTGGT 
ACTGGTGACA GCGACGGCAT CAGTGCCCTG TGCACACAAA TCAGCTCGTC TTTCGCCAGT 
GCCGGAGCAC CAGTGCCAGG GCCACCGTCT GCCACCACAG GGACGTCTGC CTGGGGTGAG 
CCCTCTGTAC CTGCTGCAAC TGCCTTCCAG CCCGGGCACA AGCGGACACC GTCGGAGGCT 
GAGCGATGGT TGGAGGAAGT GTCCCAGGTG GCTAAGGCCC AACAACAGCA GCAGCAGCAG 
CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG CAGCAGCAAC AACAACAGCA ACAAGCCACC 
TCCGTGCCAC CAATGCCCAC CATGGCCCCC ACCCTTCAAC CCTTCTCCAC CCCAGTGGGG 
CCCTTTGACA CTGCAGCTGC CCAGGTGGCT GTGTTCCTGC CACCCACACA CATGCAGCCT 
CCATTTGTGC CCGCCTACCC AGGCCTGGGT TACCCACCCA TGCCCCGGGT GCCAGTGGTG 
GGCATCACAC CTTCACAGAT GGTGGCCAAC GCCTTCTGCT CAGCTGCTCA GCTCCAGCCC 
CAACCTGCCA CACTGCTTGG AAAAGCCGGG GCCTTCCCCC CACCTACCGC ACCCAGTGCC 
CCTGGGGGCC AGGCCCGTCC ACGCCCTAAT GGGGCTCCCT GGCCCCCAGA GCCAGCGCCT 
GCCCCTGCCC CTGAGTTGGA CCCCTTTGAG GCCCAGTGGG CAGCTTTAGA AGGCAAGCCC 
GCCGTGGAGA AACCCTCCAA CCCCTTCTCT GGTGACTTGC AGAAGACCTT CGAGATTGAA 
CTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006228627.1
CDS	3079..5004
Translation	MTTRFPTREPEMEGAEEGTKSPAPTNFSLSHSLEQGGPRRPDQHLPPAPCGASGPPETFRTESDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAGDKKKAEAAAAPAVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGTGDSDGISALCTQISSSFASAGAPVPGPPSATTGTSAWGEPSVPAATAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQQQQQQATSVPPMPTMAPTLQPFSTPVGPFDTAAAQVAVFLPPTHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPTAPSAPGGQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKPAVEKPSNPFSGDLQKTFEIEL

Target ORF information:

RefSeq Version	XM_006228565.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus NUMB-like, endocytic adaptor protein (Numbl), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006228565.3

ORF Insert Sequence:

ATGACTACCA GGTTTCCTAC TAGGGAGCCT GAGATGGAGG GGGCTGAAGA GGGGACCAAA 
TCCCCTGCCC CAACAAACTT CTCATTGTCT CACTCCCTTG AGCAGGGCGG ACCCAGGAGA 
CCTGATCAGC ATTTGCCCCC AGCCCCCTGT GGGGCCTCGG GGCCCCCTGA AACCTTCAGG 
ACGGAGTCAG ACGGGGCGGG CACCATGAAC AAGTTACGGC AGAGTCTGCG GCGGAGGAAG 
CCAGCCTATG TGCCTGAGGC GTCACGCCCA CACCAGTGGC AGGCAGATGA GGATGCGGTG 
CGGAAGGGCA CATGCAGCTT CCCCGTTAGG TACCTGGGCC ACGTGGAAGT GGAGGAGTCC 
CGGGGGATGC ACGTTTGTGA AGACGCGGTG AAGAAGCTGA AGGCGATGGG CCGGAAGTCC 
GTGAAGTCTG TCCTGTGGGT GTCGGCTGAT GGGCTCCGAG TGGTGGATGA CAAGACCAAG 
GACCTGCTGG TAGACCAGAC CATCGAGAAG GTGTCCTTCT GTGCTCCTGA CCGCAACCTG 
GACAAGGCAT TCTCCTACAT ATGCCGTGAT GGCACCACAC GCCGCTGGAT CTGCCACTGT 
TTCCTGGCCC TCAAGGACTC TGGTGAGAGG CTGAGCCACG CTGTGGGCTG CGCGTTCGCT 
GCCTGCCTGG AGAGGAAGCA GCGACGGGAG AAGGAGTGCG GAGTCACCGC CGCCTTCGAT 
GCCAGTCGCA CCAGCTTTGC CCGCGAGGGC TCCTTCCGCC TGTCCGGTGG CGGGCGGCCT 
GCGGAGCGCG AGGCTGGGGA CAAGAAGAAA GCAGAAGCAG CAGCTGCTCC TGCTGTGGCT 
CCTGGCCCTG CCCAGCCTGG GCACGTTTCT CCGACACCGG CCACTACATC CCCTGGTGAG 
AAGGGAGAGG CGGGTACCCC AGTGGCTGCA GGCACCACTG CTGCTGCCAT TCCCCGGCGC 
CATGCACCTC TGGAACAGCT GGTTCGCCAG GGCTCCTTTC GTGGGTTTCC TGCCCTCAGC 
CAGAAGAACT CACCTTTCAA ACGTCAGCTG AGTCTACGGT TGAATGAGCT GCCATCCACA 
CTGCAGCGCC GTACAGACTT CCAGGTGAAG GGCACAGTGC CTGAGATGGA GCCTCCTGGT 
ACTGGTGACA GCGACGGCAT CAGTGCCCTG TGCACACAAA TCAGCTCGTC TTTCGCCAGT 
GCCGGAGCAC CAGTGCCAGG GCCACCGTCT GCCACCACAG GGACGTCTGC CTGGGGTGAG 
CCCTCTGTAC CTGCTGCAAC TGCCTTCCAG CCCGGGCACA AGCGGACACC GTCGGAGGCT 
GAGCGATGGT TGGAGGAAGT GTCCCAGGTG GCTAAGGCCC AACAACAGCA GCAGCAGCAG 
CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG CAGCAGCAAC AACAACAGCA ACAAGCCACC 
TCCGTGCCAC CAATGCCCAC CATGGCCCCC ACCCTTCAAC CCTTCTCCAC CCCAGTGGGG 
CCCTTTGACA CTGCAGCTGC CCAGGTGGCT GTGTTCCTGC CACCCACACA CATGCAGCCT 
CCATTTGTGC CCGCCTACCC AGGCCTGGGT TACCCACCCA TGCCCCGGGT GCCAGTGGTG 
GGCATCACAC CTTCACAGAT GGTGGCCAAC GCCTTCTGCT CAGCTGCTCA GCTCCAGCCC 
CAACCTGCCA CACTGCTTGG AAAAGCCGGG GCCTTCCCCC CACCTACCGC ACCCAGTGCC 
CCTGGGGGCC AGGCCCGTCC ACGCCCTAAT GGGGCTCCCT GGCCCCCAGA GCCAGCGCCT 
GCCCCTGCCC CTGAGTTGGA CCCCTTTGAG GCCCAGTGGG CAGCTTTAGA AGGCAAGCCC 
GCCGTGGAGA AACCCTCCAA CCCCTTCTCT GGTGACTTGC AGAAGACCTT CGAGATTGAA 
CTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Numbl ( XM_006228566.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006228628.1 Rattus norvegicus NUMB-like, endocytic adaptor protein (Numbl), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa22475
Clone ID Related Accession (Same CDS sequence)	XM_006228566.3
Accession Version	XM_006228566.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1923bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	numb-like protein isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006228566.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACTACCA GGTTTCCTAC TAGGGAGCCT GAGATGGAGG GGGCTGAAGA GGGGACCAAA 
TCCCCTGCCC CAACAAACTT CTCATTGTCT CACTCCCTTG AGCAGGGCGG ACCCAGGAGA 
CCTGATCAGC ATTTGCCCCC AGCCCCCTGT GGGGCCTCGG GGCCCCCTGA AACCTTCAGG 
ACGGAGTCAG ACGGGGCGGG CACCATGAAC AAGTTACGGC AGAGTCTGCG GCGGAGGAAG 
CCAGCCTATG TGCCTGAGGC GTCACGCCCA CACCAGTGGC AGGCAGATGA GGATGCGGTG 
CGGAAGGGCA CATGCAGCTT CCCCGTTAGG TACCTGGGCC ACGTGGAAGT GGAGGAGTCC 
CGGGGGATGC ACGTTTGTGA AGACGCGGTG AAGAAGCTGA AGGCGATGGG CCGGAAGTCC 
GTGAAGTCTG TCCTGTGGGT GTCGGCTGAT GGGCTCCGAG TGGTGGATGA CAAGACCAAG 
GACCTGCTGG TAGACCAGAC CATCGAGAAG GTGTCCTTCT GTGCTCCTGA CCGCAACCTG 
GACAAGGCAT TCTCCTACAT ATGCCGTGAT GGCACCACAC GCCGCTGGAT CTGCCACTGT 
TTCCTGGCCC TCAAGGACTC TGGTGAGAGG CTGAGCCACG CTGTGGGCTG CGCGTTCGCT 
GCCTGCCTGG AGAGGAAGCA GCGACGGGAG AAGGAGTGCG GAGTCACCGC CGCCTTCGAT 
GCCAGTCGCA CCAGCTTTGC CCGCGAGGGC TCCTTCCGCC TGTCCGGTGG CGGGCGGCCT 
GCGGAGCGCG AGGCTGGGGA CAAGAAGAAA GAAGCAGCAG CTGCTCCTGC TGTGGCTCCT 
GGCCCTGCCC AGCCTGGGCA CGTTTCTCCG ACACCGGCCA CTACATCCCC TGGTGAGAAG 
GGAGAGGCGG GTACCCCAGT GGCTGCAGGC ACCACTGCTG CTGCCATTCC CCGGCGCCAT 
GCACCTCTGG AACAGCTGGT TCGCCAGGGC TCCTTTCGTG GGTTTCCTGC CCTCAGCCAG 
AAGAACTCAC CTTTCAAACG TCAGCTGAGT CTACGGTTGA ATGAGCTGCC ATCCACACTG 
CAGCGCCGTA CAGACTTCCA GGTGAAGGGC ACAGTGCCTG AGATGGAGCC TCCTGGTACT 
GGTGACAGCG ACGGCATCAG TGCCCTGTGC ACACAAATCA GCTCGTCTTT CGCCAGTGCC 
GGAGCACCAG TGCCAGGGCC ACCGTCTGCC ACCACAGGGA CGTCTGCCTG GGGTGAGCCC 
TCTGTACCTG CTGCAACTGC CTTCCAGCCC GGGCACAAGC GGACACCGTC GGAGGCTGAG 
CGATGGTTGG AGGAAGTGTC CCAGGTGGCT AAGGCCCAAC AACAGCAGCA GCAGCAGCAG 
CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG CAGCAACAAC AACAGCAACA AGCCACCTCC 
GTGCCACCAA TGCCCACCAT GGCCCCCACC CTTCAACCCT TCTCCACCCC AGTGGGGCCC 
TTTGACACTG CAGCTGCCCA GGTGGCTGTG TTCCTGCCAC CCACACACAT GCAGCCTCCA 
TTTGTGCCCG CCTACCCAGG CCTGGGTTAC CCACCCATGC CCCGGGTGCC AGTGGTGGGC 
ATCACACCTT CACAGATGGT GGCCAACGCC TTCTGCTCAG CTGCTCAGCT CCAGCCCCAA 
CCTGCCACAC TGCTTGGAAA AGCCGGGGCC TTCCCCCCAC CTACCGCACC CAGTGCCCCT 
GGGGGCCAGG CCCGTCCACG CCCTAATGGG GCTCCCTGGC CCCCAGAGCC AGCGCCTGCC 
CCTGCCCCTG AGTTGGACCC CTTTGAGGCC CAGTGGGCAG CTTTAGAAGG CAAGCCCGCC 
GTGGAGAAAC CCTCCAACCC CTTCTCTGGT GACTTGCAGA AGACCTTCGA GATTGAACTG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006228628.1
CDS	3079..5001
Translation	MTTRFPTREPEMEGAEEGTKSPAPTNFSLSHSLEQGGPRRPDQHLPPAPCGASGPPETFRTESDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAGDKKKEAAAAPAVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGTGDSDGISALCTQISSSFASAGAPVPGPPSATTGTSAWGEPSVPAATAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQQQQQQATSVPPMPTMAPTLQPFSTPVGPFDTAAAQVAVFLPPTHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPTAPSAPGGQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKPAVEKPSNPFSGDLQKTFEIEL

Target ORF information:

RefSeq Version	XM_006228566.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus NUMB-like, endocytic adaptor protein (Numbl), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006228566.3

ORF Insert Sequence:

ATGACTACCA GGTTTCCTAC TAGGGAGCCT GAGATGGAGG GGGCTGAAGA GGGGACCAAA 
TCCCCTGCCC CAACAAACTT CTCATTGTCT CACTCCCTTG AGCAGGGCGG ACCCAGGAGA 
CCTGATCAGC ATTTGCCCCC AGCCCCCTGT GGGGCCTCGG GGCCCCCTGA AACCTTCAGG 
ACGGAGTCAG ACGGGGCGGG CACCATGAAC AAGTTACGGC AGAGTCTGCG GCGGAGGAAG 
CCAGCCTATG TGCCTGAGGC GTCACGCCCA CACCAGTGGC AGGCAGATGA GGATGCGGTG 
CGGAAGGGCA CATGCAGCTT CCCCGTTAGG TACCTGGGCC ACGTGGAAGT GGAGGAGTCC 
CGGGGGATGC ACGTTTGTGA AGACGCGGTG AAGAAGCTGA AGGCGATGGG CCGGAAGTCC 
GTGAAGTCTG TCCTGTGGGT GTCGGCTGAT GGGCTCCGAG TGGTGGATGA CAAGACCAAG 
GACCTGCTGG TAGACCAGAC CATCGAGAAG GTGTCCTTCT GTGCTCCTGA CCGCAACCTG 
GACAAGGCAT TCTCCTACAT ATGCCGTGAT GGCACCACAC GCCGCTGGAT CTGCCACTGT 
TTCCTGGCCC TCAAGGACTC TGGTGAGAGG CTGAGCCACG CTGTGGGCTG CGCGTTCGCT 
GCCTGCCTGG AGAGGAAGCA GCGACGGGAG AAGGAGTGCG GAGTCACCGC CGCCTTCGAT 
GCCAGTCGCA CCAGCTTTGC CCGCGAGGGC TCCTTCCGCC TGTCCGGTGG CGGGCGGCCT 
GCGGAGCGCG AGGCTGGGGA CAAGAAGAAA GAAGCAGCAG CTGCTCCTGC TGTGGCTCCT 
GGCCCTGCCC AGCCTGGGCA CGTTTCTCCG ACACCGGCCA CTACATCCCC TGGTGAGAAG 
GGAGAGGCGG GTACCCCAGT GGCTGCAGGC ACCACTGCTG CTGCCATTCC CCGGCGCCAT 
GCACCTCTGG AACAGCTGGT TCGCCAGGGC TCCTTTCGTG GGTTTCCTGC CCTCAGCCAG 
AAGAACTCAC CTTTCAAACG TCAGCTGAGT CTACGGTTGA ATGAGCTGCC ATCCACACTG 
CAGCGCCGTA CAGACTTCCA GGTGAAGGGC ACAGTGCCTG AGATGGAGCC TCCTGGTACT 
GGTGACAGCG ACGGCATCAG TGCCCTGTGC ACACAAATCA GCTCGTCTTT CGCCAGTGCC 
GGAGCACCAG TGCCAGGGCC ACCGTCTGCC ACCACAGGGA CGTCTGCCTG GGGTGAGCCC 
TCTGTACCTG CTGCAACTGC CTTCCAGCCC GGGCACAAGC GGACACCGTC GGAGGCTGAG 
CGATGGTTGG AGGAAGTGTC CCAGGTGGCT AAGGCCCAAC AACAGCAGCA GCAGCAGCAG 
CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG CAGCAACAAC AACAGCAACA AGCCACCTCC 
GTGCCACCAA TGCCCACCAT GGCCCCCACC CTTCAACCCT TCTCCACCCC AGTGGGGCCC 
TTTGACACTG CAGCTGCCCA GGTGGCTGTG TTCCTGCCAC CCACACACAT GCAGCCTCCA 
TTTGTGCCCG CCTACCCAGG CCTGGGTTAC CCACCCATGC CCCGGGTGCC AGTGGTGGGC 
ATCACACCTT CACAGATGGT GGCCAACGCC TTCTGCTCAG CTGCTCAGCT CCAGCCCCAA 
CCTGCCACAC TGCTTGGAAA AGCCGGGGCC TTCCCCCCAC CTACCGCACC CAGTGCCCCT 
GGGGGCCAGG CCCGTCCACG CCCTAATGGG GCTCCCTGGC CCCCAGAGCC AGCGCCTGCC 
CCTGCCCCTG AGTTGGACCC CTTTGAGGCC CAGTGGGCAG CTTTAGAAGG CAAGCCCGCC 
GTGGAGAAAC CCTCCAACCC CTTCTCTGGT GACTTGCAGA AGACCTTCGA GATTGAACTG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Numbl ( XM_006228567.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006228629.1 Rattus norvegicus NUMB-like, endocytic adaptor protein (Numbl), transcript variant X3, mRNA.

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CloneID	ORa22476
Clone ID Related Accession (Same CDS sequence)	XM_006228567.3
Accession Version	XM_006228567.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1845bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	numb-like protein isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006228567.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCCGCA GCGCGGCGGC CAGCGGCGGA CCCAGGAGAC CTGATCAGCA TTTGCCCCCA 
GCCCCCTGTG GGGCCTCGGG GCCCCCTGAA ACCTTCAGGA CGGAGTCAGA CGGGGCGGGC 
ACCATGAACA AGTTACGGCA GAGTCTGCGG CGGAGGAAGC CAGCCTATGT GCCTGAGGCG 
TCACGCCCAC ACCAGTGGCA GGCAGATGAG GATGCGGTGC GGAAGGGCAC ATGCAGCTTC 
CCCGTTAGGT ACCTGGGCCA CGTGGAAGTG GAGGAGTCCC GGGGGATGCA CGTTTGTGAA 
GACGCGGTGA AGAAGCTGAA GGCGATGGGC CGGAAGTCCG TGAAGTCTGT CCTGTGGGTG 
TCGGCTGATG GGCTCCGAGT GGTGGATGAC AAGACCAAGG ACCTGCTGGT AGACCAGACC 
ATCGAGAAGG TGTCCTTCTG TGCTCCTGAC CGCAACCTGG ACAAGGCATT CTCCTACATA 
TGCCGTGATG GCACCACACG CCGCTGGATC TGCCACTGTT TCCTGGCCCT CAAGGACTCT 
GGTGAGAGGC TGAGCCACGC TGTGGGCTGC GCGTTCGCTG CCTGCCTGGA GAGGAAGCAG 
CGACGGGAGA AGGAGTGCGG AGTCACCGCC GCCTTCGATG CCAGTCGCAC CAGCTTTGCC 
CGCGAGGGCT CCTTCCGCCT GTCCGGTGGC GGGCGGCCTG CGGAGCGCGA GGCTGGGGAC 
AAGAAGAAAG CAGAAGCAGC AGCTGCTCCT GCTGTGGCTC CTGGCCCTGC CCAGCCTGGG 
CACGTTTCTC CGACACCGGC CACTACATCC CCTGGTGAGA AGGGAGAGGC GGGTACCCCA 
GTGGCTGCAG GCACCACTGC TGCTGCCATT CCCCGGCGCC ATGCACCTCT GGAACAGCTG 
GTTCGCCAGG GCTCCTTTCG TGGGTTTCCT GCCCTCAGCC AGAAGAACTC ACCTTTCAAA 
CGTCAGCTGA GTCTACGGTT GAATGAGCTG CCATCCACAC TGCAGCGCCG TACAGACTTC 
CAGGTGAAGG GCACAGTGCC TGAGATGGAG CCTCCTGGTA CTGGTGACAG CGACGGCATC 
AGTGCCCTGT GCACACAAAT CAGCTCGTCT TTCGCCAGTG CCGGAGCACC AGTGCCAGGG 
CCACCGTCTG CCACCACAGG GACGTCTGCC TGGGGTGAGC CCTCTGTACC TGCTGCAACT 
GCCTTCCAGC CCGGGCACAA GCGGACACCG TCGGAGGCTG AGCGATGGTT GGAGGAAGTG 
TCCCAGGTGG CTAAGGCCCA ACAACAGCAG CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG 
CAGCAGCAGC AGCAGCAACA ACAACAGCAA CAAGCCACCT CCGTGCCACC AATGCCCACC 
ATGGCCCCCA CCCTTCAACC CTTCTCCACC CCAGTGGGGC CCTTTGACAC TGCAGCTGCC 
CAGGTGGCTG TGTTCCTGCC ACCCACACAC ATGCAGCCTC CATTTGTGCC CGCCTACCCA 
GGCCTGGGTT ACCCACCCAT GCCCCGGGTG CCAGTGGTGG GCATCACACC TTCACAGATG 
GTGGCCAACG CCTTCTGCTC AGCTGCTCAG CTCCAGCCCC AACCTGCCAC ACTGCTTGGA 
AAAGCCGGGG CCTTCCCCCC ACCTACCGCA CCCAGTGCCC CTGGGGGCCA GGCCCGTCCA 
CGCCCTAATG GGGCTCCCTG GCCCCCAGAG CCAGCGCCTG CCCCTGCCCC TGAGTTGGAC 
CCCTTTGAGG CCCAGTGGGC AGCTTTAGAA GGCAAGCCCG CCGTGGAGAA ACCCTCCAAC 
CCCTTCTCTG GTGACTTGCA GAAGACCTTC GAGATTGAAC TGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006228629.1
CDS	208..2052
Translation	MSRSAAASGGPRRPDQHLPPAPCGASGPPETFRTESDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAGDKKKAEAAAAPAVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGTGDSDGISALCTQISSSFASAGAPVPGPPSATTGTSAWGEPSVPAATAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQQQQQQATSVPPMPTMAPTLQPFSTPVGPFDTAAAQVAVFLPPTHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPTAPSAPGGQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKPAVEKPSNPFSGDLQKTFEIEL

Target ORF information:

RefSeq Version	XM_006228567.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus NUMB-like, endocytic adaptor protein (Numbl), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006228567.3

ORF Insert Sequence:

ATGTCCCGCA GCGCGGCGGC CAGCGGCGGA CCCAGGAGAC CTGATCAGCA TTTGCCCCCA 
GCCCCCTGTG GGGCCTCGGG GCCCCCTGAA ACCTTCAGGA CGGAGTCAGA CGGGGCGGGC 
ACCATGAACA AGTTACGGCA GAGTCTGCGG CGGAGGAAGC CAGCCTATGT GCCTGAGGCG 
TCACGCCCAC ACCAGTGGCA GGCAGATGAG GATGCGGTGC GGAAGGGCAC ATGCAGCTTC 
CCCGTTAGGT ACCTGGGCCA CGTGGAAGTG GAGGAGTCCC GGGGGATGCA CGTTTGTGAA 
GACGCGGTGA AGAAGCTGAA GGCGATGGGC CGGAAGTCCG TGAAGTCTGT CCTGTGGGTG 
TCGGCTGATG GGCTCCGAGT GGTGGATGAC AAGACCAAGG ACCTGCTGGT AGACCAGACC 
ATCGAGAAGG TGTCCTTCTG TGCTCCTGAC CGCAACCTGG ACAAGGCATT CTCCTACATA 
TGCCGTGATG GCACCACACG CCGCTGGATC TGCCACTGTT TCCTGGCCCT CAAGGACTCT 
GGTGAGAGGC TGAGCCACGC TGTGGGCTGC GCGTTCGCTG CCTGCCTGGA GAGGAAGCAG 
CGACGGGAGA AGGAGTGCGG AGTCACCGCC GCCTTCGATG CCAGTCGCAC CAGCTTTGCC 
CGCGAGGGCT CCTTCCGCCT GTCCGGTGGC GGGCGGCCTG CGGAGCGCGA GGCTGGGGAC 
AAGAAGAAAG CAGAAGCAGC AGCTGCTCCT GCTGTGGCTC CTGGCCCTGC CCAGCCTGGG 
CACGTTTCTC CGACACCGGC CACTACATCC CCTGGTGAGA AGGGAGAGGC GGGTACCCCA 
GTGGCTGCAG GCACCACTGC TGCTGCCATT CCCCGGCGCC ATGCACCTCT GGAACAGCTG 
GTTCGCCAGG GCTCCTTTCG TGGGTTTCCT GCCCTCAGCC AGAAGAACTC ACCTTTCAAA 
CGTCAGCTGA GTCTACGGTT GAATGAGCTG CCATCCACAC TGCAGCGCCG TACAGACTTC 
CAGGTGAAGG GCACAGTGCC TGAGATGGAG CCTCCTGGTA CTGGTGACAG CGACGGCATC 
AGTGCCCTGT GCACACAAAT CAGCTCGTCT TTCGCCAGTG CCGGAGCACC AGTGCCAGGG 
CCACCGTCTG CCACCACAGG GACGTCTGCC TGGGGTGAGC CCTCTGTACC TGCTGCAACT 
GCCTTCCAGC CCGGGCACAA GCGGACACCG TCGGAGGCTG AGCGATGGTT GGAGGAAGTG 
TCCCAGGTGG CTAAGGCCCA ACAACAGCAG CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG 
CAGCAGCAGC AGCAGCAACA ACAACAGCAA CAAGCCACCT CCGTGCCACC AATGCCCACC 
ATGGCCCCCA CCCTTCAACC CTTCTCCACC CCAGTGGGGC CCTTTGACAC TGCAGCTGCC 
CAGGTGGCTG TGTTCCTGCC ACCCACACAC ATGCAGCCTC CATTTGTGCC CGCCTACCCA 
GGCCTGGGTT ACCCACCCAT GCCCCGGGTG CCAGTGGTGG GCATCACACC TTCACAGATG 
GTGGCCAACG CCTTCTGCTC AGCTGCTCAG CTCCAGCCCC AACCTGCCAC ACTGCTTGGA 
AAAGCCGGGG CCTTCCCCCC ACCTACCGCA CCCAGTGCCC CTGGGGGCCA GGCCCGTCCA 
CGCCCTAATG GGGCTCCCTG GCCCCCAGAG CCAGCGCCTG CCCCTGCCCC TGAGTTGGAC 
CCCTTTGAGG CCCAGTGGGC AGCTTTAGAA GGCAAGCCCG CCGTGGAGAA ACCCTCCAAC 
CCCTTCTCTG GTGACTTGCA GAAGACCTTC GAGATTGAAC TGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dynamic change of Numbl expression after sciatic nerve crush and its role in Schwann cell differentiation.
Journal of neuroscience research90(8)1557-65(2012 Aug)
Zhu L,Yan Y,Ke K,Wu X,Gao Y,Shen A,Li J,Kang L,Zhang G,Wu Q,Yang H

Expression of Numb and Numb-like in the development of mammalian auditory sensory epithelium.
Neuroreport22(2)49-54(2011 Jan)
Gao Z,Chi FL,Huang YB,Yang JM,Cong N,Li W

NUMBL interacts with TRAF6 and promotes the degradation of TRAF6.
Biochemical and biophysical research communications392(3)409-14(2010 Feb)
Zhou L,Ma Q,Shi H,Huo K

NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation.
Cellular signalling20(6)1044-51(2008 Jun)
Ma Q,Zhou L,Shi H,Huo K

Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors.
Nature neuroscience10(7)819-27(2007 Jul)
Rasin MR,Gazula VR,Breunig JJ,Kwan KY,Johnson MB,Liu-Chen S,Li HS,Jan LY,Jan YN,Rakic P,Sestan N

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Numbl cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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