Nat8l cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nat8l
Entrez Gene ID	289727
Full Name	N-acetyltransferase 8-like
Synonyms	RGD1305719
General protein information	Preferred Names N-acetyltransferase 8-like Names N-acetylaspartate synthetase N-acetyltransferase 8-like protein NAA synthetase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14q21

mRNA and Protein(s)

mRNA	Protein	Name
NM_001191681.1	NP_001178610.1	N-acetylaspartate synthetase

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	NAT8L	XP_853267.2
Homo sapiens (human)	NAT8L	NP_848652.2
Mus musculus (house mouse)	Nat8l	NP_001001985.3
Xenopus tropicalis (tropical clawed frog)	nat8l	NP_001096350.1
Rattus norvegicus (Norway rat)	Nat8l	NP_001178610.1
Gallus gallus (chicken)	NAT8L	XP_420835.4
Danio rerio (zebrafish)	nat8l	NP_001077308.1

Gene Ontology
Bibliography

Related articles in PubMed

The molecular mechanisms affecting N-acetylaspartate homeostasis following experimental graded traumatic brain injury.
Di Pietro V, Amorini AM, Tavazzi B, Vagnozzi R, Logan A, Lazzarino G, Signoretti S, Lazzarino G, Belli A
Molecular medicine (Cambridge, Mass.)20147-57(2014 Mar)

Molecular characterization of N-acetylaspartylglutamate synthetase.
Becker I, Lodder J, Gieselmann V, Eckhardt M
The Journal of biological chemistry285(38)29156-64(2010 Sep)

Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNS.
Ariyannur PS, Moffett JR, Manickam P, Pattabiraman N, Arun P, Nitta A, Nabeshima T, Madhavarao CN, Namboodiri AM
Brain research13351-13(2010 Jun)

Molecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartia.
Wiame E, Tyteca D, Pierrot N, Collard F, Amyere M, Noel G, Desmedt J, Nassogne MC, Vikkula M, Octave JN, Vincent MF, Courtoy PJ, Boltshauser E, van Schaftingen E
The Biochemical journal425(1)127-36(2009 Dec)

Evidence for mitochondrial and cytoplasmic N-acetylaspartate synthesis in SH-SY5Y neuroblastoma cells.
Arun P, Moffett JR, Namboodiri AM
Neurochemistry international55(4)219-25(2009 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The decrease in N-acetylaspartate following severe traumatic brain injury was characterized by profound mitochondrial malfunctioning, dramatic repression of Nat8l gene and concomitant increase in the ASPA gene and protein levels.
Title: The molecular mechanisms affecting N-acetylaspartate homeostasis following experimental graded traumatic brain injury.

Asp-NAT/NAT8L and NAA immunoreactivities correlate very well in rat brain, with primary localization in neurons, including cortical pyramidal neurons and granule cells of the hippocampus.
Title: Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNS.

The following Nat8l gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nat8l cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07389	NM_001191681.1 Latest version!	Rattus norvegicus N-acetyltransferase 8-like (Nat8l), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nat8l ( NM_001191681.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001178610.1 Rattus norvegicus N-acetyltransferase 8-like (Nat8l), mRNA.

Price & Availability↑

CloneID	ORa07389
Clone ID Related Accession (Same CDS sequence)	NM_001191681.1
Accession Version	NM_001191681.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 900bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-23
Organism	Rattus norvegicus(Norway rat)
Product	N-acetylaspartate synthetase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR07072416.1. On Jul 17, 2010 this sequence version replaced XM_223538.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CB787393.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCATTGTG GGCCTCCCGA CATGGTCTGC GAGACGAAGA TCGTGGCTAC GGAGGACCAT 
GAGGCACTGC CGGGGGCCAA GAAGGACGCG CTGCTCGCCG CCGCCGGAGC CATGTGGCCC 
CCGCTGCCCG CCGCGCCCGG GCCGGCTGCC GCACCCCCAC CCGCGGCAGG TCCCCAGCCC 
CACGGAGGCA CCGGGGGCGC GGGGCCGCCG GAGGGGCGCG GCGTGTGCAT CCGCGAGTTC 
CGCGCAGCCG AGCAGGAGGC GGCGCGCCGC ATCTTCTACG ACGGCATCTT GGAGCGCATC 
CCCAACACGG CTTTCCGAGG CCTGCGGCAG CACCCGCGCA CCCAGCTGCT CTACGCCCTG 
CTGGCGGCCC TCTGTTTTGC TGTGACCCGC TCACTGCTGC TGACATGCCT GGTGCCGGCC 
GGGCTCCTGG CCCTGCGCTA CTACTACAGT CGCAAGGTGA TTCTGGCCTA CCTGGAGTGT 
GCGCTGCACA CGGACATGGC TGACATTGAA CAGTACTACA TGAAGCCACC TGGTTCCTGT 
TTCTGGGTGG CTGTGCTGGA CGGCAATGTT GTGGGCATCG TGGCGGCTCG GGCCCATGAG 
GAAGACAACA CAGTGGAGCT GCTCCGCATG TCCGTGGACT CGCGCTTCCG CGGCAAAGGC 
ATCGCCAAGG CCCTGGGCAG GAGGGTGTTG GAGTTTGCCA TGCTGCACAA CTACTCTGCA 
GTGGTACTGG GCACCACAGC CGTTAAGGTG GCCGCCCACA AGCTCTATGA GTCACTGGGC 
TTCAGACACA TGGGCGCGAG TGATCACTAC GTGCTGCCTG GCATGACCCT CTCGCTGGCC 
GAGCGCCTCT TCTTCCAGGT CCGCTACCAC CGCTACCGCC TGCAGCTGCG CGAGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001178610.1
CDS	1..900
Translation	MHCGPPDMVCETKIVATEDHEALPGAKKDALLAAAGAMWPPLPAAPGPAAAPPPAAGPQPHGGTGGAGPPEGRGVCIREFRAAEQEAARRIFYDGILERIPNTAFRGLRQHPRTQLLYALLAALCFAVTRSLLLTCLVPAGLLALRYYYSRKVILAYLECALHTDMADIEQYYMKPPGSCFWVAVLDGNVVGIVAARAHEEDNTVELLRMSVDSRFRGKGIAKALGRRVLEFAMLHNYSAVVLGTTAVKVAAHKLYESLGFRHMGASDHYVLPGMTLSLAERLFFQVRYHRYRLQLREE

Target ORF information:

RefSeq Version	NM_001191681.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus N-acetyltransferase 8-like (Nat8l), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001191681.1

ORF Insert Sequence:

ATGCATTGTG GGCCTCCCGA CATGGTCTGC GAGACGAAGA TCGTGGCTAC GGAGGACCAT 
GAGGCACTGC CGGGGGCCAA GAAGGACGCG CTGCTCGCCG CCGCCGGAGC CATGTGGCCC 
CCGCTGCCCG CCGCGCCCGG GCCGGCTGCC GCACCCCCAC CCGCGGCAGG TCCCCAGCCC 
CACGGAGGCA CCGGGGGCGC GGGGCCGCCG GAGGGGCGCG GCGTGTGCAT CCGCGAGTTC 
CGCGCAGCCG AGCAGGAGGC GGCGCGCCGC ATCTTCTACG ACGGCATCTT GGAGCGCATC 
CCCAACACGG CTTTCCGAGG CCTGCGGCAG CACCCGCGCA CCCAGCTGCT CTACGCCCTG 
CTGGCGGCCC TCTGTTTTGC TGTGACCCGC TCACTGCTGC TGACATGCCT GGTGCCGGCC 
GGGCTCCTGG CCCTGCGCTA CTACTACAGT CGCAAGGTGA TTCTGGCCTA CCTGGAGTGT 
GCGCTGCACA CGGACATGGC TGACATTGAA CAGTACTACA TGAAGCCACC TGGTTCCTGT 
TTCTGGGTGG CTGTGCTGGA CGGCAATGTT GTGGGCATCG TGGCGGCTCG GGCCCATGAG 
GAAGACAACA CAGTGGAGCT GCTCCGCATG TCCGTGGACT CGCGCTTCCG CGGCAAAGGC 
ATCGCCAAGG CCCTGGGCAG GAGGGTGTTG GAGTTTGCCA TGCTGCACAA CTACTCTGCA 
GTGGTACTGG GCACCACAGC CGTTAAGGTG GCCGCCCACA AGCTCTATGA GTCACTGGGC 
TTCAGACACA TGGGCGCGAG TGATCACTAC GTGCTGCCTG GCATGACCCT CTCGCTGGCC 
GAGCGCCTCT TCTTCCAGGT CCGCTACCAC CGCTACCGCC TGCAGCTGCG CGAGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The molecular mechanisms affecting N-acetylaspartate homeostasis following experimental graded traumatic brain injury.
Molecular medicine (Cambridge, Mass.)20147-57(2014 Mar)
Di Pietro V,Amorini AM,Tavazzi B,Vagnozzi R,Logan A,Lazzarino G,Signoretti S,Lazzarino G,Belli A

Molecular characterization of N-acetylaspartylglutamate synthetase.
The Journal of biological chemistry285(38)29156-64(2010 Sep)
Becker I,Lodder J,Gieselmann V,Eckhardt M

Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNS.
Brain research13351-13(2010 Jun)
Ariyannur PS,Moffett JR,Manickam P,Pattabiraman N,Arun P,Nitta A,Nabeshima T,Madhavarao CN,Namboodiri AM

Molecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartia.
The Biochemical journal425(1)127-36(2009 Dec)
Wiame E,Tyteca D,Pierrot N,Collard F,Amyere M,Noel G,Desmedt J,Nassogne MC,Vikkula M,Octave JN,Vincent MF,Courtoy PJ,Boltshauser E,van Schaftingen E

Evidence for mitochondrial and cytoplasmic N-acetylaspartate synthesis in SH-SY5Y neuroblastoma cells.
Neurochemistry international55(4)219-25(2009 Sep)
Arun P,Moffett JR,Namboodiri AM

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Nat8l cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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