Ppm1d cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ppm1d
Entrez Gene ID	287585
Full Name	protein phosphatase, Mg2+/Mn2+ dependent, 1D
Synonyms	Wip1
General protein information	Preferred Names protein phosphatase, Mg2+/Mn2+ dependent, 1D Names protein phosphatase 1D p53-induced protein phosphatase 1 protein phosphatase 1D magnesium-dependent, delta isoform
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q26

mRNA and Protein(s)

mRNA	Protein	Name
NM_001105825.2	NP_001099295.2	protein phosphatase 1D

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PPM1D	XP_852759.2
Rattus norvegicus (Norway rat)	Ppm1d	NP_001099295.2
Danio rerio (zebrafish)	ppm1da	NP_957384.2
	PPM1D	XP_001110891.1
Mus musculus (house mouse)	Ppm1d	NP_058606.3
Xenopus tropicalis (tropical clawed frog)	ppm1d	XP_002933883.2
Homo sapiens (human)	PPM1D	NP_003611.1
Pan troglodytes (chimpanzee)	PPM1D	NP_001233479.1
Danio rerio (zebrafish)	ppm1db	NP_001007341.1
Gallus gallus (chicken)	PPM1D	XP_415890.3
Bos taurus (cattle)	PPM1D	NP_001178373.1

Gene Ontology
Bibliography

Related articles in PubMed

Interaction of Wip1 and NF-?B regulates neuroinflammatory response in astrocytes.
Xu F, Chen L, Zhao X, Zhong H, Cui L, Jiang L, Huang H, Li L, Zeng S, Li M
Inflammation research : official journal of the European Histamine Research Society ... [et al.]66(11)1011-1019(2017 Nov)

De Novo Truncating Mutations in the Last and Penultimate Exons of PPM1D Cause an Intellectual Disability Syndrome.
Jansen S, Geuer S, Pfundt R, Brough R, Ghongane P, Herkert JC, Marco EJ, Willemsen MH, Kleefstra T, Hannibal M, Shieh JT, Lynch SA, Flinter F, FitzPatrick DR, Gardham A, Bernhard B, Ragge N, Newbury-Ecob R, Bernier R, Kvarnung M, Magnusson EA, Wessels MW, van Slegtenhorst MA, Monaghan KG, de Vries P, Veltman JA, , Lord CJ, Vissers LE, de Vries BB
American journal of human genetics100(4)650-658(2017 Apr)

Up-regulation of Wip1 involves in neuroinflammation of retinal astrocytes after optic nerve crush via NF-?B signaling pathway.
Zhong H, Cui L, Xu F, Chen L, Jiang L, Huang H, Xu J, Zhao X, Li L, Zeng S, Li M
Inflammation research : official journal of the European Histamine Research Society ... [et al.]65(9)709-15(2016 Sep)

Involvement of dysregulated Wip1 in manganese-induced p53 signaling and neuronal apoptosis.
Ma X, Han J, Wu Q, Liu H, Shi S, Wang C, Wang Y, Xiao J, Zhao J, Jiang J, Wan C
Toxicology letters235(1)17-27(2015 May)

Wip1 controls global heterochromatin silencing via ATM/BRCA1-dependent DNA methylation.
Filipponi D, Muller J, Emelyanov A, Bulavin DV
Cancer cell24(4)528-41(2013 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Wip1 might participate in astrocyte activation in optic nerve (ON) injury-induced retinal neuroinflammation via regulating NF-kappaB signaling, which may be closely associated with ON injury
Title: Up-regulation of Wip1 involves in neuroinflammation of retinal astrocytes after optic nerve crush via NF-?B signaling pathway.

Suggest that downregulated Wip1 expression plays an important role in Mn-induced neuronal death in the brain striatum via the modulation of p53 signaling.
Title: Involvement of dysregulated Wip1 in manganese-induced p53 signaling and neuronal apoptosis.

The following Ppm1d gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ppm1d cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04340	NM_001105825.2 Latest version!	Rattus norvegicus protein phosphatase, Mg2+/Mn2+ dependent, 1D (Ppm1d), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ppm1d ( NM_001105825.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001099295.2 Rattus norvegicus protein phosphatase, Mg2+/Mn2+ dependent, 1D (Ppm1d), mRNA.

Price & Availability↑

CloneID	ORa04340
Clone ID Related Accession (Same CDS sequence)	NM_001105825.2
Accession Version	NM_001105825.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1797bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-07-28
Organism	Rattus norvegicus(Norway rat)
Product	protein phosphatase 1D
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC162058.1, FM140338.1 and AABR07030169.1. On Sep 27, 2011 this sequence version replaced NM_001105825.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC162058.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGGGC TGTACTCTCT GGGAGTGAGC GTCTTCTCTG ACCAGGGCGG GAGGAAGTAC 
ATGGAGGACG TAACTCAGAT TGTGGTGGAA CCCGAGCCCG CTGCGGAGGA CAAGCCGGCG 
CCGGTACCCC GGCGGGCGCT CGGGCTGCCG GCGACCCCAT CTCTCGTCGG CGTCGGGCCA 
TCGGGAAAAG GCCCGGCGGC GGCCCGCGAC CCTGCCCCGG ACGCCGCGGC CTCGCTACCC 
GCTGGACGCT GCTGTCGCCG CCGCTCCTCG GTGGCCTTCT TCGCTGTGTG CGACGGGCAC 
GGCGGGCGGG AGGCGGCACA GTTTGCCCGG GAGCACTTGT GGGGTTTCAT CAAGAAGCAG 
AAAGGCTTCA CCTCGTCCGA GCCCGCCAAG GTGTGCGCTG CCATCCGCAA AGGCTTCCTC 
GCCTGTCACC TCGCCATGTG GAAGAAACTG GCAGAATGGC CAAAGACTAT GACAGGTCTT 
CCCAGCACGT CCGGAACAAC TGCCAGTGTG GTTATCATAC GGGGCATGAA GATGTATGTA 
GCTCATGTAG GTGACTCTGG AGTGGTCCTT GGAATTCAGG ATGACCCAAA GGATGATTTT 
GTGAGAGCTG TGGAGGTGAC ACAAGATCAC AAGCCAGAAC TTCCCAAGGA AAGAGAAAGA 
ATTGAAGGAC TTGGCGGGAG TGTGATGAAC AAGTCTGGAG TGAATCGTGT AGTTTGGAAA 
AGACCTCGGC TCACTCACAG TGGACCTGTG AGAAGGAGTA CAGTCATTGA TCAGATTCCT 
TTCTTGGCCG TAGCAAGAGC ACTTGGTGAC TTGTGGAGCT ATGATTTCTT CAGTGGTAAG 
TTTGTGGTGT CACCTGAACC GGACACCAGT GTCCACACAC TTGACCCCCA GAAGCACAAG 
TATATTATCC TGGGAAGTGA TGGGCTTTGG AATATGGTTC CACCTCAAGA TGCCATCTCC 
ATGTGCCAAG ACCAAGAGGA GAAAAAATAC TTGATGGGTG AGCAAGGACA GTCTTGTGCT 
AAAATGCTTG TGAATCGAGC ACTTGGCCGC TGGAGGCAGC GTATGCTTCG AGCAGATAAC 
ACAAGTGCCA TAGTAATCTG CATCTCTCCA GAAGTAGATA ATCAAGGGAA CTTTACCAAT 
GAAGATGAGC TCTTTCTGAA CCTGACTGAT AGCCCTACTT ACAACAGCCA AGAAACCTGT 
GTGATGACTC CTTCTCCAAG TTCTACACCA CCAGTCAAGT CACTGGAAGA AGATCCATGG 
CCAAGGCTGA ACTCTAAGGA CCATATACCT GCCCTTGTTC GCAGTAATGC CTTCTCAGAG 
AAGTTTTTAG AGGTCCCAGC TGAGATAGCT CGAGGAAGTA TCCAGACTGT AGTCATGACC 
TCAAAAGACT CAGAGACACT TGAAGAAAAT TGCCCCAAAG CCCTGACTTT AAGGATTCAT 
GATTCTTTGA ATAATACTCT GTCAGTTGGC CTCATGCCAA CCAATTCAAC AAATACTATC 
ATGGACCAAA AAAATTTAAA GATGTCAACT CCAGGTCAAA TGAAAGCTCA AGAAGTTGAA 
AGAACCCCTC CAGCCAATTT TAAAAGGACA TTAGAAGAAT CCAACTCTGG TCCCCTTATG 
AAGAAGCATC GACGAAATGG CTTAAGTCGA AATAGCGGGG CCCAAGCTTC GAGTCTCCCC 
ACAGCATCCC AGCGCAGGCA CTCTGTCACA CTGACCATGA GGCGCAGACT CCGGGGCCAG 
AAGAAGATGG GGAATCCTCT TTTACATCAG CACCGGAAAA CAGTGTGTGT GTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099295.2
CDS	219..2015
Translation	MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPAAEDKPAPVPRRALGLPATPSLVGVGPSGKGPAAARDPAPDAAASLPAGRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHSGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGKFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMVPPQDAISMCQDQEEKKYLMGEQGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQGNFTNEDELFLNLTDSPTYNSQETCVMTPSPSSTPPVKSLEEDPWPRLNSKDHIPALVRSNAFSEKFLEVPAEIARGSIQTVVMTSKDSETLEENCPKALTLRIHDSLNNTLSVGLMPTNSTNTIMDQKNLKMSTPGQMKAQEVERTPPANFKRTLEESNSGPLMKKHRRNGLSRNSGAQASSLPTASQRRHSVTLTMRRRLRGQKKMGNPLLHQHRKTVCVC

Target ORF information:

RefSeq Version	NM_001105825.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein phosphatase, Mg2+/Mn2+ dependent, 1D (Ppm1d), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001105825.2

ORF Insert Sequence:

ATGGCGGGGC TGTACTCTCT GGGAGTGAGC GTCTTCTCTG ACCAGGGCGG GAGGAAGTAC 
ATGGAGGACG TAACTCAGAT TGTGGTGGAA CCCGAGCCCG CTGCGGAGGA CAAGCCGGCG 
CCGGTACCCC GGCGGGCGCT CGGGCTGCCG GCGACCCCAT CTCTCGTCGG CGTCGGGCCA 
TCGGGAAAAG GCCCGGCGGC GGCCCGCGAC CCTGCCCCGG ACGCCGCGGC CTCGCTACCC 
GCTGGACGCT GCTGTCGCCG CCGCTCCTCG GTGGCCTTCT TCGCTGTGTG CGACGGGCAC 
GGCGGGCGGG AGGCGGCACA GTTTGCCCGG GAGCACTTGT GGGGTTTCAT CAAGAAGCAG 
AAAGGCTTCA CCTCGTCCGA GCCCGCCAAG GTGTGCGCTG CCATCCGCAA AGGCTTCCTC 
GCCTGTCACC TCGCCATGTG GAAGAAACTG GCAGAATGGC CAAAGACTAT GACAGGTCTT 
CCCAGCACGT CCGGAACAAC TGCCAGTGTG GTTATCATAC GGGGCATGAA GATGTATGTA 
GCTCATGTAG GTGACTCTGG AGTGGTCCTT GGAATTCAGG ATGACCCAAA GGATGATTTT 
GTGAGAGCTG TGGAGGTGAC ACAAGATCAC AAGCCAGAAC TTCCCAAGGA AAGAGAAAGA 
ATTGAAGGAC TTGGCGGGAG TGTGATGAAC AAGTCTGGAG TGAATCGTGT AGTTTGGAAA 
AGACCTCGGC TCACTCACAG TGGACCTGTG AGAAGGAGTA CAGTCATTGA TCAGATTCCT 
TTCTTGGCCG TAGCAAGAGC ACTTGGTGAC TTGTGGAGCT ATGATTTCTT CAGTGGTAAG 
TTTGTGGTGT CACCTGAACC GGACACCAGT GTCCACACAC TTGACCCCCA GAAGCACAAG 
TATATTATCC TGGGAAGTGA TGGGCTTTGG AATATGGTTC CACCTCAAGA TGCCATCTCC 
ATGTGCCAAG ACCAAGAGGA GAAAAAATAC TTGATGGGTG AGCAAGGACA GTCTTGTGCT 
AAAATGCTTG TGAATCGAGC ACTTGGCCGC TGGAGGCAGC GTATGCTTCG AGCAGATAAC 
ACAAGTGCCA TAGTAATCTG CATCTCTCCA GAAGTAGATA ATCAAGGGAA CTTTACCAAT 
GAAGATGAGC TCTTTCTGAA CCTGACTGAT AGCCCTACTT ACAACAGCCA AGAAACCTGT 
GTGATGACTC CTTCTCCAAG TTCTACACCA CCAGTCAAGT CACTGGAAGA AGATCCATGG 
CCAAGGCTGA ACTCTAAGGA CCATATACCT GCCCTTGTTC GCAGTAATGC CTTCTCAGAG 
AAGTTTTTAG AGGTCCCAGC TGAGATAGCT CGAGGAAGTA TCCAGACTGT AGTCATGACC 
TCAAAAGACT CAGAGACACT TGAAGAAAAT TGCCCCAAAG CCCTGACTTT AAGGATTCAT 
GATTCTTTGA ATAATACTCT GTCAGTTGGC CTCATGCCAA CCAATTCAAC AAATACTATC 
ATGGACCAAA AAAATTTAAA GATGTCAACT CCAGGTCAAA TGAAAGCTCA AGAAGTTGAA 
AGAACCCCTC CAGCCAATTT TAAAAGGACA TTAGAAGAAT CCAACTCTGG TCCCCTTATG 
AAGAAGCATC GACGAAATGG CTTAAGTCGA AATAGCGGGG CCCAAGCTTC GAGTCTCCCC 
ACAGCATCCC AGCGCAGGCA CTCTGTCACA CTGACCATGA GGCGCAGACT CCGGGGCCAG 
AAGAAGATGG GGAATCCTCT TTTACATCAG CACCGGAAAA CAGTGTGTGT GTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Interaction of Wip1 and NF-?B regulates neuroinflammatory response in astrocytes.
Inflammation research : official journal of the European Histamine Research Society ... [et al.]66(11)1011-1019(2017 Nov)
Xu F,Chen L,Zhao X,Zhong H,Cui L,Jiang L,Huang H,Li L,Zeng S,Li M

De Novo Truncating Mutations in the Last and Penultimate Exons of PPM1D Cause an Intellectual Disability Syndrome.
American journal of human genetics100(4)650-658(2017 Apr)
Jansen S,Geuer S,Pfundt R,Brough R,Ghongane P,Herkert JC,Marco EJ,Willemsen MH,Kleefstra T,Hannibal M,Shieh JT,Lynch SA,Flinter F,FitzPatrick DR,Gardham A,Bernhard B,Ragge N,Newbury-Ecob R,Bernier R,Kvarnung M,Magnusson EA,Wessels MW,van Slegtenhorst MA,Monaghan KG,de Vries P,Veltman JA,,Lord CJ,Vissers LE,de Vries BB

Up-regulation of Wip1 involves in neuroinflammation of retinal astrocytes after optic nerve crush via NF-?B signaling pathway.
Inflammation research : official journal of the European Histamine Research Society ... [et al.]65(9)709-15(2016 Sep)
Zhong H,Cui L,Xu F,Chen L,Jiang L,Huang H,Xu J,Zhao X,Li L,Zeng S,Li M

Involvement of dysregulated Wip1 in manganese-induced p53 signaling and neuronal apoptosis.
Toxicology letters235(1)17-27(2015 May)
Ma X,Han J,Wu Q,Liu H,Shi S,Wang C,Wang Y,Xiao J,Zhao J,Jiang J,Wan C

Wip1 controls global heterochromatin silencing via ATM/BRCA1-dependent DNA methylation.
Cancer cell24(4)528-41(2013 Oct)
Filipponi D,Muller J,Emelyanov A,Bulavin DV

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Ppm1d cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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