Gene Symbol | PPM1D |
Entrez Gene ID | 8493 |
Full Name | protein phosphatase, Mg2+/Mn2+ dependent 1D |
Synonyms | IDDGIP,PP2C-DELTA,WIP1 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | Intellectual developmental disorder with gastrointestinal difficulties and high pain threshold, 617450 (3); Breast cancer, somatic, 114480 (3) |