Abcc9 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Abcc9
Entrez Gene ID	25560
Full Name	ATP binding cassette subfamily C member 9
Synonyms	Sur2
General protein information	Preferred Names ATP binding cassette subfamily C member 9 Names ATP-binding cassette sub-family C member 9 ATP-binding cassette transporter sub-family C member 9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 ATP-binding cassette, sub-family C, member 9-like ATP-binding cassette, subfamily C (CFTR/MRP), member 9 Sulfonylurea receptor 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q44
Summary	ATP-sensitive potassium channel subunit that confers ATP sensitivity and acts as receptor for sulfonylurea; may play a role in mesangial cell contractility in response to calcium ion transients [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013040.2	NP_037172.2	ATP-binding cassette sub-family C member 9

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ABCC9	XP_001149414.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009799	XP_553659.3
Canis lupus familiaris (dog)	ABCC9	XP_852746.1
Mus musculus (house mouse)	Abcc9	NP_035641.1
Gallus gallus (chicken)	ABCC9	XP_004938045.1
Xenopus tropicalis (tropical clawed frog)	abcc9	XP_004920363.1
Bos taurus (cattle)	ABCC9	XP_005207020.1
Rattus norvegicus (Norway rat)	Abcc9	NP_037172.2
Danio rerio (zebrafish)	abcc9	NP_001025325.1
Homo sapiens (human)	ABCC9	NP_005682.2
	ABCC9	XP_001098888.1
Drosophila melanogaster (fruit fly)	Sur	NP_477472.2

Gene Ontology
Bibliography

Related articles in PubMed

Cantu syndrome-associated SUR2 (ABCC9) mutations in distinct structural domains result in K
McClenaghan C, Hanson A, Sala-Rabanal M, Roessler HI, Josifova D, Grange DK, van Haaften G, Nichols CG
The Journal of biological chemistry(2017 Dec)

Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel.
Cooper PE, McClenaghan C, Chen X, Stary-Weinzinger A, Nichols CG
The Journal of biological chemistry292(42)17387-17398(2017 10)

Altered KATP Channel Subunits Expression and Vascular Reactivity in Spontaneously Hypertensive Rats With Age.
Liu X, Duan P, Hu X, Li R, Zhu Q
Journal of cardiovascular pharmacology68(2)143-9(2016 Aug)

Differential mechanisms of Cant? syndrome-associated gain of function mutations in the ABCC9 (SUR2) subunit of the KATP channel.
Cooper PE, Sala-Rabanal M, Lee SJ, Nichols CG
The Journal of general physiology146(6)527-40(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In vascular smooth muscle KATP channel subunits Kir6.1 and SUR2B contribute to modify the functionality of this channel in hypertension with age.
Title: Altered KATP Channel Subunits Expression and Vascular Reactivity in Spontaneously Hypertensive Rats With Age.

These data provide insights into the molecular basis by which phosphorylation of SUR2B NBD1 activates KATP channels.
Title: Phosphorylation-dependent changes in nucleotide binding, conformation, and dynamics of the first nucleotide binding domain (NBD1) of the sulfonylurea receptor 2B (SUR2B).

Suggest that the increase in KATP channel subunits, SUR2 and Kir6.1, in the rostral ventrolateral medulla may be responsible for the greater sympathetic outflow and pressor effect of hydroxylamine in Ad-cystathionine beta-synthetase injected rats.
Title: Gene transfer of cystathionine ?-synthase into RVLM increases hydrogen sulfide-mediated suppression of sympathetic outflow via KATP channel in normotensive rats.

Electrophysiological studies employing SUR2A/Kir6.2-expressing HEK cells showed that increasing endogenous or exogenous Phosphatidylinositol 4,5-bisphosphate diminished the inhibitory effect of Syn-1A on KATP currents.
Title: Phosphatidylinositol 4,5-biphosphate (PIP2) modulates syntaxin-1A binding to sulfonylurea receptor 2A to regulate cardiac ATP-sensitive potassium (KATP) channels.

Results demonstrate differential and highly localized expression pattern of sulphonylurea receptor proteins SUR2A and 2B (SUR1) in rat kidney.
Title: Localization of sulphonylurea receptor proteins SUR2A and SUR2B and/or SUR1 in rat kidney.

The following Abcc9 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Abcc9 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01743	NM_013040.2 Latest version!	Rattus norvegicus ATP binding cassette subfamily C member 9 (Abcc9), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	24-26	$811.30 $1159.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Abcc9 ( NM_013040.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037172.2 Rattus norvegicus ATP binding cassette subfamily C member 9 (Abcc9), mRNA.

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CloneID	ORa01743
Clone ID Related Accession (Same CDS sequence)	NM_013040.2
Accession Version	NM_013040.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4638bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	ATP-binding cassette sub-family C member 9
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF019628.1. On Apr 4, 2002 this sequence version replaced NM_013040.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF019628.1, AF087838.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAGCCTTT CCTTCTGTGG TAACAACATC TCCTCCTACA ACATCTACCA TGGTGTTCTC 
CAAAACCCCT GCTTTGTGGA CGCACTCAAC CTGGTCCCTC ACGTCTTCCT GCTGTTTATC 
ACCTTTCCGA TCCTGTTCAT TGGATGGGGG AGCCAAAGCT CAAAAGTGCA AATTCATCAC 
AACACATGGC TTCATTTTCC TGGACACAAC CTGAGATGGA TTCTGACGTT TGCACTCCTG 
TTTGTGCATG TCTGCGAGAT AGCAGAAGGC ATTGTTTCAG ACTCGCAACG GGCGTCCAGG 
CATCTCCACC TTTTCATGCC GGCTGTGATG GGATTTGTCG CCACCACCAC ATCCATTGTG 
TATTACCACA ACATTGAAAC ATCAAACTTC CCTAAATTAC TTTTAGCTTT ATTCCTGTAC 
TGGGTCATGG CCTTCATTAC AAAGACAATA AAGTTGGTCA AATACTGGCA GTTGGGGTGG 
GGAATGTCAG ACCTGCGCTT CTGCATCACG GGAGTGATGG TCATCTTGAA TGGACTGCTG 
ATGGCTGTGG AGATCAATGT CATCCGGGTC CGAAGATATG TTTTCTTCAT GAATCCTCAG 
AAAGTGAAGC CTCCAGAGGA CCTCCAGGAC CTGGGCGTGA GGTTCCTCCA GCCGTTTGTG 
AATTTGCTGT CCAAAGCTAC TTACTGGTGG ATGAACACGC TTATCATATC AGCTCACAGG 
AAACCTATTG ATCTGAAGGC GATCGGAAAG TTGCCGATAG CAATGAGGGC GGTGACGAAT 
TATGTTTGCT TGAAGGAGGC CTACGAAGAG CAGAAGAAAA AGGCTGCGGA TCATCCGAAT 
CGGACTCCCT CCATATGGCT GGCCATGTAC AGGGCTTTTG GGAGACCGAT CCTGCTGAGC 
AGCACGTTCC GCTACTTGGC TGACTTGCTG GGCTTTGCCG GCCCTCTTTG TATTTCCGGA 
ATCGTCCAGC GTGTGAATGA ACCGAAGAAT AACACGACGA GATTTTCAGA GACACTCTCA 
TCAAAGGAGT TTCTGGAAAA TGCCCATGTG CTGGCTGTCC TGCTCTTCCT GGCCCTCATC 
CTGCAAAGAA CATTTTTGCA GGCTTCGTAC TATGTGACCA TAGAGACCGG CATCAACCTG 
CGTGGGGCTC TGCTGGCTAT GATCTACAAC AAAATCCTTC GACTGTCTAC TTCTAACCTA 
TCCATGGGCG AGATGACCCT GGGACAGATC AACAACTTGG TTGCCATAGA AACCAATCAG 
CTCATGTGGT TCTTGTTCCT GTGTCCCAAT CTGTGGGCCA TGCCCGTTCA GATCATAATG 
GGGGTGATCC TGCTCTATAA TCTGCTTGGG TCAAGCGCAC TGGTAGGCGC GGCGGTCATC 
GTGCTCCTCG CACCGATTCA GTACTTCATC GCCACGAAGC TGGCGGAGGC TCAGAAGAGC 
ACTCTGGATT ATTCCACCGA GAGGCTGAAG AAGACAAACG AGATACTGAA AGGCATCAAG 
CTCCTTAAGC TGTATGCCTG GGAGCACATT TTCTGCAAGA GCGTGGAAGA GACTAGAATG 
AAGGAGCTCT CCAGCCTCAA AACCTTCGCG CTCTACACGT CGCTTTCCAT CTTCATGAAC 
GCAGCCATTC CCATCGCAGC CGTTCTTGCA ACATTTGTGA CCCATGCCTA TGCCAGTGGC 
AACAACCTGA AACCCGCAGA GGCCTTTGCC TCTCTGTCTC TCTTCCACAT CCTCGTCACA 
CCGCTCTTCC TGCTGTCCAC GGTGGTCAGA TTCGCAGTGA AAGCCATCAT CAGCGTTCAG 
AAGCTGAATG AGTTTCTCTT GAGCGATGAG ATTGGCGAGG ACAGCTGGAG GACTGGGGAG 
GGGACGCTGC CTTTTGAGTC CTGTAAGAAG CACACCGGAG TGCAATCAAA ACCGATAAAC 
AGGAAGCAGC CTGGAAGGTA CCACCTGGAC AACTACGAGC AGGCGCGGCG TCTTCGGCCT 
GCTGAGACTG AAGATGTTGC CATAAAGGTG ACGAACGGAT ACTTCTCATG GGGCAGTGGT 
TTAGCCACAT TATCCAATAT TGACATTCGA ATTCCAACAG GTCAGCTAAC CATGATTGTG 
GGTCAGGTGG GTTGTGGCAA ATCGTCTCTC CTCCTTGCCA TCCTTGGTGA GATGCAGACC 
CTGGAAGGAA AAGTTTACTG GAACAATGTA AATGAATCTG AGCCTTCTTT TGAAGCAACC 
CGAAGCAGAA GCAGGTACTC TGTGGCTTAT GCTGCCCAGA AGCCTTGGCT CCTCAATGCT 
ACGGTCGAGG AAAACATCAC TTTTGGAAGT TCTTTCAACA GACAGAGGTA CAAGGCTGTC 
ACCGATGCCT GCTCTCTGCA GCCAGACATT GATTTGTTAC CCTTTGGAGA CCAAACTGAA 
ATTGGAGAGA GGGGTATCAA CCTGAGTGGG GGTCAGAGGC AGAGAATCTG CGTGGCCCGG 
GCACTCTACC AGAACACCAA TATTGTCTTC TTGGACGATC CATTCTCCGC TCTGGACATC 
CACCTGAGCG ACCACTTGAT GCAGGAAGGG ATCCTGAAGT TTCTCCAGGA CGACAAGAGG 
ACGGTCGTCC TTGTGACTCA CAAACTACAG TACCTGACGC ACGCGGACTG GATCATAGCC 
ATGAAGGATG GGAGTGTGTT AAGGGAAGGG ACTTTGAAAG ACATCCAGAC CAAAGACGTG 
GAGCTCTATG AACACTGGAA AACCCTCATG AATCGGCAAG ATCAGGAATT AGAAAAGGAC 
ATGGAAGCCG ACCAAACAAC GCTGGAGAGG AAGACTCTCC GAAGAGCTAT GTACTCAAGG 
GAGGCCAAAG CACAGATGGA GGATGAAGAT GAAGAGGAGG AGGAGGAGGA AGATGAGGAC 
GACAACATGT CAACTGTAAT GAGGCTCAGG ACGAAGATGC CCTGGAAGAC CTGTTGGTGG 
TACCTCACTT CAGGAGGGTT TTTCCTGCTC TTCCTCATGA TCTTCTCTAA GCTTTTGAAG 
CACTCTGTGA TCGTGGCCAT CGACTACTGG CTAGCTACGT GGACCTCCGA GTACAGTATA 
AACGACCCAG GGAAAGCTGA CCAGACCTTC TATGTGGCTG GGTTCAGCAT CCTCTGTGGA 
GCGGGCATTT TCCTTTGCCT CGTCACCTCC CTCACTGTAG AATGGATGGG TCTCACCGCC 
GCCAAGAACC TCCACCACAA TCTCCTCAAT AAGATAATTC TGGGCCCAAT AAGGTTCTTT 
GATACCACGC CCCTGGGACT GATCCTCAAT CGGTTTTCTG CTGATACCAA CATCATCGAC 
CAACATATCC CTCCGACCTT GGAGTCGCTG ACCCGCTCTA CCCTGCTCTG CCTGTCGGCT 
ATTGGGATGA TCTCCTATGC TACACCCGTG TTTCTCATCG CTCTTGCGCC CCTGGGCGTC 
GCCTTTTATT TCATCCAGAA ATACTTCCGG GTTGCCTCTA AGGATCTCCA GGAACTCGAT 
GACAGCACCC AGCTCCCCCT GCTTTGTCAC TTCTCAGAAA CAGCTGAAGG GCTTACCACT 
ATCCGGGCCT TCAGGCATGA AACCAGATTC AAGCAACGCA TGCTGGAGCT GACAGACACA 
AACAACATTG CCTACTTATT TCTCTCCGCA GCCAACAGAT GGCTGGAGGT CAGGACGGAC 
TACCTGGGAG CTTGCATTGT TCTGACGGCC TCCATTGCAT CCATCAGTGG CTCTTCCAAC 
TCTGGACTAG TGGGCTTGGG CCTTCTGTAT GCCCTCACGA TAACCAATTA CCTGAATTGG 
GTTGTAAGGA ACTTGGCCGA CCTCGAAGTC CAGATGGGCG CAGTGAAGAA AGTGAACAGT 
TTCTTAACTA TGGAGTCTGA GAACTATGAA GGCACCATGG ATCCTTCTCA AGTCCCAGAG 
CATTGGCCAC AGGAAGGTGA GATCAAGATT CACGATCTAT GCGTCAGATA TGAAAATAAC 
CTGAAGCCCG TTCTGAAACA TGTCAAGGCT TACATCAAGC CTGGGCAGAA GGTGGGCATC 
TGTGGTCGCA CCGGTAGTGG GAAGTCCTCT CTATCTCTGG CTTTCTTCAG AATGGTCGAC 
ATATTTGATG GAAAGATAGT CATTGATGGA ATAGACATTT CCAAGCTGCC CTTGCACACG 
CTCCGCTCTA GACTGTCCAT CATTCTCCAG GACCCAATCC TGTTCAGCGG CTCTATCAGA 
TTTAACTTGG ATCCTGAATG CAAGTGCACA GACGACAGGC TCTGGGAGGC TCTGGAAATT 
GCTCAGTTGA AGAATATGGT CAAATCTCTG CCAGGAGGCC TAGACGCCAC TGTCACCGAA 
GGTGGTGAGA ACTTCAGCGT TGGACAGAGA CAGCTGTTCT GCCTGGCCAG GGCCTTTGTT 
CGAAAGAGCA GCATACTCAT TATGGATGAG GCCACGGCCT CCATCGACAT GGCCACGGAA 
AACATTTTGC AGAAAGTAGT CATGACAGCC TTTGCGGATC GCACGGTTGT AACCATAGCT 
CATCGGGTTC ACACCATTCT GACTGCTGAC CTGGTCATTG TGATGAAGAG AGGAAACATT 
TTGGAATACG ACACCCCGGA AAGCCTCTTG GCCCAGGAGG ATGGAGTGTT CGCCTCGTTC 
GTTCGTGCGG ACATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037172.2
CDS	271..4908
Translation	MSLSFCGNNISSYNIYHGVLQNPCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSQRASRHLHLFMPAVMGFVATTTSIVYYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYWQLGWGMSDLRFCITGVMVILNGLLMAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHRKPIDLKAIGKLPIAMRAVTNYVCLKEAYEEQKKKAADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNEPKNNTTRFSETLSSKEFLENAHVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGEDSWRTGEGTLPFESCKKHTGVQSKPINRKQPGRYHLDNYEQARRLRPAETEDVAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVYWNNVNESEPSFEATRSRSRYSVAYAAQKPWLLNATVEENITFGSSFNRQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTVVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWWYLTSGGFFLLFLMIFSKLLKHSVIVAIDYWLATWTSEYSINDPGKADQTFYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLIALAPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQEDGVFASFVRADM

Target ORF information:

RefSeq Version	NM_013040.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ATP binding cassette subfamily C member 9 (Abcc9), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013040.2

ORF Insert Sequence:

ATGAGCCTTT CCTTCTGTGG TAACAACATC TCCTCCTACA ACATCTACCA TGGTGTTCTC 
CAAAACCCCT GCTTTGTGGA CGCACTCAAC CTGGTCCCTC ACGTCTTCCT GCTGTTTATC 
ACCTTTCCGA TCCTGTTCAT TGGATGGGGG AGCCAAAGCT CAAAAGTGCA AATTCATCAC 
AACACATGGC TTCATTTTCC TGGACACAAC CTGAGATGGA TTCTGACGTT TGCACTCCTG 
TTTGTGCATG TCTGCGAGAT AGCAGAAGGC ATTGTTTCAG ACTCGCAACG GGCGTCCAGG 
CATCTCCACC TTTTCATGCC GGCTGTGATG GGATTTGTCG CCACCACCAC ATCCATTGTG 
TATTACCACA ACATTGAAAC ATCAAACTTC CCTAAATTAC TTTTAGCTTT ATTCCTGTAC 
TGGGTCATGG CCTTCATTAC AAAGACAATA AAGTTGGTCA AATACTGGCA GTTGGGGTGG 
GGAATGTCAG ACCTGCGCTT CTGCATCACG GGAGTGATGG TCATCTTGAA TGGACTGCTG 
ATGGCTGTGG AGATCAATGT CATCCGGGTC CGAAGATATG TTTTCTTCAT GAATCCTCAG 
AAAGTGAAGC CTCCAGAGGA CCTCCAGGAC CTGGGCGTGA GGTTCCTCCA GCCGTTTGTG 
AATTTGCTGT CCAAAGCTAC TTACTGGTGG ATGAACACGC TTATCATATC AGCTCACAGG 
AAACCTATTG ATCTGAAGGC GATCGGAAAG TTGCCGATAG CAATGAGGGC GGTGACGAAT 
TATGTTTGCT TGAAGGAGGC CTACGAAGAG CAGAAGAAAA AGGCTGCGGA TCATCCGAAT 
CGGACTCCCT CCATATGGCT GGCCATGTAC AGGGCTTTTG GGAGACCGAT CCTGCTGAGC 
AGCACGTTCC GCTACTTGGC TGACTTGCTG GGCTTTGCCG GCCCTCTTTG TATTTCCGGA 
ATCGTCCAGC GTGTGAATGA ACCGAAGAAT AACACGACGA GATTTTCAGA GACACTCTCA 
TCAAAGGAGT TTCTGGAAAA TGCCCATGTG CTGGCTGTCC TGCTCTTCCT GGCCCTCATC 
CTGCAAAGAA CATTTTTGCA GGCTTCGTAC TATGTGACCA TAGAGACCGG CATCAACCTG 
CGTGGGGCTC TGCTGGCTAT GATCTACAAC AAAATCCTTC GACTGTCTAC TTCTAACCTA 
TCCATGGGCG AGATGACCCT GGGACAGATC AACAACTTGG TTGCCATAGA AACCAATCAG 
CTCATGTGGT TCTTGTTCCT GTGTCCCAAT CTGTGGGCCA TGCCCGTTCA GATCATAATG 
GGGGTGATCC TGCTCTATAA TCTGCTTGGG TCAAGCGCAC TGGTAGGCGC GGCGGTCATC 
GTGCTCCTCG CACCGATTCA GTACTTCATC GCCACGAAGC TGGCGGAGGC TCAGAAGAGC 
ACTCTGGATT ATTCCACCGA GAGGCTGAAG AAGACAAACG AGATACTGAA AGGCATCAAG 
CTCCTTAAGC TGTATGCCTG GGAGCACATT TTCTGCAAGA GCGTGGAAGA GACTAGAATG 
AAGGAGCTCT CCAGCCTCAA AACCTTCGCG CTCTACACGT CGCTTTCCAT CTTCATGAAC 
GCAGCCATTC CCATCGCAGC CGTTCTTGCA ACATTTGTGA CCCATGCCTA TGCCAGTGGC 
AACAACCTGA AACCCGCAGA GGCCTTTGCC TCTCTGTCTC TCTTCCACAT CCTCGTCACA 
CCGCTCTTCC TGCTGTCCAC GGTGGTCAGA TTCGCAGTGA AAGCCATCAT CAGCGTTCAG 
AAGCTGAATG AGTTTCTCTT GAGCGATGAG ATTGGCGAGG ACAGCTGGAG GACTGGGGAG 
GGGACGCTGC CTTTTGAGTC CTGTAAGAAG CACACCGGAG TGCAATCAAA ACCGATAAAC 
AGGAAGCAGC CTGGAAGGTA CCACCTGGAC AACTACGAGC AGGCGCGGCG TCTTCGGCCT 
GCTGAGACTG AAGATGTTGC CATAAAGGTG ACGAACGGAT ACTTCTCATG GGGCAGTGGT 
TTAGCCACAT TATCCAATAT TGACATTCGA ATTCCAACAG GTCAGCTAAC CATGATTGTG 
GGTCAGGTGG GTTGTGGCAA ATCGTCTCTC CTCCTTGCCA TCCTTGGTGA GATGCAGACC 
CTGGAAGGAA AAGTTTACTG GAACAATGTA AATGAATCTG AGCCTTCTTT TGAAGCAACC 
CGAAGCAGAA GCAGGTACTC TGTGGCTTAT GCTGCCCAGA AGCCTTGGCT CCTCAATGCT 
ACGGTCGAGG AAAACATCAC TTTTGGAAGT TCTTTCAACA GACAGAGGTA CAAGGCTGTC 
ACCGATGCCT GCTCTCTGCA GCCAGACATT GATTTGTTAC CCTTTGGAGA CCAAACTGAA 
ATTGGAGAGA GGGGTATCAA CCTGAGTGGG GGTCAGAGGC AGAGAATCTG CGTGGCCCGG 
GCACTCTACC AGAACACCAA TATTGTCTTC TTGGACGATC CATTCTCCGC TCTGGACATC 
CACCTGAGCG ACCACTTGAT GCAGGAAGGG ATCCTGAAGT TTCTCCAGGA CGACAAGAGG 
ACGGTCGTCC TTGTGACTCA CAAACTACAG TACCTGACGC ACGCGGACTG GATCATAGCC 
ATGAAGGATG GGAGTGTGTT AAGGGAAGGG ACTTTGAAAG ACATCCAGAC CAAAGACGTG 
GAGCTCTATG AACACTGGAA AACCCTCATG AATCGGCAAG ATCAGGAATT AGAAAAGGAC 
ATGGAAGCCG ACCAAACAAC GCTGGAGAGG AAGACTCTCC GAAGAGCTAT GTACTCAAGG 
GAGGCCAAAG CACAGATGGA GGATGAAGAT GAAGAGGAGG AGGAGGAGGA AGATGAGGAC 
GACAACATGT CAACTGTAAT GAGGCTCAGG ACGAAGATGC CCTGGAAGAC CTGTTGGTGG 
TACCTCACTT CAGGAGGGTT TTTCCTGCTC TTCCTCATGA TCTTCTCTAA GCTTTTGAAG 
CACTCTGTGA TCGTGGCCAT CGACTACTGG CTAGCTACGT GGACCTCCGA GTACAGTATA 
AACGACCCAG GGAAAGCTGA CCAGACCTTC TATGTGGCTG GGTTCAGCAT CCTCTGTGGA 
GCGGGCATTT TCCTTTGCCT CGTCACCTCC CTCACTGTAG AATGGATGGG TCTCACCGCC 
GCCAAGAACC TCCACCACAA TCTCCTCAAT AAGATAATTC TGGGCCCAAT AAGGTTCTTT 
GATACCACGC CCCTGGGACT GATCCTCAAT CGGTTTTCTG CTGATACCAA CATCATCGAC 
CAACATATCC CTCCGACCTT GGAGTCGCTG ACCCGCTCTA CCCTGCTCTG CCTGTCGGCT 
ATTGGGATGA TCTCCTATGC TACACCCGTG TTTCTCATCG CTCTTGCGCC CCTGGGCGTC 
GCCTTTTATT TCATCCAGAA ATACTTCCGG GTTGCCTCTA AGGATCTCCA GGAACTCGAT 
GACAGCACCC AGCTCCCCCT GCTTTGTCAC TTCTCAGAAA CAGCTGAAGG GCTTACCACT 
ATCCGGGCCT TCAGGCATGA AACCAGATTC AAGCAACGCA TGCTGGAGCT GACAGACACA 
AACAACATTG CCTACTTATT TCTCTCCGCA GCCAACAGAT GGCTGGAGGT CAGGACGGAC 
TACCTGGGAG CTTGCATTGT TCTGACGGCC TCCATTGCAT CCATCAGTGG CTCTTCCAAC 
TCTGGACTAG TGGGCTTGGG CCTTCTGTAT GCCCTCACGA TAACCAATTA CCTGAATTGG 
GTTGTAAGGA ACTTGGCCGA CCTCGAAGTC CAGATGGGCG CAGTGAAGAA AGTGAACAGT 
TTCTTAACTA TGGAGTCTGA GAACTATGAA GGCACCATGG ATCCTTCTCA AGTCCCAGAG 
CATTGGCCAC AGGAAGGTGA GATCAAGATT CACGATCTAT GCGTCAGATA TGAAAATAAC 
CTGAAGCCCG TTCTGAAACA TGTCAAGGCT TACATCAAGC CTGGGCAGAA GGTGGGCATC 
TGTGGTCGCA CCGGTAGTGG GAAGTCCTCT CTATCTCTGG CTTTCTTCAG AATGGTCGAC 
ATATTTGATG GAAAGATAGT CATTGATGGA ATAGACATTT CCAAGCTGCC CTTGCACACG 
CTCCGCTCTA GACTGTCCAT CATTCTCCAG GACCCAATCC TGTTCAGCGG CTCTATCAGA 
TTTAACTTGG ATCCTGAATG CAAGTGCACA GACGACAGGC TCTGGGAGGC TCTGGAAATT 
GCTCAGTTGA AGAATATGGT CAAATCTCTG CCAGGAGGCC TAGACGCCAC TGTCACCGAA 
GGTGGTGAGA ACTTCAGCGT TGGACAGAGA CAGCTGTTCT GCCTGGCCAG GGCCTTTGTT 
CGAAAGAGCA GCATACTCAT TATGGATGAG GCCACGGCCT CCATCGACAT GGCCACGGAA 
AACATTTTGC AGAAAGTAGT CATGACAGCC TTTGCGGATC GCACGGTTGT AACCATAGCT 
CATCGGGTTC ACACCATTCT GACTGCTGAC CTGGTCATTG TGATGAAGAG AGGAAACATT 
TTGGAATACG ACACCCCGGA AAGCCTCTTG GCCCAGGAGG ATGGAGTGTT CGCCTCGTTC 
GTTCGTGCGG ACATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cantu syndrome-associated SUR2 (ABCC9) mutations in distinct structural domains result in K
The Journal of biological chemistry(2017 Dec)
McClenaghan C,Hanson A,Sala-Rabanal M,Roessler HI,Josifova D,Grange DK,van Haaften G,Nichols CG

Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel.
The Journal of biological chemistry292(42)17387-17398(2017 10)
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Altered KATP Channel Subunits Expression and Vascular Reactivity in Spontaneously Hypertensive Rats With Age.
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Differential mechanisms of Cant? syndrome-associated gain of function mutations in the ABCC9 (SUR2) subunit of the KATP channel.
The Journal of general physiology146(6)527-40(2015 Dec)
Cooper PE,Sala-Rabanal M,Lee SJ,Nichols CG

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Abcc9 cDNA ORF clone, Rattus norvegicus(Norway rat)

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