P2rx1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	P2rx1
Entrez Gene ID	25505
Full Name	purinergic receptor P2X 1
Synonyms	P2XMR
General protein information	Preferred Names purinergic receptor P2X 1 Names P2X purinoceptor 1 ATP receptor P2X1 RP-2 protein purinergic receptor P2X, ligand-gated ion channel, 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q24
Summary	ligand-gated cation-selective ion channel with relatively high calcium permeability; activated by ATP and may be involved in synaptic transmission [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001285415.1	NP_001272344.1	P2X purinoceptor 1 isoform 3
NM_001142367.2	NP_001135839.1	P2X purinoceptor 1 isoform 2
NM_012997.3	NP_037129.1	P2X purinoceptor 1 isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	P2RX1	XP_511276.2
Mus musculus (house mouse)	P2rx1	NP_032797.3
	P2RX1	XP_001092205.1
Xenopus tropicalis (tropical clawed frog)	p2rx1	XP_002932325.2
Gallus gallus (chicken)	P2RX1	NP_989850.1
Danio rerio (zebrafish)	p2rx1	NP_945333.1
Homo sapiens (human)	P2RX1	NP_002549.1
Canis lupus familiaris (dog)	P2RX1	XP_548344.1
Bos taurus (cattle)	P2RX1	NP_001192729.1
Rattus norvegicus (Norway rat)	P2rx1	NP_037129.1

Gene Ontology
Bibliography

Related articles in PubMed

Physiopathological implications of P2X
Franco M, Bautista-P?rez R, Cano-Mart?nez A, Pacheco U, Santamar?a J, Del Valle Mondrag?n L, P?rez-M?ndez O, Navar LG
American journal of physiology. Renal physiology313(1)F9-F19(2017 Jul)

P2X1 Receptor-Mediated Ca
Back MJ, Lee HK, Lee JH, Fu Z, Son MW, Choi SZ, Go HS, Yoo S, Hwang SW, Kim DK
ACS chemical neuroscience7(11)1488-1498(2016 Nov)

Presynaptic P2X1-3 and ?3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus.
Rodrigues RJ, Almeida T, D?az-Hern?ndez M, Marques JM, Franco R, Solsona C, Miras-Portugal MT, Ciruela F, Cunha RA
Neuropharmacology105241-257(2016 06)

Molecular identification of P2X receptors in vascular smooth muscle cells from rat anterior, posterior, and basilar arteries.
Harhun MI, Sukhanova K, Gordienko D, Dyskina Y
Pharmacological reports : PR67(6)1055-60(2015 Dec)

Phenotypes of ATP-activated current associated with their genotypes of P2X1-6 subunits in neurons innervating tooth-pulp.
Liu Y, Tian X, Wu Y, Chen L, Yi CL, Li ZW, Zhang Y, Li CY
Biochemical and biophysical research communications458(3)596-600(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Indicate a predominant role for P2X1R and P2X7R in the control of glomerular hemodynamics in ANG II hypertension.
Title: Physiopathological implications of P2X

Study demonstrated that P2X1 receptor-mediated calcium ion influx triggered by DA-9801 potentiated the Nerve Growth Factor-induced neurite outgrowth. The results obtained in this study imply a possible relationship between P2X1 and neuroregeneration.
Title: P2X1 Receptor-Mediated Ca

work identified that in major arteries of rat cerebral circulation Vascular Smooth Muscle Cells express only P2X1 and P2X4 receptors subunits.
Title: Molecular identification of P2X receptors in vascular smooth muscle cells from rat anterior, posterior, and basilar arteries.

The study explores the association of the phenotype of ATP-activated current with the genotype of P2X1-6 subunits in neurons innervating tooth-pulp.
Title: Phenotypes of ATP-activated current associated with their genotypes of P2X1-6 subunits in neurons innervating tooth-pulp.

heteromeric P2X1/4Rs contribute to the sustained component of the purinergic-mediated vasoconstriction in rat middle cerebral arteries.
Title: ATP-evoked sustained vasoconstrictions mediated by heteromeric P2X1/4 receptors in cerebral arteries.

The following P2rx1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the P2rx1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa01595	NM_012997.3 Latest version!	Rattus norvegicus purinergic receptor P2X 1 (P2rx1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa04318	NM_001142367.2 Latest version!	Rattus norvegicus purinergic receptor P2X 1 (P2rx1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa11944	NM_001285415.1 Latest version!	Rattus norvegicus purinergic receptor P2X 1 (P2rx1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

P2rx1 ( NM_012997.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037129.1 Rattus norvegicus purinergic receptor P2X 1 (P2rx1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa01595
Clone ID Related Accession (Same CDS sequence)	NM_012997.3
Accession Version	NM_012997.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1200bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	P2X purinoceptor 1 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from X80477.1 and BC061742.1. On Oct 18, 2013 this sequence version replaced NM_012997.2. Transcript Variant: This variant (1) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061742.1, X80477.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGGCTCGGC GGCTGCAAGA TGAGCTGTCA GCCTTCTTCT TTGAATATGA CACTCCCCGG 
ATGGTGCTGG TACGAAACAA GAAGGTGGGA GTCATTTTCC GTCTGATCCA GTTGGTGGTT 
CTGGTCTACG TCATTGGGTG GGTGTTTGTC TATGAAAAAG GATACCAGAC CTCAAGTGAC 
CTCATCAGCA GTGTGTCCGT GAAGCTCAAG GGCTTGGCTG TGACCCAGCT CCAGGGCCTG 
GGACCCCAGG TCTGGGACGT GGCTGACTAT GTCTTCCCAG CACACGGGGA CAGCTCCTTT 
GTAGTTATGA CCAACTTCAT CGTGACCCCT CAGCAGACTC AAGGCCATTG TGCAGAGAAC 
CCAGAAGGTG GCATATGCCA GGATGACAGT GGCTGCACTC CAGGAAAAGC AGAAAGGAAA 
GCCCAAGGTA TTCGCACAGG CAACTGTGTG CCCTTCAATG GCACTGTGAA GACATGTGAG 
ATCTTTGGTT GGTGTCCTGT AGAGGTGGAT GACAAGATCC CAAGCCCTGC TCTTCTTCGT 
GAGGCTGAGA ACTTCACCCT CTTCATCAAA AACAGCATCA GCTTTCCACG CTTCAAGGTC 
AACAGGCGCA ACCTGGTAGA GGAGGTGAAT GGCACCTACA TGAAGAAGTG CCTCTATCAC 
AAGATTCAAC ACCCCCTGTG CCCAGTCTTC AACCTTGGCT ATGTGGTGCG AGAGTCAGGC 
CAGGACTTCC GCAGCCTTGC TGAGAAGGGT GGGGTGGTTG GTATCACCAT TGACTGGAAG 
TGTGATCTGG ACTGGCACGT TCGGCACTGC AAACCCATCT ACCAGTTCCA CGGACTGTAT 
GGGGAGAAGA ACCTGTCTCC AGGCTTCAAC TTCAGATTTG CCAGGCATTT CGTGCAGAAT 
GGGACAAACC GTCGTCACCT CTTCAAGGTG TTTGGGATTC ACTTTGATAT CCTTGTGGAT 
GGCAAGGCTG GGAAGTTTGA CATCATCCCT ACTATGACTA CTATCGGTTC TGGGATTGGC 
ATCTTTGGAG TGGCCACAGT GCTTTGTGAT CTCTTATTGC TCCACATCCT GCCTAAGAGG 
CACTACTACA AGCAGAAGAA GTTCAAATAT GCCGAGGACA TGGGGCCGGG AGAGGGTGAA 
CATGACCCCG TGGCCACCAG CTCCACTCTG GGCCTGCAGG AGAACATGAG GACCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037129.1
CDS	210..1409
Translation	MARRLQDELSAFFFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFVYEKGYQTSSDLISSVSVKLKGLAVTQLQGLGPQVWDVADYVFPAHGDSSFVVMTNFIVTPQQTQGHCAENPEGGICQDDSGCTPGKAERKAQGIRTGNCVPFNGTVKTCEIFGWCPVEVDDKIPSPALLREAENFTLFIKNSISFPRFKVNRRNLVEEVNGTYMKKCLYHKIQHPLCPVFNLGYVVRESGQDFRSLAEKGGVVGITIDWKCDLDWHVRHCKPIYQFHGLYGEKNLSPGFNFRFARHFVQNGTNRRHLFKVFGIHFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKFKYAEDMGPGEGEHDPVATSSTLGLQENMRTS

Target ORF information:

RefSeq Version	NM_012997.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus purinergic receptor P2X 1 (P2rx1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012997.3

ORF Insert Sequence:

ATGGCTCGGC GGCTGCAAGA TGAGCTGTCA GCCTTCTTCT TTGAATATGA CACTCCCCGG 
ATGGTGCTGG TACGAAACAA GAAGGTGGGA GTCATTTTCC GTCTGATCCA GTTGGTGGTT 
CTGGTCTACG TCATTGGGTG GGTGTTTGTC TATGAAAAAG GATACCAGAC CTCAAGTGAC 
CTCATCAGCA GTGTGTCCGT GAAGCTCAAG GGCTTGGCTG TGACCCAGCT CCAGGGCCTG 
GGACCCCAGG TCTGGGACGT GGCTGACTAT GTCTTCCCAG CACACGGGGA CAGCTCCTTT 
GTAGTTATGA CCAACTTCAT CGTGACCCCT CAGCAGACTC AAGGCCATTG TGCAGAGAAC 
CCAGAAGGTG GCATATGCCA GGATGACAGT GGCTGCACTC CAGGAAAAGC AGAAAGGAAA 
GCCCAAGGTA TTCGCACAGG CAACTGTGTG CCCTTCAATG GCACTGTGAA GACATGTGAG 
ATCTTTGGTT GGTGTCCTGT AGAGGTGGAT GACAAGATCC CAAGCCCTGC TCTTCTTCGT 
GAGGCTGAGA ACTTCACCCT CTTCATCAAA AACAGCATCA GCTTTCCACG CTTCAAGGTC 
AACAGGCGCA ACCTGGTAGA GGAGGTGAAT GGCACCTACA TGAAGAAGTG CCTCTATCAC 
AAGATTCAAC ACCCCCTGTG CCCAGTCTTC AACCTTGGCT ATGTGGTGCG AGAGTCAGGC 
CAGGACTTCC GCAGCCTTGC TGAGAAGGGT GGGGTGGTTG GTATCACCAT TGACTGGAAG 
TGTGATCTGG ACTGGCACGT TCGGCACTGC AAACCCATCT ACCAGTTCCA CGGACTGTAT 
GGGGAGAAGA ACCTGTCTCC AGGCTTCAAC TTCAGATTTG CCAGGCATTT CGTGCAGAAT 
GGGACAAACC GTCGTCACCT CTTCAAGGTG TTTGGGATTC ACTTTGATAT CCTTGTGGAT 
GGCAAGGCTG GGAAGTTTGA CATCATCCCT ACTATGACTA CTATCGGTTC TGGGATTGGC 
ATCTTTGGAG TGGCCACAGT GCTTTGTGAT CTCTTATTGC TCCACATCCT GCCTAAGAGG 
CACTACTACA AGCAGAAGAA GTTCAAATAT GCCGAGGACA TGGGGCCGGG AGAGGGTGAA 
CATGACCCCG TGGCCACCAG CTCCACTCTG GGCCTGCAGG AGAACATGAG GACCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

P2rx1 ( NM_001142367.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001135839.1 Rattus norvegicus purinergic receptor P2X 1 (P2rx1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa04318
Clone ID Related Accession (Same CDS sequence)	NM_001142367.2
Accession Version	NM_001142367.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1119bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Rattus norvegicus(Norway rat)
Product	P2X purinoceptor 1 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from X80477.1 and BC061742.1. On Oct 18, 2013 this sequence version replaced NM_001142367.1. Transcript Variant: This variant (2) has an alternate splice junction in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FJ424511.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2689594, SAMEA2689599 [ECO:0000350] ##Evidence-Data-END##

ATGGCTCGGC GGCTGCAAGA TGAGCTGTCA GCCTTCTTCT TTGAATATGA CACTCCCCGG 
ATGGTGCTGG TACGAAACAA GAAGGTGGGA GTCATTTTCC GTCTGATCCA GTTGGTGGTT 
CTGGTCTACG TCATTGGGTG GGTGTTTGTC TATGAAAAAG GATACCAGAC CTCAAGTGAC 
CTCATCAGCA GTGTGTCCGT GAAGCTCAAG GGCTTGGCTG TGACCCAGCT CCAGGGCCTG 
GGACCCCAGG TCTGGGACGT GGCTGACTAT GTCTTCCCAG CACACGGGGA CAGCTCCTTT 
GTAGTTATGA CCAACTTCAT CGTGACCCCT CAGCAGACTC AAGGCCATTG TGCAGAGAAC 
CCAGAAGGTG GCATATGCCA GGATGACAGT GGCTGCACTC CAGGAAAAGC AGAAAGGAAA 
GCCCAAGGTA TTCGCACAGG CAACTGTGTG CCCTTCAATG GCACTGTGAA GACATGTGAG 
ATCTTTGGTT GGTGTCCTGT AGAGGTGGAT GACAAGATCC CAAGCCCTGC TCTTCTTCGT 
GAGGTGAATG GCACCTACAT GAAGAAGTGC CTCTATCACA AGATTCAACA CCCCCTGTGC 
CCAGTCTTCA ACCTTGGCTA TGTGGTGCGA GAGTCAGGCC AGGACTTCCG CAGCCTTGCT 
GAGAAGGGTG GGGTGGTTGG TATCACCATT GACTGGAAGT GTGATCTGGA CTGGCACGTT 
CGGCACTGCA AACCCATCTA CCAGTTCCAC GGACTGTATG GGGAGAAGAA CCTGTCTCCA 
GGCTTCAACT TCAGATTTGC CAGGCATTTC GTGCAGAATG GGACAAACCG TCGTCACCTC 
TTCAAGGTGT TTGGGATTCA CTTTGATATC CTTGTGGATG GCAAGGCTGG GAAGTTTGAC 
ATCATCCCTA CTATGACTAC TATCGGTTCT GGGATTGGCA TCTTTGGAGT GGCCACAGTG 
CTTTGTGATC TCTTATTGCT CCACATCCTG CCTAAGAGGC ACTACTACAA GCAGAAGAAG 
TTCAAATATG CCGAGGACAT GGGGCCGGGA GAGGGTGAAC ATGACCCCGT GGCCACCAGC 
TCCACTCTGG GCCTGCAGGA GAACATGAGG ACCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001135839.1
CDS	210..1328
Translation	MARRLQDELSAFFFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFVYEKGYQTSSDLISSVSVKLKGLAVTQLQGLGPQVWDVADYVFPAHGDSSFVVMTNFIVTPQQTQGHCAENPEGGICQDDSGCTPGKAERKAQGIRTGNCVPFNGTVKTCEIFGWCPVEVDDKIPSPALLREVNGTYMKKCLYHKIQHPLCPVFNLGYVVRESGQDFRSLAEKGGVVGITIDWKCDLDWHVRHCKPIYQFHGLYGEKNLSPGFNFRFARHFVQNGTNRRHLFKVFGIHFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKFKYAEDMGPGEGEHDPVATSSTLGLQENMRTS

Target ORF information:

RefSeq Version	NM_001142367.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus purinergic receptor P2X 1 (P2rx1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142367.2

ORF Insert Sequence:

ATGGCTCGGC GGCTGCAAGA TGAGCTGTCA GCCTTCTTCT TTGAATATGA CACTCCCCGG 
ATGGTGCTGG TACGAAACAA GAAGGTGGGA GTCATTTTCC GTCTGATCCA GTTGGTGGTT 
CTGGTCTACG TCATTGGGTG GGTGTTTGTC TATGAAAAAG GATACCAGAC CTCAAGTGAC 
CTCATCAGCA GTGTGTCCGT GAAGCTCAAG GGCTTGGCTG TGACCCAGCT CCAGGGCCTG 
GGACCCCAGG TCTGGGACGT GGCTGACTAT GTCTTCCCAG CACACGGGGA CAGCTCCTTT 
GTAGTTATGA CCAACTTCAT CGTGACCCCT CAGCAGACTC AAGGCCATTG TGCAGAGAAC 
CCAGAAGGTG GCATATGCCA GGATGACAGT GGCTGCACTC CAGGAAAAGC AGAAAGGAAA 
GCCCAAGGTA TTCGCACAGG CAACTGTGTG CCCTTCAATG GCACTGTGAA GACATGTGAG 
ATCTTTGGTT GGTGTCCTGT AGAGGTGGAT GACAAGATCC CAAGCCCTGC TCTTCTTCGT 
GAGGTGAATG GCACCTACAT GAAGAAGTGC CTCTATCACA AGATTCAACA CCCCCTGTGC 
CCAGTCTTCA ACCTTGGCTA TGTGGTGCGA GAGTCAGGCC AGGACTTCCG CAGCCTTGCT 
GAGAAGGGTG GGGTGGTTGG TATCACCATT GACTGGAAGT GTGATCTGGA CTGGCACGTT 
CGGCACTGCA AACCCATCTA CCAGTTCCAC GGACTGTATG GGGAGAAGAA CCTGTCTCCA 
GGCTTCAACT TCAGATTTGC CAGGCATTTC GTGCAGAATG GGACAAACCG TCGTCACCTC 
TTCAAGGTGT TTGGGATTCA CTTTGATATC CTTGTGGATG GCAAGGCTGG GAAGTTTGAC 
ATCATCCCTA CTATGACTAC TATCGGTTCT GGGATTGGCA TCTTTGGAGT GGCCACAGTG 
CTTTGTGATC TCTTATTGCT CCACATCCTG CCTAAGAGGC ACTACTACAA GCAGAAGAAG 
TTCAAATATG CCGAGGACAT GGGGCCGGGA GAGGGTGAAC ATGACCCCGT GGCCACCAGC 
TCCACTCTGG GCCTGCAGGA GAACATGAGG ACCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

P2rx1 ( NM_001285415.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001272344.1 Rattus norvegicus purinergic receptor P2X 1 (P2rx1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	ORa11944
Clone ID Related Accession (Same CDS sequence)	NM_001285415.1
Accession Version	NM_001285415.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1119bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Rattus norvegicus(Norway rat)
Product	P2X purinoceptor 1 isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from X80477.1 and BC061742.1. Transcript Variant: This variant (3) lacks an in-frame coding exon, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF231010.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMN01906347 [ECO:0000348] ##Evidence-Data-END##

ATGGCTCGGC GGCTGCAAGA TGAGCTGTCA GCCTTCTTCT TTGAATATGA CACTCCCCGG 
ATGGTGCTGG TACGAAACAA GAAGGTGGGA GTCATTTTCC GTCTGATCCA GTTGGTGGTT 
CTGGTCTACG TCATTGGGTG GGTGTTTGTC TATGAAAAAG GATACCAGAC CTCAAGTGAC 
CTCATCAGCA GTGTGTCCGT GAAGCTCAAG GGCTTGGCTG TGACCCAGCT CCAGGGCCTG 
GGACCCCAGG TCTGGGACGT GGCTGACTAT GTCTTCCCAG CACACGGGGA CAGCTCCTTT 
GTAGTTATGA CCAACTTCAT CGTGACCCCT CAGCAGACTC AAGGCCATTG TGCAGAGAAC 
CCAGAAGGTG GCATATGCCA GGATGACAGT GGCTGCACTC CAGGAAAAGC AGAAAGGAAA 
GCCCAAGGTA TTCGCACAGG CAACTGTGTG CCCTTCAATG GCACTGTGAA GACATGTGAG 
ATCTTTGGTT GGTGTCCTGT AGAGGTGGAT GACAAGATCC CAAGGCGCAA CCTGGTAGAG 
GAGGTGAATG GCACCTACAT GAAGAAGTGC CTCTATCACA AGATTCAACA CCCCCTGTGC 
CCAGTCTTCA ACCTTGGCTA TGTGGTGCGA GAGTCAGGCC AGGACTTCCG CAGCCTTGCT 
GAGAAGGGTG GGGTGGTTGG TATCACCATT GACTGGAAGT GTGATCTGGA CTGGCACGTT 
CGGCACTGCA AACCCATCTA CCAGTTCCAC GGACTGTATG GGGAGAAGAA CCTGTCTCCA 
GGCTTCAACT TCAGATTTGC CAGGCATTTC GTGCAGAATG GGACAAACCG TCGTCACCTC 
TTCAAGGTGT TTGGGATTCA CTTTGATATC CTTGTGGATG GCAAGGCTGG GAAGTTTGAC 
ATCATCCCTA CTATGACTAC TATCGGTTCT GGGATTGGCA TCTTTGGAGT GGCCACAGTG 
CTTTGTGATC TCTTATTGCT CCACATCCTG CCTAAGAGGC ACTACTACAA GCAGAAGAAG 
TTCAAATATG CCGAGGACAT GGGGCCGGGA GAGGGTGAAC ATGACCCCGT GGCCACCAGC 
TCCACTCTGG GCCTGCAGGA GAACATGAGG ACCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001272344.1
CDS	210..1328
Translation	MARRLQDELSAFFFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFVYEKGYQTSSDLISSVSVKLKGLAVTQLQGLGPQVWDVADYVFPAHGDSSFVVMTNFIVTPQQTQGHCAENPEGGICQDDSGCTPGKAERKAQGIRTGNCVPFNGTVKTCEIFGWCPVEVDDKIPRRNLVEEVNGTYMKKCLYHKIQHPLCPVFNLGYVVRESGQDFRSLAEKGGVVGITIDWKCDLDWHVRHCKPIYQFHGLYGEKNLSPGFNFRFARHFVQNGTNRRHLFKVFGIHFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKFKYAEDMGPGEGEHDPVATSSTLGLQENMRTS

Target ORF information:

RefSeq Version	NM_001285415.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus purinergic receptor P2X 1 (P2rx1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001285415.1

ORF Insert Sequence:

ATGGCTCGGC GGCTGCAAGA TGAGCTGTCA GCCTTCTTCT TTGAATATGA CACTCCCCGG 
ATGGTGCTGG TACGAAACAA GAAGGTGGGA GTCATTTTCC GTCTGATCCA GTTGGTGGTT 
CTGGTCTACG TCATTGGGTG GGTGTTTGTC TATGAAAAAG GATACCAGAC CTCAAGTGAC 
CTCATCAGCA GTGTGTCCGT GAAGCTCAAG GGCTTGGCTG TGACCCAGCT CCAGGGCCTG 
GGACCCCAGG TCTGGGACGT GGCTGACTAT GTCTTCCCAG CACACGGGGA CAGCTCCTTT 
GTAGTTATGA CCAACTTCAT CGTGACCCCT CAGCAGACTC AAGGCCATTG TGCAGAGAAC 
CCAGAAGGTG GCATATGCCA GGATGACAGT GGCTGCACTC CAGGAAAAGC AGAAAGGAAA 
GCCCAAGGTA TTCGCACAGG CAACTGTGTG CCCTTCAATG GCACTGTGAA GACATGTGAG 
ATCTTTGGTT GGTGTCCTGT AGAGGTGGAT GACAAGATCC CAAGGCGCAA CCTGGTAGAG 
GAGGTGAATG GCACCTACAT GAAGAAGTGC CTCTATCACA AGATTCAACA CCCCCTGTGC 
CCAGTCTTCA ACCTTGGCTA TGTGGTGCGA GAGTCAGGCC AGGACTTCCG CAGCCTTGCT 
GAGAAGGGTG GGGTGGTTGG TATCACCATT GACTGGAAGT GTGATCTGGA CTGGCACGTT 
CGGCACTGCA AACCCATCTA CCAGTTCCAC GGACTGTATG GGGAGAAGAA CCTGTCTCCA 
GGCTTCAACT TCAGATTTGC CAGGCATTTC GTGCAGAATG GGACAAACCG TCGTCACCTC 
TTCAAGGTGT TTGGGATTCA CTTTGATATC CTTGTGGATG GCAAGGCTGG GAAGTTTGAC 
ATCATCCCTA CTATGACTAC TATCGGTTCT GGGATTGGCA TCTTTGGAGT GGCCACAGTG 
CTTTGTGATC TCTTATTGCT CCACATCCTG CCTAAGAGGC ACTACTACAA GCAGAAGAAG 
TTCAAATATG CCGAGGACAT GGGGCCGGGA GAGGGTGAAC ATGACCCCGT GGCCACCAGC 
TCCACTCTGG GCCTGCAGGA GAACATGAGG ACCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Physiopathological implications of P2X
American journal of physiology. Renal physiology313(1)F9-F19(2017 Jul)
Franco M,Bautista-P?rez R,Cano-Mart?nez A,Pacheco U,Santamar?a J,Del Valle Mondrag?n L,P?rez-M?ndez O,Navar LG

P2X1 Receptor-Mediated Ca
ACS chemical neuroscience7(11)1488-1498(2016 Nov)
Back MJ,Lee HK,Lee JH,Fu Z,Son MW,Choi SZ,Go HS,Yoo S,Hwang SW,Kim DK

Presynaptic P2X1-3 and ?3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus.
Neuropharmacology105241-257(2016 06)
Rodrigues RJ,Almeida T,D?az-Hern?ndez M,Marques JM,Franco R,Solsona C,Miras-Portugal MT,Ciruela F,Cunha RA

Molecular identification of P2X receptors in vascular smooth muscle cells from rat anterior, posterior, and basilar arteries.
Pharmacological reports : PR67(6)1055-60(2015 Dec)
Harhun MI,Sukhanova K,Gordienko D,Dyskina Y

Phenotypes of ATP-activated current associated with their genotypes of P2X1-6 subunits in neurons innervating tooth-pulp.
Biochemical and biophysical research communications458(3)596-600(2015 Mar)
Liu Y,Tian X,Wu Y,Chen L,Yi CL,Li ZW,Zhang Y,Li CY

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P2rx1 cDNA ORF clone, Rattus norvegicus(Norway rat)

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ORF Insert Sequence:

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