Fshr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fshr
Entrez Gene ID	25449
Full Name	follicle stimulating hormone receptor
General protein information	Preferred Names follicle stimulating hormone receptor Names follicle-stimulating hormone receptor FSH-R follitropin receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q12
Summary	testicular receptor for follicle stimulating hormone; stimulates adenylyl cyclase activity [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_199237.1	NP_954707.1	follicle-stimulating hormone receptor precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	FSHR	XP_538488.2
Bos taurus (cattle)	FSHR	NP_776486.1
Rattus norvegicus (Norway rat)	Fshr	NP_954707.1
Homo sapiens (human)	FSHR	NP_000136.2
Pan troglodytes (chimpanzee)	FSHR	XP_525753.2
	FSHR	XP_001114171.1
Danio rerio (zebrafish)	fshr	NP_001001812.1
Mus musculus (house mouse)	Fshr	NP_038551.3
Xenopus tropicalis (tropical clawed frog)	fshr	XP_002935422.1
Gallus gallus (chicken)	FSHR	NP_990410.1

Gene Ontology
Bibliography

Related articles in PubMed

LHCGR Expression During Follicle Stimulating Hormone-Induced Follicle Growth Is Negatively Regulated by Eukaryotic Initiation Factor 5A.
Gulappa T, Menon B, Menon KMJ
Endocrinology158(8)2672-2679(2017 Aug)

Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer.
Jiang X, Fischer D, Chen X, McKenna SD, Liu H, Sriraman V, Yu HN, Goutopoulos A, Arkinstall S, He X
The Journal of biological chemistry289(20)14273-82(2014 May)

Dysregulation of ovarian follicular development in female rat: LH decreases FSH sensitivity during preantral-early antral transition.
Orisaka M, Hattori K, Fukuda S, Mizutani T, Miyamoto K, Sato T, Tsang BK, Kotsuji F, Yoshida Y
Endocrinology154(8)2870-80(2013 Aug)

Alteration of cell membrane proteoglycans impairs FSH receptor/Gs coupling and ERK activation through PP2A-dependent mechanisms in immature rat Sertoli cells.
Levallet G, Bonnamy PJ, Levallet J
Biochimica et biophysica acta1830(6)3466-75(2013 Jun)

Molecular analysis of a mutated FSH receptor detected in a patient with spontaneous ovarian hyperstimulation syndrome.
Uchida S, Uchida H, Maruyama T, Kajitani T, Oda H, Miyazaki K, Kagami M, Yoshimura Y
PloS one8(9)e75478(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results of this study support the notion that by inhibiting eIF5A hypusination, FSH reduces the expression of an LHCGR mRNA-binding protein (LRBP), and then this increases LHCGR mRNA expression by abrogating the inhibitory action of LRBP.
Title: LHCGR Expression During Follicle Stimulating Hormone-Induced Follicle Growth Is Negatively Regulated by Eukaryotic Initiation Factor 5A.

Data indicate that sustained follicle stimulation by luteinizing hormone (LH) decreases follicle stimulating hormone (FSH) receptor mRNA levels and FSH receptor signaling and inhibits FSH-induced follicular growth.
Title: Dysregulation of ovarian follicular development in female rat: LH decreases FSH sensitivity during preantral-early antral transition.

In 20-day-old rat Sertoli cells, transmembrane cell PGs, through tethering/activation of PP2A activity exerts regulatory control on both FSH receptor/Gs coupling and ERK phosphorylation.
Title: Alteration of cell membrane proteoglycans impairs FSH receptor/Gs coupling and ERK activation through PP2A-dependent mechanisms in immature rat Sertoli cells.

The data suggested that, during prepubertal Sertoli cell maturation, the ability of FSH receptor to respond to FSH is significantly augmented and is associated with the robust differentiation of repopulating spermatogonia.
Title: A switch in Sertoli cell responsiveness to FSH may be responsible for robust onset of germ cell differentiation during prepubartal testicular maturation in rats.

report of inhibition of FSHR expression by WT1 in ovarian tissue; inhibition probably occurs via direct interaction with the FSHR promoter
Title: Regulation of FSH receptor expression by the Wilms' tumor 1 gene product (WT1) in immature rat granulosa cells.

The following Fshr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fshr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04648	NM_199237.1 Latest version!	Rattus norvegicus follicle stimulating hormone receptor (Fshr), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$405.30 $579.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fshr ( NM_199237.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_954707.1 Rattus norvegicus follicle stimulating hormone receptor (Fshr), mRNA.

Price & Availability↑

CloneID	ORa04648
Clone ID Related Accession (Same CDS sequence)	NM_199237.1
Accession Version	NM_199237.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2079bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	follicle-stimulating hormone receptor precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L02842.1. On Jan 1, 2004 this sequence version replaced XM_345635.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L02842.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689601, SAMEA2689604 [ECO:0000348] ##Evidence-Data-END##

ATGGCCTTGC TCCTGGTCTC CTTGCTGGCA TTCTTGGGCA CGGGATCTGG ATGTCATCAC 
TGGCTGTGTC ATTGCTCTAA TAGGGTCTTT CTCTGCCAAG ACAGCAAGGT GACAGAGATT 
CCGACCGACC TCCCCCGGAA CGCCATTGAA CTGAGGTTTG TGCTCACCAA GCTTCGAGTC 
ATCCCGAAAG GATCATTTGC TGGATTTGGA GACCTGGAGA AAATAGAGAT CTCTCAGAAT 
GATGTCTTGG AAGTAATAGA GGCAGATGTG TTCTCCAACC TACCCAAGTT GCATGAAATT 
AGGATTGAAA AGGCCAACAA TCTTCTGTAC ATCAACCCGG AGGCCTTCCA GAATCTCCCC 
AGTCTCAGAT ATCTGTTAAT ATCCAACACA GGCATTAAGC ACTTGCCAGC TGTTCACAAG 
ATCCAGTCTC TCCAAAAGGT TCTACTAGAC ATTCAAGATA ACATAAACAT CCACATCGTT 
GCCAGGAACT CCTTCATGGG ACTGAGTTTT GAAAGTGTGA TTTTATGGCT GAGTAAGAAT 
GGGATTGAAG AAATACACAA CTGTGCATTC AACGGAACTC AGCTAGATGA ACTGAATCTA 
AGCGATAACA ATAATTTGGA AGAATTGCCT AATGACGTTT TCCAGGGAGC CTCTGGGCCA 
GTCATTTTAG ATATCTCAAG GACAAAGGTC CATTCCTTAC CAAACCATGG CTTAGAAAAT 
CTGAAGAAGC TGAGGGCCAG GTCAACATAC CGCTTGAAAA AGCTCCCTAA TCTGGACAAG 
TTTGTCACCC TCATGGAGGC CAGCCTCACC TACCCCAGCC ACTGCTGTGC TTTTGCAAAC 
TTGAAGCGGC AAATCTCTGA ACTTCATCCA ATTTGCAACA AGTCTATTTT AAGGCAAGAT 
ATTGATGATA TGACTCAAAT TGGGGATCAG AGAGTCTCTC TGATAGATGA TGAACCCAGT 
TATGGAAAAG GATCTGACAT GATGTACAAT GAATTTGATT ATGACTTATG TAATGAAGTT 
GTTGATGTGA CCTGCTCACC AAAGCCAGAT GCATTTAATC CATGTGAAGA TATCATGGGG 
TACAACATCC TCAGGGTCTT GATATGGTTT ATTAGCATCC TGGCCATTAC TGGGAACACC 
ACAGTGCTGG TGGTCCTGAC CACAAGCCAA TACAAACTAA CTGTGCCCCG GTTTCTTATG 
TGTAACCTCG CCTTCGCTGA TCTCTGCATA GGCATCTACT TGCTACTTAT AGCATCAGTT 
GACATCCATA CCAAGAGCCA GTACCACAAC TATGCCATTG ACTGGCAAAC AGGAGCAGGC 
TGTGATGCTG CTGGCTTTTT CACTGTCTTT GCCAGTGAAC TGTCAGTCTA CACATTGACA 
GCCATCACCC TAGAAAGATG GCATACCATC ACACATGCTA TGCAACTGGA ATGCAAGGTG 
CAGCTCCGGC ATGCTGCCAG CGTCATGGTA TTGGGCTGGA CTTTTGCCTT CGCAGCTGCT 
CTCTTCCCCA TCTTTGGCAT CAGTAGCTAC ATGAAAGTGA GCATCTGCCT GCCCATGGAT 
ATCGACAGCC CTTTGTCACA GCTGTATGTT ATGGCCCTCC TTGTCCTCAA TGTCCTGGCC 
TTTGTGGTCA TCTGTGGCTG CTATACCCAC ATCTACCTCA CAGTGAGGAA TCCTACCATT 
GTGTCCTCAT CAAGCGACAC CAAGATTGCC AAGCGCATGG CCACACTCAT CTTCACAGAC 
TTTCTCTGCA TGGCCCCCAT TTCATTCTTT GCCATTTCTG CCTCCCTCAA GGTGCCGCTC 
ATCACTGTGT CCAAGGCCAA GATTCTCCTA GTTCTGTTCT ACCCCATCAA TTCTTGTGCC 
AATCCTTTCC TCTACGCCAT TTTCACCAAG AACTTCCGCA GGGACTTCTT CATCCTGCTG 
AGCAAGTTTG GCTGTTATGA AATGCAAGCC CAGATTTACA GGACAGAAAC CTCATCCGCT 
ACCCACAACT TCCATGCCCG AAAGAGCCAC TGCTCCTCAG CTCCCAGAGT CACCAATAGT 
TACGTGCTTG TCCCTCTTAA TCATTCATCC CAGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_954707.1
CDS	71..2149
Translation	MALLLVSLLAFLGTGSGCHHWLCHCSNRVFLCQDSKVTEIPTDLPRNAIELRFVLTKLRVIPKGSFAGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPSLRYLLISNTGIKHLPAVHKIQSLQKVLLDIQDNINIHIVARNSFMGLSFESVILWLSKNGIEEIHNCAFNGTQLDELNLSDNNNLEELPNDVFQGASGPVILDISRTKVHSLPNHGLENLKKLRARSTYRLKKLPNLDKFVTLMEASLTYPSHCCAFANLKRQISELHPICNKSILRQDIDDMTQIGDQRVSLIDDEPSYGKGSDMMYNEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNTTVLVVLTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASVMVLGWTFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMALLVLNVLAFVVICGCYTHIYLTVRNPTIVSSSSDTKIAKRMATLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFYPINSCANPFLYAIFTKNFRRDFFILLSKFGCYEMQAQIYRTETSSATHNFHARKSHCSSAPRVTNSYVLVPLNHSSQN

Target ORF information:

RefSeq Version	NM_199237.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus follicle stimulating hormone receptor (Fshr), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_199237.1

ORF Insert Sequence:

ATGGCCTTGC TCCTGGTCTC CTTGCTGGCA TTCTTGGGCA CGGGATCTGG ATGTCATCAC 
TGGCTGTGTC ATTGCTCTAA TAGGGTCTTT CTCTGCCAAG ACAGCAAGGT GACAGAGATT 
CCGACCGACC TCCCCCGGAA CGCCATTGAA CTGAGGTTTG TGCTCACCAA GCTTCGAGTC 
ATCCCGAAAG GATCATTTGC TGGATTTGGA GACCTGGAGA AAATAGAGAT CTCTCAGAAT 
GATGTCTTGG AAGTAATAGA GGCAGATGTG TTCTCCAACC TACCCAAGTT GCATGAAATT 
AGGATTGAAA AGGCCAACAA TCTTCTGTAC ATCAACCCGG AGGCCTTCCA GAATCTCCCC 
AGTCTCAGAT ATCTGTTAAT ATCCAACACA GGCATTAAGC ACTTGCCAGC TGTTCACAAG 
ATCCAGTCTC TCCAAAAGGT TCTACTAGAC ATTCAAGATA ACATAAACAT CCACATCGTT 
GCCAGGAACT CCTTCATGGG ACTGAGTTTT GAAAGTGTGA TTTTATGGCT GAGTAAGAAT 
GGGATTGAAG AAATACACAA CTGTGCATTC AACGGAACTC AGCTAGATGA ACTGAATCTA 
AGCGATAACA ATAATTTGGA AGAATTGCCT AATGACGTTT TCCAGGGAGC CTCTGGGCCA 
GTCATTTTAG ATATCTCAAG GACAAAGGTC CATTCCTTAC CAAACCATGG CTTAGAAAAT 
CTGAAGAAGC TGAGGGCCAG GTCAACATAC CGCTTGAAAA AGCTCCCTAA TCTGGACAAG 
TTTGTCACCC TCATGGAGGC CAGCCTCACC TACCCCAGCC ACTGCTGTGC TTTTGCAAAC 
TTGAAGCGGC AAATCTCTGA ACTTCATCCA ATTTGCAACA AGTCTATTTT AAGGCAAGAT 
ATTGATGATA TGACTCAAAT TGGGGATCAG AGAGTCTCTC TGATAGATGA TGAACCCAGT 
TATGGAAAAG GATCTGACAT GATGTACAAT GAATTTGATT ATGACTTATG TAATGAAGTT 
GTTGATGTGA CCTGCTCACC AAAGCCAGAT GCATTTAATC CATGTGAAGA TATCATGGGG 
TACAACATCC TCAGGGTCTT GATATGGTTT ATTAGCATCC TGGCCATTAC TGGGAACACC 
ACAGTGCTGG TGGTCCTGAC CACAAGCCAA TACAAACTAA CTGTGCCCCG GTTTCTTATG 
TGTAACCTCG CCTTCGCTGA TCTCTGCATA GGCATCTACT TGCTACTTAT AGCATCAGTT 
GACATCCATA CCAAGAGCCA GTACCACAAC TATGCCATTG ACTGGCAAAC AGGAGCAGGC 
TGTGATGCTG CTGGCTTTTT CACTGTCTTT GCCAGTGAAC TGTCAGTCTA CACATTGACA 
GCCATCACCC TAGAAAGATG GCATACCATC ACACATGCTA TGCAACTGGA ATGCAAGGTG 
CAGCTCCGGC ATGCTGCCAG CGTCATGGTA TTGGGCTGGA CTTTTGCCTT CGCAGCTGCT 
CTCTTCCCCA TCTTTGGCAT CAGTAGCTAC ATGAAAGTGA GCATCTGCCT GCCCATGGAT 
ATCGACAGCC CTTTGTCACA GCTGTATGTT ATGGCCCTCC TTGTCCTCAA TGTCCTGGCC 
TTTGTGGTCA TCTGTGGCTG CTATACCCAC ATCTACCTCA CAGTGAGGAA TCCTACCATT 
GTGTCCTCAT CAAGCGACAC CAAGATTGCC AAGCGCATGG CCACACTCAT CTTCACAGAC 
TTTCTCTGCA TGGCCCCCAT TTCATTCTTT GCCATTTCTG CCTCCCTCAA GGTGCCGCTC 
ATCACTGTGT CCAAGGCCAA GATTCTCCTA GTTCTGTTCT ACCCCATCAA TTCTTGTGCC 
AATCCTTTCC TCTACGCCAT TTTCACCAAG AACTTCCGCA GGGACTTCTT CATCCTGCTG 
AGCAAGTTTG GCTGTTATGA AATGCAAGCC CAGATTTACA GGACAGAAAC CTCATCCGCT 
ACCCACAACT TCCATGCCCG AAAGAGCCAC TGCTCCTCAG CTCCCAGAGT CACCAATAGT 
TACGTGCTTG TCCCTCTTAA TCATTCATCC CAGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

LHCGR Expression During Follicle Stimulating Hormone-Induced Follicle Growth Is Negatively Regulated by Eukaryotic Initiation Factor 5A.
Endocrinology158(8)2672-2679(2017 Aug)
Gulappa T,Menon B,Menon KMJ

Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer.
The Journal of biological chemistry289(20)14273-82(2014 May)
Jiang X,Fischer D,Chen X,McKenna SD,Liu H,Sriraman V,Yu HN,Goutopoulos A,Arkinstall S,He X

Dysregulation of ovarian follicular development in female rat: LH decreases FSH sensitivity during preantral-early antral transition.
Endocrinology154(8)2870-80(2013 Aug)
Orisaka M,Hattori K,Fukuda S,Mizutani T,Miyamoto K,Sato T,Tsang BK,Kotsuji F,Yoshida Y

Alteration of cell membrane proteoglycans impairs FSH receptor/Gs coupling and ERK activation through PP2A-dependent mechanisms in immature rat Sertoli cells.
Biochimica et biophysica acta1830(6)3466-75(2013 Jun)
Levallet G,Bonnamy PJ,Levallet J

Molecular analysis of a mutated FSH receptor detected in a patient with spontaneous ovarian hyperstimulation syndrome.
PloS one8(9)e75478(2013)
Uchida S,Uchida H,Maruyama T,Kajitani T,Oda H,Miyazaki K,Kagami M,Yoshimura Y

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Fshr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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