Ctse cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ctse
Entrez Gene ID	25424
Full Name	cathepsin E
Synonyms	CEA,CEB,Ctsea
General protein information	Preferred Names cathepsin E Names cathepsin E
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q13
Summary	intracellular, nonlysosomal aspartic proteinase; may mediate absorption, secretion, and digestion of various cellular components [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006249748.2	XP_006249810.1	cathepsin E isoform X1
XM_017598677.1	XP_017454166.1	cathepsin E isoform X1
NM_012938.1	NP_037070.1	cathepsin E precursor
XM_006249749.2	XP_006249811.1	cathepsin E isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Ctse	NP_037070.1
Xenopus tropicalis (tropical clawed frog)	ctse	NP_001120469.1
Mus musculus (house mouse)	Ctse	NP_031825.2
Homo sapiens (human)	CTSE	NP_001901.1
Pan troglodytes (chimpanzee)	CTSE	XP_001163151.1
	CTSE	XP_001090284.1
Canis lupus familiaris (dog)	CTSE	XP_545694.3
Gallus gallus (chicken)	CTSE	XP_001235024.2

Gene Ontology
Bibliography

Related articles in PubMed

Overexpression of Cathepsin E Interferes with Neuronal Differentiation of P19 Embryonal Teratocarcinoma Cells by Degradation of N-cadherin.
Harada Y, Takayama F, Tanabe K, Ni J, Hayashi Y, Yamamoto K, Wu Z, Nakanishi H
Cellular and molecular neurobiology37(3)437-443(2017 Apr)

[Screen and validation of differentially expressing genes related to silicotic pulmonary fibrosis in rats].
Xu HR, Wang XH, Ma XB, Hou WN, Zhu L, Xiang JC, Sun RJ
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases30(1)45-51(2012 Jan)

Cathepsin D-mediated proteolysis of apolipoprotein E: possible role in Alzheimer's disease.
Zhou W, Scott SA, Shelton SB, Crutcher KA
Neuroscience143(3)689-701(2006 Dec)

Characterization of rat cathepsin E and mutants with changed active-site residues and lacking propeptides and N-glycosylation, expressed in human embryonic kidney 293T cells.
Tsukuba T, Ikeda S, Okamoto K, Yasuda Y, Sakai E, Kadowaki T, Sakai H, Yamamoto K
The FEBS journal273(1)219-29(2006 Jan)

Cathepsin E: a novel target for regulation by class II transactivator.
Yee CS, Yao Y, Li P, Klemsz MJ, Blum JS, Chang CH
Journal of immunology (Baltimore, Md. : 1950)172(9)5528-34(2004 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These observations suggest that the overexpression of CatE interferes with neuronal differentiation of P19 cells through an impairment of cell aggregate formation, possibly through proteolytic degradation of N-cadherin.
Title: Overexpression of Cathepsin E Interferes with Neuronal Differentiation of P19 Embryonal Teratocarcinoma Cells by Degradation of N-cadherin.

The mRNA and protein expression levels of MMP-12 and Cathepsin E were significantly up-regulated in lung tissues of rats with silicotic pulmonary fibrosis.
Title: [Screen and validation of differentially expressing genes related to silicotic pulmonary fibrosis in rats].

These data indicate that the catalytic activity, propeptides, and N-glycosylation of this protein are all essential for its processing, maturation, and trafficking.
Title: Characterization of rat cathepsin E and mutants with changed active-site residues and lacking propeptides and N-glycosylation, expressed in human embryonic kidney 293T cells.

These results suggest the possible involvement of cathepsin E in disruption of the structural and functional integrity of alpha 2-macroglobulin in the endolysosome system.
Title: Disruption of structural and functional integrity of alpha 2-macroglobulin by cathepsin E.

examination of the significance of residues in the motifs of rat cathepsin E by substitution of Asp98, Asp283, and Thr284 with other residues using site-directed mutagenesis
Title: Mutational analysis of residues in two consensus motifs in the active sites of cathepsin E.

The following Ctse gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ctse cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa01376	NM_012938.1 Latest version!	Rattus norvegicus cathepsin E (Ctse), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa35290	XM_006249748.2 Latest version!	Rattus norvegicus cathepsin E (Ctse), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa35290	XM_017598677.1 Latest version!	Rattus norvegicus cathepsin E (Ctse), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa35290	XM_006249749.2 Latest version!	Rattus norvegicus cathepsin E (Ctse), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ctse ( NM_012938.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037070.1 Rattus norvegicus cathepsin E (Ctse), mRNA.

Price & Availability↑

CloneID	ORa01376
Clone ID Related Accession (Same CDS sequence)	NM_012938.1
Accession Version	NM_012938.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1098bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Rattus norvegicus(Norway rat)
Product	cathepsin E precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D38104.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D38104.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2689594, SAMEA2689599 [ECO:0000350] ##Evidence-Data-END##

ATGAAACCTC TCTTCGTGCT GCTGCTGCTG CTGCTGCTCC TGGACCTGGC ACAGGCCCAA 
GGGGTGCTGC ACAGGGTGCC CCTCAGAAGA CATCAGTCCC TCCGGAAGAA ACTACGGGCC 
CAAGGCCAGC TCTCAGACTT CTGGAGATCT CATAACTTGG ACATGATCGA ATTCAGCGAG 
TCCTGTAATG TGGATAAGGG TATCAATGAG CCCCTCATCA ACTACCTGGA TATGGAATAC 
TTTGGCACCG TCTCCATCGG CTCCCCATCG CAGAACTTCA CCGTCATCTT TGACACGGGC 
TCATCCAACC TCTGGGTCCC TTCTGTGTAC TGCACCAGCT CAGCATGCAA GGCACACCCG 
GTGTTCCACC CATCGCAGTC CAGCACCTAC ATGGAGGTAG GGAATCACTT CTCCATCCAG 
TATGGTACTG GGAGCCTGAC AGGAATCATT GGAGCTGACC AAGTCTCTGT GGAAGGGTTG 
ACTGTGGAAG GCCAGCAATT TGGAGAAAGT GTCAAGGAGC CTGGTCAGAC CTTTGTGAAT 
GCGGAGTTTG ACGGGATTCT GGGCCTGGGA TACCCCTCAT TGGCTGTTGG AGGAGTGACC 
CCAGTGTTTG ATAACATGAT GGCCCAGAAC CTTGTGGCTC TGCCTATGTT TTCTGTCTAC 
TTGAGCAGTG ACCCACAAGG TGGCTCAGGC AGTGAACTGA CTTTCGGAGG CTATGACCCC 
TCTCATTTCT CTGGGAGCCT CAATTGGATC CCAGTCACCA AGCAAGGCTA CTGGCAGATT 
GCCCTGGATG GAATCCAGGT GGGAGACACT GTGATGTTCT GCTCTGAGGG CTGCCAGGCC 
ATAGTGGACA CAGGGACCTC CCTCATCACT GGCCCCCCCA AGAAGATCAA ACAGCTTCAA 
GAGGCCATTG GGGCCACACC CATGGATGGA GAAGACTTGG TGGATGGAAT GCAGTTCTGC 
GGCAGTGGCT TTCAAGGACT TGACATTCAA CCTCCGGCTG GACCCCTCTG GATCCTGGGG 
GATGTCTTCA TCCGAAAGTT TTACTCAGTC TTTGATCGTG GAAATAACCA AGTGGGATTG 
GCCCCCGCAG TCCCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037070.1
CDS	204..1301
Translation	MKPLFVLLLLLLLLDLAQAQGVLHRVPLRRHQSLRKKLRAQGQLSDFWRSHNLDMIEFSESCNVDKGINEPLINYLDMEYFGTVSIGSPSQNFTVIFDTGSSNLWVPSVYCTSSACKAHPVFHPSQSSTYMEVGNHFSIQYGTGSLTGIIGADQVSVEGLTVEGQQFGESVKEPGQTFVNAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVALPMFSVYLSSDPQGGSGSELTFGGYDPSHFSGSLNWIPVTKQGYWQIALDGIQVGDTVMFCSEGCQAIVDTGTSLITGPPKKIKQLQEAIGATPMDGEDLVDGMQFCGSGFQGLDIQPPAGPLWILGDVFIRKFYSVFDRGNNQVGLAPAVP

Target ORF information:

RefSeq Version	NM_012938.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cathepsin E (Ctse), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012938.1

ORF Insert Sequence:

ATGAAACCTC TCTTCGTGCT GCTGCTGCTG CTGCTGCTCC TGGACCTGGC ACAGGCCCAA 
GGGGTGCTGC ACAGGGTGCC CCTCAGAAGA CATCAGTCCC TCCGGAAGAA ACTACGGGCC 
CAAGGCCAGC TCTCAGACTT CTGGAGATCT CATAACTTGG ACATGATCGA ATTCAGCGAG 
TCCTGTAATG TGGATAAGGG TATCAATGAG CCCCTCATCA ACTACCTGGA TATGGAATAC 
TTTGGCACCG TCTCCATCGG CTCCCCATCG CAGAACTTCA CCGTCATCTT TGACACGGGC 
TCATCCAACC TCTGGGTCCC TTCTGTGTAC TGCACCAGCT CAGCATGCAA GGCACACCCG 
GTGTTCCACC CATCGCAGTC CAGCACCTAC ATGGAGGTAG GGAATCACTT CTCCATCCAG 
TATGGTACTG GGAGCCTGAC AGGAATCATT GGAGCTGACC AAGTCTCTGT GGAAGGGTTG 
ACTGTGGAAG GCCAGCAATT TGGAGAAAGT GTCAAGGAGC CTGGTCAGAC CTTTGTGAAT 
GCGGAGTTTG ACGGGATTCT GGGCCTGGGA TACCCCTCAT TGGCTGTTGG AGGAGTGACC 
CCAGTGTTTG ATAACATGAT GGCCCAGAAC CTTGTGGCTC TGCCTATGTT TTCTGTCTAC 
TTGAGCAGTG ACCCACAAGG TGGCTCAGGC AGTGAACTGA CTTTCGGAGG CTATGACCCC 
TCTCATTTCT CTGGGAGCCT CAATTGGATC CCAGTCACCA AGCAAGGCTA CTGGCAGATT 
GCCCTGGATG GAATCCAGGT GGGAGACACT GTGATGTTCT GCTCTGAGGG CTGCCAGGCC 
ATAGTGGACA CAGGGACCTC CCTCATCACT GGCCCCCCCA AGAAGATCAA ACAGCTTCAA 
GAGGCCATTG GGGCCACACC CATGGATGGA GAAGACTTGG TGGATGGAAT GCAGTTCTGC 
GGCAGTGGCT TTCAAGGACT TGACATTCAA CCTCCGGCTG GACCCCTCTG GATCCTGGGG 
GATGTCTTCA TCCGAAAGTT TTACTCAGTC TTTGATCGTG GAAATAACCA AGTGGGATTG 
GCCCCCGCAG TCCCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ctse ( XM_006249748.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006249810.1 Rattus norvegicus cathepsin E (Ctse), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa35290
Clone ID Related Accession (Same CDS sequence)	XM_006249748.2 , XM_017598677.1 , XM_006249749.2
Accession Version	XM_006249748.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1197bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cathepsin E isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005112.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006249748.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAACCTC TCTTCGTGCT GCTGCTGCTG CTGCTGCTCC TGGACCTGGC ACAGGCCCAA 
GGGGTGCTGC ACAGGGTGCC CCTCAGAAGA CATCAGTCCC TCCGGAAGAA ACTACGGGCC 
CAAGGCCAGC TCTCAGACTT CTGGAGATCT CATAACTTGG ACATGATCGA ATTCAGCGAG 
TCCTGTAATG TGGATAAGGG TATCAATGAG CCCCTCATCA ACTACCTGGA TATGGAATAC 
TTTGGCACCG TCTCCATCGG CTCCCCATCG CAGAACTTCA CCGTCATCTT TGACACGGGC 
TCATCCAACC TCTGGGTCCC TTCTGTGTAC TGCACCAGCC CAGCATGCAA GGCACACCCG 
GTGTTCCACC CATCGCAGTC CAGCACCTAC ATGGAGGTAG GGAATCACTT CTCCATCCAG 
TATGGTACTG GGAGCCTGAC AGGAATCATT GGAGCTGACC AAGTCTCTGT GGAAGGGTTG 
ACTGTGGAAG GCCAGCAATT TGGAGAAAGT GTCAAGGAGC CTGGTCAGAC CTTTGTGAAT 
GCGGAGTTTG ACGGGATTCT GGGCCTGGGA TACCCCTCAT TGGCTGTTGG AGGAGTGACC 
CCAGTGTTTG ATAACATGAT GGCCCAGAAC CTTGTGGCTC TGCCTATGTT TTCTGTCTAC 
TTGAGCAGTG ACCCACAAGG TGGCTCAGGC AGTGAACTGA CTTTCGGAGG CTATGACCCC 
TCTCATTTCT CTGGGAGCCT CAATTGGATC CCAGTCACCA AGCAAGGCTA CTGGCAGATT 
GCCCTGGATG GAATCCAGGT GGGAGACACT GTGATGTTCT GCTCTGAGGG CTGCCAGGCC 
ATAGTGGACA CAGGGACCTC CCTCATCACT GGCCCCCCCA AGAAGATCAA ACAGCTTCAA 
GAGGCCATTG GGGCCACACC CATGGATGGA GAATATGCGG TGGATTGTGC CACTCTCAAC 
ATGATGCCAA ACGTCACCTT CCTCATCAAC GGGGTTTCAT ACACCCTCAG CCCAACTGCC 
TACATCCTGC CGGACTTGGT GGATGGAATG CAGTTCTGCG GCAGTGGCTT TCAAGGACTT 
GACATTCAAC CTCCGGCTGG ACCCCTCTGG ATCCTGGGGG ATGTCTTCAT CCGAAAGTTT 
TACTCAGTCT TTGATCGTGG AAATAACCAA GTGGGATTGG CCCCCGCAGT CCCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006249810.1
CDS	409..1605
Translation	MKPLFVLLLLLLLLDLAQAQGVLHRVPLRRHQSLRKKLRAQGQLSDFWRSHNLDMIEFSESCNVDKGINEPLINYLDMEYFGTVSIGSPSQNFTVIFDTGSSNLWVPSVYCTSPACKAHPVFHPSQSSTYMEVGNHFSIQYGTGSLTGIIGADQVSVEGLTVEGQQFGESVKEPGQTFVNAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVALPMFSVYLSSDPQGGSGSELTFGGYDPSHFSGSLNWIPVTKQGYWQIALDGIQVGDTVMFCSEGCQAIVDTGTSLITGPPKKIKQLQEAIGATPMDGEYAVDCATLNMMPNVTFLINGVSYTLSPTAYILPDLVDGMQFCGSGFQGLDIQPPAGPLWILGDVFIRKFYSVFDRGNNQVGLAPAVP

Target ORF information:

RefSeq Version	XM_006249748.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cathepsin E (Ctse), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006249748.2

ORF Insert Sequence:

ATGAAACCTC TCTTCGTGCT GCTGCTGCTG CTGCTGCTCC TGGACCTGGC ACAGGCCCAA 
GGGGTGCTGC ACAGGGTGCC CCTCAGAAGA CATCAGTCCC TCCGGAAGAA ACTACGGGCC 
CAAGGCCAGC TCTCAGACTT CTGGAGATCT CATAACTTGG ACATGATCGA ATTCAGCGAG 
TCCTGTAATG TGGATAAGGG TATCAATGAG CCCCTCATCA ACTACCTGGA TATGGAATAC 
TTTGGCACCG TCTCCATCGG CTCCCCATCG CAGAACTTCA CCGTCATCTT TGACACGGGC 
TCATCCAACC TCTGGGTCCC TTCTGTGTAC TGCACCAGCC CAGCATGCAA GGCACACCCG 
GTGTTCCACC CATCGCAGTC CAGCACCTAC ATGGAGGTAG GGAATCACTT CTCCATCCAG 
TATGGTACTG GGAGCCTGAC AGGAATCATT GGAGCTGACC AAGTCTCTGT GGAAGGGTTG 
ACTGTGGAAG GCCAGCAATT TGGAGAAAGT GTCAAGGAGC CTGGTCAGAC CTTTGTGAAT 
GCGGAGTTTG ACGGGATTCT GGGCCTGGGA TACCCCTCAT TGGCTGTTGG AGGAGTGACC 
CCAGTGTTTG ATAACATGAT GGCCCAGAAC CTTGTGGCTC TGCCTATGTT TTCTGTCTAC 
TTGAGCAGTG ACCCACAAGG TGGCTCAGGC AGTGAACTGA CTTTCGGAGG CTATGACCCC 
TCTCATTTCT CTGGGAGCCT CAATTGGATC CCAGTCACCA AGCAAGGCTA CTGGCAGATT 
GCCCTGGATG GAATCCAGGT GGGAGACACT GTGATGTTCT GCTCTGAGGG CTGCCAGGCC 
ATAGTGGACA CAGGGACCTC CCTCATCACT GGCCCCCCCA AGAAGATCAA ACAGCTTCAA 
GAGGCCATTG GGGCCACACC CATGGATGGA GAATATGCGG TGGATTGTGC CACTCTCAAC 
ATGATGCCAA ACGTCACCTT CCTCATCAAC GGGGTTTCAT ACACCCTCAG CCCAACTGCC 
TACATCCTGC CGGACTTGGT GGATGGAATG CAGTTCTGCG GCAGTGGCTT TCAAGGACTT 
GACATTCAAC CTCCGGCTGG ACCCCTCTGG ATCCTGGGGG ATGTCTTCAT CCGAAAGTTT 
TACTCAGTCT TTGATCGTGG AAATAACCAA GTGGGATTGG CCCCCGCAGT CCCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ctse ( XM_017598677.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017454166.1 Rattus norvegicus cathepsin E (Ctse), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa35290
Clone ID Related Accession (Same CDS sequence)	XM_006249748.2 , XM_017598677.1 , XM_006249749.2
Accession Version	XM_017598677.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1197bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cathepsin E isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005112.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAACCTC TCTTCGTGCT GCTGCTGCTG CTGCTGCTCC TGGACCTGGC ACAGGCCCAA 
GGGGTGCTGC ACAGGGTGCC CCTCAGAAGA CATCAGTCCC TCCGGAAGAA ACTACGGGCC 
CAAGGCCAGC TCTCAGACTT CTGGAGATCT CATAACTTGG ACATGATCGA ATTCAGCGAG 
TCCTGTAATG TGGATAAGGG TATCAATGAG CCCCTCATCA ACTACCTGGA TATGGAATAC 
TTTGGCACCG TCTCCATCGG CTCCCCATCG CAGAACTTCA CCGTCATCTT TGACACGGGC 
TCATCCAACC TCTGGGTCCC TTCTGTGTAC TGCACCAGCC CAGCATGCAA GGCACACCCG 
GTGTTCCACC CATCGCAGTC CAGCACCTAC ATGGAGGTAG GGAATCACTT CTCCATCCAG 
TATGGTACTG GGAGCCTGAC AGGAATCATT GGAGCTGACC AAGTCTCTGT GGAAGGGTTG 
ACTGTGGAAG GCCAGCAATT TGGAGAAAGT GTCAAGGAGC CTGGTCAGAC CTTTGTGAAT 
GCGGAGTTTG ACGGGATTCT GGGCCTGGGA TACCCCTCAT TGGCTGTTGG AGGAGTGACC 
CCAGTGTTTG ATAACATGAT GGCCCAGAAC CTTGTGGCTC TGCCTATGTT TTCTGTCTAC 
TTGAGCAGTG ACCCACAAGG TGGCTCAGGC AGTGAACTGA CTTTCGGAGG CTATGACCCC 
TCTCATTTCT CTGGGAGCCT CAATTGGATC CCAGTCACCA AGCAAGGCTA CTGGCAGATT 
GCCCTGGATG GAATCCAGGT GGGAGACACT GTGATGTTCT GCTCTGAGGG CTGCCAGGCC 
ATAGTGGACA CAGGGACCTC CCTCATCACT GGCCCCCCCA AGAAGATCAA ACAGCTTCAA 
GAGGCCATTG GGGCCACACC CATGGATGGA GAATATGCGG TGGATTGTGC CACTCTCAAC 
ATGATGCCAA ACGTCACCTT CCTCATCAAC GGGGTTTCAT ACACCCTCAG CCCAACTGCC 
TACATCCTGC CGGACTTGGT GGATGGAATG CAGTTCTGCG GCAGTGGCTT TCAAGGACTT 
GACATTCAAC CTCCGGCTGG ACCCCTCTGG ATCCTGGGGG ATGTCTTCAT CCGAAAGTTT 
TACTCAGTCT TTGATCGTGG AAATAACCAA GTGGGATTGG CCCCCGCAGT CCCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017454166.1
CDS	271..1467
Translation	MKPLFVLLLLLLLLDLAQAQGVLHRVPLRRHQSLRKKLRAQGQLSDFWRSHNLDMIEFSESCNVDKGINEPLINYLDMEYFGTVSIGSPSQNFTVIFDTGSSNLWVPSVYCTSPACKAHPVFHPSQSSTYMEVGNHFSIQYGTGSLTGIIGADQVSVEGLTVEGQQFGESVKEPGQTFVNAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVALPMFSVYLSSDPQGGSGSELTFGGYDPSHFSGSLNWIPVTKQGYWQIALDGIQVGDTVMFCSEGCQAIVDTGTSLITGPPKKIKQLQEAIGATPMDGEYAVDCATLNMMPNVTFLINGVSYTLSPTAYILPDLVDGMQFCGSGFQGLDIQPPAGPLWILGDVFIRKFYSVFDRGNNQVGLAPAVP

Target ORF information:

RefSeq Version	XM_017598677.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cathepsin E (Ctse), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017598677.1

ORF Insert Sequence:

ATGAAACCTC TCTTCGTGCT GCTGCTGCTG CTGCTGCTCC TGGACCTGGC ACAGGCCCAA 
GGGGTGCTGC ACAGGGTGCC CCTCAGAAGA CATCAGTCCC TCCGGAAGAA ACTACGGGCC 
CAAGGCCAGC TCTCAGACTT CTGGAGATCT CATAACTTGG ACATGATCGA ATTCAGCGAG 
TCCTGTAATG TGGATAAGGG TATCAATGAG CCCCTCATCA ACTACCTGGA TATGGAATAC 
TTTGGCACCG TCTCCATCGG CTCCCCATCG CAGAACTTCA CCGTCATCTT TGACACGGGC 
TCATCCAACC TCTGGGTCCC TTCTGTGTAC TGCACCAGCC CAGCATGCAA GGCACACCCG 
GTGTTCCACC CATCGCAGTC CAGCACCTAC ATGGAGGTAG GGAATCACTT CTCCATCCAG 
TATGGTACTG GGAGCCTGAC AGGAATCATT GGAGCTGACC AAGTCTCTGT GGAAGGGTTG 
ACTGTGGAAG GCCAGCAATT TGGAGAAAGT GTCAAGGAGC CTGGTCAGAC CTTTGTGAAT 
GCGGAGTTTG ACGGGATTCT GGGCCTGGGA TACCCCTCAT TGGCTGTTGG AGGAGTGACC 
CCAGTGTTTG ATAACATGAT GGCCCAGAAC CTTGTGGCTC TGCCTATGTT TTCTGTCTAC 
TTGAGCAGTG ACCCACAAGG TGGCTCAGGC AGTGAACTGA CTTTCGGAGG CTATGACCCC 
TCTCATTTCT CTGGGAGCCT CAATTGGATC CCAGTCACCA AGCAAGGCTA CTGGCAGATT 
GCCCTGGATG GAATCCAGGT GGGAGACACT GTGATGTTCT GCTCTGAGGG CTGCCAGGCC 
ATAGTGGACA CAGGGACCTC CCTCATCACT GGCCCCCCCA AGAAGATCAA ACAGCTTCAA 
GAGGCCATTG GGGCCACACC CATGGATGGA GAATATGCGG TGGATTGTGC CACTCTCAAC 
ATGATGCCAA ACGTCACCTT CCTCATCAAC GGGGTTTCAT ACACCCTCAG CCCAACTGCC 
TACATCCTGC CGGACTTGGT GGATGGAATG CAGTTCTGCG GCAGTGGCTT TCAAGGACTT 
GACATTCAAC CTCCGGCTGG ACCCCTCTGG ATCCTGGGGG ATGTCTTCAT CCGAAAGTTT 
TACTCAGTCT TTGATCGTGG AAATAACCAA GTGGGATTGG CCCCCGCAGT CCCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ctse ( XM_006249749.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006249811.1 Rattus norvegicus cathepsin E (Ctse), transcript variant X2, mRNA.

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CloneID	ORa35290
Clone ID Related Accession (Same CDS sequence)	XM_006249748.2 , XM_017598677.1 , XM_006249749.2
Accession Version	XM_006249749.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1197bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cathepsin E isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005112.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006249749.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAACCTC TCTTCGTGCT GCTGCTGCTG CTGCTGCTCC TGGACCTGGC ACAGGCCCAA 
GGGGTGCTGC ACAGGGTGCC CCTCAGAAGA CATCAGTCCC TCCGGAAGAA ACTACGGGCC 
CAAGGCCAGC TCTCAGACTT CTGGAGATCT CATAACTTGG ACATGATCGA ATTCAGCGAG 
TCCTGTAATG TGGATAAGGG TATCAATGAG CCCCTCATCA ACTACCTGGA TATGGAATAC 
TTTGGCACCG TCTCCATCGG CTCCCCATCG CAGAACTTCA CCGTCATCTT TGACACGGGC 
TCATCCAACC TCTGGGTCCC TTCTGTGTAC TGCACCAGCC CAGCATGCAA GGCACACCCG 
GTGTTCCACC CATCGCAGTC CAGCACCTAC ATGGAGGTAG GGAATCACTT CTCCATCCAG 
TATGGTACTG GGAGCCTGAC AGGAATCATT GGAGCTGACC AAGTCTCTGT GGAAGGGTTG 
ACTGTGGAAG GCCAGCAATT TGGAGAAAGT GTCAAGGAGC CTGGTCAGAC CTTTGTGAAT 
GCGGAGTTTG ACGGGATTCT GGGCCTGGGA TACCCCTCAT TGGCTGTTGG AGGAGTGACC 
CCAGTGTTTG ATAACATGAT GGCCCAGAAC CTTGTGGCTC TGCCTATGTT TTCTGTCTAC 
TTGAGCAGTG ACCCACAAGG TGGCTCAGGC AGTGAACTGA CTTTCGGAGG CTATGACCCC 
TCTCATTTCT CTGGGAGCCT CAATTGGATC CCAGTCACCA AGCAAGGCTA CTGGCAGATT 
GCCCTGGATG GAATCCAGGT GGGAGACACT GTGATGTTCT GCTCTGAGGG CTGCCAGGCC 
ATAGTGGACA CAGGGACCTC CCTCATCACT GGCCCCCCCA AGAAGATCAA ACAGCTTCAA 
GAGGCCATTG GGGCCACACC CATGGATGGA GAATATGCGG TGGATTGTGC CACTCTCAAC 
ATGATGCCAA ACGTCACCTT CCTCATCAAC GGGGTTTCAT ACACCCTCAG CCCAACTGCC 
TACATCCTGC CGGACTTGGT GGATGGAATG CAGTTCTGCG GCAGTGGCTT TCAAGGACTT 
GACATTCAAC CTCCGGCTGG ACCCCTCTGG ATCCTGGGGG ATGTCTTCAT CCGAAAGTTT 
TACTCAGTCT TTGATCGTGG AAATAACCAA GTGGGATTGG CCCCCGCAGT CCCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006249811.1
CDS	467..1663
Translation	MKPLFVLLLLLLLLDLAQAQGVLHRVPLRRHQSLRKKLRAQGQLSDFWRSHNLDMIEFSESCNVDKGINEPLINYLDMEYFGTVSIGSPSQNFTVIFDTGSSNLWVPSVYCTSPACKAHPVFHPSQSSTYMEVGNHFSIQYGTGSLTGIIGADQVSVEGLTVEGQQFGESVKEPGQTFVNAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVALPMFSVYLSSDPQGGSGSELTFGGYDPSHFSGSLNWIPVTKQGYWQIALDGIQVGDTVMFCSEGCQAIVDTGTSLITGPPKKIKQLQEAIGATPMDGEYAVDCATLNMMPNVTFLINGVSYTLSPTAYILPDLVDGMQFCGSGFQGLDIQPPAGPLWILGDVFIRKFYSVFDRGNNQVGLAPAVP

Target ORF information:

RefSeq Version	XM_006249749.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cathepsin E (Ctse), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006249749.2

ORF Insert Sequence:

ATGAAACCTC TCTTCGTGCT GCTGCTGCTG CTGCTGCTCC TGGACCTGGC ACAGGCCCAA 
GGGGTGCTGC ACAGGGTGCC CCTCAGAAGA CATCAGTCCC TCCGGAAGAA ACTACGGGCC 
CAAGGCCAGC TCTCAGACTT CTGGAGATCT CATAACTTGG ACATGATCGA ATTCAGCGAG 
TCCTGTAATG TGGATAAGGG TATCAATGAG CCCCTCATCA ACTACCTGGA TATGGAATAC 
TTTGGCACCG TCTCCATCGG CTCCCCATCG CAGAACTTCA CCGTCATCTT TGACACGGGC 
TCATCCAACC TCTGGGTCCC TTCTGTGTAC TGCACCAGCC CAGCATGCAA GGCACACCCG 
GTGTTCCACC CATCGCAGTC CAGCACCTAC ATGGAGGTAG GGAATCACTT CTCCATCCAG 
TATGGTACTG GGAGCCTGAC AGGAATCATT GGAGCTGACC AAGTCTCTGT GGAAGGGTTG 
ACTGTGGAAG GCCAGCAATT TGGAGAAAGT GTCAAGGAGC CTGGTCAGAC CTTTGTGAAT 
GCGGAGTTTG ACGGGATTCT GGGCCTGGGA TACCCCTCAT TGGCTGTTGG AGGAGTGACC 
CCAGTGTTTG ATAACATGAT GGCCCAGAAC CTTGTGGCTC TGCCTATGTT TTCTGTCTAC 
TTGAGCAGTG ACCCACAAGG TGGCTCAGGC AGTGAACTGA CTTTCGGAGG CTATGACCCC 
TCTCATTTCT CTGGGAGCCT CAATTGGATC CCAGTCACCA AGCAAGGCTA CTGGCAGATT 
GCCCTGGATG GAATCCAGGT GGGAGACACT GTGATGTTCT GCTCTGAGGG CTGCCAGGCC 
ATAGTGGACA CAGGGACCTC CCTCATCACT GGCCCCCCCA AGAAGATCAA ACAGCTTCAA 
GAGGCCATTG GGGCCACACC CATGGATGGA GAATATGCGG TGGATTGTGC CACTCTCAAC 
ATGATGCCAA ACGTCACCTT CCTCATCAAC GGGGTTTCAT ACACCCTCAG CCCAACTGCC 
TACATCCTGC CGGACTTGGT GGATGGAATG CAGTTCTGCG GCAGTGGCTT TCAAGGACTT 
GACATTCAAC CTCCGGCTGG ACCCCTCTGG ATCCTGGGGG ATGTCTTCAT CCGAAAGTTT 
TACTCAGTCT TTGATCGTGG AAATAACCAA GTGGGATTGG CCCCCGCAGT CCCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Overexpression of Cathepsin E Interferes with Neuronal Differentiation of P19 Embryonal Teratocarcinoma Cells by Degradation of N-cadherin.
Cellular and molecular neurobiology37(3)437-443(2017 Apr)
Harada Y,Takayama F,Tanabe K,Ni J,Hayashi Y,Yamamoto K,Wu Z,Nakanishi H

[Screen and validation of differentially expressing genes related to silicotic pulmonary fibrosis in rats].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases30(1)45-51(2012 Jan)
Xu HR,Wang XH,Ma XB,Hou WN,Zhu L,Xiang JC,Sun RJ

Cathepsin D-mediated proteolysis of apolipoprotein E: possible role in Alzheimer's disease.
Neuroscience143(3)689-701(2006 Dec)
Zhou W,Scott SA,Shelton SB,Crutcher KA

Characterization of rat cathepsin E and mutants with changed active-site residues and lacking propeptides and N-glycosylation, expressed in human embryonic kidney 293T cells.
The FEBS journal273(1)219-29(2006 Jan)
Tsukuba T,Ikeda S,Okamoto K,Yasuda Y,Sakai E,Kadowaki T,Sakai H,Yamamoto K

Cathepsin E: a novel target for regulation by class II transactivator.
Journal of immunology (Baltimore, Md. : 1950)172(9)5528-34(2004 May)
Yee CS,Yao Y,Li P,Klemsz MJ,Blum JS,Chang CH

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Ctse cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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