Ctse cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ctse
Entrez Gene ID	13034
Full Name	cathepsin E
Synonyms	A430072O03Rik,C920004C08Rik,CE,CatE
General protein information	Preferred Names cathepsin E Names cathepsin E
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 E4\|1 57.14 cM
Summary	This gene encodes a member of the peptidase A1 family of aspartate proteases and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. Homozygous knockout mice for this gene exhibit lysosomal storage disorder, impaired autophagy, mitochondrial abnormalities, dermatitis, and reduced weight gain in an obesity model. [provided by RefSeq, Aug 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_007799.3	NP_031825.2	cathepsin E preproprotein

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Ctse	NP_037070.1
Xenopus tropicalis (tropical clawed frog)	ctse	NP_001120469.1
Mus musculus (house mouse)	Ctse	NP_031825.2
Homo sapiens (human)	CTSE	NP_001901.1
Pan troglodytes (chimpanzee)	CTSE	XP_001163151.1
	CTSE	XP_001090284.1
Canis lupus familiaris (dog)	CTSE	XP_545694.3
Gallus gallus (chicken)	CTSE	XP_001235024.2

Gene Ontology
Bibliography

Related articles in PubMed

Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.
Rutledge EA, Benazet JD, McMahon AP
Development (Cambridge, England)144(17)3177-3188(2017 09)

The NANCI-Nkx2.1 gene duplex buffers Nkx2.1 expression to maintain lung development and homeostasis.
Herriges MJ, Tischfield DJ, Cui Z, Morley MP, Han Y, Babu A, Li S, Lu M, Cendan I, Garcia BA, Anderson SA, Morrisey EE
Genes & development31(9)889-903(2017 May)

The Critical Role of Proteolytic Relay through Cathepsins B and E in the Phenotypic Change of Microglia/Macrophage.
Ni J, Wu Z, Peterts C, Yamamoto K, Qing H, Nakanishi H
The Journal of neuroscience : the official journal of the Society for Neuroscience35(36)12488-501(2015 Sep)

Autophagic digestion of Leishmania major by host macrophages is associated with differential expression of BNIP3, CTSE, and the miRNAs miR-101c, miR-129, and miR-210.
Frank B, Marcu A, de Oliveira Almeida Petersen AL, Weber H, Stigloher C, Mottram JC, Scholz CJ, Schurigt U
Parasites & vectors8404(2015 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cathepsin E, mitochondrial fission, and caspase activation/apoptosis are linked in the pathogenesis of pulmonary emphysema.
Title: Cathepsin E promotes pulmonary emphysema via mitochondrial fission.

L1 stimulation triggers sumoylation and cleavage of L1, thus generating the L1-70 fragment which is cleaved by cathepsin E
Title: Cathepsin E generates a sumoylated intracellular fragment of the cell adhesion molecule L1 to promote neuronal and Schwann cell migration as well as myelination.

impaired adipose tissue development in high fat diet-induced CatE(-/-) mice was probably due to reduced infiltration of macrophages and may lead to hepatomegaly accompanied by hepatic steatosis and hypercholesterolemia
Title: Defective adipose tissue development associated with hepatomegaly in cathepsin E-deficient mice fed a high-fat diet.

These results indicate that cathepsin E deficiency causes autophagy impairment concomitantly with increased aberrant mitochondria as well as increased oxidative stress.
Title: Cathepsin E deficiency impairs autophagic proteolysis in macrophages.

Intradermal cathepsin E has pruritogenic activity, which is at least partly mediated by the production of endothelin-1.
Title: Cathepsin E induces itch-related response through the production of endothelin-1 in mice.

The following Ctse gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ctse cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21749	NM_007799.3 Latest version!	Mus musculus cathepsin E (Ctse), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ctse ( NM_007799.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031825.2 Mus musculus cathepsin E (Ctse), mRNA.

Price & Availability↑

CloneID	OMu21749
Clone ID Related Accession (Same CDS sequence)	NM_007799.3
Accession Version	NM_007799.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1194bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Mus musculus(house mouse)
Product	cathepsin E preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC120217.13, AK145875.1 and AC138277.16. On Jan 30, 2008 this sequence version replaced NM_007799.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC005432.1, AK145875.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCCCC TCCTTGTGCT GCTGCTGCTG CTGCTCCTGG ATCTGGCTCA GGCCCAAGGT 
GCTCTGCACA GAGTGCCCCT CAGAAGACAT CAGTCCCTTC GGAAGAAACT ACGGGCCCAA 
GGACAGCTCT CAGAATTCTG GAGGTCTCAT AACTTGGACA TGACCCGACT CAGCGAGTCC 
TGTAATGTGT ATTCGAGTGT CAATGAACCC CTCATCAACT ACCTGGATAT GGAATACTTT 
GGCACCATCT CCATCGGCAC CCCGCCGCAG AACTTCACTG TCATCTTTGA CACCGGTTCA 
TCCAACCTCT GGGTCCCTTC TGTGTACTGC ACCAGCCCAG CATGCAAGGC ACACCCAGTA 
TTCCATCCAT CGCAGTCCGA CACATACACG GAGGTAGGGA ATCATTTCTC CATCCAGTAT 
GGTACCGGGA GCCTGACAGG AATCATTGGA GCTGATCAAG TCTCTGTGGA AGGGTTGACT 
GTGGATGGCC AGCAGTTTGG AGAAAGTGTC AAGGAGCCAG GCCAGACCTT TGTGAATGCA 
GAGTTTGATG GGATTCTGGG TCTGGGATAC CCCTCATTGG CTGCTGGAGG AGTGACCCCA 
GTGTTTGACA ACATGATGGC CCAGAACCTT GTGGCTCTGC CTATGTTTTC TGTCTACTTG 
AGCAGTGACC CTCAAGGTGG CTCAGGCAGT GAGCTGACTT TCGGAGGCTA TGACCCCTCT 
CATTTCTCTG GGAGCCTCAA CTGGATCCCA GTCACCAAGC AAGCCTATTG GCAGATTGCC 
CTGGATGGAA TCCAGGTGGG AGACACTGTG ATGTTCTGCT CCGAAGGCTG CCAGGCCATA 
GTGGACACAG GGACCTCTCT CATCACTGGC CCCCCCGACA AGATCAAACA GCTTCAAGAG 
GCCATTGGGG CCACACCCAT TGATGGAGAA TATGCAGTGG ATTGTGCCAC TCTCGACACG 
ATGCCAAACG TTACCTTCCT CATCAACGAG GTTTCATATA CCCTCAACCC AACTGACTAC 
ATCCTGCCGG ACTTGGTGGA AGGAATGCAG TTCTGTGGCA GTGGCTTTCA AGGACTTGAC 
ATTCCACCTC CAGCTGGGCC CCTCTGGATC CTGGGGGATG TCTTCATCCG ACAGTTCTAC 
TCAGTCTTTG ACCGTGGAAA TAACCAAGTG GGATTGGCCC CCGCAGTTCC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031825.2
CDS	365..1558
Translation	MKPLLVLLLLLLLDLAQAQGALHRVPLRRHQSLRKKLRAQGQLSEFWRSHNLDMTRLSESCNVYSSVNEPLINYLDMEYFGTISIGTPPQNFTVIFDTGSSNLWVPSVYCTSPACKAHPVFHPSQSDTYTEVGNHFSIQYGTGSLTGIIGADQVSVEGLTVDGQQFGESVKEPGQTFVNAEFDGILGLGYPSLAAGGVTPVFDNMMAQNLVALPMFSVYLSSDPQGGSGSELTFGGYDPSHFSGSLNWIPVTKQAYWQIALDGIQVGDTVMFCSEGCQAIVDTGTSLITGPPDKIKQLQEAIGATPIDGEYAVDCATLDTMPNVTFLINEVSYTLNPTDYILPDLVEGMQFCGSGFQGLDIPPPAGPLWILGDVFIRQFYSVFDRGNNQVGLAPAVP

Target ORF information:

RefSeq Version	NM_007799.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus cathepsin E (Ctse), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007799.3

ORF Insert Sequence:

ATGAAGCCCC TCCTTGTGCT GCTGCTGCTG CTGCTCCTGG ATCTGGCTCA GGCCCAAGGT 
GCTCTGCACA GAGTGCCCCT CAGAAGACAT CAGTCCCTTC GGAAGAAACT ACGGGCCCAA 
GGACAGCTCT CAGAATTCTG GAGGTCTCAT AACTTGGACA TGACCCGACT CAGCGAGTCC 
TGTAATGTGT ATTCGAGTGT CAATGAACCC CTCATCAACT ACCTGGATAT GGAATACTTT 
GGCACCATCT CCATCGGCAC CCCGCCGCAG AACTTCACTG TCATCTTTGA CACCGGTTCA 
TCCAACCTCT GGGTCCCTTC TGTGTACTGC ACCAGCCCAG CATGCAAGGC ACACCCAGTA 
TTCCATCCAT CGCAGTCCGA CACATACACG GAGGTAGGGA ATCATTTCTC CATCCAGTAT 
GGTACCGGGA GCCTGACAGG AATCATTGGA GCTGATCAAG TCTCTGTGGA AGGGTTGACT 
GTGGATGGCC AGCAGTTTGG AGAAAGTGTC AAGGAGCCAG GCCAGACCTT TGTGAATGCA 
GAGTTTGATG GGATTCTGGG TCTGGGATAC CCCTCATTGG CTGCTGGAGG AGTGACCCCA 
GTGTTTGACA ACATGATGGC CCAGAACCTT GTGGCTCTGC CTATGTTTTC TGTCTACTTG 
AGCAGTGACC CTCAAGGTGG CTCAGGCAGT GAGCTGACTT TCGGAGGCTA TGACCCCTCT 
CATTTCTCTG GGAGCCTCAA CTGGATCCCA GTCACCAAGC AAGCCTATTG GCAGATTGCC 
CTGGATGGAA TCCAGGTGGG AGACACTGTG ATGTTCTGCT CCGAAGGCTG CCAGGCCATA 
GTGGACACAG GGACCTCTCT CATCACTGGC CCCCCCGACA AGATCAAACA GCTTCAAGAG 
GCCATTGGGG CCACACCCAT TGATGGAGAA TATGCAGTGG ATTGTGCCAC TCTCGACACG 
ATGCCAAACG TTACCTTCCT CATCAACGAG GTTTCATATA CCCTCAACCC AACTGACTAC 
ATCCTGCCGG ACTTGGTGGA AGGAATGCAG TTCTGTGGCA GTGGCTTTCA AGGACTTGAC 
ATTCCACCTC CAGCTGGGCC CCTCTGGATC CTGGGGGATG TCTTCATCCG ACAGTTCTAC 
TCAGTCTTTG ACCGTGGAAA TAACCAAGTG GGATTGGCCC CCGCAGTTCC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.
Development (Cambridge, England)144(17)3177-3188(2017 09)
Rutledge EA,Benazet JD,McMahon AP

The NANCI-Nkx2.1 gene duplex buffers Nkx2.1 expression to maintain lung development and homeostasis.
Genes & development31(9)889-903(2017 May)
Herriges MJ,Tischfield DJ,Cui Z,Morley MP,Han Y,Babu A,Li S,Lu M,Cendan I,Garcia BA,Anderson SA,Morrisey EE

The Critical Role of Proteolytic Relay through Cathepsins B and E in the Phenotypic Change of Microglia/Macrophage.
The Journal of neuroscience : the official journal of the Society for Neuroscience35(36)12488-501(2015 Sep)
Ni J,Wu Z,Peterts C,Yamamoto K,Qing H,Nakanishi H

Autophagic digestion of Leishmania major by host macrophages is associated with differential expression of BNIP3, CTSE, and the miRNAs miR-101c, miR-129, and miR-210.
Parasites & vectors8404(2015 Jul)
Frank B,Marcu A,de Oliveira Almeida Petersen AL,Weber H,Stigloher C,Mottram JC,Scholz CJ,Schurigt U

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Ctse cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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