Mmp7 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mmp7
Entrez Gene ID	25335
Full Name	matrix metallopeptidase 7
Synonyms	MPMM
General protein information	Preferred Names matrix metallopeptidase 7 Names matrilysin MMP-7 Matrix metalloproteinase 7 (matrilysin) matrin matrix metalloproteinase-7 pump-1 protease uterine metalloproteinase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q11
Summary	enzyme that cleaves the alpha 2(I) chain of rat gelatin [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012864.2	NP_036996.1	matrilysin precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	MMP7	NP_001229655.1
Bos taurus (cattle)	MMP7	NP_001068598.1
Homo sapiens (human)	MMP7	NP_002414.1
	MMP7	XP_001097508.2
Arabidopsis thaliana (thale cress)	AT4G16640	NP_193397.1
Rattus norvegicus (Norway rat)	Mmp7	NP_036996.1
Oryza sativa (rice)	Os10g0557900	NP_001065361.2
Pan troglodytes (chimpanzee)	MMP7	XP_508721.2
Mus musculus (house mouse)	Mmp7	NP_034940.2
Gallus gallus (chicken)	MMP7	NP_001006278.1

Gene Ontology
Bibliography

Related articles in PubMed

Increased vascular and uteroplacental matrix metalloproteinase-1 and -7 levels and collagen type I deposition in hypertension in pregnancy: role of TNF-?.
Li W, Cui N, Mazzuca MQ, Mata KM, Khalil RA
American journal of physiology. Heart and circulatory physiology313(3)H491-H507(2017 Sep)

Osteopontin promotes aromatase expression and estradiol production in human adipocytes.
Leitner L, J?rets A, Itariu BK, Keck M, Prager G, Langer F, Grablowitz V, Zeyda M, Stulnig TM
Breast cancer research and treatment154(1)63-9(2015 Nov)

Expression and significance of MMP-7, c-Jun and c-Fos in rats skin photoaging.
Shi LQ, Ruan CL
Asian Pacific journal of tropical medicine6(10)768-70(2013 Oct)

Rapamycin attenuates bladder hypertrophy during long-term outlet obstruction in vivo: tissue, matrix and mechanistic insights.
Schr?der A, Kirwan TP, Jiang JX, Aitken KJ, B?gli DJ
The Journal of urology189(6)2377-84(2013 Jun)

[Influence of Bushen Huoxue decoction on beta-catenin, MMP-7 of synoviocytes in rats with knee osteoarthritis].
Yuan Q, Kan WB, Song PF, Zhao J, Yu WG, Wang YJ
Zhongguo gu shang = China journal of orthopaedics and traumatology25(9)761-5(2012 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Placental ischemia, possibly through the release of TNF-alpha, causes increases in the levels of matrix metalloproteinase (MMP)-1 and MMP-7, which could alter collagen deposition and cause inadequate uteroplacental and vascular remodeling in hypertension in pregnancy.
Title: Increased vascular and uteroplacental matrix metalloproteinase-1 and -7 levels and collagen type I deposition in hypertension in pregnancy: role of TNF-?.

Expression of MMP-7, c-Jun and c-Fos were increased in skin photoaging.
Title: Expression and significance of MMP-7, c-Jun and c-Fos in rats skin photoaging.

Increased extracellular nerve growth factor precursor levels following seizures are stabilized by altered MMP-7 enzymatic activity, leading to increased neuronal death via activation of p75(NTR).
Title: Matrix metalloproteinase-7 regulates cleavage of pro-nerve growth factor and is neuroprotective following kainic acid-induced seizures.

MMP-7 significantly contributes to intestinal epithelial wound closure. IL-1beta increased MMP-7 levels beyond those seen during normal healing.
Title: The role of matrix metalloproteinases in intestinal epithelial wound healing during normal and inflammatory states.

Agonist signaling of both hypertension and hypertrophy depends on posttranscriptional and transcriptional mechanisms that involve MMP-7, which is transcriptionally connected with ADAM-12
Title: Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy.

The following Mmp7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mmp7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12063	NM_012864.2 Latest version!	Rattus norvegicus matrix metallopeptidase 7 (Mmp7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mmp7 ( NM_012864.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036996.1 Rattus norvegicus matrix metallopeptidase 7 (Mmp7), mRNA.

Price & Availability↑

CloneID	ORa12063
Clone ID Related Accession (Same CDS sequence)	NM_012864.2
Accession Version	NM_012864.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	matrilysin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC064657.1. On Jan 25, 2008 this sequence version replaced NM_012864.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC064657.1, L24374.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689599, SAMEA2689601 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGCTA TGAGGCTCAC CCTGTTCCGC ATTGTGTGTC TGCTGCCAGG CTGCCTGGCC 
CTGCCACTGT CCCAGGAAGC CGGAGAAGTG ACCGCACTTC AGTGGGAACA GGCGCAGAAT 
TATCTTAGGA AATTTTACCT TCACGACTCT AAAACAAAGA AGGCCACCAG TGCAGTGGAC 
AAACTGAGGG AAATGCAGAA GTTCTTCGGT TTGCCGGAGA CTGGAAAGCT GTCCCCCCGT 
GTCATGGAGA TAATGCAGAA GCCCAGGTGT GGAGTGCCAG ATGTTGCAGA ATTCTCACTA 
ATGCCAAACA GTCCTAAGTG GCATTCCAGA ACTGTCACCT ACAGAATCGT GTCCTATACT 
ACAGACTTGC CTCGGTTCTT AGTAGATCAA ATCGTGAAAA GAGCTCTCAG AATGTGGAGT 
ATGCAAATCC CACTGAACTT CAAGAGGGTT AGTTGGGGGA CTGCAGACAT CATAATTGGC 
TTCGCAAGGG GAGATCACGG AGACAACTTC CCATTTGATG GGCCAGGAAA CACTCTAGGC 
CATGCCTTTG CACCGGGGCC AGGCCTCGGC GGAGATGCTC ACTTTGACAA GGATGAGTAC 
TGGACGGATG GTGAGGACTC AGGAGTGAAC TTCCTGTTTG TTGCCACTCA TGAACTTGGC 
CACTCTCTGG GTCTGGGTCA CTCTTCTGTT CCCAGTTCTG TGATGTACCC TACCTATCAA 
GGAGATCATT CAGAAGACTT CAGTCTTACA AAGGACGACA TTGCAGGCAT CCAGAAGTTA 
TATGGAAAGA GGAACAAGCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036996.1
CDS	20..823
Translation	MAAMRLTLFRIVCLLPGCLALPLSQEAGEVTALQWEQAQNYLRKFYLHDSKTKKATSAVDKLREMQKFFGLPETGKLSPRVMEIMQKPRCGVPDVAEFSLMPNSPKWHSRTVTYRIVSYTTDLPRFLVDQIVKRALRMWSMQIPLNFKRVSWGTADIIIGFARGDHGDNFPFDGPGNTLGHAFAPGPGLGGDAHFDKDEYWTDGEDSGVNFLFVATHELGHSLGLGHSSVPSSVMYPTYQGDHSEDFSLTKDDIAGIQKLYGKRNKL

Target ORF information:

RefSeq Version	NM_012864.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus matrix metallopeptidase 7 (Mmp7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012864.2

ORF Insert Sequence:

ATGGCAGCTA TGAGGCTCAC CCTGTTCCGC ATTGTGTGTC TGCTGCCAGG CTGCCTGGCC 
CTGCCACTGT CCCAGGAAGC CGGAGAAGTG ACCGCACTTC AGTGGGAACA GGCGCAGAAT 
TATCTTAGGA AATTTTACCT TCACGACTCT AAAACAAAGA AGGCCACCAG TGCAGTGGAC 
AAACTGAGGG AAATGCAGAA GTTCTTCGGT TTGCCGGAGA CTGGAAAGCT GTCCCCCCGT 
GTCATGGAGA TAATGCAGAA GCCCAGGTGT GGAGTGCCAG ATGTTGCAGA ATTCTCACTA 
ATGCCAAACA GTCCTAAGTG GCATTCCAGA ACTGTCACCT ACAGAATCGT GTCCTATACT 
ACAGACTTGC CTCGGTTCTT AGTAGATCAA ATCGTGAAAA GAGCTCTCAG AATGTGGAGT 
ATGCAAATCC CACTGAACTT CAAGAGGGTT AGTTGGGGGA CTGCAGACAT CATAATTGGC 
TTCGCAAGGG GAGATCACGG AGACAACTTC CCATTTGATG GGCCAGGAAA CACTCTAGGC 
CATGCCTTTG CACCGGGGCC AGGCCTCGGC GGAGATGCTC ACTTTGACAA GGATGAGTAC 
TGGACGGATG GTGAGGACTC AGGAGTGAAC TTCCTGTTTG TTGCCACTCA TGAACTTGGC 
CACTCTCTGG GTCTGGGTCA CTCTTCTGTT CCCAGTTCTG TGATGTACCC TACCTATCAA 
GGAGATCATT CAGAAGACTT CAGTCTTACA AAGGACGACA TTGCAGGCAT CCAGAAGTTA 
TATGGAAAGA GGAACAAGCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Increased vascular and uteroplacental matrix metalloproteinase-1 and -7 levels and collagen type I deposition in hypertension in pregnancy: role of TNF-?.
American journal of physiology. Heart and circulatory physiology313(3)H491-H507(2017 Sep)
Li W,Cui N,Mazzuca MQ,Mata KM,Khalil RA

Osteopontin promotes aromatase expression and estradiol production in human adipocytes.
Breast cancer research and treatment154(1)63-9(2015 Nov)
Leitner L,J?rets A,Itariu BK,Keck M,Prager G,Langer F,Grablowitz V,Zeyda M,Stulnig TM

Expression and significance of MMP-7, c-Jun and c-Fos in rats skin photoaging.
Asian Pacific journal of tropical medicine6(10)768-70(2013 Oct)
Shi LQ,Ruan CL

Rapamycin attenuates bladder hypertrophy during long-term outlet obstruction in vivo: tissue, matrix and mechanistic insights.
The Journal of urology189(6)2377-84(2013 Jun)
Schr?der A,Kirwan TP,Jiang JX,Aitken KJ,B?gli DJ

[Influence of Bushen Huoxue decoction on beta-catenin, MMP-7 of synoviocytes in rats with knee osteoarthritis].
Zhongguo gu shang = China journal of orthopaedics and traumatology25(9)761-5(2012 Sep)
Yuan Q,Kan WB,Song PF,Zhao J,Yu WG,Wang YJ

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Mmp7 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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