MMP7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MMP7
Entrez Gene ID	4316
Full Name	matrix metallopeptidase 7
Synonyms	MMP-7,MPSL1,PUMP-1
General protein information	Preferred Names matrix metallopeptidase 7 Names matrilysin matrin matrix metallopeptidase 7 (matrilysin, uterine) matrix metalloproteinase 7 (matrilysin, uterine) matrix metalloproteinase-7 pump-1 protease uterine matrilysin uterine metalloproteinase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q22.2
Summary	This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016].
Disorder MIM:	178990

mRNA and Protein(s)

mRNA	Protein	Name
NM_002423.4	NP_002414.1	matrilysin preproprotein
NM_002423.5	NP_002414.1	matrilysin preproprotein

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	MMP7	NP_001229655.1
Bos taurus (cattle)	MMP7	NP_001068598.1
Homo sapiens (human)	MMP7	NP_002414.1
	MMP7	XP_001097508.2
Arabidopsis thaliana (thale cress)	AT4G16640	NP_193397.1
Rattus norvegicus (Norway rat)	Mmp7	NP_036996.1
Oryza sativa (rice)	Os10g0557900	NP_001065361.2
Pan troglodytes (chimpanzee)	MMP7	XP_508721.2
Mus musculus (house mouse)	Mmp7	NP_034940.2
Gallus gallus (chicken)	MMP7	NP_001006278.1

Gene Ontology
Bibliography

Related articles in PubMed

Contribution of Matrix Metalloproteinase-7 Genotypes to the Risk of Non-solid Tumor, Childhood Leukemia.
Pei JS, Chou AK, Hsu PC, Tsai CW, Chang WS, Wu MF, Wu MH, Hsia TC, Cheng SP, Bau DT
Anticancer research37(12)6679-6684(2017 12)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results indicate that the matrix metallopeptidase 7 (MMP7)A-181G genotype interacts with age and gender and may serve as an early and predictive biomarker for childhood acute lymphoblastic leukemia (ALL).
Title: Contribution of Matrix Metalloproteinase-7 Genotypes to the Risk of Non-solid Tumor, Childhood Leukemia.

Matrix Metalloproteinase-7 Promoter polymorphism is associated with breast Cancer.
Title: The Contribution of Matrix Metalloproteinase-7 Promoter Genotypes in Breast Cancer in Taiwan.

Data suggest that the cytoplasmic domain of Sdc2 is involved in regulation of expression of MMP7 in colon carcinoma/adenocarcinoma cells; induction of MMP7 involves protein kinase C gamma-mediated FAK/ERK signaling. (Sdc2 = syndecan-2; MMP7 = matrix metalloproteinase-7; FAK = focal adhesion kinase 1)
Title: Syndecan-2 cytoplasmic domain up-regulates matrix metalloproteinase-7 expression via the protein kinase C?-mediated FAK/ERK signaling pathway in colon cancer.

No significant differences were found between MMP-7 A-181G, C-115T, and TIMP-2 G-418C polymorphism and coronary artery disease and myocardial infarction in a Turkish population.
Title: Analysis of MMP-7 and TIMP-2 gene polymorphisms in coronary artery disease and myocardial infarction: A Turkish case-control study.

We conclude that in the resected esophageal cancer an increased mRNA expression of MMP-7, MMP-10 and TIMP-1 correlated with clinicopathologic features. We suggest that these genes may play a role during progression of the disease MMP-10, MMP-7, TIMP-1, TIMP-2 were overexpressed in 73%, 85%, 55% and 42% of esophageal cancer samples, respectively.
Title: MMP-10, MMP-7, TIMP-1 and TIMP-2 mRNA expression in esophageal cancer.

The following MMP7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MMP7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26921	NM_002423.5 Latest version!	Homo sapiens matrix metallopeptidase 7 (MMP7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu26921	NM_002423.4	Homo sapiens matrix metallopeptidase 7 (MMP7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MMP7 ( NM_002423.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002414.1 Homo sapiens matrix metallopeptidase 7 (MMP7), mRNA.

Price & Availability↑

CloneID	OHu26921
Clone ID Related Accession (Same CDS sequence)	NM_002423.4 , NM_002423.5
Accession Version	NM_002423.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	matrilysin preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB109660.1, BC003635.2 and X07819.1. On Nov 22, 2018 this sequence version replaced NM_002423.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189667.102394.1, SRR5189658.160444.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000260227.5/ ENSP00000260227.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCGACTCA CCGTGCTGTG TGCTGTGTGC CTGCTGCCTG GCAGCCTGGC CCTGCCGCTG 
CCTCAGGAGG CGGGAGGCAT GAGTGAGCTA CAGTGGGAAC AGGCTCAGGA CTATCTCAAG 
AGATTTTATC TCTATGACTC AGAAACAAAA AATGCCAACA GTTTAGAAGC CAAACTCAAG 
GAGATGCAAA AATTCTTTGG CCTACCTATA ACTGGAATGT TAAACTCCCG CGTCATAGAA 
ATAATGCAGA AGCCCAGATG TGGAGTGCCA GATGTTGCAG AATACTCACT ATTTCCAAAT 
AGCCCAAAAT GGACTTCCAA AGTGGTCACC TACAGGATCG TATCATATAC TCGAGACTTA 
CCGCATATTA CAGTGGATCG ATTAGTGTCA AAGGCTTTAA ACATGTGGGG CAAAGAGATC 
CCCCTGCATT TCAGGAAAGT TGTATGGGGA ACTGCTGACA TCATGATTGG CTTTGCGCGA 
GGAGCTCATG GGGACTCCTA CCCATTTGAT GGGCCAGGAA ACACGCTGGC TCATGCCTTT 
GCGCCTGGGA CAGGTCTCGG AGGAGATGCT CACTTCGATG AGGATGAACG CTGGACGGAT 
GGTAGCAGTC TAGGGATTAA CTTCCTGTAT GCTGCAACTC ATGAACTTGG CCATTCTTTG 
GGTATGGGAC ATTCCTCTGA TCCTAATGCA GTGATGTATC CAACCTATGG AAATGGAGAT 
CCCCAAAATT TTAAACTTTC CCAGGATGAT ATTAAAGGCA TTCAGAAACT ATATGGAAAG 
AGAAGTAATT CAAGAAAGAA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002414.1
CDS	48..851
Translation	MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK

Target ORF information:

RefSeq Version	NM_002423.5
Organism	Homo sapiens(human)
Definition	Homo sapiens matrix metallopeptidase 7 (MMP7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002423.5

ORF Insert Sequence:

ATGCGACTCA CCGTGCTGTG TGCTGTGTGC CTGCTGCCTG GCAGCCTGGC CCTGCCGCTG 
CCTCAGGAGG CGGGAGGCAT GAGTGAGCTA CAGTGGGAAC AGGCTCAGGA CTATCTCAAG 
AGATTTTATC TCTATGACTC AGAAACAAAA AATGCCAACA GTTTAGAAGC CAAACTCAAG 
GAGATGCAAA AATTCTTTGG CCTACCTATA ACTGGAATGT TAAACTCCCG CGTCATAGAA 
ATAATGCAGA AGCCCAGATG TGGAGTGCCA GATGTTGCAG AATACTCACT ATTTCCAAAT 
AGCCCAAAAT GGACTTCCAA AGTGGTCACC TACAGGATCG TATCATATAC TCGAGACTTA 
CCGCATATTA CAGTGGATCG ATTAGTGTCA AAGGCTTTAA ACATGTGGGG CAAAGAGATC 
CCCCTGCATT TCAGGAAAGT TGTATGGGGA ACTGCTGACA TCATGATTGG CTTTGCGCGA 
GGAGCTCATG GGGACTCCTA CCCATTTGAT GGGCCAGGAA ACACGCTGGC TCATGCCTTT 
GCGCCTGGGA CAGGTCTCGG AGGAGATGCT CACTTCGATG AGGATGAACG CTGGACGGAT 
GGTAGCAGTC TAGGGATTAA CTTCCTGTAT GCTGCAACTC ATGAACTTGG CCATTCTTTG 
GGTATGGGAC ATTCCTCTGA TCCTAATGCA GTGATGTATC CAACCTATGG AAATGGAGAT 
CCCCAAAATT TTAAACTTTC CCAGGATGAT ATTAAAGGCA TTCAGAAACT ATATGGAAAG 
AGAAGTAATT CAAGAAAGAA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MMP7 ( NM_002423.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002414.1 Homo sapiens matrix metallopeptidase 7 (MMP7), mRNA.

Price & Availability↑

CloneID	OHu26921
Clone ID Related Accession (Same CDS sequence)	NM_002423.4 , NM_002423.5
Accession Version	NM_002423.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	matrilysin preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB109660.1, BC003635.2 and X07819.1. On Jan 20, 2016 this sequence version replaced NM_002423.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.540358.1, AK222980.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCGACTCA CCGTGCTGTG TGCTGTGTGC CTGCTGCCTG GCAGCCTGGC CCTGCCGCTG 
CCTCAGGAGG CGGGAGGCAT GAGTGAGCTA CAGTGGGAAC AGGCTCAGGA CTATCTCAAG 
AGATTTTATC TCTATGACTC AGAAACAAAA AATGCCAACA GTTTAGAAGC CAAACTCAAG 
GAGATGCAAA AATTCTTTGG CCTACCTATA ACTGGAATGT TAAACTCCCG CGTCATAGAA 
ATAATGCAGA AGCCCAGATG TGGAGTGCCA GATGTTGCAG AATACTCACT ATTTCCAAAT 
AGCCCAAAAT GGACTTCCAA AGTGGTCACC TACAGGATCG TATCATATAC TCGAGACTTA 
CCGCATATTA CAGTGGATCG ATTAGTGTCA AAGGCTTTAA ACATGTGGGG CAAAGAGATC 
CCCCTGCATT TCAGGAAAGT TGTATGGGGA ACTGCTGACA TCATGATTGG CTTTGCGCGA 
GGAGCTCATG GGGACTCCTA CCCATTTGAT GGGCCAGGAA ACACGCTGGC TCATGCCTTT 
GCGCCTGGGA CAGGTCTCGG AGGAGATGCT CACTTCGATG AGGATGAACG CTGGACGGAT 
GGTAGCAGTC TAGGGATTAA CTTCCTGTAT GCTGCAACTC ATGAACTTGG CCATTCTTTG 
GGTATGGGAC ATTCCTCTGA TCCTAATGCA GTGATGTATC CAACCTATGG AAATGGAGAT 
CCCCAAAATT TTAAACTTTC CCAGGATGAT ATTAAAGGCA TTCAGAAACT ATATGGAAAG 
AGAAGTAATT CAAGAAAGAA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002414.1
CDS	54..857
Translation	MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK

Target ORF information:

RefSeq Version	NM_002423.4
Organism	Homo sapiens(human)
Definition	Homo sapiens matrix metallopeptidase 7 (MMP7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002423.4

ORF Insert Sequence:

ATGCGACTCA CCGTGCTGTG TGCTGTGTGC CTGCTGCCTG GCAGCCTGGC CCTGCCGCTG 
CCTCAGGAGG CGGGAGGCAT GAGTGAGCTA CAGTGGGAAC AGGCTCAGGA CTATCTCAAG 
AGATTTTATC TCTATGACTC AGAAACAAAA AATGCCAACA GTTTAGAAGC CAAACTCAAG 
GAGATGCAAA AATTCTTTGG CCTACCTATA ACTGGAATGT TAAACTCCCG CGTCATAGAA 
ATAATGCAGA AGCCCAGATG TGGAGTGCCA GATGTTGCAG AATACTCACT ATTTCCAAAT 
AGCCCAAAAT GGACTTCCAA AGTGGTCACC TACAGGATCG TATCATATAC TCGAGACTTA 
CCGCATATTA CAGTGGATCG ATTAGTGTCA AAGGCTTTAA ACATGTGGGG CAAAGAGATC 
CCCCTGCATT TCAGGAAAGT TGTATGGGGA ACTGCTGACA TCATGATTGG CTTTGCGCGA 
GGAGCTCATG GGGACTCCTA CCCATTTGAT GGGCCAGGAA ACACGCTGGC TCATGCCTTT 
GCGCCTGGGA CAGGTCTCGG AGGAGATGCT CACTTCGATG AGGATGAACG CTGGACGGAT 
GGTAGCAGTC TAGGGATTAA CTTCCTGTAT GCTGCAACTC ATGAACTTGG CCATTCTTTG 
GGTATGGGAC ATTCCTCTGA TCCTAATGCA GTGATGTATC CAACCTATGG AAATGGAGAT 
CCCCAAAATT TTAAACTTTC CCAGGATGAT ATTAAAGGCA TTCAGAAACT ATATGGAAAG 
AGAAGTAATT CAAGAAAGAA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Contribution of Matrix Metalloproteinase-7 Genotypes to the Risk of Non-solid Tumor, Childhood Leukemia.
Anticancer research37(12)6679-6684(2017 12)
Pei JS,Chou AK,Hsu PC,Tsai CW,Chang WS,Wu MF,Wu MH,Hsia TC,Cheng SP,Bau DT

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MMP7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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