Sry cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sry
Entrez Gene ID	25221
Full Name	sex determining region Y
Synonyms	SRYGENE,Sry1,Sry3BI,Tdf,Tdy
General protein information	Preferred Names sex determining region Y Names sex-determining region Y protein HMG box transcription factor Sry1 HMG box transcription factor Sry3BI Testis determining locus sex determining region of Chr Y sex determining region on Y testis-determining factor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: Y Map Location: Yq11
Summary	transcriptional activator; involved in male sex determination [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012772.1	NP_036904.1	sex-determining region Y protein

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Human Sex Determination at the Edge of Ambiguity: INHERITED XY SEX REVERSAL DUE TO ENHANCED UBIQUITINATION AND PROTEASOMAL DEGRADATION OF A MASTER TRANSCRIPTION FACTOR.
Racca JD, Chen YS, Yang Y, Phillips NB, Weiss MA
The Journal of biological chemistry291(42)22173-22195(2016 Oct)

A Novel Missense Mutation 224G>T (R75M) in SRY Coding Region Interferes with Nuclear Import and Results in 46, XY Complete Gonadal Dysgenesis.
Fan W, Wang B, He S, Zhang T, Yin C, Chen Y, Zheng S, Zhang J, Li L
PloS one11(12)e0168484(2016)

Similarities and differences of X and Y chromosome homologous genes, SRY and SOX3, in regulating the renin-angiotensin system promoters.
Araujo FC, Milsted A, Watanabe IK, Del Puerto HL, Santos RA, Lazar J, Reis FM, Prokop JW
Physiological genomics47(5)177-86(2015 May)

The male-specific factor Sry harbors an oncogenic function.
Murakami S, Chishima S, Uemoto H, Sakamoto E, Sato T, Kurabe N, Kawasaki Y, Shibata T, Akiyama H, Tashiro F
Oncogene33(23)2978-86(2014 Jun)

The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling.
Correa RG, Krajewska M, Ware CF, Gerlic M, Reed JC
Oncotarget5(6)1666-82(2014 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Chemical proteasome inhibition restored native-like SRY expression and transcriptional activity in association with restored occupancy of a sex-specific enhancer element in principal downstream gene Sox9, demonstrating that the variant SRY exhibits essentially native activity on a per molecule basis.
Title: Human Sex Determination at the Edge of Ambiguity: INHERITED XY SEX REVERSAL DUE TO ENHANCED UBIQUITINATION AND PROTEASOMAL DEGRADATION OF A MASTER TRANSCRIPTION FACTOR.

These results suggest that SRY regulation of the renin-angiotensin system is partially shared with its X-chromosome homolog SOX3.
Title: Similarities and differences of X and Y chromosome homologous genes, SRY and SOX3, in regulating the renin-angiotensin system promoters.

Data show that Sry is involved in male-specific malignant conversion of rodent hepatocellular carcinoma via Sgf29 upregulation.
Title: The male-specific factor Sry harbors an oncogenic function.

Data suggest that Sry and Tcf21 (transcription factor 21) induce initial stages of embryonic Sertoli cell differentiation; Scx (scleraxis) induces later stages. This cascade--Sry>Tcf21>Scx--appears to promote subsequent sex differentiation.
Title: SRY induced TCF21 genome-wide targets and cascade of bHLH factors during Sertoli cell differentiation and male sex determination in rats.

The specific DNA sequence binding site motifs for both SRY and SOX9 were identified.
Title: Global genome analysis of the downstream binding targets of testis determining factor SRY and SOX9.

The following Sry gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sry cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42466	NM_012772.1 Latest version!	Rattus norvegicus sex determining region Y (Sry), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sry ( NM_012772.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036904.1 Rattus norvegicus sex determining region Y (Sry), mRNA.

Price & Availability↑

CloneID	ORa42466
Clone ID Related Accession (Same CDS sequence)	NM_012772.1
Accession Version	NM_012772.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 510bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Rattus norvegicus(Norway rat)
Product	sex-determining region Y protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF274872.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGGAGGGCC ATGTCAAGCG CCCCATGAAT GCATTTATGG TGTGGTCCCG TGGAGAGAGG 
CGCAAGTTGG CTCAACAGAA TCCCAGCATG CAGAATTCAG AGATCAGCAA GCATCTGGGA 
TATCAGTGGA AAAGCCTTAC AGAAGCCGAA AAAAGGCCCT TTTTCCAGGA GGCGCAGAGA 
CTGAAGACCC TACACAGAGA GAAATATCCA AACTATAAAT ATCAGCCTCA TCGAAGGGTT 
AAAGTGCCAC AGAGGAGTTA TACTTTGCAG CGTGAAGTTG CCTCAACAAA ACTGTACAAC 
CTGCTGCAAT GGGACAACAA CCTACACACT ATCATATACG GACAGGACTG GGCTAGAGCT 
GCACACCAGT CCTCCAAGAA CCAGAAAAGC ATTTATTTAC AGCCTGTGGA CATCCCCACT 
GGATACCCAC TACAGCAGAA ACAGCAGCAC CAGCAGCAGC AGCACGTGCA CCTGCAGCAG 
CAGCAGCAGC AGCAGCACCA GTTCCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036904.1
CDS	1..510
Translation	MEGHVKRPMNAFMVWSRGERRKLAQQNPSMQNSEISKHLGYQWKSLTEAEKRPFFQEAQRLKTLHREKYPNYKYQPHRRVKVPQRSYTLQREVASTKLYNLLQWDNNLHTIIYGQDWARAAHQSSKNQKSIYLQPVDIPTGYPLQQKQQHQQQQHVHLQQQQQQQHQFH

Target ORF information:

RefSeq Version	NM_012772.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus sex determining region Y (Sry), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012772.1

ORF Insert Sequence:

ATGGAGGGCC ATGTCAAGCG CCCCATGAAT GCATTTATGG TGTGGTCCCG TGGAGAGAGG 
CGCAAGTTGG CTCAACAGAA TCCCAGCATG CAGAATTCAG AGATCAGCAA GCATCTGGGA 
TATCAGTGGA AAAGCCTTAC AGAAGCCGAA AAAAGGCCCT TTTTCCAGGA GGCGCAGAGA 
CTGAAGACCC TACACAGAGA GAAATATCCA AACTATAAAT ATCAGCCTCA TCGAAGGGTT 
AAAGTGCCAC AGAGGAGTTA TACTTTGCAG CGTGAAGTTG CCTCAACAAA ACTGTACAAC 
CTGCTGCAAT GGGACAACAA CCTACACACT ATCATATACG GACAGGACTG GGCTAGAGCT 
GCACACCAGT CCTCCAAGAA CCAGAAAAGC ATTTATTTAC AGCCTGTGGA CATCCCCACT 
GGATACCCAC TACAGCAGAA ACAGCAGCAC CAGCAGCAGC AGCACGTGCA CCTGCAGCAG 
CAGCAGCAGC AGCAGCACCA GTTCCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human Sex Determination at the Edge of Ambiguity: INHERITED XY SEX REVERSAL DUE TO ENHANCED UBIQUITINATION AND PROTEASOMAL DEGRADATION OF A MASTER TRANSCRIPTION FACTOR.
The Journal of biological chemistry291(42)22173-22195(2016 Oct)
Racca JD,Chen YS,Yang Y,Phillips NB,Weiss MA

A Novel Missense Mutation 224G>T (R75M) in SRY Coding Region Interferes with Nuclear Import and Results in 46, XY Complete Gonadal Dysgenesis.
PloS one11(12)e0168484(2016)
Fan W,Wang B,He S,Zhang T,Yin C,Chen Y,Zheng S,Zhang J,Li L

Similarities and differences of X and Y chromosome homologous genes, SRY and SOX3, in regulating the renin-angiotensin system promoters.
Physiological genomics47(5)177-86(2015 May)
Araujo FC,Milsted A,Watanabe IK,Del Puerto HL,Santos RA,Lazar J,Reis FM,Prokop JW

The male-specific factor Sry harbors an oncogenic function.
Oncogene33(23)2978-86(2014 Jun)
Murakami S,Chishima S,Uemoto H,Sakamoto E,Sato T,Kurabe N,Kawasaki Y,Shibata T,Akiyama H,Tashiro F

The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling.
Oncotarget5(6)1666-82(2014 Mar)
Correa RG,Krajewska M,Ware CF,Gerlic M,Reed JC

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Sry cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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