Pgr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pgr
Entrez Gene ID	25154
Full Name	progesterone receptor
General protein information	Preferred Names progesterone receptor Names progesterone receptor PR nuclear receptor subfamily 3 group C member 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q11
Summary	receptor for progesterone; regulates glutamic acid decarboxylase expression in the hypothalamus during proestrus; may mediate production of the GnRH and LH surge [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022847.1	NP_074038.1	progesterone receptor

Pathways from BioSystems

Homologies

Homo sapiens (human)	PGR	NP_000917.3
Bos taurus (cattle)	PGR	NP_001192285.1
	PGR	XP_002799839.1
Gallus gallus (chicken)	PGR	NP_990593.1
Mus musculus (house mouse)	Pgr	NP_032855.2
Pan troglodytes (chimpanzee)	PGR	NP_001129085.1
Canis lupus familiaris (dog)	PGR	NP_001003074.1
Rattus norvegicus (Norway rat)	Pgr	NP_074038.1

Gene Ontology
Bibliography

Related articles in PubMed

Estrogen receptors ? and ? have different roles in the induction and trafficking of progesterone receptors in hypothalamic ventromedial neurons.
S? SI, Fonseca BM, Teixeira N, Madeira MD
The FEBS journal282(6)1126-36(2015 Mar)

Influence of domain interactions on conformational mobility of the progesterone receptor detected by hydrogen/deuterium exchange mass spectrometry.
Goswami D, Callaway C, Pascal BD, Kumar R, Edwards DP, Griffin PR
Structure (London, England : 1993)22(7)961-73(2014 Jul)

CDC2 mediates progestin initiated endometrial stromal cell proliferation: a PR signaling to gene expression independently of its binding to chromatin.
Vallejo G, La Greca AD, Tarifa-Reischle IC, Mestre-Citrinovitz AC, Ballar? C, Beato M, Sarag?eta P
PloS one9(5)e97311(2014)

Loss of progesterone receptor-mediated actions induce preterm cellular and structural remodeling of the cervix and premature birth.
Yellon SM, Dobyns AE, Beck HL, Kurtzman JT, Garfield RE, Kirby MA
PloS one8(12)e81340(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

individual and simultaneous activation of ERalpha and ERbeta have different effects on the levels and subcellular location of PRs in VMNvl neurons
Title: Estrogen receptors ? and ? have different roles in the induction and trafficking of progesterone receptors in hypothalamic ventromedial neurons.

The present study investigated the protective role of progesterone against ischemia-reperfusion-induced acute kidney injury (AKI) and possible involvement of progesterone receptors in ascorbic acid-mediated renoprotection in rats.
Title: Involvement of progesterone receptors in ascorbic?acid-mediated protection against ischemia-reperfusion-induced acute kidney injury.

progestin-induced proliferation of endometrial stromal cells is mediated by ERK1-2 and AKT dependent early regulation of USF1, which directly induces Cdc2
Title: CDC2 mediates progestin initiated endometrial stromal cell proliferation: a PR signaling to gene expression independently of its binding to chromatin.

there is a switch of progesterone receptor isoforms expression during the evening of proestrus that is related to the differential gene methylation patterns of their promoter regions, mainly for the isoform B promoter.
Title: Differential DNA methylation pattern in the A and B promoters of the progesterone receptor is associated with differential mRNA expression in the female rat hypothalamus during proestrus.

interactions between cells may facilitate the loss of progesterone receptor-mediated actions as part of a final common mechanism that remodels the cervix in certain etiologies of preterm and with parturition at term
Title: Loss of progesterone receptor-mediated actions induce preterm cellular and structural remodeling of the cervix and premature birth.

The following Pgr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pgr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13370	NM_022847.1 Latest version!	Rattus norvegicus progesterone receptor (Pgr), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pgr ( NM_022847.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_074038.1 Rattus norvegicus progesterone receptor (Pgr), mRNA.

Price & Availability↑

CloneID	ORa13370
Clone ID Related Accession (Same CDS sequence)	NM_022847.1
Accession Version	NM_022847.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2772bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	progesterone receptor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L16922.1. On Jan 6, 2005 this sequence version replaced XM_346818.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L16922.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGACTGAGC TGCAGGCAAA GGATCCGCGG ACTCTCCACA CATCTGGCGC CGCGCCCTCC 
CCCACCCACG TCGGGTCTCC CTTGCTTGCA CGCTTGGACC CGGATCCCTT CCAGGGGAGT 
CAGCACTCGG ACGCATCGTC TGTAGTCTCG CCAATACCGA TCTCCCTGGA CCGGCTGCTC 
TTCTCTCGGT CCTGCCAGGC TCAGGAGCTC CCAGACGAAA AGACACAAAA TCAGCAGTCG 
CTGTCCGACG TGGAGGGAGC TTTCTCTGGA GTGGAAGCCT CGCGCCGAAG AAGCAGAAAT 
CCCAGAGCTC CGGAGAAGGA CAGCAGACTC TTAGACAGTG TCTTAGACAC CCTGTTGGCG 
CCCTCGGGGC CCGAGCAAAG CCAAACCAGC CCTCCAGCCT GCGAGGCCAT CACTTCTTGG 
TGTCTCTTTG GGCCAGAGCT TCCAGAAGAC CCCCGCAGTG TCCCCGCTAC CAAGGGGTTG 
TTGTCCCCGC TCATGAGCCG GCCAGAGAGC AAGGCTGGCG ACAGCTCCGG GACAGGAGCA 
GGGCAGAAGG TGCTGCCCAA AGCGGTGTCA CCACCCCGGC AGCTGTTGCT CCCGACCTCG 
GGGAGTGCTC ACTGGCCCGG GGCAGGGGTG AAGCCATCTC AGCAGCCTGC TACGGTGGAG 
GTGGAGGAGG ACGGTGGTCT CGAGACCGAG GGCTCTGCGG GTCCGCTTCT GAAGAGCAAA 
CCTCGAGCAC TGGAAGGCAT GTGTAGCGGA GGAGGAGTCA CAGCCAACGC GCCCGGCGCG 
GCCCCAGGAG GCGTCACCTT GGTCCCCAAG GAAGATTCCC GGTTTTCTGC TCCCAGGGTC 
TCCTTGGAGC AAGACGCTCC AGTTGCCCCC GGGCGCTCCC CACTGGCCAC CACAGTGGTG 
GATTTCATTC ACGTGCCCAT TCTGCCTCTG AACCACGCTC TCCTAGCCGC CCGCACCCGG 
CAGCTGCTGG AGGGAGACAG CTACGACGGC GGGGCTGCAG CGCAAGTCCC TTTTGCTCCA 
CCTCGGGGCT CGCCCTCCGC GCCATCCCCG CCGGTGCCCT GCGGTGACTT CCCAGACTGC 
ACCTACCCTC CAGAAGGCGA CCCTAAAGAG GACGGGTTCC CAGTTTACGG CGAATTCCAG 
CCTCCCGGCT TGAAGATCAA GGAGGAGGAG GAGGGCACGG AGGCTGCTTC CCGCTCGCCG 
CGCCCCTACC TGTTGGCCGG AGCCAGCGCC GCCACCTTCC CAGACTTCCC GCTGCCGCCG 
CGGCCGCCGC GAGCGCCACC CTCCAGGCCC GGAGAGGCGG CGGTAGCCGC CCCGAGCGCC 
GCGGTGTCGC CAGTGTCCTC GTCGGGCTCC GCACTGGAGT GCATCCTGTA CAAAGCGGAG 
GGCGCGCCGC CCACGCAGGG TTCGTTCGCC CCATTGCCCT GTAAACCCCC GGCCGCCAGC 
TCCTGCCTGC TTCCCCGGGA CAGCCTGCCC GCCGCTCCGA CCTCCTCGGC AGCACCGGCC 
ATCTACCCGC CGCTCGGCCT CAATGGGCTC CCTCAGCTGG GTTACCAGGC CGCGGTGCTC 
AAGGACAGCC TGCCCCAAGT CTACCCGCCC TACCTCAACT ACCTGAGGCC AGATTCAGAA 
GCCAGCCAGA GCCCACAATA TGGCTTTGAT TCCTTACCTC AGAAGATCTG TTTAATCTGC 
GGGGATGAAG CATCTGGCTG TCACTATGGT GTGCTTACCT GTGGGAGCTG CAAGGTCTTC 
TTTAAGAGGG CGATGGAAGG GCAGCATAAC TATTTATGTG CCGGAAGAAA TGATTGCATT 
GTTGATAAAA TCCGCAGAAA AAACTGTCCA GCATGTCGTC TGAGAAAGTG CTGTCAGGCT 
GGCATGGTCC TTGGAGGTCG TAAGTTTAAG AAGTTCAATA AAGTCCGAGT TATGAGAGCC 
CTCGATGGTG TTGCTCTCCC CCAGTCAGTG GCCTTTCCTA ATGAGAGCCA GACCCTGGGC 
CAGAGAATCA CATTTTCACC AAATCAAGAG ATTCAACTGG TTCCGCCACT CATCAACCTG 
CTCATGAGCA TTGAACCTGA TGTGGTTTAT GCAGGGCATG ACAACACAAA GCCCGACACT 
TCCAGCTCTT TGCTGACCAG TCTCAACCAA CTAGGCGAGA GGCAGCTGCT TTCAGTAGTC 
AAATGGTCTA AGTCTCTGCC AGGTTTCCGG AACTTACACA TCGATGACCA GATAACCCTG 
ATTCAGTACT CCTGGATGAG CCTGATGGTG TTTGGCCTGG GGTGGAGGTC GTACAAGCAT 
GTCAGTGGAC AGATGCTATA TTTTGCACCT GATCTAATCC TGAATGAGCA GAGGATGAAG 
GAGTTGTCAT TCTACTCGCT GTGCCTTACC ATGTGGCAAA TCCCACAGGA GTTTGTCAAG 
CTCCAGGTGA CCCACGAGGA GTTCCTCTGT ATGAAAGTCT TACTTCTTCT TAACACAATT 
CCTTTGGAAG GCCTGAGGAG TCAAAGCCAG TTTGAAGAGA TGAGGTCAAG CTATATTCGG 
GAATTGATCA AGGCAATTGG CTTAAGACAG AAAGGGGTGG TCCCCAGTTC ACAACGCTTC 
TATCAACTTA CAAAACTTCT TGACAGCTTG CATGATCTTG TGAAACAGCT CCACCTGTAC 
TGCTTGAATA CGTTCATCCA ATCCCGGGCA CTGGCTGTGG AATTTCCGGA AATGATGTCT 
GAAGTTATTG CTGCCCAGTT GCCCAAGATC CTGGCGGGCA TGGTGAAGCC TCTCCTCTTT 
CACAAAAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_074038.1
CDS	1..2772
Translation	MTELQAKDPRTLHTSGAAPSPTHVGSPLLARLDPDPFQGSQHSDASSVVSPIPISLDRLLFSRSCQAQELPDEKTQNQQSLSDVEGAFSGVEASRRRSRNPRAPEKDSRLLDSVLDTLLAPSGPEQSQTSPPACEAITSWCLFGPELPEDPRSVPATKGLLSPLMSRPESKAGDSSGTGAGQKVLPKAVSPPRQLLLPTSGSAHWPGAGVKPSQQPATVEVEEDGGLETEGSAGPLLKSKPRALEGMCSGGGVTANAPGAAPGGVTLVPKEDSRFSAPRVSLEQDAPVAPGRSPLATTVVDFIHVPILPLNHALLAARTRQLLEGDSYDGGAAAQVPFAPPRGSPSAPSPPVPCGDFPDCTYPPEGDPKEDGFPVYGEFQPPGLKIKEEEEGTEAASRSPRPYLLAGASAATFPDFPLPPRPPRAPPSRPGEAAVAAPSAAVSPVSSSGSALECILYKAEGAPPTQGSFAPLPCKPPAASSCLLPRDSLPAAPTSSAAPAIYPPLGLNGLPQLGYQAAVLKDSLPQVYPPYLNYLRPDSEASQSPQYGFDSLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVMRALDGVALPQSVAFPNESQTLGQRITFSPNQEIQLVPPLINLLMSIEPDVVYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKELSFYSLCLTMWQIPQEFVKLQVTHEEFLCMKVLLLLNTIPLEGLRSQSQFEEMRSSYIRELIKAIGLRQKGVVPSSQRFYQLTKLLDSLHDLVKQLHLYCLNTFIQSRALAVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK

Target ORF information:

RefSeq Version	NM_022847.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus progesterone receptor (Pgr), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022847.1

ORF Insert Sequence:

ATGACTGAGC TGCAGGCAAA GGATCCGCGG ACTCTCCACA CATCTGGCGC CGCGCCCTCC 
CCCACCCACG TCGGGTCTCC CTTGCTTGCA CGCTTGGACC CGGATCCCTT CCAGGGGAGT 
CAGCACTCGG ACGCATCGTC TGTAGTCTCG CCAATACCGA TCTCCCTGGA CCGGCTGCTC 
TTCTCTCGGT CCTGCCAGGC TCAGGAGCTC CCAGACGAAA AGACACAAAA TCAGCAGTCG 
CTGTCCGACG TGGAGGGAGC TTTCTCTGGA GTGGAAGCCT CGCGCCGAAG AAGCAGAAAT 
CCCAGAGCTC CGGAGAAGGA CAGCAGACTC TTAGACAGTG TCTTAGACAC CCTGTTGGCG 
CCCTCGGGGC CCGAGCAAAG CCAAACCAGC CCTCCAGCCT GCGAGGCCAT CACTTCTTGG 
TGTCTCTTTG GGCCAGAGCT TCCAGAAGAC CCCCGCAGTG TCCCCGCTAC CAAGGGGTTG 
TTGTCCCCGC TCATGAGCCG GCCAGAGAGC AAGGCTGGCG ACAGCTCCGG GACAGGAGCA 
GGGCAGAAGG TGCTGCCCAA AGCGGTGTCA CCACCCCGGC AGCTGTTGCT CCCGACCTCG 
GGGAGTGCTC ACTGGCCCGG GGCAGGGGTG AAGCCATCTC AGCAGCCTGC TACGGTGGAG 
GTGGAGGAGG ACGGTGGTCT CGAGACCGAG GGCTCTGCGG GTCCGCTTCT GAAGAGCAAA 
CCTCGAGCAC TGGAAGGCAT GTGTAGCGGA GGAGGAGTCA CAGCCAACGC GCCCGGCGCG 
GCCCCAGGAG GCGTCACCTT GGTCCCCAAG GAAGATTCCC GGTTTTCTGC TCCCAGGGTC 
TCCTTGGAGC AAGACGCTCC AGTTGCCCCC GGGCGCTCCC CACTGGCCAC CACAGTGGTG 
GATTTCATTC ACGTGCCCAT TCTGCCTCTG AACCACGCTC TCCTAGCCGC CCGCACCCGG 
CAGCTGCTGG AGGGAGACAG CTACGACGGC GGGGCTGCAG CGCAAGTCCC TTTTGCTCCA 
CCTCGGGGCT CGCCCTCCGC GCCATCCCCG CCGGTGCCCT GCGGTGACTT CCCAGACTGC 
ACCTACCCTC CAGAAGGCGA CCCTAAAGAG GACGGGTTCC CAGTTTACGG CGAATTCCAG 
CCTCCCGGCT TGAAGATCAA GGAGGAGGAG GAGGGCACGG AGGCTGCTTC CCGCTCGCCG 
CGCCCCTACC TGTTGGCCGG AGCCAGCGCC GCCACCTTCC CAGACTTCCC GCTGCCGCCG 
CGGCCGCCGC GAGCGCCACC CTCCAGGCCC GGAGAGGCGG CGGTAGCCGC CCCGAGCGCC 
GCGGTGTCGC CAGTGTCCTC GTCGGGCTCC GCACTGGAGT GCATCCTGTA CAAAGCGGAG 
GGCGCGCCGC CCACGCAGGG TTCGTTCGCC CCATTGCCCT GTAAACCCCC GGCCGCCAGC 
TCCTGCCTGC TTCCCCGGGA CAGCCTGCCC GCCGCTCCGA CCTCCTCGGC AGCACCGGCC 
ATCTACCCGC CGCTCGGCCT CAATGGGCTC CCTCAGCTGG GTTACCAGGC CGCGGTGCTC 
AAGGACAGCC TGCCCCAAGT CTACCCGCCC TACCTCAACT ACCTGAGGCC AGATTCAGAA 
GCCAGCCAGA GCCCACAATA TGGCTTTGAT TCCTTACCTC AGAAGATCTG TTTAATCTGC 
GGGGATGAAG CATCTGGCTG TCACTATGGT GTGCTTACCT GTGGGAGCTG CAAGGTCTTC 
TTTAAGAGGG CGATGGAAGG GCAGCATAAC TATTTATGTG CCGGAAGAAA TGATTGCATT 
GTTGATAAAA TCCGCAGAAA AAACTGTCCA GCATGTCGTC TGAGAAAGTG CTGTCAGGCT 
GGCATGGTCC TTGGAGGTCG TAAGTTTAAG AAGTTCAATA AAGTCCGAGT TATGAGAGCC 
CTCGATGGTG TTGCTCTCCC CCAGTCAGTG GCCTTTCCTA ATGAGAGCCA GACCCTGGGC 
CAGAGAATCA CATTTTCACC AAATCAAGAG ATTCAACTGG TTCCGCCACT CATCAACCTG 
CTCATGAGCA TTGAACCTGA TGTGGTTTAT GCAGGGCATG ACAACACAAA GCCCGACACT 
TCCAGCTCTT TGCTGACCAG TCTCAACCAA CTAGGCGAGA GGCAGCTGCT TTCAGTAGTC 
AAATGGTCTA AGTCTCTGCC AGGTTTCCGG AACTTACACA TCGATGACCA GATAACCCTG 
ATTCAGTACT CCTGGATGAG CCTGATGGTG TTTGGCCTGG GGTGGAGGTC GTACAAGCAT 
GTCAGTGGAC AGATGCTATA TTTTGCACCT GATCTAATCC TGAATGAGCA GAGGATGAAG 
GAGTTGTCAT TCTACTCGCT GTGCCTTACC ATGTGGCAAA TCCCACAGGA GTTTGTCAAG 
CTCCAGGTGA CCCACGAGGA GTTCCTCTGT ATGAAAGTCT TACTTCTTCT TAACACAATT 
CCTTTGGAAG GCCTGAGGAG TCAAAGCCAG TTTGAAGAGA TGAGGTCAAG CTATATTCGG 
GAATTGATCA AGGCAATTGG CTTAAGACAG AAAGGGGTGG TCCCCAGTTC ACAACGCTTC 
TATCAACTTA CAAAACTTCT TGACAGCTTG CATGATCTTG TGAAACAGCT CCACCTGTAC 
TGCTTGAATA CGTTCATCCA ATCCCGGGCA CTGGCTGTGG AATTTCCGGA AATGATGTCT 
GAAGTTATTG CTGCCCAGTT GCCCAAGATC CTGGCGGGCA TGGTGAAGCC TCTCCTCTTT 
CACAAAAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Estrogen receptors ? and ? have different roles in the induction and trafficking of progesterone receptors in hypothalamic ventromedial neurons.
The FEBS journal282(6)1126-36(2015 Mar)
S? SI,Fonseca BM,Teixeira N,Madeira MD

Influence of domain interactions on conformational mobility of the progesterone receptor detected by hydrogen/deuterium exchange mass spectrometry.
Structure (London, England : 1993)22(7)961-73(2014 Jul)
Goswami D,Callaway C,Pascal BD,Kumar R,Edwards DP,Griffin PR

CDC2 mediates progestin initiated endometrial stromal cell proliferation: a PR signaling to gene expression independently of its binding to chromatin.
PloS one9(5)e97311(2014)
Vallejo G,La Greca AD,Tarifa-Reischle IC,Mestre-Citrinovitz AC,Ballar? C,Beato M,Sarag?eta P

Loss of progesterone receptor-mediated actions induce preterm cellular and structural remodeling of the cervix and premature birth.
PloS one8(12)e81340(2013)
Yellon SM,Dobyns AE,Beck HL,Kurtzman JT,Garfield RE,Kirby MA

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Pgr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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