Igf2r cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Igf2r
Entrez Gene ID	25151
Full Name	insulin-like growth factor 2 receptor
Synonyms	IGF-IIR,Igfr2
General protein information	Preferred Names insulin-like growth factor 2 receptor Names cation-independent mannose-6-phosphate receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q11
Summary	mediates internalization of insulin-like growth factor II; plays a role in lysosomal enzyme transport [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012756.2	NP_036888.2	cation-independent mannose-6-phosphate receptor precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	IGF2R	NP_776777.1
Xenopus tropicalis (tropical clawed frog)	igf2r	XP_002933917.2
Mus musculus (house mouse)	Igf2r	NP_034645.2
Danio rerio (zebrafish)	igf2r	NP_001034716.1
	IGF2R	XP_002804004.1
Canis lupus familiaris (dog)	IGF2R	NP_001116074.1
Pan troglodytes (chimpanzee)	IGF2R	XP_003311618.2
Homo sapiens (human)	IGF2R	NP_000867.2
Rattus norvegicus (Norway rat)	Igf2r	NP_036888.1
Gallus gallus (chicken)	IGF2R	NP_990301.1

Gene Ontology
Bibliography

Related articles in PubMed

Cardiac apoptosis induced under high glucose condition involves activation of IGF2R signaling in H9c2 cardiomyoblasts and streptozotocin-induced diabetic rat hearts.
Feng CC, Pandey S, Lin CY, Shen CY, Chang RL, Chang TT, Chen RJ, Viswanadha VP, Lin YM, Huang CY
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie97880-885(2018 Jan)

Tanshinone-induced ERs suppresses IGFII activation to alleviate Ang II-mediated cardiac hypertrophy.
Chen YF, Lee NH, Pai PY, Chung LC, Shen CY, Rajendran P, Chen YF, Chen RJ, Padma Viswanadha V, Kuo WW, Huang CY
Journal of receptor and signal transduction research37(5)493-499(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Angiotensin II activates ERK/GSK3 to phosphorylate HSF1, resulting in RNF126 degradation, which stabilizes IGF-IIR protein expression and eventually results in cardiac hypertrophy.
Title: HSF1 phosphorylation by ERK/GSK3 suppresses RNF126 to sustain IGF-IIR expression for hypertension-induced cardiomyocyte hypertrophy.

results demonstrate that NFIL3 is an important negative transcription factor, which through binding to the promoter of IGF2R, suppresses the apoptosis induced by IGF2R signaling in H9c2 cardiomyoblast cells under hypoxic conditions.
Title: NFIL3 suppresses hypoxia-induced apoptotic cell death by targeting the insulin-like growth factor 2 receptor.

The antioxidant effect of IGF-II is at least partially mediated by IGF-II receptors.
Title: Involvement of IGF-II receptors in the antioxidant and neuroprotective effects of IGF-II on adult cortical neuronal cultures.

The role of the M6P/IGF-IIR is produced in sufficient amounts to ensure adequate delivery of nascent lysosomal enzymes to late endosomes/lysosomes.
Title: Enhanced activity of lysosomal proteases in activated rat hepatic stellate cells is associated with a concomitant increase in the number of the mannose-6-phosphate/insulin-like growth factor II receptor.

Danshen exerts strong estrogenic activity against IGF2R signaling that blocks cardiomyoblast apoptosis.
Title: Danshen mediates through estrogen receptors to activate Akt and inhibit apoptosis effect of Leu27IGF-II-induced IGF-II receptor signaling activation in cardiomyoblasts.

The following Igf2r gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Igf2r cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa63207	NM_012756.2 Latest version!	Rattus norvegicus insulin-like growth factor 2 receptor (Igf2r), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	29-31	$1301.30 $1859.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Igf2r ( NM_012756.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036888.2 Rattus norvegicus insulin-like growth factor 2 receptor (Igf2r), mRNA.

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CloneID	ORa63207
Clone ID Related Accession (Same CDS sequence)	NM_012756.2
Accession Version	NM_012756.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 7446bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Rattus norvegicus(Norway rat)
Product	cation-independent mannose-6-phosphate receptor precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC129234.5 and AC114389.7. On Sep 1, 2015 this sequence version replaced NM_012756.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U59809.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGGGCCG TTCTGCCGGG ACCCGTGCCC TCCGGGCCGC GCGTCGCGCT CCTGCTGCCG 
CTCCTGCTGC TGCTGCTCGT GGCGGCCGCG GGCTCCGCGC AGGCCCAGGC CGTGGACTTG 
GACGCCTTGT GCAGTTACAC ATGGGAAGCT GTTGATTCCA AAAATAATGC AGTTTATAAA 
ATCAACCCCT GTGGACATGT GGATAATCCC AGGTGTGGGC CGACAAGTGC TGTCTGTATG 
TGTGACCTAA AGTCAGAAAA CTGCCGGTCA GTGGGTGACT CACTTTTGAG AAGTTCAGCC 
AAATCACTCC TGGAATTTAA CACCACTACG GGCTGCCAGC CTTCAGAGCA CAGAATCCAG 
ACTAGCATTA CATTTCTGTG TGGGAAGACC CTGGGAACTC CTGAATTTGT AACTGCCACA 
GACTGTGTGC ATTACTTCGA ATGGAGGACT ACTGCAGCCT GCAAGAAAGA CATATTTAAA 
GCTGATAAGG AGGTGCCATG CTATGTATTT GATGACAAGT TACAGAAGCA TGATTTGAAC 
CCACTGATCA AGCTGAATGG CGGCTACCTG GTGGATGACT CTGACGCTGA CGCATCTCTG 
TTCATCAATG TGTGTAGAGA CATAGACTCC CTTCGGGACC CCAGCACACA GCTGAGAGTC 
TGCCCTGCTG GCACTGCTGC CTGTCTGCTG AAGGGGAACC AGGCATTTGA TGTTGGCCGG 
CCCAAGGAGG GGCTGAAGCT ATTGAGCAAG GACAGGCTCG TTCTGACTTA TGTTAAGGAA 
GAAGGAGAAA AGCCAGACTT CTGTAATGGT CACAGCCCTG CAGTGACAGT AACATTTGTG 
TGCCCATCTG AGCGGAGAGA GGGCACCATT CCTAAACTCA CTGCCAAGTC CAACTGTCGC 
TATGAAGTTG AGTGGATCAC TGAGTATGCC TGCCACAGAG ATTACTTGGA GAGTGAAACC 
TGCTCCCTCA GCAGTGAGCA GCATGATATT GCTATTGACC TTAGTCCCTT GGCCCAGCAT 
GAAGAAGGGT CCCCCTATGT AGCTGATGGA GGAGAATATA GGTTTTTTAT GAATGTCTGT 
GGGGACACAA AGGTCTCACT CTGTAACAAA GAGGCTGCTG TTTGTCAAGA GAAAAAGGTG 
GATTCCACTC AAGTCAAAAT AGCAGGAAGA CACCAGAACC AGACACTCCG GTACTCAGAT 
GGAGATCTCA CCCTAATCTA TTCTGGAGGT GATGAGTGTA GTTCCGGCTT CCAGCGGATG 
AGTGTCATAA ACTTTGAGTG CAACAAAACC GCAGGTCAAG ATGGGAGAGG AGAGCCTGTG 
TTCACAGGTG AGGTGGACTG CACATACTTC TTCACGTGGG ACACTAAATA TGCCTGTGTA 
AAAGAGAAGG AAGATCTCCT CTGCGGGGCC ATCGACGGCA AGAAACGTTA CGACCTGTCT 
GTGCTGGCTC GTCACTCAGA ATCAGAACAG AATTGGGAAG CAGTGGATGG CAGCCAGGCT 
GAGTCAGAAA AGAGGAATTT CTTCATCAAT GTCTGTCACC GGGTGCTGCA GGCGGGAAAG 
GCCAAGAACT GTCCTGAAGG TGCTGCCGTG TGTGCTGTGG ATAAGAGTGG AAGTAAAAAT 
CTAGGAAAAT TTGTCTCTTC TCCTACAAAA GAGAAAGGAC ACATTCAGCT CTCTTACTCT 
GATGGCGATG ACTGTGGTAA TGATAAGAAA ATAACAACTA ACATCACATT TGTGTGCAAA 
CCAGGTGATC TGGAAAGTGC TCCAGTGCTG AGAGCTGCAG GGCCCGATGG CTGCTCCTAT 
GAGTTTGAGT GGCACACAGC TGCTGCCTGT GTCCTGTCGC AGACGGAGGG AGAAAACTGC 
ACTGTCCTTG ATGCTCAGGC AGGGTTTTCT TTTGATTTGT CACTCCTCAC AAAGAAGAAT 
GGTGCATATA AAGTTGAGAC AGACAAGTAT GACTTCTACA TAAATGTTTG TGGCCCTGTA 
TCCGTGAACC TGTGTCAGTC AAACTCAGGA GCCTGCCAGG TAGCAAAAAG TGGTAAGTCT 
TGGAACTTGG GGCTGAGTAA TACTAAGCTT ACGTACTATG ATGGGATGAT CCAGCTGAGC 
TACAGGAATG GCACGCTGTA TAACAATGAA AAGCACACAC CGAGATCCAC ACTGATTACC 
TTCCTCTGTG ACCGTGATGC TGGAGTGGGC TTCCCAGAAT ATCAGGAAGA GGACAACTCT 
ACCTACAACT TCCGGTGGTA CACCAGTTAT GCTTGCCCGG AAGAGCCCCT GGAGTGCATG 
GTGACAGACC CCTCCATGAT GGAGCAATAT GACCTCTCCA GTCTAGTGAA GTTTGAAGGT 
GGCCGTGGAG GAAACTGGTA TGCCATGGAA AACTCCCGAG AACATTTCAC ACGGAGGAAA 
TACTACCTCA ACGTGTGCCG GCCTCTGAAT CCTGTGCCAG GCTGTGATCG ATATGCATCT 
GCTTGCCAGA TGAAATACGA AAACAATGAG GGCTCCTTGG CAGAGACTGT GGCCATCAGT 
AACTTGGGAG TTGCAAAGAC AGGCCCTGTG GTGGAGGAGA GCGGCAGCCT CCTCTTAGAG 
TATGTGAACG GCTCTGCGTG CACCACCAGT GATGGCCGGC TAACCACCTA CAGCACCAGG 
ATCCATCTTG TGTGTGGTCG AGGAACTATG AATTCCCATC CCATATTCAC TTTCAACTGG 
GAATGTGTGG TCAGTTTCTT GTGGAACACG GAGGCTGCCT GCCCCATCCA GACGATCACA 
GATTCAGACC AGGCTTGCTC TATAAGGGAC CCCAACAGCG GATTTGTGTT TAATCTGAGC 
CCACTTAACT ATTCTCAAGG ACACATGGTC TTAGGCATTG GGAAGACTTT TGTGTTCAAT 
ATCTGTGGTA CAATGCCTGC CTGTGGAACG GTTGCAGGGA AGCCAGCCCT TGGCTGTGAG 
GCAGAAACTA AGATCAAAGA CATTAAGGAT CTGAAGCCAG AAAGGCCAGT CGGGATGGAG 
AAGAGCCTCC AGTTGTCTGC CGAGGGGTTC CTCACTCTGA CCTACAAAGG CTCTTCTCCT 
TCTGACAGAG GCACAGCCTT CATCATCCGT TTCATTTGCA ATGGTGACAT TTACCCAGGG 
ACCCCCAAGT TCCTGCATCA GGACATTGAC TCTGCACGAG GGATCCGGAA CACCTTCTTT 
GAGTTTGAAA CTGCATTGGC TTGTATTCCT TCTGTAGTGG ATTGTCAAGT GACTGACCCA 
GCTGGGAACG AGTACGACCT GAGTGCCCTG AGCATGGTCA GGAAGCCGTG GACTGCTGTG 
GACACGTCTG TGCATGGGAA GAAGAGGCGC TTCTATCTGA GCGTGTGCAC CCCACTGCCT 
TACATTCCTG GCTGCGATGG CATTGCAATG GGGTCCTGCA TGGTGTCAGA AGACAAAAGT 
CAGAACTTGG GTGTGGTGCA GATCAGTCCT CAAGCTACTG GAAACGGATC TCTCAGCATC 
CTGTATGTGA ATGGGGATAG GTGTGGAAAC CAGCGCTACT CCACCAGGAT AGTGTTCGAA 
TGTGCCCAGA CGTCGGGCTC ACCTATGTTC CAGCTCCTGA ACAACTGTGA GTATGTGTTT 
GTGTGGCGAA CAGTGGAGGC CTGCCCTGTG GTCAGAGAGG AAGGAGACAA CTGCCAGGTG 
AAAGACCCCA GACACGGCAA TTTGTATGAC CTGAAGCCCC TGGCCCTCAA TGACACCATC 
ATCAGTGCTG GCGAGTACAC CTACTACTTC CGGGTCTGTG GAAAGCTGTC CTTAGATGTG 
TGCTCTGCCC ATGATGGGTC CAAGGCAGTC TCATCATGCC AGGAAAAGAA AGGACCACAA 
GGATTCCAGA AAGTGGCAGG GCTCCTTAAT CAGAAGCTGA CTTTCGAAAA TGGACTGTTG 
AAAATGAACT ACAGTGGGGG GGACACCTGC CATAAGGTGT ATCAGCGCTC CACAACCATC 
TATTTCTACT GTGACCGGAC GACTCAGAAG CCAGTGTTTC TGAAGGAAAC TTTGGACTGC 
TCCTATTTGT TTGAGTGGCG AACACAGTAT GCCTGCCCAC CTTTCAATGT GACAGAGTGC 
TCTATCCAGG ATGAGGCTGG CAACTCCATT GACCTCTCCT CACTGTCAAG ATACAGTGAC 
AACTGGGAGG CTGTGACCAG GACAGGGGCC ACTGAGCATT ACCTCATCAA CGTATGCAAG 
TCTCTGTCTC CACAGGCTGG CACAGATCCA TGCCCTCCAG AGGCAGCTGT TTGTCTGCTG 
GATGGCTCCA AGCCTGTGAA CCTCGGCAGG GTGAGGGATG GTCCTCAGTG GACAGCTGGT 
GTGACTGTCC TGAAGTATGT GGATGGTGAC TTGTGCCCCG ACAAAATTCG GAAAAGGTCA 
ACCATTATTC GCTTCACCTG CAGTGACAGC CAAGTGAACT CCAGGCCTCT GTTCATCAGT 
GCTGTACAGG ACTGTGAGTA CACATTTTCC TGGCCCACAC CTGCTGCCTG TCCTGTGAAG 
AGCAACATAC ACGATGACTG CCAAGTCACC AACCCCAGCA CAGGCCACCT GTTTGACCTG 
AGCTCCCTAA GTGGCAAAGC TGGCATCACA GCCTCCTACA GCGAGAAGGG GATGGTCTTC 
ATGAGCATCT GTGAGGAGAA TGTGAACTGT AGCCCTGGAG TAGGGGCCTG CTTTGGACAG 
ACCAGGATCA GTGTGGGCCA GGCCAGCAAG AGGCTGAGCT ACAAGGATCA GGTCTTGCAG 
CTGGTGTATG AGAATGGGTC CCCATGCCCC TCCAAGTCAG GCCTGAGGTA CAAGAGTGTC 
ATCAGCTTCG TGTGCCGGCC GGAGGCTGGA CCCACCAACA GGCCCATGCT CATCTCCTTG 
GACAAGCAGT CGTGTACACT CTTCTTCTCC TGGCACACGC CCCTGGCCTG TGAGCAGGCG 
ACGGAATGCA CCGTGCGGAA TGGAAGCTCG ATTATTGACC TGTCACCTCT CATCCACCGC 
ACTGGTGGTT ATGAAGCATA CGATGAGAGT GAGGACGACA CCTCTGATAC CACCCCTGAC 
TTCTACATCA ACATCTGTCA GCCACTGAAT CCCATGCATG GAGTGCCCTG CCCTGCAGGC 
GCCTCAGTAT GCAAAGTCCC CGTGGACGGG CCCCCTATAG ATATTGGGAG AGTCACAGGC 
CCTCCAATAT TCAATCCCGT GGCCAATGAG GTCTACCTGA ACTTTGAGAG CAGCACTCCT 
TGCTTAGCGG ACAAATATAT GAACTACACC TCACTAATTG CGTTTCACTG CAGGAGAGGG 
ATCAGCATGG GAACTCCTAA GCTGATAAGG AACAATGACT GTGACTTTGT GTTTGAGTGG 
GAGACTCCGA TTGTCTGTCC TGACGAAGTG AAGACACAGG GCTGTGCTGT AACAGATGAG 
CAGCTGCTCT ATAGCTTCAA CCTGACGAGC CTTTCCACAA GCACTTTCAA AGTCACTCGG 
GACGCTCACA CATACAGTAT AGGGGTGTGC ACAACGGCAG CTGACTTAGA CCAGGAAGGC 
TGCAAGGACG GCGGGGTCTG TCTGCTCTCT GGGAGCAAAG GAGCTTCTTT TGGGCGCCTA 
GCGTCGATGC AGCTGGATTA CAGGCACCAG GATGAAGCAG TCATCCTGAG TTATGTGAAC 
GGTGATCCTT GCCCTCCAGA AACGGAAGAT GGCGAGCCCT GTGTCTTCCC CTTCATTTAC 
AAAGGGGAGA CCTATGACGA ATGTGTATTA GAGGGACGAG CGAAACTGTG GTGTAGCAAA 
ACTGCGAATT ACGATCGTGA CCACGAGTGG GGCTTCTGCA GACCGAGCAA CAGTCACCGG 
ATGTCTGCGA TCATATTTAC TTGTGATGAG AACGAAGATA TTGGGAGGCC AGAAGTGTTC 
AGTGAAGATC GTGGGTGTGA GGTGACATTT GAGTGGAAAA CAAAAGTTGT CTGCCCTCCG 
AAGAAGATGG AGTGCAAGTT TGTTCAGAAG CATAAAACCT ATGACTTGCG ATTGCTCTCA 
TCCCTCACGG GGTCCTGGGA TTTTGTGCAT GAAGGAAACT CGTACTTTAT CAATCTGTGC 
CAAAGAGTAT ATAAAGGTCC CCTGGACTGC TCTGAGAGAG CCAGCATTTG CAAGAAGAGT 
GCCACTGGTC AAGTCCAGGT TTTGGGGCTT GTTCATACTC AAAAACTGGA AGTCATAGAT 
GAAACAGTCC TTGTCACTTA CTCAAAAGGC CATTCTTGTG GTGGGAATAA GACTGCATCC 
TCAGTGATCG AGTTGACCTG TGCAAAGACT GTGGGCAGGC CTGCATTCAA GAGGTTTGAT 
ATTGACAGCT GCACCTACTA CTTTTACTGG TACTCACGGG CTGCCTGTGC TGTGAGACCT 
CAGGAGGTGA ACATGGTGAA TGGAACTCTT ACCAACCCTG TGACTGGCAA GAGCTTCAGC 
CTCGGGGAAA TTTATTTTAA GCTGTTCAGC GCCTCTGGGG ACATGAGAAG CAATGGGGAC 
AACTATCTGT ATGAGATCCA GCTCTCCTCT ATCTCCAGCT CTTCTAACCC TGCGTGCTCC 
GGTGCCAACA TCTGCCAGGT GAAGCCCAAT GACCAGCACT TCAGCAGGAA AGTGGGCACC 
TCTGACATGA CCAAGTACTA CGTCCAAGAC GGTGATCTGG ATGTGGTGTT TACCTCTTCC 
TCCACGTGTG GCAAAGATAA GACCAAGTCT GTGTCTTCCA CCATCTTCTT CCACTGTGAC 
CCTCTGCTGA AGGACGGGGT CCCCGAGTTC AGCCACGAGA CTGCTGACTG CCAGTACCTT 
TTCTCCTGGT ACACTTCAGC TGTGTGTCCT CTGGGTGTGG ACTTTGATGA TGAGAATGCT 
GTGCCAGAGT ATAAAGGGCT CTCAGAGCGG AGTCAGGCCG TTGGGGCAGT CCTCAGTCTC 
CTCCTGGTGG CACTGACTGG CTGTCTGCTG GCCTTGCTGC TTCATAAGAA GGAGAGAAGG 
GAAACTGTGA TAAACAAGCT GACCAATTGC TGCAGAAGGA GCTCGGGGGT GTCCTATAAG 
TACTCAAAGG TCAGCAAGGA GGAGGAGACA GATGAGAATG AGACAGAATG GCTGATGGAA 
GAGATCCAGG TGCCAGCCGC CAGACTAGGC AAGGACGGGC AGGAGAACGG CCACATTACC 
ACCAAGACGG TGAAAGCAGA AGCTCTCACT TCCCTGCATG GGGATGACCA AGACAGTGAG 
GATGAGGTCC TGACCATCCC AGAGGTGAAA GTTCACACAG GCAGAGGAGC CGAGGTGGAA 
AGCTCACAGC CCCTGAGAAA TCCCCAGCGC AAGGTCCTGA AGGAAAGGGA GGGGGAGAGG 
ATGGGGCTGG TCCGCGGTGA GAAGGCCAGA AGAGGGAAGT TCAGACCCGG ACAGCGCAAG 
CCAACAACCC CTGCCAAGCT GGTGTCCTTC CATGATGACA GTGACGAGGA CCTCCTACAC 
ATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036888.2
CDS	96..7541
Translation	MRAVLPGPVPSGPRVALLLPLLLLLLVAAAGSAQAQAVDLDALCSYTWEAVDSKNNAVYKINPCGHVDNPRCGPTSAVCMCDLKSENCRSVGDSLLRSSAKSLLEFNTTTGCQPSEHRIQTSITFLCGKTLGTPEFVTATDCVHYFEWRTTAACKKDIFKADKEVPCYVFDDKLQKHDLNPLIKLNGGYLVDDSDADASLFINVCRDIDSLRDPSTQLRVCPAGTAACLLKGNQAFDVGRPKEGLKLLSKDRLVLTYVKEEGEKPDFCNGHSPAVTVTFVCPSERREGTIPKLTAKSNCRYEVEWITEYACHRDYLESETCSLSSEQHDIAIDLSPLAQHEEGSPYVADGGEYRFFMNVCGDTKVSLCNKEAAVCQEKKVDSTQVKIAGRHQNQTLRYSDGDLTLIYSGGDECSSGFQRMSVINFECNKTAGQDGRGEPVFTGEVDCTYFFTWDTKYACVKEKEDLLCGAIDGKKRYDLSVLARHSESEQNWEAVDGSQAESEKRNFFINVCHRVLQAGKAKNCPEGAAVCAVDKSGSKNLGKFVSSPTKEKGHIQLSYSDGDDCGNDKKITTNITFVCKPGDLESAPVLRAAGPDGCSYEFEWHTAAACVLSQTEGENCTVLDAQAGFSFDLSLLTKKNGAYKVETDKYDFYINVCGPVSVNLCQSNSGACQVAKSGKSWNLGLSNTKLTYYDGMIQLSYRNGTLYNNEKHTPRSTLITFLCDRDAGVGFPEYQEEDNSTYNFRWYTSYACPEEPLECMVTDPSMMEQYDLSSLVKFEGGRGGNWYAMENSREHFTRRKYYLNVCRPLNPVPGCDRYASACQMKYENNEGSLAETVAISNLGVAKTGPVVEESGSLLLEYVNGSACTTSDGRLTTYSTRIHLVCGRGTMNSHPIFTFNWECVVSFLWNTEAACPIQTITDSDQACSIRDPNSGFVFNLSPLNYSQGHMVLGIGKTFVFNICGTMPACGTVAGKPALGCEAETKIKDIKDLKPERPVGMEKSLQLSAEGFLTLTYKGSSPSDRGTAFIIRFICNGDIYPGTPKFLHQDIDSARGIRNTFFEFETALACIPSVVDCQVTDPAGNEYDLSALSMVRKPWTAVDTSVHGKKRRFYLSVCTPLPYIPGCDGIAMGSCMVSEDKSQNLGVVQISPQATGNGSLSILYVNGDRCGNQRYSTRIVFECAQTSGSPMFQLLNNCEYVFVWRTVEACPVVREEGDNCQVKDPRHGNLYDLKPLALNDTIISAGEYTYYFRVCGKLSLDVCSAHDGSKAVSSCQEKKGPQGFQKVAGLLNQKLTFENGLLKMNYSGGDTCHKVYQRSTTIYFYCDRTTQKPVFLKETLDCSYLFEWRTQYACPPFNVTECSIQDEAGNSIDLSSLSRYSDNWEAVTRTGATEHYLINVCKSLSPQAGTDPCPPEAAVCLLDGSKPVNLGRVRDGPQWTAGVTVLKYVDGDLCPDKIRKRSTIIRFTCSDSQVNSRPLFISAVQDCEYTFSWPTPAACPVKSNIHDDCQVTNPSTGHLFDLSSLSGKAGITASYSEKGMVFMSICEENVNCSPGVGACFGQTRISVGQASKRLSYKDQVLQLVYENGSPCPSKSGLRYKSVISFVCRPEAGPTNRPMLISLDKQSCTLFFSWHTPLACEQATECTVRNGSSIIDLSPLIHRTGGYEAYDESEDDTSDTTPDFYINICQPLNPMHGVPCPAGASVCKVPVDGPPIDIGRVTGPPIFNPVANEVYLNFESSTPCLADKYMNYTSLIAFHCRRGISMGTPKLIRNNDCDFVFEWETPIVCPDEVKTQGCAVTDEQLLYSFNLTSLSTSTFKVTRDAHTYSIGVCTTAADLDQEGCKDGGVCLLSGSKGASFGRLASMQLDYRHQDEAVILSYVNGDPCPPETEDGEPCVFPFIYKGETYDECVLEGRAKLWCSKTANYDRDHEWGFCRPSNSHRMSAIIFTCDENEDIGRPEVFSEDRGCEVTFEWKTKVVCPPKKMECKFVQKHKTYDLRLLSSLTGSWDFVHEGNSYFINLCQRVYKGPLDCSERASICKKSATGQVQVLGLVHTQKLEVIDETVLVTYSKGHSCGGNKTASSVIELTCAKTVGRPAFKRFDIDSCTYYFYWYSRAACAVRPQEVNMVNGTLTNPVTGKSFSLGEIYFKLFSASGDMRSNGDNYLYEIQLSSISSSSNPACSGANICQVKPNDQHFSRKVGTSDMTKYYVQDGDLDVVFTSSSTCGKDKTKSVSSTIFFHCDPLLKDGVPEFSHETADCQYLFSWYTSAVCPLGVDFDDENAVPEYKGLSERSQAVGAVLSLLLVALTGCLLALLLHKKERRETVINKLTNCCRRSSGVSYKYSKVSKEEETDENETEWLMEEIQVPAARLGKDGQENGHITTKTVKAEALTSLHGDDQDSEDEVLTIPEVKVHTGRGAEVESSQPLRNPQRKVLKEREGERMGLVRGEKARRGKFRPGQRKPTTPAKLVSFHDDSDEDLLHI

Target ORF information:

RefSeq Version	NM_012756.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus insulin-like growth factor 2 receptor (Igf2r), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012756.2

ORF Insert Sequence:

ATGCGGGCCG TTCTGCCGGG ACCCGTGCCC TCCGGGCCGC GCGTCGCGCT CCTGCTGCCG 
CTCCTGCTGC TGCTGCTCGT GGCGGCCGCG GGCTCCGCGC AGGCCCAGGC CGTGGACTTG 
GACGCCTTGT GCAGTTACAC ATGGGAAGCT GTTGATTCCA AAAATAATGC AGTTTATAAA 
ATCAACCCCT GTGGACATGT GGATAATCCC AGGTGTGGGC CGACAAGTGC TGTCTGTATG 
TGTGACCTAA AGTCAGAAAA CTGCCGGTCA GTGGGTGACT CACTTTTGAG AAGTTCAGCC 
AAATCACTCC TGGAATTTAA CACCACTACG GGCTGCCAGC CTTCAGAGCA CAGAATCCAG 
ACTAGCATTA CATTTCTGTG TGGGAAGACC CTGGGAACTC CTGAATTTGT AACTGCCACA 
GACTGTGTGC ATTACTTCGA ATGGAGGACT ACTGCAGCCT GCAAGAAAGA CATATTTAAA 
GCTGATAAGG AGGTGCCATG CTATGTATTT GATGACAAGT TACAGAAGCA TGATTTGAAC 
CCACTGATCA AGCTGAATGG CGGCTACCTG GTGGATGACT CTGACGCTGA CGCATCTCTG 
TTCATCAATG TGTGTAGAGA CATAGACTCC CTTCGGGACC CCAGCACACA GCTGAGAGTC 
TGCCCTGCTG GCACTGCTGC CTGTCTGCTG AAGGGGAACC AGGCATTTGA TGTTGGCCGG 
CCCAAGGAGG GGCTGAAGCT ATTGAGCAAG GACAGGCTCG TTCTGACTTA TGTTAAGGAA 
GAAGGAGAAA AGCCAGACTT CTGTAATGGT CACAGCCCTG CAGTGACAGT AACATTTGTG 
TGCCCATCTG AGCGGAGAGA GGGCACCATT CCTAAACTCA CTGCCAAGTC CAACTGTCGC 
TATGAAGTTG AGTGGATCAC TGAGTATGCC TGCCACAGAG ATTACTTGGA GAGTGAAACC 
TGCTCCCTCA GCAGTGAGCA GCATGATATT GCTATTGACC TTAGTCCCTT GGCCCAGCAT 
GAAGAAGGGT CCCCCTATGT AGCTGATGGA GGAGAATATA GGTTTTTTAT GAATGTCTGT 
GGGGACACAA AGGTCTCACT CTGTAACAAA GAGGCTGCTG TTTGTCAAGA GAAAAAGGTG 
GATTCCACTC AAGTCAAAAT AGCAGGAAGA CACCAGAACC AGACACTCCG GTACTCAGAT 
GGAGATCTCA CCCTAATCTA TTCTGGAGGT GATGAGTGTA GTTCCGGCTT CCAGCGGATG 
AGTGTCATAA ACTTTGAGTG CAACAAAACC GCAGGTCAAG ATGGGAGAGG AGAGCCTGTG 
TTCACAGGTG AGGTGGACTG CACATACTTC TTCACGTGGG ACACTAAATA TGCCTGTGTA 
AAAGAGAAGG AAGATCTCCT CTGCGGGGCC ATCGACGGCA AGAAACGTTA CGACCTGTCT 
GTGCTGGCTC GTCACTCAGA ATCAGAACAG AATTGGGAAG CAGTGGATGG CAGCCAGGCT 
GAGTCAGAAA AGAGGAATTT CTTCATCAAT GTCTGTCACC GGGTGCTGCA GGCGGGAAAG 
GCCAAGAACT GTCCTGAAGG TGCTGCCGTG TGTGCTGTGG ATAAGAGTGG AAGTAAAAAT 
CTAGGAAAAT TTGTCTCTTC TCCTACAAAA GAGAAAGGAC ACATTCAGCT CTCTTACTCT 
GATGGCGATG ACTGTGGTAA TGATAAGAAA ATAACAACTA ACATCACATT TGTGTGCAAA 
CCAGGTGATC TGGAAAGTGC TCCAGTGCTG AGAGCTGCAG GGCCCGATGG CTGCTCCTAT 
GAGTTTGAGT GGCACACAGC TGCTGCCTGT GTCCTGTCGC AGACGGAGGG AGAAAACTGC 
ACTGTCCTTG ATGCTCAGGC AGGGTTTTCT TTTGATTTGT CACTCCTCAC AAAGAAGAAT 
GGTGCATATA AAGTTGAGAC AGACAAGTAT GACTTCTACA TAAATGTTTG TGGCCCTGTA 
TCCGTGAACC TGTGTCAGTC AAACTCAGGA GCCTGCCAGG TAGCAAAAAG TGGTAAGTCT 
TGGAACTTGG GGCTGAGTAA TACTAAGCTT ACGTACTATG ATGGGATGAT CCAGCTGAGC 
TACAGGAATG GCACGCTGTA TAACAATGAA AAGCACACAC CGAGATCCAC ACTGATTACC 
TTCCTCTGTG ACCGTGATGC TGGAGTGGGC TTCCCAGAAT ATCAGGAAGA GGACAACTCT 
ACCTACAACT TCCGGTGGTA CACCAGTTAT GCTTGCCCGG AAGAGCCCCT GGAGTGCATG 
GTGACAGACC CCTCCATGAT GGAGCAATAT GACCTCTCCA GTCTAGTGAA GTTTGAAGGT 
GGCCGTGGAG GAAACTGGTA TGCCATGGAA AACTCCCGAG AACATTTCAC ACGGAGGAAA 
TACTACCTCA ACGTGTGCCG GCCTCTGAAT CCTGTGCCAG GCTGTGATCG ATATGCATCT 
GCTTGCCAGA TGAAATACGA AAACAATGAG GGCTCCTTGG CAGAGACTGT GGCCATCAGT 
AACTTGGGAG TTGCAAAGAC AGGCCCTGTG GTGGAGGAGA GCGGCAGCCT CCTCTTAGAG 
TATGTGAACG GCTCTGCGTG CACCACCAGT GATGGCCGGC TAACCACCTA CAGCACCAGG 
ATCCATCTTG TGTGTGGTCG AGGAACTATG AATTCCCATC CCATATTCAC TTTCAACTGG 
GAATGTGTGG TCAGTTTCTT GTGGAACACG GAGGCTGCCT GCCCCATCCA GACGATCACA 
GATTCAGACC AGGCTTGCTC TATAAGGGAC CCCAACAGCG GATTTGTGTT TAATCTGAGC 
CCACTTAACT ATTCTCAAGG ACACATGGTC TTAGGCATTG GGAAGACTTT TGTGTTCAAT 
ATCTGTGGTA CAATGCCTGC CTGTGGAACG GTTGCAGGGA AGCCAGCCCT TGGCTGTGAG 
GCAGAAACTA AGATCAAAGA CATTAAGGAT CTGAAGCCAG AAAGGCCAGT CGGGATGGAG 
AAGAGCCTCC AGTTGTCTGC CGAGGGGTTC CTCACTCTGA CCTACAAAGG CTCTTCTCCT 
TCTGACAGAG GCACAGCCTT CATCATCCGT TTCATTTGCA ATGGTGACAT TTACCCAGGG 
ACCCCCAAGT TCCTGCATCA GGACATTGAC TCTGCACGAG GGATCCGGAA CACCTTCTTT 
GAGTTTGAAA CTGCATTGGC TTGTATTCCT TCTGTAGTGG ATTGTCAAGT GACTGACCCA 
GCTGGGAACG AGTACGACCT GAGTGCCCTG AGCATGGTCA GGAAGCCGTG GACTGCTGTG 
GACACGTCTG TGCATGGGAA GAAGAGGCGC TTCTATCTGA GCGTGTGCAC CCCACTGCCT 
TACATTCCTG GCTGCGATGG CATTGCAATG GGGTCCTGCA TGGTGTCAGA AGACAAAAGT 
CAGAACTTGG GTGTGGTGCA GATCAGTCCT CAAGCTACTG GAAACGGATC TCTCAGCATC 
CTGTATGTGA ATGGGGATAG GTGTGGAAAC CAGCGCTACT CCACCAGGAT AGTGTTCGAA 
TGTGCCCAGA CGTCGGGCTC ACCTATGTTC CAGCTCCTGA ACAACTGTGA GTATGTGTTT 
GTGTGGCGAA CAGTGGAGGC CTGCCCTGTG GTCAGAGAGG AAGGAGACAA CTGCCAGGTG 
AAAGACCCCA GACACGGCAA TTTGTATGAC CTGAAGCCCC TGGCCCTCAA TGACACCATC 
ATCAGTGCTG GCGAGTACAC CTACTACTTC CGGGTCTGTG GAAAGCTGTC CTTAGATGTG 
TGCTCTGCCC ATGATGGGTC CAAGGCAGTC TCATCATGCC AGGAAAAGAA AGGACCACAA 
GGATTCCAGA AAGTGGCAGG GCTCCTTAAT CAGAAGCTGA CTTTCGAAAA TGGACTGTTG 
AAAATGAACT ACAGTGGGGG GGACACCTGC CATAAGGTGT ATCAGCGCTC CACAACCATC 
TATTTCTACT GTGACCGGAC GACTCAGAAG CCAGTGTTTC TGAAGGAAAC TTTGGACTGC 
TCCTATTTGT TTGAGTGGCG AACACAGTAT GCCTGCCCAC CTTTCAATGT GACAGAGTGC 
TCTATCCAGG ATGAGGCTGG CAACTCCATT GACCTCTCCT CACTGTCAAG ATACAGTGAC 
AACTGGGAGG CTGTGACCAG GACAGGGGCC ACTGAGCATT ACCTCATCAA CGTATGCAAG 
TCTCTGTCTC CACAGGCTGG CACAGATCCA TGCCCTCCAG AGGCAGCTGT TTGTCTGCTG 
GATGGCTCCA AGCCTGTGAA CCTCGGCAGG GTGAGGGATG GTCCTCAGTG GACAGCTGGT 
GTGACTGTCC TGAAGTATGT GGATGGTGAC TTGTGCCCCG ACAAAATTCG GAAAAGGTCA 
ACCATTATTC GCTTCACCTG CAGTGACAGC CAAGTGAACT CCAGGCCTCT GTTCATCAGT 
GCTGTACAGG ACTGTGAGTA CACATTTTCC TGGCCCACAC CTGCTGCCTG TCCTGTGAAG 
AGCAACATAC ACGATGACTG CCAAGTCACC AACCCCAGCA CAGGCCACCT GTTTGACCTG 
AGCTCCCTAA GTGGCAAAGC TGGCATCACA GCCTCCTACA GCGAGAAGGG GATGGTCTTC 
ATGAGCATCT GTGAGGAGAA TGTGAACTGT AGCCCTGGAG TAGGGGCCTG CTTTGGACAG 
ACCAGGATCA GTGTGGGCCA GGCCAGCAAG AGGCTGAGCT ACAAGGATCA GGTCTTGCAG 
CTGGTGTATG AGAATGGGTC CCCATGCCCC TCCAAGTCAG GCCTGAGGTA CAAGAGTGTC 
ATCAGCTTCG TGTGCCGGCC GGAGGCTGGA CCCACCAACA GGCCCATGCT CATCTCCTTG 
GACAAGCAGT CGTGTACACT CTTCTTCTCC TGGCACACGC CCCTGGCCTG TGAGCAGGCG 
ACGGAATGCA CCGTGCGGAA TGGAAGCTCG ATTATTGACC TGTCACCTCT CATCCACCGC 
ACTGGTGGTT ATGAAGCATA CGATGAGAGT GAGGACGACA CCTCTGATAC CACCCCTGAC 
TTCTACATCA ACATCTGTCA GCCACTGAAT CCCATGCATG GAGTGCCCTG CCCTGCAGGC 
GCCTCAGTAT GCAAAGTCCC CGTGGACGGG CCCCCTATAG ATATTGGGAG AGTCACAGGC 
CCTCCAATAT TCAATCCCGT GGCCAATGAG GTCTACCTGA ACTTTGAGAG CAGCACTCCT 
TGCTTAGCGG ACAAATATAT GAACTACACC TCACTAATTG CGTTTCACTG CAGGAGAGGG 
ATCAGCATGG GAACTCCTAA GCTGATAAGG AACAATGACT GTGACTTTGT GTTTGAGTGG 
GAGACTCCGA TTGTCTGTCC TGACGAAGTG AAGACACAGG GCTGTGCTGT AACAGATGAG 
CAGCTGCTCT ATAGCTTCAA CCTGACGAGC CTTTCCACAA GCACTTTCAA AGTCACTCGG 
GACGCTCACA CATACAGTAT AGGGGTGTGC ACAACGGCAG CTGACTTAGA CCAGGAAGGC 
TGCAAGGACG GCGGGGTCTG TCTGCTCTCT GGGAGCAAAG GAGCTTCTTT TGGGCGCCTA 
GCGTCGATGC AGCTGGATTA CAGGCACCAG GATGAAGCAG TCATCCTGAG TTATGTGAAC 
GGTGATCCTT GCCCTCCAGA AACGGAAGAT GGCGAGCCCT GTGTCTTCCC CTTCATTTAC 
AAAGGGGAGA CCTATGACGA ATGTGTATTA GAGGGACGAG CGAAACTGTG GTGTAGCAAA 
ACTGCGAATT ACGATCGTGA CCACGAGTGG GGCTTCTGCA GACCGAGCAA CAGTCACCGG 
ATGTCTGCGA TCATATTTAC TTGTGATGAG AACGAAGATA TTGGGAGGCC AGAAGTGTTC 
AGTGAAGATC GTGGGTGTGA GGTGACATTT GAGTGGAAAA CAAAAGTTGT CTGCCCTCCG 
AAGAAGATGG AGTGCAAGTT TGTTCAGAAG CATAAAACCT ATGACTTGCG ATTGCTCTCA 
TCCCTCACGG GGTCCTGGGA TTTTGTGCAT GAAGGAAACT CGTACTTTAT CAATCTGTGC 
CAAAGAGTAT ATAAAGGTCC CCTGGACTGC TCTGAGAGAG CCAGCATTTG CAAGAAGAGT 
GCCACTGGTC AAGTCCAGGT TTTGGGGCTT GTTCATACTC AAAAACTGGA AGTCATAGAT 
GAAACAGTCC TTGTCACTTA CTCAAAAGGC CATTCTTGTG GTGGGAATAA GACTGCATCC 
TCAGTGATCG AGTTGACCTG TGCAAAGACT GTGGGCAGGC CTGCATTCAA GAGGTTTGAT 
ATTGACAGCT GCACCTACTA CTTTTACTGG TACTCACGGG CTGCCTGTGC TGTGAGACCT 
CAGGAGGTGA ACATGGTGAA TGGAACTCTT ACCAACCCTG TGACTGGCAA GAGCTTCAGC 
CTCGGGGAAA TTTATTTTAA GCTGTTCAGC GCCTCTGGGG ACATGAGAAG CAATGGGGAC 
AACTATCTGT ATGAGATCCA GCTCTCCTCT ATCTCCAGCT CTTCTAACCC TGCGTGCTCC 
GGTGCCAACA TCTGCCAGGT GAAGCCCAAT GACCAGCACT TCAGCAGGAA AGTGGGCACC 
TCTGACATGA CCAAGTACTA CGTCCAAGAC GGTGATCTGG ATGTGGTGTT TACCTCTTCC 
TCCACGTGTG GCAAAGATAA GACCAAGTCT GTGTCTTCCA CCATCTTCTT CCACTGTGAC 
CCTCTGCTGA AGGACGGGGT CCCCGAGTTC AGCCACGAGA CTGCTGACTG CCAGTACCTT 
TTCTCCTGGT ACACTTCAGC TGTGTGTCCT CTGGGTGTGG ACTTTGATGA TGAGAATGCT 
GTGCCAGAGT ATAAAGGGCT CTCAGAGCGG AGTCAGGCCG TTGGGGCAGT CCTCAGTCTC 
CTCCTGGTGG CACTGACTGG CTGTCTGCTG GCCTTGCTGC TTCATAAGAA GGAGAGAAGG 
GAAACTGTGA TAAACAAGCT GACCAATTGC TGCAGAAGGA GCTCGGGGGT GTCCTATAAG 
TACTCAAAGG TCAGCAAGGA GGAGGAGACA GATGAGAATG AGACAGAATG GCTGATGGAA 
GAGATCCAGG TGCCAGCCGC CAGACTAGGC AAGGACGGGC AGGAGAACGG CCACATTACC 
ACCAAGACGG TGAAAGCAGA AGCTCTCACT TCCCTGCATG GGGATGACCA AGACAGTGAG 
GATGAGGTCC TGACCATCCC AGAGGTGAAA GTTCACACAG GCAGAGGAGC CGAGGTGGAA 
AGCTCACAGC CCCTGAGAAA TCCCCAGCGC AAGGTCCTGA AGGAAAGGGA GGGGGAGAGG 
ATGGGGCTGG TCCGCGGTGA GAAGGCCAGA AGAGGGAAGT TCAGACCCGG ACAGCGCAAG 
CCAACAACCC CTGCCAAGCT GGTGTCCTTC CATGATGACA GTGACGAGGA CCTCCTACAC 
ATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cardiac apoptosis induced under high glucose condition involves activation of IGF2R signaling in H9c2 cardiomyoblasts and streptozotocin-induced diabetic rat hearts.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie97880-885(2018 Jan)
Feng CC,Pandey S,Lin CY,Shen CY,Chang RL,Chang TT,Chen RJ,Viswanadha VP,Lin YM,Huang CY

Tanshinone-induced ERs suppresses IGFII activation to alleviate Ang II-mediated cardiac hypertrophy.
Journal of receptor and signal transduction research37(5)493-499(2017 Oct)
Chen YF,Lee NH,Pai PY,Chung LC,Shen CY,Rajendran P,Chen YF,Chen RJ,Padma Viswanadha V,Kuo WW,Huang CY

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Igf2r cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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