Pld2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pld2
Entrez Gene ID	25097
Full Name	phospholipase D2
Synonyms	Pldc
General protein information	Preferred Names phospholipase D2 Names phospholipase D2 PLD 2 PLD1C choline phosphatase 2 phosphatidylcholine-hydrolyzing phospholipase D2 phospholipase D gene 2 rPLD2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q24
Summary	catalyzes hydrolysis of phosphatidylcholine (PC) to phosphatidic acid and choline; involved in important cellular processes such as signal transduction, membrane trafficking, and mitosis regulation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017597033.1	XP_017452522.1	phospholipase D2 isoform X1
NM_033299.2	NP_150641.2	phospholipase D2

Pathways from BioSystems

Homologies

	PLD2	XP_001117754.2
Canis lupus familiaris (dog)	PLD2	XP_005620373.1
Pan troglodytes (chimpanzee)	PLD2	XP_511291.3
Homo sapiens (human)	PLD2	NP_002654.3
Mus musculus (house mouse)	Pld2	NP_032902.1
Rattus norvegicus (Norway rat)	Pld2	NP_150641.2
Danio rerio (zebrafish)	pld2	XP_694649.4
Bos taurus (cattle)	PLD2	NP_001069295.1
Xenopus tropicalis (tropical clawed frog)	pld2	NP_001135641.1

Gene Ontology
Bibliography

Related articles in PubMed

Phospholipase D2: a pivotal player modulating RBL-2H3 mast cell structure.
Marchini-Alves CM, Nicoletti LM, Mazucato VM, de Souza LB, Hitomi T, Alves Cde P, Jamur MC, Oliver C
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society60(5)386-96(2012 May)

Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes.
Jaafar R, Zeiller C, Pirola L, Di Grazia A, Naro F, Vidal H, Lefai E, N?moz G
The Journal of biological chemistry286(25)22609-21(2011 Jun)

Cell invasion of highly metastatic MTLn3 cancer cells is dependent on phospholipase D2 (PLD2) and Janus kinase 3 (JAK3).
Henkels KM, Farkaly T, Mahankali M, Segall JE, Gomez-Cambronero J
Journal of molecular biology408(5)850-62(2011 May)

Phospholipase D family member 4, a transmembrane glycoprotein with no phospholipase D activity, expression in spleen and early postnatal microglia.
Yoshikawa F, Banno Y, Otani Y, Yamaguchi Y, Nagakura-Takagi Y, Morita N, Sato Y, Saruta C, Nishibe H, Sadakata T, Shinoda Y, Hayashi K, Mishima Y, Baba H, Furuichi T
PloS one5(11)e13932(2010 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Phosphatidic acid produced by PLD2 plays an important role in regulating cell morphology in mast cells.
Title: Phospholipase D2: a pivotal player modulating RBL-2H3 mast cell structure.

new insights in the intricate way PLD and mTOR cooperate to control myogenesis
Title: Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes.

A high level of cell invasiveness of cancer cells can be explained for the first time by combined high JAK3/PLD2 phosphorylation and activity involving PLD2's Y415 residue, which might constitute a novel target to inhibit cancer cell invasion.
Title: Cell invasion of highly metastatic MTLn3 cancer cells is dependent on phospholipase D2 (PLD2) and Janus kinase 3 (JAK3).

Data demonstrate that alpha-syn is an inhibitor of PLD2 in vivo.
Title: ?-Synuclein expression in rat substantia nigra suppresses phospholipase D2 toxicity and nigral neurodegeneration.

Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPARgamma by cyclic phosphatidic acid.
Title: Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPARgamma by cyclic phosphatidic acid.

The following Pld2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pld2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09099	NM_033299.2 Latest version!	Rattus norvegicus phospholipase D2 (Pld2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$552.30 $789.00
ORa57194	XM_017597033.1 Latest version!	Rattus norvegicus phospholipase D2 (Pld2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pld2 ( NM_033299.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_150641.2 Rattus norvegicus phospholipase D2 (Pld2), mRNA.

Price & Availability↑

CloneID	ORa09099
Clone ID Related Accession (Same CDS sequence)	NM_033299.2
Accession Version	NM_033299.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2802bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	phospholipase D2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D88672.1. On Jun 4, 2003 this sequence version replaced NM_033299.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D88672.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGACTGTAA CCCAGACGGA CCTCTTTCCC TATGGGGACT ACCTGAACTC CAGCCAGTTG 
CACATGGAGC CAGATGAGGT TGACACTCTG AAGGAAGGAG AGGATCCAGC TGATCGAATG 
CATCCCTTTC TGGCCATCTA TGACCTTCAG CCTCTGAGAG CACACCCCTT GGTGTTTGCT 
CCTGGGGTCC CTGTTATAGC CCAGGTGGTA GGCACCGAAA GATACACCAG CGGATCCAAG 
GTGGGAACCT GTACTCTTTA TTCTGTTCGA TTGACCCATG GCGACTTTAC CTGGACAACC 
AAGAAGAAAT TCCGACACTT TCAGGAGCTG CATCGGGACC TCCAGAGACA CAAAGTCTTG 
ATGAGTCTGC TCCCTCTGGC TCGCTTTGCT GCGGCCCATT CTCCAGCCCG AGAGGCAGCC 
AATGAGAATA TTCCCTCCCT ACCCCGAGGA GGTTCCGAGG GCTCTGCCAG ACACACAGCC 
AGCAAGCAGA AGTACCTGGA AAATTACCTC AACCGCCTCC TGACCATGTC TTTCTATCGA 
AATTACCATG CCATGACAGA ATTTCTGGAA GTCAGTCAAC TTTCCTTTAT CCCAGACCTT 
GGCTCCAAAG GACTGGAAGG GGTGATCCGG AAGCGCTCAG GTGGGCATCG AGTTCCTGGC 
TTCACCTGCT GTGGTCGAGA CCAAGTTTGT TATCGATGGT CCAAGAGGTG GCTGGTGGTG 
AAGGACTCCT TCCTGCTGTA CATGCGTCCA GAGACTGGCG CCATCTCATT TGTTCAACTT 
TTTGACCCTG GCTTTGAGGT CCAGGTGGGG AAAAGGAGCA CAGAGGCACG GTATGGGGTG 
AGGATCGACA CCTCCCACAG GTCCCTGATC CTCAAATGCA GCAGCTACCG GCAGGCACGG 
TGGTGGGGCC AGGAGATCAC GGAGCTGGCA CAGGGTCCGG GCAGAGATTT TCTACAGCTA 
CACCAGCATG ACAGCTATGC CCCACCCCGG CCTGGCACCC TGGCCCGGTG GTTTGTGAAT 
GGGGCAGGTT ACTTTGCTGC TGTGGCAGAT GCCATCCTCC GAGCTCGAGA GGAGATTTTC 
ATCACAGACT GGTGGCTGAG TCCTGAGATT TACCTGAAGC GTCCAGCCCA CTCAGATGAC 
TGGAGACTGG ACATTATGCT CAAGAGGAAG GCGGAAGAAG GTGTCCGTGT TTCCATACTG 
CTGTTTAAGG AAGTGGAACT GGCCTTGGGC ATCAACAGTG GCTATAGCAA GAGGACACTG 
ATGCTACTGC ACCCCAACAT AAAGGTGATG CGACACCCAG ACCTTGTAAC ATTGTGGGCT 
CATCATGAGA AGCTCCTGGT GGTAGACCAA GCGGTGGCAT TCTTGGGTGG GCTGGACCTT 
GCCTATGGCC GCTGGGATGA TGTGCAGTAC CGACTGACTG ACCTGGGGGA CCCCTCCGAA 
TCTGCAGATT CACAGACTCC CACGCCAGGT TCAGATCCTG CAGCCACTCC AGACCTCTCG 
CATAATCACT TCTTCTGGCT GGGAAAAGAC TACAGCAACC TCATTACCAA GGACTGGGTA 
CAGCTGGACC GGCCTTTTGA AGATTTCATC GACAGGGAGA CCACACCCAG AATGCCATGG 
AGGGATGTTG GAGTGGTTGT ACATGGAGTA GCTGCCCGGG ACCTTGCCCG GCACTTCATC 
CAGCGCTGGA ACTTCACCAA GACCATCAAG GCCAGATACA AGATACCTCA GTACCCCTAC 
CTGCTGCCTA AGTCCGCCAG CACTGCAAAC CATCTTCCCT TCATAATCCC AGGCGCGCAG 
TGCGCCACTG TGCAGGTCTT GCGGTCTGTG GATCGATGGT CAGCAGGGAC TTTGGAGAGC 
TCCATCCTCA ATGCCTACCT ACATACCATC CGAGAGAGCC AGCACTTTCT CTACATTGAG 
AATCAGTTCT TCATCAGCTG CTCAGATGGG CGTACAGTTC TGAACAAGGT GGGCGATGAG 
ATTGTGGACA GGATCCTAAA GGCTCATGAA CAGGGGCAGT GTTTCCGAGT CTACGTGCTT 
CTGCCTTTGC TCCCTGGCTT TGAGGGGGAC ATCTCCACAG GGGGTGGCAA CTCCATCCAG 
GCCATTCTGC ACTTCACCTA CAGGACCCTG TGTCGTGGGG AATATTCAAT CTTACATCGT 
CTCAAAGCAG CCATGGGGAC AGCATGGCGG GATTACATGT CCATCTGTGG GCTTCGCACA 
CATGGAGAGC TGGGCGGGCA CCCGATCTCC GAGCTCATCT ATATCCACAG CAAGTTGCTC 
ATTGCAGATG ACAGAACAGT CATCATCGGC TCTGCAAACA TCAACGACAG GAGCTTGCTG 
GGGAAGCGCG ACAGTGAGCT AGCCATACTG ATCGAGGACA CAGAAATGGA GCCATCCCTC 
ATGGATGGGG TGGAGTACCA GGCAGGCAGA TTTGCCTTGA GTCTGCGGAA GCACTGTTTC 
AGTGTCATTC TTGGGGCAAA TACCTGGCCA GACCTGGATC TCCGAGACCC TGTCTGTGAT 
GACTTCTTCC AGCTGTGGCA GGAAACAGCG GAGAACAATG CCACCATCTA TGAGCAGATC 
TTCCGCTGCC TGCCGTCCAA TGCTACTCGT TCCCTGCGGG CTCTCCGGGA GTACGTGGCT 
GTGGAGTCCT TGGCTACAGT CAGCCCTTCT TTGGCTCAGT CTGAGCTTGC CCACATCCGG 
GGCCACTTAG TTCACTTCCC CCTCAAGTTT CTGGAGGATG AGTCCTTGTT GCCTCCACTG 
GGGAGCAAAG AGGGGATGAT ACCTTTAGAA GTGTGGACAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_150641.2
CDS	337..3138
Translation	MTVTQTDLFPYGDYLNSSQLHMEPDEVDTLKEGEDPADRMHPFLAIYDLQPLRAHPLVFAPGVPVIAQVVGTERYTSGSKVGTCTLYSVRLTHGDFTWTTKKKFRHFQELHRDLQRHKVLMSLLPLARFAAAHSPAREAANENIPSLPRGGSEGSARHTASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGSKGLEGVIRKRSGGHRVPGFTCCGRDQVCYRWSKRWLVVKDSFLLYMRPETGAISFVQLFDPGFEVQVGKRSTEARYGVRIDTSHRSLILKCSSYRQARWWGQEITELAQGPGRDFLQLHQHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAREEIFITDWWLSPEIYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRTLMLLHPNIKVMRHPDLVTLWAHHEKLLVVDQAVAFLGGLDLAYGRWDDVQYRLTDLGDPSESADSQTPTPGSDPAATPDLSHNHFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPWRDVGVVVHGVAARDLARHFIQRWNFTKTIKARYKIPQYPYLLPKSASTANHLPFIIPGAQCATVQVLRSVDRWSAGTLESSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDEIVDRILKAHEQGQCFRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEYSILHRLKAAMGTAWRDYMSICGLRTHGELGGHPISELIYIHSKLLIADDRTVIIGSANINDRSLLGKRDSELAILIEDTEMEPSLMDGVEYQAGRFALSLRKHCFSVILGANTWPDLDLRDPVCDDFFQLWQETAENNATIYEQIFRCLPSNATRSLRALREYVAVESLATVSPSLAQSELAHIRGHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT

Target ORF information:

RefSeq Version	NM_033299.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus phospholipase D2 (Pld2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033299.2

ORF Insert Sequence:

ATGACTGTAA CCCAGACGGA CCTCTTTCCC TATGGGGACT ACCTGAACTC CAGCCAGTTG 
CACATGGAGC CAGATGAGGT TGACACTCTG AAGGAAGGAG AGGATCCAGC TGATCGAATG 
CATCCCTTTC TGGCCATCTA TGACCTTCAG CCTCTGAGAG CACACCCCTT GGTGTTTGCT 
CCTGGGGTCC CTGTTATAGC CCAGGTGGTA GGCACCGAAA GATACACCAG CGGATCCAAG 
GTGGGAACCT GTACTCTTTA TTCTGTTCGA TTGACCCATG GCGACTTTAC CTGGACAACC 
AAGAAGAAAT TCCGACACTT TCAGGAGCTG CATCGGGACC TCCAGAGACA CAAAGTCTTG 
ATGAGTCTGC TCCCTCTGGC TCGCTTTGCT GCGGCCCATT CTCCAGCCCG AGAGGCAGCC 
AATGAGAATA TTCCCTCCCT ACCCCGAGGA GGTTCCGAGG GCTCTGCCAG ACACACAGCC 
AGCAAGCAGA AGTACCTGGA AAATTACCTC AACCGCCTCC TGACCATGTC TTTCTATCGA 
AATTACCATG CCATGACAGA ATTTCTGGAA GTCAGTCAAC TTTCCTTTAT CCCAGACCTT 
GGCTCCAAAG GACTGGAAGG GGTGATCCGG AAGCGCTCAG GTGGGCATCG AGTTCCTGGC 
TTCACCTGCT GTGGTCGAGA CCAAGTTTGT TATCGATGGT CCAAGAGGTG GCTGGTGGTG 
AAGGACTCCT TCCTGCTGTA CATGCGTCCA GAGACTGGCG CCATCTCATT TGTTCAACTT 
TTTGACCCTG GCTTTGAGGT CCAGGTGGGG AAAAGGAGCA CAGAGGCACG GTATGGGGTG 
AGGATCGACA CCTCCCACAG GTCCCTGATC CTCAAATGCA GCAGCTACCG GCAGGCACGG 
TGGTGGGGCC AGGAGATCAC GGAGCTGGCA CAGGGTCCGG GCAGAGATTT TCTACAGCTA 
CACCAGCATG ACAGCTATGC CCCACCCCGG CCTGGCACCC TGGCCCGGTG GTTTGTGAAT 
GGGGCAGGTT ACTTTGCTGC TGTGGCAGAT GCCATCCTCC GAGCTCGAGA GGAGATTTTC 
ATCACAGACT GGTGGCTGAG TCCTGAGATT TACCTGAAGC GTCCAGCCCA CTCAGATGAC 
TGGAGACTGG ACATTATGCT CAAGAGGAAG GCGGAAGAAG GTGTCCGTGT TTCCATACTG 
CTGTTTAAGG AAGTGGAACT GGCCTTGGGC ATCAACAGTG GCTATAGCAA GAGGACACTG 
ATGCTACTGC ACCCCAACAT AAAGGTGATG CGACACCCAG ACCTTGTAAC ATTGTGGGCT 
CATCATGAGA AGCTCCTGGT GGTAGACCAA GCGGTGGCAT TCTTGGGTGG GCTGGACCTT 
GCCTATGGCC GCTGGGATGA TGTGCAGTAC CGACTGACTG ACCTGGGGGA CCCCTCCGAA 
TCTGCAGATT CACAGACTCC CACGCCAGGT TCAGATCCTG CAGCCACTCC AGACCTCTCG 
CATAATCACT TCTTCTGGCT GGGAAAAGAC TACAGCAACC TCATTACCAA GGACTGGGTA 
CAGCTGGACC GGCCTTTTGA AGATTTCATC GACAGGGAGA CCACACCCAG AATGCCATGG 
AGGGATGTTG GAGTGGTTGT ACATGGAGTA GCTGCCCGGG ACCTTGCCCG GCACTTCATC 
CAGCGCTGGA ACTTCACCAA GACCATCAAG GCCAGATACA AGATACCTCA GTACCCCTAC 
CTGCTGCCTA AGTCCGCCAG CACTGCAAAC CATCTTCCCT TCATAATCCC AGGCGCGCAG 
TGCGCCACTG TGCAGGTCTT GCGGTCTGTG GATCGATGGT CAGCAGGGAC TTTGGAGAGC 
TCCATCCTCA ATGCCTACCT ACATACCATC CGAGAGAGCC AGCACTTTCT CTACATTGAG 
AATCAGTTCT TCATCAGCTG CTCAGATGGG CGTACAGTTC TGAACAAGGT GGGCGATGAG 
ATTGTGGACA GGATCCTAAA GGCTCATGAA CAGGGGCAGT GTTTCCGAGT CTACGTGCTT 
CTGCCTTTGC TCCCTGGCTT TGAGGGGGAC ATCTCCACAG GGGGTGGCAA CTCCATCCAG 
GCCATTCTGC ACTTCACCTA CAGGACCCTG TGTCGTGGGG AATATTCAAT CTTACATCGT 
CTCAAAGCAG CCATGGGGAC AGCATGGCGG GATTACATGT CCATCTGTGG GCTTCGCACA 
CATGGAGAGC TGGGCGGGCA CCCGATCTCC GAGCTCATCT ATATCCACAG CAAGTTGCTC 
ATTGCAGATG ACAGAACAGT CATCATCGGC TCTGCAAACA TCAACGACAG GAGCTTGCTG 
GGGAAGCGCG ACAGTGAGCT AGCCATACTG ATCGAGGACA CAGAAATGGA GCCATCCCTC 
ATGGATGGGG TGGAGTACCA GGCAGGCAGA TTTGCCTTGA GTCTGCGGAA GCACTGTTTC 
AGTGTCATTC TTGGGGCAAA TACCTGGCCA GACCTGGATC TCCGAGACCC TGTCTGTGAT 
GACTTCTTCC AGCTGTGGCA GGAAACAGCG GAGAACAATG CCACCATCTA TGAGCAGATC 
TTCCGCTGCC TGCCGTCCAA TGCTACTCGT TCCCTGCGGG CTCTCCGGGA GTACGTGGCT 
GTGGAGTCCT TGGCTACAGT CAGCCCTTCT TTGGCTCAGT CTGAGCTTGC CCACATCCGG 
GGCCACTTAG TTCACTTCCC CCTCAAGTTT CTGGAGGATG AGTCCTTGTT GCCTCCACTG 
GGGAGCAAAG AGGGGATGAT ACCTTTAGAA GTGTGGACAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pld2 ( XM_017597033.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017452522.1 Rattus norvegicus phospholipase D2 (Pld2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa57194
Clone ID Related Accession (Same CDS sequence)	XM_017597033.1
Accession Version	XM_017597033.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2766bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	phospholipase D2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 1% of CDS bases ##RefSeq-Attributes-END##

ATGACTGTAA CCCAGACGGA CCTCTTTCCC TATGGGGACT ACCTGAACTC CAGCCAGTTG 
CACATGGAGC CAGATGAGGT TGACACTCTG AAGGAAGGAG AGGATCCAGC TGATCGAATG 
CATCCCTTTC TGGCCATCTA TGACCTTCAG CCTCTGAGAG CACACCCCTT GGTGTTTGCT 
CCTGGGGTCC CTGTTATAGC CCAGGTGGTA GGCACCGAAA GATACACCAG CGGATCCAAG 
GTGGGAACCT GTACTCTTTA TTCTGTTCGA TTGACCCATG GCGACTTTAC CTGGACAACC 
AAGAAGAAAT TCCGACACTT TCAGGAGCTG CATCGGGACC TCCAGAGACA CAAAGTCTTG 
ATGAGTCTGC TCCCTCTGGC TCGCTTTGCT GCGGCCCATT CTCCAGCCCG AGAGGCAGCC 
AATGAGAATA TTCCCTCCCT ACCCCGAGGA GGTTCCGAGG GCTCTGCCAG ACACACAGCC 
AGCAAGCAGA AGTACCTGGA AAATTACCTC AACCGCCTCC TGACCATGTC TTTCTATCGA 
AATTACCATG CCATGACAGA ATTTCTGGAA GTCAGTCAAC TTTCCTTTAT CCCAGACCTT 
GGCTCCAAAG GACTGGAAGG GGTGATCCGG AAGCGCTCAG GTGGGCATCG AGTTCCTGGC 
TTCACCTGCT GTGGTCGAGA CCAAGTTTGT TATCGATGGT CCAAGAGGTG GCTGGTGGTG 
AAGGACTCCT TCCTGCTGTA CATGCGTCCA GAGACTGGCG CCATCTCATT TGTTCAACTT 
TTTGACCCTG GCTTTGAGGT CCAGGTGGGG AAAAGGAGCA CAGAGGCACG GTATGGGGTG 
AGGATCGACA CCTCCCACAG GTCCCTGATC CTCAAATGCA GCAGCTACCG GCAGGCACGG 
TGGTGGGGCC AGGAGATCAC GGAGCTGGCA CAGGGTCCGG GCAGAGATTT TCTACAGCTA 
CACCAGCATG ACAGCTATGC CCCACCCCGG CCTGGCACCC TGGCCCGGTG GTTTGTGAAT 
GGGGCAGGTT ACTTTGCTGC TGTGGCAGAT GCCATCCTCC GAGCTCGAGA GGAGATTTTC 
ATCACAGACT GGTGGCTGAG TCCTGAGATT TACCTGAAGC GTCCAGCCCA CTCAGATGAC 
TGGAGACTGG ACATTATGCT CAAGAGGAAG GCGGAAGAAG GTGTCCGTGT TTCCATACTG 
CTGTTTAAGG AAGTGGAACT GGCCTTGGGC ATCAACAGTG GCTATAGCAA GAGGACACTG 
ATGCTACTGC ACCCCAACAT AAAGGTGATG CGACACCCAG ACCTTGTAAC ATTGTGGGCT 
CATCATGAGA AGCTCCTGGT GGTAGACCAA GCGGTGGCAT TCTTGGGTGG GCTGGACCTT 
GCCTATGGCC GCTGGGATGA TGTGCAGTAC CAACATATTT CTCTGATCTT AAGTCAGGAC 
ACGGAACTCA ACCAGAGGCA GGAACCTGGA GGGCTGCTGC TTCTCTGGCT CATTCCTGTG 
GATAGCTCGG TCTCCTTTCT TCCAGAACCC AGGACCACCA CCCCAGATTT CATCGACAGG 
GAGACCACAC CCAGAATGCC ATGGAGGGAT GTTGGAGTGG TTGTACATGG AGTAGCTGCC 
CGGGACCTTG CCCGGCACTT CATCCAGCGC TGGAACTTCA CCAAGACCAT CAAGGCCAGA 
TACAAGATAC CTCAGTACCC CTACCTGCTG CCTAAGTCCG CCAGCACTGC AAACCATCTT 
CCCTTCATAA TCCCAGGCGC GCAGTGCGCC ACTGTGCAGG TCTTGCGGTC TGTGGATCGA 
TGGTCAGCAG GGACTTTGGA GAGCTCCATC CTCAATGCCT ACCTACATAC CATCCGAGAG 
AGCCAGCACT TTCTCTACAT TGAGAATCAG TTCTTCATCA GCTGCTCAGA TGGGCGTACA 
GTTCTGAACA AGGTGGGCGA TGAGATTGTG GACAGGATCC TAAAGGCTCA TGAACAGGGG 
CAGTGTTTCC GAGTCTACGT GCTTCTGCCT TTGCTCCCTG GCTTTGAGGG GGACATCTCC 
ACAGGGGGTG GCAACTCCAT CCAGGCCATT CTGCACTTCA CCTACAGGAC CCTGTGTCGT 
GGGGAATATT CAATCTTACA TCGTCTCAAA GCAGCCATGG GGACAGCATG GCGGGATTAC 
ATGTCCATCT GTGGGCTTCG CACACATGGA GAGCTGGGCG GGCACCCGAT CTCCGAGCTC 
ATCTATATCC ACAGCAAGTT GCTCATTGCA GATGACAGAA CAGTCATCAT CGGCTCTGCA 
AACATCAACG ACAGGAGCTT GCTGGGGAAG CGCGACAGTG AGCTAGCCAT ACTGATCGAG 
GACACAGAAA TGGAGCCATC CCTCATGGAT GGGGTGGAGT ACCAGGCAGG CAGATTTGCC 
TTGAGTCTGC GGAAGCACTG TTTCAGTGTC ATTCTTGGGG CAAATACCTG GCCAGACCTG 
GATCTCCGAG ACCCTGTCTG TGATGACTTC TTCCAGCTGT GGCAGGAAAC AGCGGAGAAC 
AATGCCACCA TCTATGAGCA GATCTTCCGC TGCCTGCCGT CCAATGCTAC TCGTTCCCTG 
CGGGCTCTCC GGGAGTACGT GGCTGTGGAG TCCTTGGCTA CAGTCAGCCC TTCTTTGGCT 
CAGTCTGAGC TTGCCCACAT CCGGGGCCAC TTAGTTCACT TCCCCCTCAA GTTTCTGGAG 
GATGAGTCCT TGTTGCCTCC ACTGGGGAGC AAAGAGGGGA TGATACCTTT AGAAGTGTGG 
ACATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017452522.1
CDS	1021..3786
Translation	MTVTQTDLFPYGDYLNSSQLHMEPDEVDTLKEGEDPADRMHPFLAIYDLQPLRAHPLVFAPGVPVIAQVVGTERYTSGSKVGTCTLYSVRLTHGDFTWTTKKKFRHFQELHRDLQRHKVLMSLLPLARFAAAHSPAREAANENIPSLPRGGSEGSARHTASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGSKGLEGVIRKRSGGHRVPGFTCCGRDQVCYRWSKRWLVVKDSFLLYMRPETGAISFVQLFDPGFEVQVGKRSTEARYGVRIDTSHRSLILKCSSYRQARWWGQEITELAQGPGRDFLQLHQHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAREEIFITDWWLSPEIYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRTLMLLHPNIKVMRHPDLVTLWAHHEKLLVVDQAVAFLGGLDLAYGRWDDVQYQHISLILSQDTELNQRQEPGGLLLLWLIPVDSSVSFLPEPRTTTPDFIDRETTPRMPWRDVGVVVHGVAARDLARHFIQRWNFTKTIKARYKIPQYPYLLPKSASTANHLPFIIPGAQCATVQVLRSVDRWSAGTLESSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDEIVDRILKAHEQGQCFRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEYSILHRLKAAMGTAWRDYMSICGLRTHGELGGHPISELIYIHSKLLIADDRTVIIGSANINDRSLLGKRDSELAILIEDTEMEPSLMDGVEYQAGRFALSLRKHCFSVILGANTWPDLDLRDPVCDDFFQLWQETAENNATIYEQIFRCLPSNATRSLRALREYVAVESLATVSPSLAQSELAHIRGHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT

Target ORF information:

RefSeq Version	XM_017597033.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus phospholipase D2 (Pld2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017597033.1

ORF Insert Sequence:

ATGACTGTAA CCCAGACGGA CCTCTTTCCC TATGGGGACT ACCTGAACTC CAGCCAGTTG 
CACATGGAGC CAGATGAGGT TGACACTCTG AAGGAAGGAG AGGATCCAGC TGATCGAATG 
CATCCCTTTC TGGCCATCTA TGACCTTCAG CCTCTGAGAG CACACCCCTT GGTGTTTGCT 
CCTGGGGTCC CTGTTATAGC CCAGGTGGTA GGCACCGAAA GATACACCAG CGGATCCAAG 
GTGGGAACCT GTACTCTTTA TTCTGTTCGA TTGACCCATG GCGACTTTAC CTGGACAACC 
AAGAAGAAAT TCCGACACTT TCAGGAGCTG CATCGGGACC TCCAGAGACA CAAAGTCTTG 
ATGAGTCTGC TCCCTCTGGC TCGCTTTGCT GCGGCCCATT CTCCAGCCCG AGAGGCAGCC 
AATGAGAATA TTCCCTCCCT ACCCCGAGGA GGTTCCGAGG GCTCTGCCAG ACACACAGCC 
AGCAAGCAGA AGTACCTGGA AAATTACCTC AACCGCCTCC TGACCATGTC TTTCTATCGA 
AATTACCATG CCATGACAGA ATTTCTGGAA GTCAGTCAAC TTTCCTTTAT CCCAGACCTT 
GGCTCCAAAG GACTGGAAGG GGTGATCCGG AAGCGCTCAG GTGGGCATCG AGTTCCTGGC 
TTCACCTGCT GTGGTCGAGA CCAAGTTTGT TATCGATGGT CCAAGAGGTG GCTGGTGGTG 
AAGGACTCCT TCCTGCTGTA CATGCGTCCA GAGACTGGCG CCATCTCATT TGTTCAACTT 
TTTGACCCTG GCTTTGAGGT CCAGGTGGGG AAAAGGAGCA CAGAGGCACG GTATGGGGTG 
AGGATCGACA CCTCCCACAG GTCCCTGATC CTCAAATGCA GCAGCTACCG GCAGGCACGG 
TGGTGGGGCC AGGAGATCAC GGAGCTGGCA CAGGGTCCGG GCAGAGATTT TCTACAGCTA 
CACCAGCATG ACAGCTATGC CCCACCCCGG CCTGGCACCC TGGCCCGGTG GTTTGTGAAT 
GGGGCAGGTT ACTTTGCTGC TGTGGCAGAT GCCATCCTCC GAGCTCGAGA GGAGATTTTC 
ATCACAGACT GGTGGCTGAG TCCTGAGATT TACCTGAAGC GTCCAGCCCA CTCAGATGAC 
TGGAGACTGG ACATTATGCT CAAGAGGAAG GCGGAAGAAG GTGTCCGTGT TTCCATACTG 
CTGTTTAAGG AAGTGGAACT GGCCTTGGGC ATCAACAGTG GCTATAGCAA GAGGACACTG 
ATGCTACTGC ACCCCAACAT AAAGGTGATG CGACACCCAG ACCTTGTAAC ATTGTGGGCT 
CATCATGAGA AGCTCCTGGT GGTAGACCAA GCGGTGGCAT TCTTGGGTGG GCTGGACCTT 
GCCTATGGCC GCTGGGATGA TGTGCAGTAC CAACATATTT CTCTGATCTT AAGTCAGGAC 
ACGGAACTCA ACCAGAGGCA GGAACCTGGA GGGCTGCTGC TTCTCTGGCT CATTCCTGTG 
GATAGCTCGG TCTCCTTTCT TCCAGAACCC AGGACCACCA CCCCAGATTT CATCGACAGG 
GAGACCACAC CCAGAATGCC ATGGAGGGAT GTTGGAGTGG TTGTACATGG AGTAGCTGCC 
CGGGACCTTG CCCGGCACTT CATCCAGCGC TGGAACTTCA CCAAGACCAT CAAGGCCAGA 
TACAAGATAC CTCAGTACCC CTACCTGCTG CCTAAGTCCG CCAGCACTGC AAACCATCTT 
CCCTTCATAA TCCCAGGCGC GCAGTGCGCC ACTGTGCAGG TCTTGCGGTC TGTGGATCGA 
TGGTCAGCAG GGACTTTGGA GAGCTCCATC CTCAATGCCT ACCTACATAC CATCCGAGAG 
AGCCAGCACT TTCTCTACAT TGAGAATCAG TTCTTCATCA GCTGCTCAGA TGGGCGTACA 
GTTCTGAACA AGGTGGGCGA TGAGATTGTG GACAGGATCC TAAAGGCTCA TGAACAGGGG 
CAGTGTTTCC GAGTCTACGT GCTTCTGCCT TTGCTCCCTG GCTTTGAGGG GGACATCTCC 
ACAGGGGGTG GCAACTCCAT CCAGGCCATT CTGCACTTCA CCTACAGGAC CCTGTGTCGT 
GGGGAATATT CAATCTTACA TCGTCTCAAA GCAGCCATGG GGACAGCATG GCGGGATTAC 
ATGTCCATCT GTGGGCTTCG CACACATGGA GAGCTGGGCG GGCACCCGAT CTCCGAGCTC 
ATCTATATCC ACAGCAAGTT GCTCATTGCA GATGACAGAA CAGTCATCAT CGGCTCTGCA 
AACATCAACG ACAGGAGCTT GCTGGGGAAG CGCGACAGTG AGCTAGCCAT ACTGATCGAG 
GACACAGAAA TGGAGCCATC CCTCATGGAT GGGGTGGAGT ACCAGGCAGG CAGATTTGCC 
TTGAGTCTGC GGAAGCACTG TTTCAGTGTC ATTCTTGGGG CAAATACCTG GCCAGACCTG 
GATCTCCGAG ACCCTGTCTG TGATGACTTC TTCCAGCTGT GGCAGGAAAC AGCGGAGAAC 
AATGCCACCA TCTATGAGCA GATCTTCCGC TGCCTGCCGT CCAATGCTAC TCGTTCCCTG 
CGGGCTCTCC GGGAGTACGT GGCTGTGGAG TCCTTGGCTA CAGTCAGCCC TTCTTTGGCT 
CAGTCTGAGC TTGCCCACAT CCGGGGCCAC TTAGTTCACT TCCCCCTCAA GTTTCTGGAG 
GATGAGTCCT TGTTGCCTCC ACTGGGGAGC AAAGAGGGGA TGATACCTTT AGAAGTGTGG 
ACATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Phospholipase D2: a pivotal player modulating RBL-2H3 mast cell structure.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society60(5)386-96(2012 May)
Marchini-Alves CM,Nicoletti LM,Mazucato VM,de Souza LB,Hitomi T,Alves Cde P,Jamur MC,Oliver C

Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes.
The Journal of biological chemistry286(25)22609-21(2011 Jun)
Jaafar R,Zeiller C,Pirola L,Di Grazia A,Naro F,Vidal H,Lefai E,N?moz G

Cell invasion of highly metastatic MTLn3 cancer cells is dependent on phospholipase D2 (PLD2) and Janus kinase 3 (JAK3).
Journal of molecular biology408(5)850-62(2011 May)
Henkels KM,Farkaly T,Mahankali M,Segall JE,Gomez-Cambronero J

Phospholipase D family member 4, a transmembrane glycoprotein with no phospholipase D activity, expression in spleen and early postnatal microglia.
PloS one5(11)e13932(2010 Nov)
Yoshikawa F,Banno Y,Otani Y,Yamaguchi Y,Nagakura-Takagi Y,Morita N,Sato Y,Saruta C,Nishibe H,Sadakata T,Shinoda Y,Hayashi K,Mishima Y,Baba H,Furuichi T

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Pld2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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