Sds cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sds
Entrez Gene ID	25044
Full Name	serine dehydratase
Synonyms	RATSDHE1,SDH2,Sdh,Sdhe1,TDH
General protein information	Preferred Names serine dehydratase Names L-serine dehydratase/L-threonine deaminase L-serine deaminase L-threonine dehydratase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q16
Summary	enzyme that converts L-serine to pyruvate and ammonia; involved in gluconeogenesis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053962.3	NP_446414.3	L-serine dehydratase/L-threonine deaminase

Pathways from BioSystems

Homologies

Homo sapiens (human)	SDS	NP_006834.2
Bos taurus (cattle)	SDS	NP_001069130.1
Mus musculus (house mouse)	Sds	NP_663540.1
Rattus norvegicus (Norway rat)	Sds	NP_446414.3
Neurospora crassa	NCU03761	XP_961108.1
	SDS	XP_001111661.1
Pan troglodytes (chimpanzee)	SDS	XP_509398.2
Magnaporthe oryzae (rice blast fungus)	MGG_06950	XP_003709693.1
Xenopus tropicalis (tropical clawed frog)	sds	XP_002939238.2

Gene Ontology
Bibliography

Related articles in PubMed

Angiotensin receptor blockade recovers hepatic UCP2 expression and aconitase and SDH activities and ameliorates hepatic oxidative damage in insulin resistant rats.
Montez P, V?zquez-Medina JP, Rodr?guez R, Thorwald MA, Viscarra JA, Lam L, Peti-Peterdi J, Nakano D, Nishiyama A, Ortiz RM
Endocrinology153(12)5746-59(2012 Dec)

Adaptational modification of serine and threonine metabolism in the liver to essential amino acid deficiency in rats.
Nagao K, Bannai M, Seki S, Mori M, Takahashi M
Amino acids36(3)555-62(2009 Mar)

Effects of 3,4-dichloroaniline on testicle enzymes as biological markers in rats.
Zhang B, Lin S
Biomedical and environmental sciences : BES22(1)40-3(2009 Feb)

A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies.
Yamada T, Komoto J, Kasuya T, Takata Y, Ogawa H, Mori H, Takusagawa F
Biochimica et biophysica acta1780(5)809-18(2008 May)

Excess leucine intake induces serine dehydratase in rat liver.
Zhong B, Sakai S, Saeki T, Kanamoto R
Bioscience, biotechnology, and biochemistry71(10)2614-7(2007 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Angiotensin receptor blockade recovers hepatic UCP2 expression and aconitase and SDH activities and ameliorates hepatic oxidative damage in insulin resistant rats
Title: Angiotensin receptor blockade recovers hepatic UCP2 expression and aconitase and SDH activities and ameliorates hepatic oxidative damage in insulin resistant rats.

Excess leucine intake induces Sdh in rat liver.
Title: Excess leucine intake induces serine dehydratase in rat liver.

The changes found in SerDH expression are part of an overall metabolic response of liver to maintain acid-base homeostasis during acidosis.
Title: Downregulation in the expression of the serine dehydratase in the rat liver during chronic metabolic acidosis.

A detailed catalytic mechanism of SDH is proposed based on the crystal structures of apo-SDH and pyridoxal 5'-phosphate-O-methylserine aldimine-bound SDH.
Title: Crystal structure of serine dehydratase from rat liver.

quantity as well as quality of dietary protein has an influence on serine dehydratase gene expression
Title: Quantity as well as quality of dietary protein affects serine dehydratase gene expression in rat liver.

The following Sds gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sds cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11190	NM_053962.3 Latest version!	Rattus norvegicus serine dehydratase (Sds), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sds ( NM_053962.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446414.3 Rattus norvegicus serine dehydratase (Sds), mRNA.

Price & Availability↑

CloneID	ORa11190
Clone ID Related Accession (Same CDS sequence)	NM_053962.3
Accession Version	NM_053962.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Rattus norvegicus(Norway rat)
Product	L-serine dehydratase/L-threonine deaminase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC088110.1. On Oct 19, 2007 this sequence version replaced NM_053962.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC088110.1, Y00752.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2689597, SAMEA2689598 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCCC AGGAGTCCCT GCACGTGAAG ACCCCACTAC GTGACAGCAT GGCATTGTCC 
AAAGTGGCCG GCACTAGTGT GTTCCTTAAG ATGGACAGCT CTCAGCCCTC TGGCTCCTTC 
AAGATCCGAG GCATTGGGCA TCTCTGCAAG ATGAAGGCAA AACAAGGCTG TAAACATTTC 
GTCTGCTCTT CAGCGGGCAA CGCGGGCATG GCGACTGCCT ATGCTGCCAG GAGGCTGGGC 
CTCCCAGCCA CTATTGTTGT GCCAAGCACC ACACCTGCCC TCACCATTGA GCGGCTGAAG 
AACGAAGGGG CCACAGTTGA AGTGGTGGGA GAGATGCTGG ATGAGGCCAT CCAACTGGCC 
AAGGCTCTGG AAAAGAACAA CCCAGGTTGG GTGTACATCT CCCCCTTCGA TGACCCTCTC 
ATCTGGGAAG GCCACACTTC CCTTGTGAAG GAGCTGAAGG AGACACTGAG CGCCAAGCCC 
GGGGCCATTG TGCTGTCTGT GGGCGGTGGA GGCCTGCTGT GCGGAGTGGT CCAGGGGCTG 
CGGGAGGTGG GCTGGGAGGA TGTGCCCATC ATCGCCATGG AGACCTTCGG CGCCCACAGC 
TTCCACGCTG CCGTCAAGGA AGGAAAGCTG GTCACCCTGC CCAAGATCAC CAGTGTTGCC 
AAGGCCTTGG GTGTGAACAC TGTGGGGGCA CAGACCCTGA AGCTGTTTTA CGAACACCCC 
ATTTTCTCTG AGGTCATCTC AGACCAGGAG GCTGTGACTG CTATCGAGAA GTTCGTAGAC 
GATGAGAAGA TCCTGGTGGA GCCCGCGTGT GGCGCTGCCC TGGCTGCAGT GTACAGCGGT 
GTGGTGTGCA GGCTGCAGGC TGAGGGCCGA CTGCAAACCC CACTGGCCTC GCTGGTTGTC 
ATTGTGTGTG GTGGCAGCAA CATCAGCCTG GCACAGCTGC AGGCACTCAA GGCACAGCTG 
GGCCTGAATG AGCTACTCAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446414.3
CDS	132..1115
Translation	MAAQESLHVKTPLRDSMALSKVAGTSVFLKMDSSQPSGSFKIRGIGHLCKMKAKQGCKHFVCSSAGNAGMATAYAARRLGLPATIVVPSTTPALTIERLKNEGATVEVVGEMLDEAIQLAKALEKNNPGWVYISPFDDPLIWEGHTSLVKELKETLSAKPGAIVLSVGGGGLLCGVVQGLREVGWEDVPIIAMETFGAHSFHAAVKEGKLVTLPKITSVAKALGVNTVGAQTLKLFYEHPIFSEVISDQEAVTAIEKFVDDEKILVEPACGAALAAVYSGVVCRLQAEGRLQTPLASLVVIVCGGSNISLAQLQALKAQLGLNELLK

Target ORF information:

RefSeq Version	NM_053962.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus serine dehydratase (Sds), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053962.3

ORF Insert Sequence:

ATGGCTGCCC AGGAGTCCCT GCACGTGAAG ACCCCACTAC GTGACAGCAT GGCATTGTCC 
AAAGTGGCCG GCACTAGTGT GTTCCTTAAG ATGGACAGCT CTCAGCCCTC TGGCTCCTTC 
AAGATCCGAG GCATTGGGCA TCTCTGCAAG ATGAAGGCAA AACAAGGCTG TAAACATTTC 
GTCTGCTCTT CAGCGGGCAA CGCGGGCATG GCGACTGCCT ATGCTGCCAG GAGGCTGGGC 
CTCCCAGCCA CTATTGTTGT GCCAAGCACC ACACCTGCCC TCACCATTGA GCGGCTGAAG 
AACGAAGGGG CCACAGTTGA AGTGGTGGGA GAGATGCTGG ATGAGGCCAT CCAACTGGCC 
AAGGCTCTGG AAAAGAACAA CCCAGGTTGG GTGTACATCT CCCCCTTCGA TGACCCTCTC 
ATCTGGGAAG GCCACACTTC CCTTGTGAAG GAGCTGAAGG AGACACTGAG CGCCAAGCCC 
GGGGCCATTG TGCTGTCTGT GGGCGGTGGA GGCCTGCTGT GCGGAGTGGT CCAGGGGCTG 
CGGGAGGTGG GCTGGGAGGA TGTGCCCATC ATCGCCATGG AGACCTTCGG CGCCCACAGC 
TTCCACGCTG CCGTCAAGGA AGGAAAGCTG GTCACCCTGC CCAAGATCAC CAGTGTTGCC 
AAGGCCTTGG GTGTGAACAC TGTGGGGGCA CAGACCCTGA AGCTGTTTTA CGAACACCCC 
ATTTTCTCTG AGGTCATCTC AGACCAGGAG GCTGTGACTG CTATCGAGAA GTTCGTAGAC 
GATGAGAAGA TCCTGGTGGA GCCCGCGTGT GGCGCTGCCC TGGCTGCAGT GTACAGCGGT 
GTGGTGTGCA GGCTGCAGGC TGAGGGCCGA CTGCAAACCC CACTGGCCTC GCTGGTTGTC 
ATTGTGTGTG GTGGCAGCAA CATCAGCCTG GCACAGCTGC AGGCACTCAA GGCACAGCTG 
GGCCTGAATG AGCTACTCAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Angiotensin receptor blockade recovers hepatic UCP2 expression and aconitase and SDH activities and ameliorates hepatic oxidative damage in insulin resistant rats.
Endocrinology153(12)5746-59(2012 Dec)
Montez P,V?zquez-Medina JP,Rodr?guez R,Thorwald MA,Viscarra JA,Lam L,Peti-Peterdi J,Nakano D,Nishiyama A,Ortiz RM

Adaptational modification of serine and threonine metabolism in the liver to essential amino acid deficiency in rats.
Amino acids36(3)555-62(2009 Mar)
Nagao K,Bannai M,Seki S,Mori M,Takahashi M

Effects of 3,4-dichloroaniline on testicle enzymes as biological markers in rats.
Biomedical and environmental sciences : BES22(1)40-3(2009 Feb)
Zhang B,Lin S

A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies.
Biochimica et biophysica acta1780(5)809-18(2008 May)
Yamada T,Komoto J,Kasuya T,Takata Y,Ogawa H,Mori H,Takusagawa F

Excess leucine intake induces serine dehydratase in rat liver.
Bioscience, biotechnology, and biochemistry71(10)2614-7(2007 Oct)
Zhong B,Sakai S,Saeki T,Kanamoto R

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Sds cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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