SDS cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SDS
Entrez Gene ID	10993
Full Name	serine dehydratase
Synonyms	SDH
General protein information	Preferred Names serine dehydratase Names L-serine dehydratase/L-threonine deaminase L-serine ammonia-lyase L-serine deaminase L-serine dehydratase L-threonine dehydratase TDH
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q24.13
Summary	This gene encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver. [provided by RefSeq, Jul 2008].
Disorder MIM:	182128

mRNA and Protein(s)

mRNA	Protein	Name
NM_006843.2	NP_006834.2	L-serine dehydratase/L-threonine deaminase
NM_006843.3	NP_006834.2	L-serine dehydratase/L-threonine deaminase

Pathways from BioSystems

Homologies

Homo sapiens (human)	SDS	NP_006834.2
Bos taurus (cattle)	SDS	NP_001069130.1
Mus musculus (house mouse)	Sds	NP_663540.1
Rattus norvegicus (Norway rat)	Sds	NP_446414.3
Neurospora crassa	NCU03761	XP_961108.1
	SDS	XP_001111661.1
Pan troglodytes (chimpanzee)	SDS	XP_509398.2
Magnaporthe oryzae (rice blast fungus)	MGG_06950	XP_003709693.1
Xenopus tropicalis (tropical clawed frog)	sds	XP_002939238.2

Gene Ontology
Bibliography

Related articles in PubMed

Human gingiva transcriptome during wound healing.
Wang Y, Tatakis DN
Journal of clinical periodontology44(4)394-402(2017 Apr)

Modulating the function of human serine racemase and human serine dehydratase by protein engineering.
Wang CY, Ku SC, Lee CC, Wang AH
Protein engineering, design & selection : PEDS25(11)741-9(2012 Nov)

A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies.
Yamada T, Komoto J, Kasuya T, Takata Y, Ogawa H, Mori H, Takusagawa F
Biochimica et biophysica acta1780(5)809-18(2008 May)

Association between sorbitol dehydrogenase gene polymorphisms and type 2 diabetic retinopathy.
Szaflik JP, Majsterek I, Kowalski M, Rusin P, Sobczuk A, Borucka AI, Szaflik J, Blasiak J
Experimental eye research86(4)647-52(2008 Apr)

Crystal structure of the pyridoxal-5'-phosphate-dependent serine dehydratase from human liver.
Sun L, Bartlam M, Liu Y, Pang H, Rao Z
Protein science : a publication of the Protein Society14(3)791-8(2005 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SDS expression is significantly upregulated in human masticatory mucosa during wound healing
Title: Human gingiva transcriptome during wound healing.

S84A serine racemase mutant behaved like serine dehydratase, whereas A65S serine dehydratase mutant acquired an additional function of using D-serine as a substrate.
Title: Modulating the function of human serine racemase and human serine dehydratase by protein engineering.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association between sorbitol dehydrogenase gene polymorphisms and type 2 diabetic retinopathy.

The following SDS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SDS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05769	NM_006843.3 Latest version!	Homo sapiens serine dehydratase (SDS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu05769	NM_006843.2	Homo sapiens serine dehydratase (SDS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SDS ( NM_006843.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006834.2 Homo sapiens serine dehydratase (SDS), mRNA.

Price & Availability↑

CloneID	OHu05769
Clone ID Related Accession (Same CDS sequence)	NM_006843.2 , NM_006843.3
Accession Version	NM_006843.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 987bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	L-serine dehydratase/L-threonine deaminase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG534053.1, BC020750.1, BG566257.1, J05037.1 and BU740747.1. On Aug 7, 2003 this sequence version replaced NM_006843.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK292760.1, ERR279843.4650.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGTCTG GAGAACCCCT GCACGTGAAG ACCCCCATCC GTGACAGCAT GGCCCTGTCC 
AAAATGGCCG GCACCAGCGT CTACCTCAAG ATGGACAGTG CCCAGCCCTC CGGCTCCTTC 
AAGATCCGGG GCATTGGGCA CTTCTGCAAG AGGTGGGCCA AGCAAGGCTG TGCACATTTT 
GTCTGCTCCT CGGCGGGCAA CGCAGGCATG GCGGCTGCAT ATGCGGCCAG GCAACTCGGC 
GTCCCCGCCA CCATCGTGGT GCCCAGCACC ACACCTGCTC TCACCATTGA GCGCCTCAAG 
AATGAAGGTG CCACAGTCAA GGTGGTGGGT GAGTTATTGG ATGAAGCCTT CGAGCTGGCC 
AAGGCCCTAG CGAAGAACAA CCCGGGTTGG GTCTACATTC CCCCCTTTGA TGACCCCCTC 
ATCTGGGAAG GCCACGCTTC CATCGTGAAA GAGCTGAAGG AGACACTGTG GGAAAAGCCG 
GGGGCCATCG CGCTGTCAGT GGGCGGCGGG GGCCTGCTGT GTGGAGTGGT CCAGGGGCTG 
CAGGAGGTGG GCTGGGGGGA CGTGCCTGTC ATCGCCATGG AGACTTTTGG TGCCCACAGC 
TTCCACGCTG CCACCACCGC AGGCAAACTT GTCTCCCTGC CCAAGATCAC CAGTGTTGCC 
AAGGCCCTGG GCGTGAAGAC TGTGGGGGCT CAGGCCCTGA AGCTGTTTCA GGAACACCCC 
ATTTTCTCTG AAGTTATCTC GGACCAGGAG GCTGTGGCCG CCATTGAGAA GTTCGTGGAT 
GATGAGAAGA TCCTGGTGGA GCCCGCCTGC GGGGCAGCCC TGGCCGCTGT CTATAGCCAC 
GTGATCCAGA AGCTCCAACT GGAGGGGAAT CTCCGAACCC CGCTGCCATC CCTCGTGGTC 
ATCGTCTGCG GGGGCAGCAA CATCAGCCTG GCCCAGCTGC GGGCGCTCAA GGAACAGCTG 
GGCATGACAA ATAGGTTGCC CAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006834.2
CDS	123..1109
Translation	MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCKRWAKQGCAHFVCSSAGNAGMAAAYAARQLGVPATIVVPSTTPALTIERLKNEGATVKVVGELLDEAFELAKALAKNNPGWVYIPPFDDPLIWEGHASIVKELKETLWEKPGAIALSVGGGGLLCGVVQGLQEVGWGDVPVIAMETFGAHSFHAATTAGKLVSLPKITSVAKALGVKTVGAQALKLFQEHPIFSEVISDQEAVAAIEKFVDDEKILVEPACGAALAAVYSHVIQKLQLEGNLRTPLPSLVVIVCGGSNISLAQLRALKEQLGMTNRLPK

Target ORF information:

RefSeq Version	NM_006843.2
Organism	Homo sapiens(human)
Definition	Homo sapiens serine dehydratase (SDS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006843.2

ORF Insert Sequence:

ATGATGTCTG GAGAACCCCT GCACGTGAAG ACCCCCATCC GTGACAGCAT GGCCCTGTCC 
AAAATGGCCG GCACCAGCGT CTACCTCAAG ATGGACAGTG CCCAGCCCTC CGGCTCCTTC 
AAGATCCGGG GCATTGGGCA CTTCTGCAAG AGGTGGGCCA AGCAAGGCTG TGCACATTTT 
GTCTGCTCCT CGGCGGGCAA CGCAGGCATG GCGGCTGCAT ATGCGGCCAG GCAACTCGGC 
GTCCCCGCCA CCATCGTGGT GCCCAGCACC ACACCTGCTC TCACCATTGA GCGCCTCAAG 
AATGAAGGTG CCACAGTCAA GGTGGTGGGT GAGTTATTGG ATGAAGCCTT CGAGCTGGCC 
AAGGCCCTAG CGAAGAACAA CCCGGGTTGG GTCTACATTC CCCCCTTTGA TGACCCCCTC 
ATCTGGGAAG GCCACGCTTC CATCGTGAAA GAGCTGAAGG AGACACTGTG GGAAAAGCCG 
GGGGCCATCG CGCTGTCAGT GGGCGGCGGG GGCCTGCTGT GTGGAGTGGT CCAGGGGCTG 
CAGGAGGTGG GCTGGGGGGA CGTGCCTGTC ATCGCCATGG AGACTTTTGG TGCCCACAGC 
TTCCACGCTG CCACCACCGC AGGCAAACTT GTCTCCCTGC CCAAGATCAC CAGTGTTGCC 
AAGGCCCTGG GCGTGAAGAC TGTGGGGGCT CAGGCCCTGA AGCTGTTTCA GGAACACCCC 
ATTTTCTCTG AAGTTATCTC GGACCAGGAG GCTGTGGCCG CCATTGAGAA GTTCGTGGAT 
GATGAGAAGA TCCTGGTGGA GCCCGCCTGC GGGGCAGCCC TGGCCGCTGT CTATAGCCAC 
GTGATCCAGA AGCTCCAACT GGAGGGGAAT CTCCGAACCC CGCTGCCATC CCTCGTGGTC 
ATCGTCTGCG GGGGCAGCAA CATCAGCCTG GCCCAGCTGC GGGCGCTCAA GGAACAGCTG 
GGCATGACAA ATAGGTTGCC CAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SDS ( NM_006843.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006834.2 Homo sapiens serine dehydratase (SDS), mRNA.

Price & Availability↑

CloneID	OHu05769
Clone ID Related Accession (Same CDS sequence)	NM_006843.2 , NM_006843.3
Accession Version	NM_006843.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 987bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	L-serine dehydratase/L-threonine deaminase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG534053.1, BC020750.1, BG566257.1, J05037.1 and BU740747.1. On Nov 23, 2018 this sequence version replaced NM_006843.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.600160.1, SRR5189664.1638.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000257549.9/ ENSP00000257549.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATGTCTG GAGAACCCCT GCACGTGAAG ACCCCCATCC GTGACAGCAT GGCCCTGTCC 
AAAATGGCCG GCACCAGCGT CTACCTCAAG ATGGACAGTG CCCAGCCCTC CGGCTCCTTC 
AAGATCCGGG GCATTGGGCA CTTCTGCAAG AGGTGGGCCA AGCAAGGCTG TGCACATTTT 
GTCTGCTCCT CGGCGGGCAA CGCAGGCATG GCGGCTGCAT ATGCGGCCAG GCAACTCGGC 
GTCCCCGCCA CCATCGTGGT GCCCAGCACC ACACCTGCTC TCACCATTGA GCGCCTCAAG 
AATGAAGGTG CCACAGTCAA GGTGGTGGGT GAGTTATTGG ATGAAGCCTT CGAGCTGGCC 
AAGGCCCTAG CGAAGAACAA CCCGGGTTGG GTCTACATTC CCCCCTTTGA TGACCCCCTC 
ATCTGGGAAG GCCACGCTTC CATCGTGAAA GAGCTGAAGG AGACACTGTG GGAAAAGCCG 
GGGGCCATCG CGCTGTCAGT GGGCGGCGGG GGCCTGCTGT GTGGAGTGGT CCAGGGGCTG 
CAGGAGGTGG GCTGGGGGGA CGTGCCTGTC ATCGCCATGG AGACTTTTGG TGCCCACAGC 
TTCCACGCTG CCACCACCGC AGGCAAACTT GTCTCCCTGC CCAAGATCAC CAGTGTTGCC 
AAGGCCCTGG GCGTGAAGAC TGTGGGGGCT CAGGCCCTGA AGCTGTTTCA GGAACACCCC 
ATTTTCTCTG AAGTTATCTC GGACCAGGAG GCTGTGGCCG CCATTGAGAA GTTCGTGGAT 
GATGAGAAGA TCCTGGTGGA GCCCGCCTGC GGGGCAGCCC TGGCCGCTGT CTATAGCCAC 
GTGATCCAGA AGCTCCAACT GGAGGGGAAT CTCCGAACCC CGCTGCCATC CCTCGTGGTC 
ATCGTCTGCG GGGGCAGCAA CATCAGCCTG GCCCAGCTGC GGGCGCTCAA GGAACAGCTG 
GGCATGACAA ATAGGTTGCC CAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006834.2
CDS	123..1109
Translation	MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCKRWAKQGCAHFVCSSAGNAGMAAAYAARQLGVPATIVVPSTTPALTIERLKNEGATVKVVGELLDEAFELAKALAKNNPGWVYIPPFDDPLIWEGHASIVKELKETLWEKPGAIALSVGGGGLLCGVVQGLQEVGWGDVPVIAMETFGAHSFHAATTAGKLVSLPKITSVAKALGVKTVGAQALKLFQEHPIFSEVISDQEAVAAIEKFVDDEKILVEPACGAALAAVYSHVIQKLQLEGNLRTPLPSLVVIVCGGSNISLAQLRALKEQLGMTNRLPK

Target ORF information:

RefSeq Version	NM_006843.3
Organism	Homo sapiens(human)
Definition	Homo sapiens serine dehydratase (SDS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006843.3

ORF Insert Sequence:

ATGATGTCTG GAGAACCCCT GCACGTGAAG ACCCCCATCC GTGACAGCAT GGCCCTGTCC 
AAAATGGCCG GCACCAGCGT CTACCTCAAG ATGGACAGTG CCCAGCCCTC CGGCTCCTTC 
AAGATCCGGG GCATTGGGCA CTTCTGCAAG AGGTGGGCCA AGCAAGGCTG TGCACATTTT 
GTCTGCTCCT CGGCGGGCAA CGCAGGCATG GCGGCTGCAT ATGCGGCCAG GCAACTCGGC 
GTCCCCGCCA CCATCGTGGT GCCCAGCACC ACACCTGCTC TCACCATTGA GCGCCTCAAG 
AATGAAGGTG CCACAGTCAA GGTGGTGGGT GAGTTATTGG ATGAAGCCTT CGAGCTGGCC 
AAGGCCCTAG CGAAGAACAA CCCGGGTTGG GTCTACATTC CCCCCTTTGA TGACCCCCTC 
ATCTGGGAAG GCCACGCTTC CATCGTGAAA GAGCTGAAGG AGACACTGTG GGAAAAGCCG 
GGGGCCATCG CGCTGTCAGT GGGCGGCGGG GGCCTGCTGT GTGGAGTGGT CCAGGGGCTG 
CAGGAGGTGG GCTGGGGGGA CGTGCCTGTC ATCGCCATGG AGACTTTTGG TGCCCACAGC 
TTCCACGCTG CCACCACCGC AGGCAAACTT GTCTCCCTGC CCAAGATCAC CAGTGTTGCC 
AAGGCCCTGG GCGTGAAGAC TGTGGGGGCT CAGGCCCTGA AGCTGTTTCA GGAACACCCC 
ATTTTCTCTG AAGTTATCTC GGACCAGGAG GCTGTGGCCG CCATTGAGAA GTTCGTGGAT 
GATGAGAAGA TCCTGGTGGA GCCCGCCTGC GGGGCAGCCC TGGCCGCTGT CTATAGCCAC 
GTGATCCAGA AGCTCCAACT GGAGGGGAAT CTCCGAACCC CGCTGCCATC CCTCGTGGTC 
ATCGTCTGCG GGGGCAGCAA CATCAGCCTG GCCCAGCTGC GGGCGCTCAA GGAACAGCTG 
GGCATGACAA ATAGGTTGCC CAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human gingiva transcriptome during wound healing.
Journal of clinical periodontology44(4)394-402(2017 Apr)
Wang Y,Tatakis DN

Modulating the function of human serine racemase and human serine dehydratase by protein engineering.
Protein engineering, design & selection : PEDS25(11)741-9(2012 Nov)
Wang CY,Ku SC,Lee CC,Wang AH

A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies.
Biochimica et biophysica acta1780(5)809-18(2008 May)
Yamada T,Komoto J,Kasuya T,Takata Y,Ogawa H,Mori H,Takusagawa F

Association between sorbitol dehydrogenase gene polymorphisms and type 2 diabetic retinopathy.
Experimental eye research86(4)647-52(2008 Apr)
Szaflik JP,Majsterek I,Kowalski M,Rusin P,Sobczuk A,Borucka AI,Szaflik J,Blasiak J

Crystal structure of the pyridoxal-5'-phosphate-dependent serine dehydratase from human liver.
Protein science : a publication of the Protein Society14(3)791-8(2005 Mar)
Sun L,Bartlam M,Liu Y,Pang H,Rao Z

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SDS cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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