Xrcc6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Xrcc6
Entrez Gene ID	25019
Full Name	X-ray repair cross complementing 6
Synonyms	G22p1,Ku70,Kup70
General protein information	Preferred Names X-ray repair cross complementing 6 Names X-ray repair cross-complementing protein 6 Ku70 DNA-binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa) X-ray repair complementing defective repair in Chinese hamster cells 6 thyroid autoantigen
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q34
Summary	DNA targeting component of the DNA-dependent protein kinase complex DNA-PK, which plays a role in DNA double strand break repair [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_139080.2	NP_620780.2	X-ray repair cross-complementing protein 6
XM_008765671.2	XP_008763893.1	X-ray repair cross-complementing protein 6 isoform X1

Pathways from BioSystems

Homologies

	XRCC6	XP_001105684.1
Gallus gallus (chicken)	XRCC6	NP_990258.1
Danio rerio (zebrafish)	LOC100536337	XP_003199637.1
Canis lupus familiaris (dog)	XRCC6	XP_005625882.1
Mus musculus (house mouse)	Xrcc6	NP_034377.2
Neurospora crassa	NCU08290	XP_962503.2
Xenopus tropicalis (tropical clawed frog)	xrcc6	NP_001005700.1
Danio rerio (zebrafish)	xrcc6	NP_956198.1
Arabidopsis thaliana (thale cress)	KU70	NP_564012.1
Bos taurus (cattle)	XRCC6	NP_001179175.1
Rattus norvegicus (Norway rat)	Xrcc6	NP_620780.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002690	XP_312232.5
Kluyveromyces lactis	KLLA0C06226g	XP_452475.1
Schizosaccharomyces pombe (fission yeast)	pku70	NP_588445.1
Oryza sativa (rice)	Os07g0184900	NP_001059061.1
Homo sapiens (human)	XRCC6	NP_001460.1
Pan troglodytes (chimpanzee)	XRCC6	XP_521301.3
Drosophila melanogaster (fruit fly)	Irbp	NP_536773.1
Caenorhabditis elegans (roundworm)	cku-70	NP_499438.2
Saccharomyces cerevisiae (baker's yeast)	YKU70	NP_014011.1
Magnaporthe oryzae (rice blast fungus)	MGG_01512	XP_003714485.1

Gene Ontology
Bibliography

Related articles in PubMed

HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response.
Morchikh M, Cribier A, Raffel R, Amraoui S, Cau J, Severac D, Dubois E, Schwartz O, Bennasser Y, Benkirane M
Molecular cell67(3)387-399.e5(2017 Aug)

PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway.
Chen H, Han L, Tsai H, Wang Z, Wu Y, Duo Y, Cao W, Chen L, Tan Z, Xu N, Huang X, Zhuang J, Huang L
Oncotarget7(50)83241-83257(2016 Dec)

Regulation of the Ku70 and apoptosis-related proteins in experimental diabetic nephropathy.
Tun?demir M, ?zt?rk M
Metabolism: clinical and experimental65(10)1466-77(2016 10)

Heat shock factor 1, an inhibitor of non-homologous end joining repair.
Kang GY, Kim EH, Lee HJ, Gil NY, Cha HJ, Lee YS
Oncotarget6(30)29712-24(2015 Oct)

XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair.
Craxton A, Somers J, Munnur D, Jukes-Jones R, Cain K, Malewicz M
Cell death and differentiation22(6)890-7(2015 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ku70 was increased in the tubuli and glomeruli of the untreated diabetic group, but decreased in all treated diabetic groups
Title: Regulation of the Ku70 and apoptosis-related proteins in experimental diabetic nephropathy.

TopoIIbeta is an essential component in DSBs repair in primary neurons in both Ku70 and PARP-1 dependent pathways.
Title: Topoisomerase II? associates with Ku70 and PARP-1 during double strand break repair of DNA in neurons.

Data suggest that lycopene may be beneficial for the treatment of oxidative stress-induced cell death by preventing loss of DNA repair protein Ku70.
Title: Protective effect of lycopene on oxidative stress-induced cell death of pancreatic acinar cells.

The study demonstrates that following neonatal cerebral hypoxia-ischemia there is a progression of changes in Ku70 expression that are not associated with apoptotic cells.
Title: Cerebral expression of DNA repair protein, Ku70, and its association with cell proliferation following cerebral hypoxia-ischemia in neonatal rats.

The results suggest that the involvement of NF-kappaB p65 in nuclear translocation of Ku70 may be mediated by Hsc70 degradation, which may play a key role in cell proliferation of pancreatic acinar AR42J cells.
Title: NF-kappaB p65 regulates nuclear translocation of Ku70 via degradation of heat shock cognate protein 70 in pancreatic acinar AR42J cells.

The following Xrcc6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Xrcc6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02099	NM_139080.2 Latest version!	Rattus norvegicus X-ray repair cross complementing 6 (Xrcc6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$356.30 $509.00
ORa42999	XM_008765671.2 Latest version!	Rattus norvegicus X-ray repair cross complementing 6 (Xrcc6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Xrcc6 ( NM_139080.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_620780.2 Rattus norvegicus X-ray repair cross complementing 6 (Xrcc6), mRNA.

Price & Availability↑

CloneID	ORa02099
Clone ID Related Accession (Same CDS sequence)	NM_139080.2
Accession Version	NM_139080.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1827bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	X-ray repair cross-complementing protein 6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC078718.1. On Apr 10, 2007 this sequence version replaced NM_139080.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC078718.1, BC061528.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTCAGAGT GGGAATCCTA CTACAAAACT GAGGGTGAGG AAGAGGAAGA GGAGGAGCAG 
AGCCCTGACA CAAATGGAGA ATATAAATAT TCAGGAAGAG ATAGTTTGAT TTTTCTGGTT 
GACGCCTCCA GGGCTATGTT TGAATCTCAG GGTGAAGACG AGCTCACACC TTTTGATATG 
AGCATCCAGT GTATCCAGAG TGTGTACACC AGTAAGATCA TAAGCAGCGA TCGGGATCTC 
TTGGCAGTGG TGTTCTATGG TACCGAGAAA GACAAAAATT CAGTGAACTT CAAAAGTATT 
TATGTCTTAC AAGATCTGGA TAACCCAGGA GCTAAACGAG TGTTAGAGCT TGACCGCTTT 
AAGGGACAAC AGGGGAAAAA ACATTTCCGA GACACAATTG GCCATGGGTC TGACTACTCT 
TTGAGTGAAG TGCTCTGGGT CTGTGCCAAC CTCTTCAGCG ACGTCCAGTT CAAGATGAGT 
CATAAGAGGA TCATGCTATT CACCAATGAA GATGACCCCC ATGGTAATGA CAGTGCCAAA 
GCCAGCCGGG CCAGGACCAA AGCCAGCGAT CTGCGGGACA CTGGGATCTT CCTCGACTTG 
ATGCACCTGA AGAAGCGAGG GGGCTTTGAC GTGTCCTTGT TCTACAGAGA CATCATCAGC 
ATCGCTGAGG ATGAGGACCT CGGGGTTCAC TTTGAGGAGT CAAGCAAGCT GGAAGACCTG 
CTAAGGAAGG TTCGAGCCAA GGAGACCAAA AAGCGAGTGC TGTCCAGGTT AAAGTTTAAG 
CTCGGCAAAG ACGTAGCACT CATGGTGGGC GTTTATAACT TGGTCCAGAA AGCTAACAAG 
CCTTTTCCAG TGAGGCTGTA TCGAGAAACA AACGAACCAG TGAAAACTAA GACAAGGACT 
TTTAATGTAA ACACAGGCAG TCTGCTCCTG CCCAGTGATA CCAAGCGGTC TCTGACTTTT 
GGGACGCGTC AGATTGTGCT GGAGAAAGAG GAAACAGAGG AGCTGAAGCG GTTTGATGAG 
CCAGGTTTGA TTCTCATGGG CTTTAAGCCC ATGGTAATGC TGAAGAACCA CCACTACCTG 
AGGCCCTCTC TGTTCCTGTA CCCAGAGGAG TCCTTGGTCA ACGGGAGCTC AACCTTGTTC 
AGCGCCCTGC TCACCAAGTG TGTGGAGAAG GAGGTCATAG CAGTGTGTAG ATACACAGCC 
CGAAAGAATG TCTCCCCTTA TTTTGTGGCT TTGGTGCCAC AGGAAGAGGA GCTAGATGAT 
CAGAACATTC AGGTGACTCC CGCAGGCTTC CAGCTTGTCT TCCTCCCTTA CGCCGATGAC 
AAGCGGAAGG TGCCCTTTAC GGAGAAGGTG ATGGCCAACC CGGAACAGAT AGACAAGATG 
AAGGCCATTG TTCAAAAGCT CCGCTTTACA TACAGGAGCG ACAGTTTCGA GAACCCAGTG 
CTGCAGCAGC ACTTCCGGAA CCTGGAGGCC CTAGCTTTGG ACATGATGGA GTCGGAGCAA 
GTGGTAGATC TGACACTGCC CAAGGTTGAA GCCATAAAGA AAAGACTGGG CTCCCTGGCA 
GATGAGTTTA AAGAACTTGT CTACCCTCCA GGTTATAATC CTGAGGGAAA AATTGCCAAG 
AGAAAAGCAG ACAATGAAGG TTCTGCAAGT AAAAAGCCCA AGGTAGAGTT ATCAGAAGAG 
GAGCTGAAGG ACCTTTTTGC CAAGGGCACA CTGGGCAAGC TCACTGTGCC TGCACTGAGG 
GACATCTGCA AGGCCTATGG GCTAAAGAGT GGACCGAAGA AGCAGGAACT ACTCGAGGCT 
CTCAGCAGAC ACTTGGAGAA GAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620780.2
CDS	85..1911
Translation	MSEWESYYKTEGEEEEEEEQSPDTNGEYKYSGRDSLIFLVDASRAMFESQGEDELTPFDMSIQCIQSVYTSKIISSDRDLLAVVFYGTEKDKNSVNFKSIYVLQDLDNPGAKRVLELDRFKGQQGKKHFRDTIGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDDPHGNDSAKASRARTKASDLRDTGIFLDLMHLKKRGGFDVSLFYRDIISIAEDEDLGVHFEESSKLEDLLRKVRAKETKKRVLSRLKFKLGKDVALMVGVYNLVQKANKPFPVRLYRETNEPVKTKTRTFNVNTGSLLLPSDTKRSLTFGTRQIVLEKEETEELKRFDEPGLILMGFKPMVMLKNHHYLRPSLFLYPEESLVNGSSTLFSALLTKCVEKEVIAVCRYTARKNVSPYFVALVPQEEELDDQNIQVTPAGFQLVFLPYADDKRKVPFTEKVMANPEQIDKMKAIVQKLRFTYRSDSFENPVLQQHFRNLEALALDMMESEQVVDLTLPKVEAIKKRLGSLADEFKELVYPPGYNPEGKIAKRKADNEGSASKKPKVELSEEELKDLFAKGTLGKLTVPALRDICKAYGLKSGPKKQELLEALSRHLEKN

Target ORF information:

RefSeq Version	NM_139080.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus X-ray repair cross complementing 6 (Xrcc6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_139080.2

ORF Insert Sequence:

ATGTCAGAGT GGGAATCCTA CTACAAAACT GAGGGTGAGG AAGAGGAAGA GGAGGAGCAG 
AGCCCTGACA CAAATGGAGA ATATAAATAT TCAGGAAGAG ATAGTTTGAT TTTTCTGGTT 
GACGCCTCCA GGGCTATGTT TGAATCTCAG GGTGAAGACG AGCTCACACC TTTTGATATG 
AGCATCCAGT GTATCCAGAG TGTGTACACC AGTAAGATCA TAAGCAGCGA TCGGGATCTC 
TTGGCAGTGG TGTTCTATGG TACCGAGAAA GACAAAAATT CAGTGAACTT CAAAAGTATT 
TATGTCTTAC AAGATCTGGA TAACCCAGGA GCTAAACGAG TGTTAGAGCT TGACCGCTTT 
AAGGGACAAC AGGGGAAAAA ACATTTCCGA GACACAATTG GCCATGGGTC TGACTACTCT 
TTGAGTGAAG TGCTCTGGGT CTGTGCCAAC CTCTTCAGCG ACGTCCAGTT CAAGATGAGT 
CATAAGAGGA TCATGCTATT CACCAATGAA GATGACCCCC ATGGTAATGA CAGTGCCAAA 
GCCAGCCGGG CCAGGACCAA AGCCAGCGAT CTGCGGGACA CTGGGATCTT CCTCGACTTG 
ATGCACCTGA AGAAGCGAGG GGGCTTTGAC GTGTCCTTGT TCTACAGAGA CATCATCAGC 
ATCGCTGAGG ATGAGGACCT CGGGGTTCAC TTTGAGGAGT CAAGCAAGCT GGAAGACCTG 
CTAAGGAAGG TTCGAGCCAA GGAGACCAAA AAGCGAGTGC TGTCCAGGTT AAAGTTTAAG 
CTCGGCAAAG ACGTAGCACT CATGGTGGGC GTTTATAACT TGGTCCAGAA AGCTAACAAG 
CCTTTTCCAG TGAGGCTGTA TCGAGAAACA AACGAACCAG TGAAAACTAA GACAAGGACT 
TTTAATGTAA ACACAGGCAG TCTGCTCCTG CCCAGTGATA CCAAGCGGTC TCTGACTTTT 
GGGACGCGTC AGATTGTGCT GGAGAAAGAG GAAACAGAGG AGCTGAAGCG GTTTGATGAG 
CCAGGTTTGA TTCTCATGGG CTTTAAGCCC ATGGTAATGC TGAAGAACCA CCACTACCTG 
AGGCCCTCTC TGTTCCTGTA CCCAGAGGAG TCCTTGGTCA ACGGGAGCTC AACCTTGTTC 
AGCGCCCTGC TCACCAAGTG TGTGGAGAAG GAGGTCATAG CAGTGTGTAG ATACACAGCC 
CGAAAGAATG TCTCCCCTTA TTTTGTGGCT TTGGTGCCAC AGGAAGAGGA GCTAGATGAT 
CAGAACATTC AGGTGACTCC CGCAGGCTTC CAGCTTGTCT TCCTCCCTTA CGCCGATGAC 
AAGCGGAAGG TGCCCTTTAC GGAGAAGGTG ATGGCCAACC CGGAACAGAT AGACAAGATG 
AAGGCCATTG TTCAAAAGCT CCGCTTTACA TACAGGAGCG ACAGTTTCGA GAACCCAGTG 
CTGCAGCAGC ACTTCCGGAA CCTGGAGGCC CTAGCTTTGG ACATGATGGA GTCGGAGCAA 
GTGGTAGATC TGACACTGCC CAAGGTTGAA GCCATAAAGA AAAGACTGGG CTCCCTGGCA 
GATGAGTTTA AAGAACTTGT CTACCCTCCA GGTTATAATC CTGAGGGAAA AATTGCCAAG 
AGAAAAGCAG ACAATGAAGG TTCTGCAAGT AAAAAGCCCA AGGTAGAGTT ATCAGAAGAG 
GAGCTGAAGG ACCTTTTTGC CAAGGGCACA CTGGGCAAGC TCACTGTGCC TGCACTGAGG 
GACATCTGCA AGGCCTATGG GCTAAAGAGT GGACCGAAGA AGCAGGAACT ACTCGAGGCT 
CTCAGCAGAC ACTTGGAGAA GAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Xrcc6 ( XM_008765671.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008763893.1 Rattus norvegicus X-ray repair cross complementing 6 (Xrcc6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa42999
Clone ID Related Accession (Same CDS sequence)	XM_008765671.2
Accession Version	XM_008765671.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1665bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	X-ray repair cross-complementing protein 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005106.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008765671.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCAGAGT GGGAATCCTA CTACAAAACT GAGGGTGAGG AAGAGGAAGA GGAGGAGCAG 
AGCCCTGACA CAAATGGAGA ATATAAATAT TCAGGAAGAG ATAGTTTGAT TTTTCTGGTT 
GACGCCTCCA GGGCTATGTT TGAATCTCAG GGTGAAGACG AGCTCACACC TTTTGATATG 
AGCATCCAGT GTATCCAGAG TGTGTACACC AGTAAGATCA TAAGCAGCGA TCGGGATCTC 
TTGGCAGTGG TGTTCTATGG TACCGAGAAA GACAAAAATT CAGTGAACTT CAAAAGTATT 
TATGTCTTAC AAGATCTGGA TAACCCAGGA GCTAAACGAG TGTTAGAGCT TGACCGCTTT 
AAGGGACAAC AGGGGAAAAA ACATTTCCGA GACACAATTG GCCATGGGTC TGACTACTCT 
TTGAGTGAAG TGCTCTGGGT CTGTGCCAAC CTCTTCAGCG ACGTCCAGTT CAAGATGAGT 
CATAAGAGGA TCATGCTATT CACCAATGAA GATGACCCCC ATGGTAATGA CAGTGCCAAA 
GCCAGCCGGG CCAGGACCAA AGCCAGCGAT CTGCGGGACA CTGGGATCTT CCTCGACTTG 
ATGCACCTGA AGAAGCGAGG GGGCTTTGAC GTGTCCTTGT TCTACAGAGA CATCATCAGC 
ATCGCTGAGG ATGAGGACCT CGGGGTTCAC TTTGAGGAGT CAAGCAAGCT GGAAGACCTG 
CTAAGGAAGG TTCGAGCCAA GGAGACCAAA AAGCGAGTGC TGTCCAGGTT AAAGTTTAAG 
CTCGGCAAAG ACGTAGCACT CATGGTGGGC GTTTATAACT TGGTCCAGAA AGCTAACAAG 
CCTTTTCCAG TGAGGCTGTA TCGAGAAACA AACGAACCAG TGAAAACTAA GACAAGGACT 
TTTAATGTAA ACACAGGCAG TCTGCTCCTG CCCAGTGATA CCAAGCGGTC TCTGACTTTT 
GGGACGCGTC AGATTGTGCT GGAGAAAGAG GAAACAGAGG AGCTGAAGCG GTTTGATGAG 
CCAGGTTTGA TTCTCATGGG CTTTAAGCCC ATGGTAATGC TGAAGAACCA CCACTACCTG 
AGGCCCTCTC TGTTCCTGTA CCCAGAGGAG TCCTTGGTCA ACGGCTTCCA GCTTGTCTTC 
CTCCCTTACG CCGATGACAA GCGGAAGGTG CCCTTTACGG AGAAGGTGAT GGCCAACCCG 
GAACAGATAG ACAAGATGAA GGCCATTGTT CAAAAGCTCC GCTTTACATA CAGGAGCGAC 
AGTTTCGAGA ACCCAGTGCT GCAGCAGCAC TTCCGGAACC TGGAGGCCCT AGCTTTGGAC 
ATGATGGAGT CGGAGCAAGT GGTAGATCTG ACACTGCCCA AGGTTGAAGC CATAAAGAAA 
AGACTGGGCT CCCTGGCAGA TGAGTTTAAA GAACTTGTCT ACCCTCCAGG TTATAATCCT 
GAGGGAAAAA TTGCCAAGAG AAAAGCAGAC AATGAAGGTT CTGCAAGTAA AAAGCCCAAG 
GTAGAGTTAT CAGAAGAGGA GCTGAAGGAC CTTTTTGCCA AGGGCACACT GGGCAAGCTC 
ACTGTGCCTG CACTGAGGGA CATCTGCAAG GCCTATGGGC TAAAGAGTGG ACCGAAGAAG 
CAGGAACTAC TCGAGGCTCT CAGCAGACAC TTGGAGAAGA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008763893.1
CDS	96..1760
Translation	MSEWESYYKTEGEEEEEEEQSPDTNGEYKYSGRDSLIFLVDASRAMFESQGEDELTPFDMSIQCIQSVYTSKIISSDRDLLAVVFYGTEKDKNSVNFKSIYVLQDLDNPGAKRVLELDRFKGQQGKKHFRDTIGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDDPHGNDSAKASRARTKASDLRDTGIFLDLMHLKKRGGFDVSLFYRDIISIAEDEDLGVHFEESSKLEDLLRKVRAKETKKRVLSRLKFKLGKDVALMVGVYNLVQKANKPFPVRLYRETNEPVKTKTRTFNVNTGSLLLPSDTKRSLTFGTRQIVLEKEETEELKRFDEPGLILMGFKPMVMLKNHHYLRPSLFLYPEESLVNGFQLVFLPYADDKRKVPFTEKVMANPEQIDKMKAIVQKLRFTYRSDSFENPVLQQHFRNLEALALDMMESEQVVDLTLPKVEAIKKRLGSLADEFKELVYPPGYNPEGKIAKRKADNEGSASKKPKVELSEEELKDLFAKGTLGKLTVPALRDICKAYGLKSGPKKQELLEALSRHLEKN

Target ORF information:

RefSeq Version	XM_008765671.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus X-ray repair cross complementing 6 (Xrcc6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008765671.2

ORF Insert Sequence:

ATGTCAGAGT GGGAATCCTA CTACAAAACT GAGGGTGAGG AAGAGGAAGA GGAGGAGCAG 
AGCCCTGACA CAAATGGAGA ATATAAATAT TCAGGAAGAG ATAGTTTGAT TTTTCTGGTT 
GACGCCTCCA GGGCTATGTT TGAATCTCAG GGTGAAGACG AGCTCACACC TTTTGATATG 
AGCATCCAGT GTATCCAGAG TGTGTACACC AGTAAGATCA TAAGCAGCGA TCGGGATCTC 
TTGGCAGTGG TGTTCTATGG TACCGAGAAA GACAAAAATT CAGTGAACTT CAAAAGTATT 
TATGTCTTAC AAGATCTGGA TAACCCAGGA GCTAAACGAG TGTTAGAGCT TGACCGCTTT 
AAGGGACAAC AGGGGAAAAA ACATTTCCGA GACACAATTG GCCATGGGTC TGACTACTCT 
TTGAGTGAAG TGCTCTGGGT CTGTGCCAAC CTCTTCAGCG ACGTCCAGTT CAAGATGAGT 
CATAAGAGGA TCATGCTATT CACCAATGAA GATGACCCCC ATGGTAATGA CAGTGCCAAA 
GCCAGCCGGG CCAGGACCAA AGCCAGCGAT CTGCGGGACA CTGGGATCTT CCTCGACTTG 
ATGCACCTGA AGAAGCGAGG GGGCTTTGAC GTGTCCTTGT TCTACAGAGA CATCATCAGC 
ATCGCTGAGG ATGAGGACCT CGGGGTTCAC TTTGAGGAGT CAAGCAAGCT GGAAGACCTG 
CTAAGGAAGG TTCGAGCCAA GGAGACCAAA AAGCGAGTGC TGTCCAGGTT AAAGTTTAAG 
CTCGGCAAAG ACGTAGCACT CATGGTGGGC GTTTATAACT TGGTCCAGAA AGCTAACAAG 
CCTTTTCCAG TGAGGCTGTA TCGAGAAACA AACGAACCAG TGAAAACTAA GACAAGGACT 
TTTAATGTAA ACACAGGCAG TCTGCTCCTG CCCAGTGATA CCAAGCGGTC TCTGACTTTT 
GGGACGCGTC AGATTGTGCT GGAGAAAGAG GAAACAGAGG AGCTGAAGCG GTTTGATGAG 
CCAGGTTTGA TTCTCATGGG CTTTAAGCCC ATGGTAATGC TGAAGAACCA CCACTACCTG 
AGGCCCTCTC TGTTCCTGTA CCCAGAGGAG TCCTTGGTCA ACGGCTTCCA GCTTGTCTTC 
CTCCCTTACG CCGATGACAA GCGGAAGGTG CCCTTTACGG AGAAGGTGAT GGCCAACCCG 
GAACAGATAG ACAAGATGAA GGCCATTGTT CAAAAGCTCC GCTTTACATA CAGGAGCGAC 
AGTTTCGAGA ACCCAGTGCT GCAGCAGCAC TTCCGGAACC TGGAGGCCCT AGCTTTGGAC 
ATGATGGAGT CGGAGCAAGT GGTAGATCTG ACACTGCCCA AGGTTGAAGC CATAAAGAAA 
AGACTGGGCT CCCTGGCAGA TGAGTTTAAA GAACTTGTCT ACCCTCCAGG TTATAATCCT 
GAGGGAAAAA TTGCCAAGAG AAAAGCAGAC AATGAAGGTT CTGCAAGTAA AAAGCCCAAG 
GTAGAGTTAT CAGAAGAGGA GCTGAAGGAC CTTTTTGCCA AGGGCACACT GGGCAAGCTC 
ACTGTGCCTG CACTGAGGGA CATCTGCAAG GCCTATGGGC TAAAGAGTGG ACCGAAGAAG 
CAGGAACTAC TCGAGGCTCT CAGCAGACAC TTGGAGAAGA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response.
Molecular cell67(3)387-399.e5(2017 Aug)
Morchikh M,Cribier A,Raffel R,Amraoui S,Cau J,Severac D,Dubois E,Schwartz O,Bennasser Y,Benkirane M

PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway.
Oncotarget7(50)83241-83257(2016 Dec)
Chen H,Han L,Tsai H,Wang Z,Wu Y,Duo Y,Cao W,Chen L,Tan Z,Xu N,Huang X,Zhuang J,Huang L

Regulation of the Ku70 and apoptosis-related proteins in experimental diabetic nephropathy.
Metabolism: clinical and experimental65(10)1466-77(2016 10)
Tun?demir M,?zt?rk M

Heat shock factor 1, an inhibitor of non-homologous end joining repair.
Oncotarget6(30)29712-24(2015 Oct)
Kang GY,Kim EH,Lee HJ,Gil NY,Cha HJ,Lee YS

XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair.
Cell death and differentiation22(6)890-7(2015 Jun)
Craxton A,Somers J,Munnur D,Jukes-Jones R,Cain K,Malewicz M

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Xrcc6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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