Gabrb3 cDNA ORF clone, Rattus norvegicus(Norway rat)

GARLH Family Proteins Stabilize GABA
Yamasaki T, Hoyos-Ramirez E, Martenson JS, Morimoto-Tomita M, Tomita S
Neuron93(5)1138-1152.e6(2017 Mar)

Mutagenesis and computational docking studies support the existence of a histamine binding site at the extracellular ?3+?3- interface of homooligomeric ?3 GABAA receptors.
Hoerbelt P, Ramerstorfer J, Ernst M, Sieghart W, Thomson JL, Hough LB, Fleck MW
Neuropharmacology108252-63(2016 Sep)

?-Aminobutyric Acid Type A (GABAA) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains.
Brown LE, Nicholson MW, Arama JE, Mercer A, Thomson AM, Jovanovic JN
The Journal of biological chemistry291(27)13926-42(2016 Jul)

Epileptic encephalopathy de novo GABRB mutations impair GABA
Janve VS, Hernandez CC, Verdier KM, Hu N, Macdonald RL
Annals of neurology(2016 Mar)

Computational docking analysis supports the existence of a histamine binding site at the interface of homooligomeric Beta3 GABA A receptors.
Title: Mutagenesis and computational docking studies support the existence of a histamine binding site at the extracellular ?3+?3- interface of homooligomeric ?3 GABAA receptors.

The data of this study reveal that GABAA receptor beta2 and beta3 decrease following 1 h of acute restraint stress and may play a critical role in stress-induced hyperalgesia.
Title: Role of spinal GABAA receptor reduction induced by stress in rat thermal hyperalgesia.

Both the Beta3 and delta containing GABA receptors have a unique ethanol binding site at the alpha4/6+Beta3-subunit interface.
Title: Alcohol selectivity of ?3-containing GABAA receptors: evidence for a unique extracellular alcohol/imidazobenzodiazepine Ro15-4513 binding site at the ?+?- subunit interface in ??3? GABAA receptors.

These studies identify a novel gephyrin-binding motif in GABA(A) R beta2 and beta3 large cytoplasmic loops.
Title: Direct binding of GABAA receptor ?2 and ?3 subunits to gephyrin.

Under conditions of oxygen-glucose deprivation that mimic cerebral ischemia, GABRB3 receptors are depleted from synapses in dendrites, depending on the three arginine residues motif.
Title: Stabilization of GABA(A) receptors at endocytic zones is mediated by an AP2 binding motif within the GABA(A) receptor ?3 subunit.