Stat5a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Stat5a
Entrez Gene ID	24918
Full Name	signal transducer and activator of transcription 5A
Synonyms	Stat5
General protein information	Preferred Names signal transducer and activator of transcription 5A Names signal transducer and activator of transcription 5A mammary gland factor signal transducer and activator of transcription 5
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q31
Summary	member of the STAT family of transcription factors; may mediate the biological actions of several interleukin factors (IL2, IL3, IL7) and growth hormones; may be associated with mammary gland function [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017064.1	NP_058760.1	signal transducer and activator of transcription 5A

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	STAT5A	XP_001165870.1
	STAT5A	XP_002800522.1
Anopheles gambiae (African malaria mosquito)	STAT2	XP_311053.3
Anopheles gambiae (African malaria mosquito)	STAT_ANOGA	XP_311525.1
Bos taurus (cattle)	STAT5A	NP_001012691.1
Homo sapiens (human)	STAT5A	NP_003143.2
Mus musculus (house mouse)	Stat5a	NP_035618.1
Rattus norvegicus (Norway rat)	Stat5a	NP_058760.1
Canis lupus familiaris (dog)	STAT5A	XP_859906.1

Gene Ontology
Bibliography

Related articles in PubMed

MRTF-A mediated FN and ICAM-1 expression in AGEs-induced rat glomerular mesangial cells via activating STAT5.
Chen Q, Huang J, Gong W, Chen Z, Huang J, Liu P, Huang H
Molecular and cellular endocrinology460123-133(2018 Jan)

MiR-211/STAT5A Signaling Modulates Migration of Mesenchymal Stem Cells to Improve its Therapeutic Efficacy.
Hu X, Chen P, Wu Y, Wang K, Xu Y, Chen H, Zhang L, Wu R, Webster KA, Yu H, Zhu W, Wang J
Stem cells (Dayton, Ohio)34(7)1846-58(2016 07)

Reproductive Regulation of Gene Expression in the Hypothalamic Supraoptic and Paraventricular Nuclei.
Augustine RA, Bouwer GT, Seymour AJ, Grattan DR, Brown CH
Journal of neuroendocrinology28(4)(2016 Apr)

The Toll-like receptor 4-activated neuroprotective microglia subpopulation survives via granulocyte macrophage colony-stimulating factor and JAK2/STAT5 signaling.
Kamigaki M, Hide I, Yanase Y, Shiraki H, Harada K, Tanaka Y, Seki T, Shirafuji T, Tanaka S, Hide M, Sakai N
Neurochemistry international9382-94(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

STAT3/miR-211/STAT5A signaling plays a key role in mesenchymal stem cell migration.
Title: MiR-211/STAT5A Signaling Modulates Migration of Mesenchymal Stem Cells to Improve its Therapeutic Efficacy.

results suggest that a subpopulation of TLR4-activated microglia may survive by producing GM-CSF and up-regulating GM-CSFR. This autocrine GM-CSF pathway may activate the JAK2/STAT5 signaling pathway
Title: The Toll-like receptor 4-activated neuroprotective microglia subpopulation survives via granulocyte macrophage colony-stimulating factor and JAK2/STAT5 signaling.

Basal renal IL6 mRNA and phosphorylation of its downstream signaling molecule STAT3 were increased as was the product of its action, the suppressor of cytokine signaling 3 (SOCS3) mRNA.
Title: Impaired renal growth hormone JAK/STAT5 signaling in chronic kidney disease.

Data show that STAT5 responsiveness to prolactin is enhanced by reproductive experience in multiple hypothalamic regions.
Title: Region-, neuron-, and signaling pathway-specific increases in prolactin responsiveness in reproductively experienced female rats.

Findings define a novel molecular mechanism for Jak2/Stat5 mediated Suppressor of cytokine signalling-6 (SOCS6) signalling.
Title: Suppressor of cytokine signalling-6 promotes neurite outgrowth via JAK2/STAT5-mediated signalling pathway, involving negative feedback inhibition.

The following Stat5a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Stat5a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02670	NM_017064.1 Latest version!	Rattus norvegicus signal transducer and activator of transcription 5A (Stat5a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$468.30 $669.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Stat5a ( NM_017064.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058760.1 Rattus norvegicus signal transducer and activator of transcription 5A (Stat5a), mRNA.

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CloneID	ORa02670
Clone ID Related Accession (Same CDS sequence)	NM_017064.1
Accession Version	NM_017064.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2382bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Rattus norvegicus(Norway rat)
Product	signal transducer and activator of transcription 5A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U24175.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U24175.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGGCT GGATTCAGGC CCAGCAGCTG CAGGGAGACG CTCTGCGTCA GATGCAAGTG 
TTATATGGGC AACATTTCCC CATCGAGGTC CGGCACTACC TGGCCCAGTG GATCGAGAGC 
CAGCCGTGGG ATGCTATTGA CTTGGACAAT CCCCAGGACC GAGGCCAGGC CACCCAGCTC 
CTGGAGGGCC TGGTGCAGGA GCTGCAGAAG AAGGCAGAAC ACCAGGTGGG GGAAGATGGC 
TTTGTGCTGA AGATCAAGCT GGGGCACTAT GCCACGCAGC TCCAGAACAC GTACGACCGC 
TGTCCCATGG AGCTGGTTCG CTGTATCCGT CACATTCTGT ACAATGAACA GAGGCTGGTC 
CGAGAAGCCA ACAATTGTAG CTCCCCTGCT GGTGTCCTGG TTGACGCCAT GTCCCAGAAG 
CACCTTCAGA TCAACCAAAC GTTTGAGGAG CTGCGCCTGA TCACACAGGA CACGGAGAGC 
GAGCTGAAGA AGCTGCAGCA GACCCAAGAG TACTTCATCA TCCAGTACCA GGAGAGCCTG 
CGGATCCAAG CTCAGTTTGG CCAGCTGGCC CAGCTGAACC CCCAGGAGCG CATGAGCAGG 
GAGACAGCCC TCCAGCAGAA GCAAGTGTCC CTGGAGACCT GGCTGCAGCG AGAGGCACAG 
ACACTGCAGC AGTACCGCGT GGAGCTGGTT GAAAAGCACC AGAAGACCCT GCAGTTGTTG 
AGGAAGCAGC AGACCATCAT CCTGGACGAC GAGCTGATCC AGTGGAAGCG GGGGCAGCAG 
CTGGCCGGGA ACGGGGGTCC CCCCGAGGGC AGCCTGGACG TGCTGCAGTC CTGGTGTGAG 
AAGCTGGCCG AGATCATCTG GCAGAACCGG CAGCAGATCC GCAGGGCTGA GCACCTGTGC 
CAGCAGCTGC CCATCCCTGG CCCCGTGGAG GAGATGTTGG CCGAGGTCAA CGCCACCATC 
ACAGACATCA TCTCAGCCCT GGTCACCAGC ACGTTCATCA TCGAGAAGCA GCCTCCTCAG 
GTCCTGAAGA CCCAGACCAA GTTCGCGGCC ACCGTGCGCC TGCTGGTGGG CGGGAAGCTG 
AACGTGCACA TGAACCCTCC GCAGGTGAAG GCGACCATCA TCAGCGAGCA GCAGGCCAAG 
TCCCTGCTCA AGAACGAGAA CACCCGCAAT GATTACAGTG GCGAGATCCT GAACAACTGC 
TGCGTCATGG AGTACCACCA GGCCACAGGC ACCCTCAGTG CCCACTTCAG AAACATGTCA 
CTGAAAAGAA TCAAGCGTGC TGACAGACGC GGTGCCGAGT CTGTGACGGA GGAGAAGTTC 
ACGGTGCTGT TTGAGTCTCA GTTCAGCGTT GGCAGCAACG AGCTGGTGTT CCAGGTGAAG 
ACCCTGTCCC TCCCTGTGGT CGTCATTGTT CATGGCAGCC AGGACCACAA TGCTACTGCC 
ACCGTGCTGT GGGACAATGC CTTTGCTGAG CCGGGCAGGG TGCCATTTGC CGTGCCTGAC 
AAGGTGCTGT GGCCGCAGCT GTGTGAGGCG CTCAACATGA AGTTCAAGGC TGAGGTGCAG 
AGCAACCGGG GCTTGACCAA GGAGAACCTC GTGTTCCTGG CACAGAAACT GTTCAACAGG 
AGGAGCAACC ACCTCGAGGA CTACAACAGC ATGTCCGTGT CCTGGTCCCA GTTCAACCGG 
GAGAACTTGC CCGGCTGGAA CTATACCTTC TGGCAGTGGT TCGACGGGGT GATGGAGGTG 
CTGAAGAAGC ATCATAAGCC CCACTGGAAT GATGGGGCCA TCTTGGGTTT CGTGAACAAG 
CAGCAGGCCC ATGACCTGCT CATCAACAAG CCAGATGGGA CCTTTCTGCT GCGATTCAGC 
GACTCGGAAA TCGGGGGCAT CACCATTGCT TGGAAGTTTG ACTCCCCGGA CCGAAACCTG 
TGGAATCTGA AGCCATTCAC CACTCGGGAT TTCTCCATTC GGTCCCTGGC GGACCGCCTG 
GGGGATCTGA ATTACCTCAT CTACGTGTTC CCAGACCGAC CCAAGGATGA GGTCTTTGCC 
AAGTACTACA CTCCTGTACT TGCAAAAGCA GTCGACGGAT ACGTGAAGCC ACAGATCAAG 
CAAGTGGTCC CTGAGTTTGT CAATGCTTCT GCAGATGCTG GAGCCAACGC CACCTACATG 
GACCAGGCTC CTTCCCCAGT GGTGTGCCCT CAGGCTCACT ACAACATGTA CCCACCGAAC 
CCCGACCCTG TCCTTGACCA AGATGGTGAA TTTGACCTGG ATGAGACCAT GGATGTTGCC 
AGGCATGTGG AGGAACTTTT ACGCCGGCCC ATGGACAGTC TTGACCCCCG CCTTTCCCCA 
CCTGCTGGCC TCTTCACTTC TGCCAGAAGC TCCTTGTCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058760.1
CDS	51..2432
Translation	MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRGQATQLLEGLVQELQKKAEHQVGEDGFVLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVREANNCSSPAGVLVDAMSQKHLQINQTFEELRLITQDTESELKKLQQTQEYFIIQYQESLRIQAQFGQLAQLNPQERMSRETALQQKQVSLETWLQREAQTLQQYRVELVEKHQKTLQLLRKQQTIILDDELIQWKRGQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNRRSNHLEDYNSMSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPDRNLWNLKPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVFAKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGANATYMDQAPSPVVCPQAHYNMYPPNPDPVLDQDGEFDLDETMDVARHVEELLRRPMDSLDPRLSPPAGLFTSARSSLS

Target ORF information:

RefSeq Version	NM_017064.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus signal transducer and activator of transcription 5A (Stat5a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017064.1

ORF Insert Sequence:

ATGGCGGGCT GGATTCAGGC CCAGCAGCTG CAGGGAGACG CTCTGCGTCA GATGCAAGTG 
TTATATGGGC AACATTTCCC CATCGAGGTC CGGCACTACC TGGCCCAGTG GATCGAGAGC 
CAGCCGTGGG ATGCTATTGA CTTGGACAAT CCCCAGGACC GAGGCCAGGC CACCCAGCTC 
CTGGAGGGCC TGGTGCAGGA GCTGCAGAAG AAGGCAGAAC ACCAGGTGGG GGAAGATGGC 
TTTGTGCTGA AGATCAAGCT GGGGCACTAT GCCACGCAGC TCCAGAACAC GTACGACCGC 
TGTCCCATGG AGCTGGTTCG CTGTATCCGT CACATTCTGT ACAATGAACA GAGGCTGGTC 
CGAGAAGCCA ACAATTGTAG CTCCCCTGCT GGTGTCCTGG TTGACGCCAT GTCCCAGAAG 
CACCTTCAGA TCAACCAAAC GTTTGAGGAG CTGCGCCTGA TCACACAGGA CACGGAGAGC 
GAGCTGAAGA AGCTGCAGCA GACCCAAGAG TACTTCATCA TCCAGTACCA GGAGAGCCTG 
CGGATCCAAG CTCAGTTTGG CCAGCTGGCC CAGCTGAACC CCCAGGAGCG CATGAGCAGG 
GAGACAGCCC TCCAGCAGAA GCAAGTGTCC CTGGAGACCT GGCTGCAGCG AGAGGCACAG 
ACACTGCAGC AGTACCGCGT GGAGCTGGTT GAAAAGCACC AGAAGACCCT GCAGTTGTTG 
AGGAAGCAGC AGACCATCAT CCTGGACGAC GAGCTGATCC AGTGGAAGCG GGGGCAGCAG 
CTGGCCGGGA ACGGGGGTCC CCCCGAGGGC AGCCTGGACG TGCTGCAGTC CTGGTGTGAG 
AAGCTGGCCG AGATCATCTG GCAGAACCGG CAGCAGATCC GCAGGGCTGA GCACCTGTGC 
CAGCAGCTGC CCATCCCTGG CCCCGTGGAG GAGATGTTGG CCGAGGTCAA CGCCACCATC 
ACAGACATCA TCTCAGCCCT GGTCACCAGC ACGTTCATCA TCGAGAAGCA GCCTCCTCAG 
GTCCTGAAGA CCCAGACCAA GTTCGCGGCC ACCGTGCGCC TGCTGGTGGG CGGGAAGCTG 
AACGTGCACA TGAACCCTCC GCAGGTGAAG GCGACCATCA TCAGCGAGCA GCAGGCCAAG 
TCCCTGCTCA AGAACGAGAA CACCCGCAAT GATTACAGTG GCGAGATCCT GAACAACTGC 
TGCGTCATGG AGTACCACCA GGCCACAGGC ACCCTCAGTG CCCACTTCAG AAACATGTCA 
CTGAAAAGAA TCAAGCGTGC TGACAGACGC GGTGCCGAGT CTGTGACGGA GGAGAAGTTC 
ACGGTGCTGT TTGAGTCTCA GTTCAGCGTT GGCAGCAACG AGCTGGTGTT CCAGGTGAAG 
ACCCTGTCCC TCCCTGTGGT CGTCATTGTT CATGGCAGCC AGGACCACAA TGCTACTGCC 
ACCGTGCTGT GGGACAATGC CTTTGCTGAG CCGGGCAGGG TGCCATTTGC CGTGCCTGAC 
AAGGTGCTGT GGCCGCAGCT GTGTGAGGCG CTCAACATGA AGTTCAAGGC TGAGGTGCAG 
AGCAACCGGG GCTTGACCAA GGAGAACCTC GTGTTCCTGG CACAGAAACT GTTCAACAGG 
AGGAGCAACC ACCTCGAGGA CTACAACAGC ATGTCCGTGT CCTGGTCCCA GTTCAACCGG 
GAGAACTTGC CCGGCTGGAA CTATACCTTC TGGCAGTGGT TCGACGGGGT GATGGAGGTG 
CTGAAGAAGC ATCATAAGCC CCACTGGAAT GATGGGGCCA TCTTGGGTTT CGTGAACAAG 
CAGCAGGCCC ATGACCTGCT CATCAACAAG CCAGATGGGA CCTTTCTGCT GCGATTCAGC 
GACTCGGAAA TCGGGGGCAT CACCATTGCT TGGAAGTTTG ACTCCCCGGA CCGAAACCTG 
TGGAATCTGA AGCCATTCAC CACTCGGGAT TTCTCCATTC GGTCCCTGGC GGACCGCCTG 
GGGGATCTGA ATTACCTCAT CTACGTGTTC CCAGACCGAC CCAAGGATGA GGTCTTTGCC 
AAGTACTACA CTCCTGTACT TGCAAAAGCA GTCGACGGAT ACGTGAAGCC ACAGATCAAG 
CAAGTGGTCC CTGAGTTTGT CAATGCTTCT GCAGATGCTG GAGCCAACGC CACCTACATG 
GACCAGGCTC CTTCCCCAGT GGTGTGCCCT CAGGCTCACT ACAACATGTA CCCACCGAAC 
CCCGACCCTG TCCTTGACCA AGATGGTGAA TTTGACCTGG ATGAGACCAT GGATGTTGCC 
AGGCATGTGG AGGAACTTTT ACGCCGGCCC ATGGACAGTC TTGACCCCCG CCTTTCCCCA 
CCTGCTGGCC TCTTCACTTC TGCCAGAAGC TCCTTGTCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MRTF-A mediated FN and ICAM-1 expression in AGEs-induced rat glomerular mesangial cells via activating STAT5.
Molecular and cellular endocrinology460123-133(2018 Jan)
Chen Q,Huang J,Gong W,Chen Z,Huang J,Liu P,Huang H

MiR-211/STAT5A Signaling Modulates Migration of Mesenchymal Stem Cells to Improve its Therapeutic Efficacy.
Stem cells (Dayton, Ohio)34(7)1846-58(2016 07)
Hu X,Chen P,Wu Y,Wang K,Xu Y,Chen H,Zhang L,Wu R,Webster KA,Yu H,Zhu W,Wang J

Reproductive Regulation of Gene Expression in the Hypothalamic Supraoptic and Paraventricular Nuclei.
Journal of neuroendocrinology28(4)(2016 Apr)
Augustine RA,Bouwer GT,Seymour AJ,Grattan DR,Brown CH

The Toll-like receptor 4-activated neuroprotective microglia subpopulation survives via granulocyte macrophage colony-stimulating factor and JAK2/STAT5 signaling.
Neurochemistry international9382-94(2016 Feb)
Kamigaki M,Hide I,Yanase Y,Shiraki H,Harada K,Tanaka Y,Seki T,Shirafuji T,Tanaka S,Hide M,Sakai N

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Stat5a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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