Ugt1a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ugt1a1
Entrez Gene ID	24861
Full Name	UDP glucuronosyltransferase family 1 member A1
Synonyms	UDPGT 1-1,Udpgt,Ugt1
General protein information	Preferred Names UDP glucuronosyltransferase family 1 member A1 Names UDP-glucuronosyltransferase 1-1 B1 UDP glucuronosyltransferase 1 family, polypeptide A1 UDP glycosyltransferase 1 family, polypeptide A1 UDP-glucuronosyltransferase 1 family member 1 UDP-glucuronosyltransferase 1A1 UGT1*1 UGT1-01 UGT1.1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q35
Summary	catalyzes the glucuronidation of bilirubin; plays a role in bilirubin conjugation and excretion [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012683.2	NP_036815.1	UDP-glucuronosyltransferase 1-1 precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	LOC100857136	XP_004942554.1
Danio rerio (zebrafish)	ugt1b5	NP_001170813.1
Danio rerio (zebrafish)	ugt1b3	NP_001170817.1
Mus musculus (house mouse)	Ugt1a1	NP_964007.2
Gallus gallus (chicken)	UGT1A1	XP_003641606.2
Danio rerio (zebrafish)	ugt1b7	NP_001166240.1
Danio rerio (zebrafish)	ugt1b4	NP_001166239.2
Danio rerio (zebrafish)	ugt1a6	NP_001170810.2
Danio rerio (zebrafish)	ugt1a2	NP_001166241.2
Danio rerio (zebrafish)	ugt1b1	NP_001170917.1
Danio rerio (zebrafish)	ugt1b2	NP_001170807.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008401	XP_555044.3
Homo sapiens (human)	UGT1A1	NP_000454.1
	UGT1A1	NP_001028041.1
Bos taurus (cattle)	UGT1A1	NP_001099106.1
Rattus norvegicus (Norway rat)	Ugt1a1	NP_036815.1
Danio rerio (zebrafish)	ugt1ab	NP_998587.2
Danio rerio (zebrafish)	ugt1a4	NP_001170815.2
Danio rerio (zebrafish)	ugt1a1	NP_001032505.2
Danio rerio (zebrafish)	ugt1a5	NP_001170811.2
Danio rerio (zebrafish)	ugt1a7	NP_001170805.1
Drosophila melanogaster (fruit fly)	CG10178	NP_609882.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetic Polymorphisms of SLCO1B1, CYP2E1 and UGT1A1 and Susceptibility to Anti-Tuberculosis Drug-Induced Hepatotoxicity: A Chinese Population-Based Prospective Case-Control Study.
Sun Q, Liu HP, Zheng RJ, Wang P, Liu ZB, Sha W, Xiao HP
Clinical drug investigation37(12)1125-1136(2017 Dec)

Effect of status epilepticus on expression of brain UDP-glucuronosyltransferase 1a in rats.
Asai Y, Tanaka H, Nadai M, Katoh M
Biopharmaceutics & drug disposition(2017 Nov)

Correlations between polymorphisms in the uridine diphosphate-glucuronosyltransferase 1A and C-C motif chemokine receptor 5 genes and infection with the hepatitis B virus in three ethnic groups in China.
Zhang C, He Y, Shan KR, Tan K, Zhang T, Wang CJ, Guan ZZ
The Journal of international medical research300060517730174(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that the up-regulation of phase II detoxification in the DR group was confirmed by mRNA and protein expression levels of uridinediphospho-glucuronosyltransferase and glycine-N-acyltransferase in actual liver tissues.
Title: Enhanced phase II detoxification contributes to beneficial effects of dietary restriction as revealed by multi-platform metabolomics studies.

Both fipronil and fipronil sulfone treatments induced a 2.5-fold increase in Ugt1a1 and Sult1b1 messenger RNA (mRNA) expressions.
Title: CYP450-dependent biotransformation of the insecticide fipronil into fipronil sulfone can mediate fipronil-induced thyroid disruption in rats.

Developmental stage-specific switching of regulation of the rat UGT1 gene complex was found.
Title: Ontogenic isoform switching of UDP-glucuronosyltransferase family 1 in rat liver.

Our findings show that the absence of UGT1 protein from Gunn rat hepatocytes is due to rapid degradation of the truncated UGT1 protein by the proteasome and elucidate the molecular basis underlying the deficiency in bilirubin glucuronidation.
Title: Accelerated degradation of mislocalized UDP-glucuronosyltransferase family 1 (UGT1) proteins in Gunn rat hepatocytes.

These results indicate that the expression of extrahepatic UDP-glucuronosyltransferases UGT1a1 and UGT1a6 is isoform-specific and regulated differentially in tissues by the pituitary gland.
Title: Effects on extrahepatic UDP-glucuronosyltransferases in hypophysectomized rat.

The following Ugt1a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ugt1a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12550	NM_012683.2 Latest version!	Rattus norvegicus UDP glucuronosyltransferase family 1 member A1 (Ugt1a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$314.30 $449.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ugt1a1 ( NM_012683.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036815.1 Rattus norvegicus UDP glucuronosyltransferase family 1 member A1 (Ugt1a1), mRNA.

Price & Availability↑

CloneID	ORa12550
Clone ID Related Accession (Same CDS sequence)	NM_012683.2
Accession Version	NM_012683.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1608bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-01
Organism	Rattus norvegicus(Norway rat)
Product	UDP-glucuronosyltransferase 1-1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC120922.4 and AY435128.1. On Mar 9, 2006 this sequence version replaced NM_012683.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF461736.1, AY435128.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689597, SAMEA2689598 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCGTGG TGTGCCGGAG CTCATGTTCG CTTCTGCTTC TTCCGTGCCT TCTGCTGTGT 
GTGTTGGGTC CCTCTGCGTC CCATGCTGGG AAGCTGTTAG TGATCCCCAT AGATGGCAGC 
CACTGGCTGA GTATGCTCGG AGTTATTCAG CAGCTCCAGC AAAAGGGGCA CGAAGTGGTG 
GTCATAGCAC CTGAAGCTTC GATACACATA AAAGAAGGAT CATTTTACAC TATGAGGAAG 
TACCCTGTGC CATTCCAAAA TGAAAACGTG ACAGCTGCTT TTGTGGAACT TGGGCGGAGT 
GTCTTTGATC AAGATCCTTT TCTGCTGCGT GTGGTTAAAA CATACAACAA AGTCAAAAGG 
GACTCCAGTA TGCTGCTGTC TGGCTGCTCC CACCTTCTGC ACAATGCCGA GTTTATGGCC 
TCTCTGGAAC AAAGCCACTT TGATGCTCTG CTGACAGACC CTTTCCTTCC GTGTGGCTCC 
ATTGTGGCCC AGTACCTGTC TCTGCCTGCT GTGTACTTCT TGAATGCATT GCCATGCAGC 
CTGGATTTGG AAGCCACCCA ATGCCCTGCT CCGTTGTCCT ACGTGCCCAA GAGTTTGTCC 
TCGAACACAG ATCGCATGAA CTTCCTGCAG CGGGTGAAGA ACATGATTAT TGCTTTGACA 
GAGAACTTTC TATGCAGAGT GGTTTACTCC CCCTATGGGT CACTTGCCAC TGAAATCTTA 
CAGAAAGAGG TGACTGTCAA GGACCTTCTG AGTCCTGCAT CTATCTGGCT GATGAGAAAC 
GACTTTGTGA AAGATTACCC CAGGCCCATC ATGCCCAACA TGGTTTTTAT TGGTGGGATA 
AACTGCCTTC AGAAAAAAGC CCTATCCCAG GAATTTGAAG CCTATGTCAA CGCCTCCGGA 
GAACATGGCA TCGTGGTTTT CTCTTTGGGA TCCATGGTCT CAGAGATTCC AGAGAAGAAA 
GCGATGGAAA TTGCTGAGGC TTTGGGCAGA ATTCCTCAGA CGGTCCTGTG GCGCTACACC 
GGAACTAGAC CATCGAACCT TGCAAAGAAC ACTATTCTTG TCAAATGGCT ACCCCAAAAC 
GATCTGCTTG GTCATCCAAA GGCTCGGGCG TTCATCACAC ACTCCGGTTC CCATGGTATT 
TATGAAGGAA TATGCAATGG GGTTCCAATG GTGATGATGC CCTTGTTTGG TGATCAGATG 
GACAACGCCA AGCGCATGGA AACTCGGGGA GCTGGGGTGA CCCTGAATGT CCTGGAAATG 
ACTGCCGATG ATTTGGAAAA CGCCCTTAAA ACTGTCATCA ATAACAAGAG TTACAAGGAG 
AACATCATGC GCCTCTCCAG CCTTCACAAG GACCGTCCTA TCGAGCCTCT GGACCTGGCT 
GTGTTCTGGG TGGAGTACGT GATGAGGCAC AAGGGGGCGC CACACCTGCG CCCCGCCGCC 
CACGACCTCA CCTGGTACCA GTACCACTCC TTGGACGTGA TTGGCTTTCT CCTGGCCATC 
GTGTTGACGG TGGTCTTCAT TGTCTATAAA AGTTGTGCCT ATGGCTGCCG GAAATGCTTT 
GGGGGAAAGG GTCGAGTGAA GAAATCACAC AAATCCAAGA CCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036815.1
CDS	17..1624
Translation	MSVVCRSSCSLLLLPCLLLCVLGPSASHAGKLLVIPIDGSHWLSMLGVIQQLQQKGHEVVVIAPEASIHIKEGSFYTMRKYPVPFQNENVTAAFVELGRSVFDQDPFLLRVVKTYNKVKRDSSMLLSGCSHLLHNAEFMASLEQSHFDALLTDPFLPCGSIVAQYLSLPAVYFLNALPCSLDLEATQCPAPLSYVPKSLSSNTDRMNFLQRVKNMIIALTENFLCRVVYSPYGSLATEILQKEVTVKDLLSPASIWLMRNDFVKDYPRPIMPNMVFIGGINCLQKKALSQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHKSKTH

Target ORF information:

RefSeq Version	NM_012683.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus UDP glucuronosyltransferase family 1 member A1 (Ugt1a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012683.2

ORF Insert Sequence:

ATGTCCGTGG TGTGCCGGAG CTCATGTTCG CTTCTGCTTC TTCCGTGCCT TCTGCTGTGT 
GTGTTGGGTC CCTCTGCGTC CCATGCTGGG AAGCTGTTAG TGATCCCCAT AGATGGCAGC 
CACTGGCTGA GTATGCTCGG AGTTATTCAG CAGCTCCAGC AAAAGGGGCA CGAAGTGGTG 
GTCATAGCAC CTGAAGCTTC GATACACATA AAAGAAGGAT CATTTTACAC TATGAGGAAG 
TACCCTGTGC CATTCCAAAA TGAAAACGTG ACAGCTGCTT TTGTGGAACT TGGGCGGAGT 
GTCTTTGATC AAGATCCTTT TCTGCTGCGT GTGGTTAAAA CATACAACAA AGTCAAAAGG 
GACTCCAGTA TGCTGCTGTC TGGCTGCTCC CACCTTCTGC ACAATGCCGA GTTTATGGCC 
TCTCTGGAAC AAAGCCACTT TGATGCTCTG CTGACAGACC CTTTCCTTCC GTGTGGCTCC 
ATTGTGGCCC AGTACCTGTC TCTGCCTGCT GTGTACTTCT TGAATGCATT GCCATGCAGC 
CTGGATTTGG AAGCCACCCA ATGCCCTGCT CCGTTGTCCT ACGTGCCCAA GAGTTTGTCC 
TCGAACACAG ATCGCATGAA CTTCCTGCAG CGGGTGAAGA ACATGATTAT TGCTTTGACA 
GAGAACTTTC TATGCAGAGT GGTTTACTCC CCCTATGGGT CACTTGCCAC TGAAATCTTA 
CAGAAAGAGG TGACTGTCAA GGACCTTCTG AGTCCTGCAT CTATCTGGCT GATGAGAAAC 
GACTTTGTGA AAGATTACCC CAGGCCCATC ATGCCCAACA TGGTTTTTAT TGGTGGGATA 
AACTGCCTTC AGAAAAAAGC CCTATCCCAG GAATTTGAAG CCTATGTCAA CGCCTCCGGA 
GAACATGGCA TCGTGGTTTT CTCTTTGGGA TCCATGGTCT CAGAGATTCC AGAGAAGAAA 
GCGATGGAAA TTGCTGAGGC TTTGGGCAGA ATTCCTCAGA CGGTCCTGTG GCGCTACACC 
GGAACTAGAC CATCGAACCT TGCAAAGAAC ACTATTCTTG TCAAATGGCT ACCCCAAAAC 
GATCTGCTTG GTCATCCAAA GGCTCGGGCG TTCATCACAC ACTCCGGTTC CCATGGTATT 
TATGAAGGAA TATGCAATGG GGTTCCAATG GTGATGATGC CCTTGTTTGG TGATCAGATG 
GACAACGCCA AGCGCATGGA AACTCGGGGA GCTGGGGTGA CCCTGAATGT CCTGGAAATG 
ACTGCCGATG ATTTGGAAAA CGCCCTTAAA ACTGTCATCA ATAACAAGAG TTACAAGGAG 
AACATCATGC GCCTCTCCAG CCTTCACAAG GACCGTCCTA TCGAGCCTCT GGACCTGGCT 
GTGTTCTGGG TGGAGTACGT GATGAGGCAC AAGGGGGCGC CACACCTGCG CCCCGCCGCC 
CACGACCTCA CCTGGTACCA GTACCACTCC TTGGACGTGA TTGGCTTTCT CCTGGCCATC 
GTGTTGACGG TGGTCTTCAT TGTCTATAAA AGTTGTGCCT ATGGCTGCCG GAAATGCTTT 
GGGGGAAAGG GTCGAGTGAA GAAATCACAC AAATCCAAGA CCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic Polymorphisms of SLCO1B1, CYP2E1 and UGT1A1 and Susceptibility to Anti-Tuberculosis Drug-Induced Hepatotoxicity: A Chinese Population-Based Prospective Case-Control Study.
Clinical drug investigation37(12)1125-1136(2017 Dec)
Sun Q,Liu HP,Zheng RJ,Wang P,Liu ZB,Sha W,Xiao HP

Effect of status epilepticus on expression of brain UDP-glucuronosyltransferase 1a in rats.
Biopharmaceutics & drug disposition(2017 Nov)
Asai Y,Tanaka H,Nadai M,Katoh M

Correlations between polymorphisms in the uridine diphosphate-glucuronosyltransferase 1A and C-C motif chemokine receptor 5 genes and infection with the hepatitis B virus in three ethnic groups in China.
The Journal of international medical research300060517730174(2017 Jan)
Zhang C,He Y,Shan KR,Tan K,Zhang T,Wang CJ,Guan ZZ

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Ugt1a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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