Ugt1a1 cDNA ORF clone, Mus musculus(house mouse)

UDP-glucuronosyltransferase 1a enzymes are present and active in the mouse blastocyst.
Collier AC, Yamauchi Y, Sato BL, Roug?e LR, Ward MA
Drug metabolism and disposition: the biological fate of chemicals42(11)1921-5(2014 Nov)

Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11).
Chen S, Yueh MF, Bigo C, Barbier O, Wang K, Karin M, Nguyen N, Tukey RH
Proceedings of the National Academy of Sciences of the United States of America110(47)19143-8(2013 Nov)

Rescue of bilirubin-induced neonatal lethality in a mouse model of Crigler-Najjar syndrome type I by AAV9-mediated gene transfer.
Bortolussi G, Zentilin L, Baj G, Giraudi P, Bellarosa C, Giacca M, Tiribelli C, Muro AF
FASEB journal : official publication of the Federation of American Societies for Experimental Biology26(3)1052-63(2012 Mar)

Effect of oncostatin M on uridine diphosphate-5'-glucuronosyltransferase 1A1 through cross talk with constitutive androstane receptor.
Masuyama H, Nakatsukasa H, Hiramatsu Y
Molecular endocrinology (Baltimore, Md.)24(4)745-53(2010 Apr)

data confirm that Ugt1a proteins are present and active in preimplantation murine embryos and point to a potential role for these proteins in implantation and early embryonic and fetal development
Title: UDP-glucuronosyltransferase 1a enzymes are present and active in the mouse blastocyst.

Intestinal induction of the UGT1A1 gene may serve to limit toxicity and improve the efficacy associated with CPT-11 colorectal cancer treatment.
Title: Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11).

Data observed that OSM positively augmented the CAR and UGT1A1 expressions and CAR-mediated signaling in vivo and in vitro, through cross talk between the nuclear CAR receptor and the plasma membrane OSM receptor, via the MAPK cascade.
Title: Effect of oncostatin M on uridine diphosphate-5'-glucuronosyltransferase 1A1 through cross talk with constitutive androstane receptor.

suppression of AhR signaling pathway is associated with the down-regulation of Ugt1a mRNA during urinary bladder carcinogenesis.
Title: Suppression of AhR signaling pathway is associated with the down-regulation of UDP-glucuronosyltransferases during BBN-induced urinary bladder carcinogenesis in mice.

the loss of UGT1A function in Ugt1(-/-) mice leads to a metabolic syndrome that can serve as a model to further investigate the toxicities associated with unconjugated bilirubin and the impact of this disease in humans.
Title: Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease.