Tap1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tap1
Entrez Gene ID	24811
Full Name	transporter 1, ATP binding cassette subfamily B member
Synonyms	Abcb2,Cim,Tap2
General protein information	Preferred Names transporter 1, ATP binding cassette subfamily B member Names antigen peptide transporter 1 APT1 ATP-binding cassette sub-family B member 2 peptide transporter TAP1 transporter 1 ABC (ATP binding cassette) transporter 1 ATP-binding cassette sub-family B transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20p12
Summary	has similarity to multidrug resistant transporters; may transport antigenic peptides across the endoplasmic reticulum membrane in preparation for MHC class I presentation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_032055.4	NP_114444.2	antigen peptide transporter 1 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Tap1	NP_038711.2
Rattus norvegicus (Norway rat)	Tap1	NP_114444.2
Xenopus tropicalis (tropical clawed frog)	LOC100488534	XP_002942646.1
Danio rerio (zebrafish)	tap1	XP_002665053.1
Canis lupus familiaris (dog)	TAP1	XP_005627251.1
Gallus gallus (chicken)	TAP1	NP_001129440.1
Homo sapiens (human)	TAP1	NP_000584.2
Pan troglodytes (chimpanzee)	TAP1	XP_001166911.2
	TAP1	XP_001115506.1
Bos taurus (cattle)	TAP1	NP_001091527.1

Gene Ontology
Bibliography

Related articles in PubMed

D-helix influences dimerization of the ATP-binding cassette (ABC) transporter associated with antigen processing 1 (TAP1) nucleotide-binding domain.
Vakkasoglu AS, Srikant S, Gaudet R
PloS one12(5)e0178238(2017)

Natural polymorphisms in Tap2 influence negative selection and CD4?CD8 lineage commitment in the rat.
Tuncel J, Haag S, Yau AC, Norin U, Baud A, L?nnblom E, Maratou K, Ytterberg AJ, Ekman D, Thordardottir S, Johannesson M, Gillett A, , Stridh P, Jagodic M, Olsson T, Fern?ndez-Teruel A, Zubarev RA, Mott R, Aitman TJ, Flint J, Holmdahl R
PLoS genetics10(2)e1004151(2014 Feb)

Association of TAP 1 and 2 gene polymorphisms with human immunodeficiency virus-tuberculosis co-infection.
Sunder SR, Hanumanth SR, Gaddam S, Jonnalagada S, Valluri VL
Human immunology72(10)908-11(2011 Oct)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

Down-regulation of HLA class I antigen-processing machinery components in esophageal squamous cell carcinomas: association with disease progression.
Liu Q, Hao C, Su P, Shi J
Scandinavian journal of gastroenterology44(8)960-9(2009)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study compared the biochemical properties of the nucleotide-binding domains (NBD) of human and rat TAP1; suggests that although the D-helix sequence is not conserved in ABC transporters, its precise positioning within the NBD structure has a critical role in NBD dimerization.
Title: D-helix influences dimerization of the ATP-binding cassette (ABC) transporter associated with antigen processing 1 (TAP1) nucleotide-binding domain.

The transmembrane core complex of transporter associated with antigen processing (TAP)1 and TAP2 is sufficient for UL49.5 protein of bovine herpesvirus type-1 to mediate its inhibitory activity.
Title: The varicellovirus UL49.5 protein blocks the transporter associated with antigen processing (TAP) by inhibiting essential conformational transitions in the 6+6 transmembrane TAP core complex.

TAP subunits alternate in the recruitment and loading of a single MHC class I
Title: Molecular architecture of the TAP-associated MHC class I peptide-loading complex.

the biogenesis of functional TAP depends on the assembly of preexisting TAP1 with newly synthesized TAP2, but not vice versa
Title: Biogenesis of functional antigenic peptide transporter TAP requires assembly of pre-existing TAP1 with newly synthesized TAP2.

the distinct nucleotide binding behaviour of TAP1 and TAP2 is controlled by the nonhomologous C-terminal tails of the two TAP chains
Title: The distinct nucleotide binding states of the transporter associated with antigen processing (TAP) are regulated by the nonhomologous C-terminal tails of TAP1 and TAP2.

The following Tap1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tap1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12134	NM_032055.4 Latest version!	Rattus norvegicus transporter 1, ATP binding cassette subfamily B member (Tap1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tap1 ( NM_032055.4 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_114444.2 Rattus norvegicus transporter 1, ATP binding cassette subfamily B member (Tap1), mRNA.

Price & Availability↑

CloneID	ORa12134
Clone ID Related Accession (Same CDS sequence)	NM_032055.4
Accession Version	NM_032055.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2178bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Rattus norvegicus(Norway rat)
Product	antigen peptide transporter 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX883043.1, Y10234.1 and BC101854.1. On Sep 17, 2009 this sequence version replaced NM_032055.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC101854.1, Y10230.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCGC ACGCCTGGCC GACGGCCGCC TTGCTGCTGC TGCTGGTGGA CTGGCTGCTG 
CTGCGGCCCG TGCTCCCGGG AATCTTCTCC CTGTTGGTTC CCGAGGTGCC GCTGCTCCGG 
GTCTGGGCCG TGGGCTTGAG TCGCTGGGCT ATCCTGGGAC TAGGGGTCCG CGGGGTCCTC 
GGGGTCACCG CGGGAGCCCG TGGCTGGCTG GCTGCTTTGC AGCCGCTGGT GGCGGCGCTG 
GGTTTGGCCC TGCCTGGACT TGCCTCGTTC CGAAAGCTGT CCGCCTGGGG AGCACTCCGG 
GAGGGTGACA ACGCTGGACT GCTCCACTGG AACAGTCGCT TAGATGCCTT CGTTCTCAGT 
TATGTGGCCG CATTGCCCGC AGCTGCCCTG TGGCACAAGT TGGGGGGCTT CTGGGCGCCC 
AGTGGCCACA AGGGCGCTGG AGACATGCTG TGTCGGATGC TAGGCTTCCT GGACTCCAAG 
AAGGGGCGTC TCCACCTGGT TCTGGTTCTC TTGATCCTCT CCTGCCTTGG GGAAATGGCC 
ATTCCCTTCT TCACAGGCCG CATCACTGAC TGGATCCTTC AGGATAAGAC AGCCCCCAGC 
TTCGCCCGCA ACATGTGGCT CATGTGTATT CTTACCGTAG CCAGTACAGC GCTGGAGTTT 
GCAGGAGATG GAATCTACAA CATCACCATG GGCCACATGC ACAGCCGCGT GCATGGAGAG 
GTGTTTCGGG CCGTCCTTCA CCAGGAGACA GGATTTTTCC TGAAGAACCC AACAGGTTCC 
ATCACATCTC GGGTGACTGA GGACACCTCC AACGTGTGCG AGTCCATTAG TGACAAGCTG 
AACCTGTTCC TGTGGTACCT GGGGCGAGGC CTGTGTCTCC TGGCGTTCAT GATTTGGGGG 
TCATTCTACC TCACTGTGGT CACCCTGCTC AGCCTGCCTC TGCTTTTCCT TCTGCCCAGG 
AGGCTGGGGA AAGTGTACCA GTCACTGGCA GTGAAGGTGC AGGAGTCTCT AGCAAAGTCC 
ACGCAGGTGG CCCTCGAGGC CCTGTCGGCG ATGCCTACCG TACGGAGCTT TGCCAACGAG 
GAGGGAGAGG CCCAGAAGTT TAGGCAGAAG TTGGAAGAAA TGAAGCCGCT AAACAAGAAA 
GAGGCCCTGG CTTACGTCAC CGAAGTCTGG ACCATGAGTG TCTCGGGAAT GCTGCTGAAG 
GTGGGAATTC TGTACCTCGG TGGGCAGCTG GTGGTCAGAG GGGCTGTCAG CAGCGGCAAC 
CTCGTCTCCT TTGTTCTCTA CCAGCTTCAG TTCACCAGGG CCGTGGAGGT CCTGCTCTCC 
ATCTATCCCT CCATGCAGAA GTCCGTGGGC GCCTCGGAGA AAATATTCGA ATACCTGGAC 
CGGACTCCCT GCTCTCCGCT CAGTGGCTCA CTGGCACCTT TAAACATGAA AGGCCTCGTC 
AAGTTCCAAG ATGTCTCCTT TGCCTACCCA AACCATCCCA ACGTCCAGGT GCTTCAGGGG 
CTGACTTTTA CGCTGTATCC CGGGAAGGTG ACTGCCTTGG TGGGACCCAA TGGGTCAGGG 
AAGAGCACCG TGGCCGCCCT GCTGCAGAAC CTGTACCAGC CCACCGGGGG CAAGGTGCTC 
CTGGATGGCG AGCTCCTGGT CCAGTATGAT CACCACTACC TGCACACGCA GGTGGCCGCA 
GTGGGACAAG AGCCACTGCT ATTTGGAAGA AGTTTTCGGG AAAATATTGC CTATGGCCTG 
ACGCGGACTC CAACCATGGA GGAAATCACA GCTGTGGCCA TGGAGTCCGG AGCCCACGAT 
TTCATCTCTG GATTCCCTCA GGGCTATGAC ACAGAGGTAG GTGAAACTGG GAACCAGCTG 
TCAGGAGGTC AGCGACAGGC GGTGGCCTTG GCTCGAGCCT TGATCCGGAA GCCACGCCTG 
CTTATCTTGG ACGATGCCAC CAGTGCCCTG GATGCTGGCA ACCAGCTACG GGTCCAGCGG 
CTCCTGTATG AGAGCCCCGA GTGGGCCTCT CGGACGGTTC TTCTGATCAC CCAGCAGCTC 
AGCCTGGCAG AGCGGGCCCA CCACATCCTC TTCCTCAAAG AAGGCTCTGT CTGCGAGCAG 
GGCACCCACC TGCAGCTCAT GGAGAGAGGA GGGTGTTACC GGTCCATGGT GGAGGCTCTT 
GCGGCTCCTT CAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114444.2
CDS	60..2237
Translation	MAAHAWPTAALLLLLVDWLLLRPVLPGIFSLLVPEVPLLRVWAVGLSRWAILGLGVRGVLGVTAGARGWLAALQPLVAALGLALPGLASFRKLSAWGALREGDNAGLLHWNSRLDAFVLSYVAALPAAALWHKLGGFWAPSGHKGAGDMLCRMLGFLDSKKGRLHLVLVLLILSCLGEMAIPFFTGRITDWILQDKTAPSFARNMWLMCILTVASTALEFAGDGIYNITMGHMHSRVHGEVFRAVLHQETGFFLKNPTGSITSRVTEDTSNVCESISDKLNLFLWYLGRGLCLLAFMIWGSFYLTVVTLLSLPLLFLLPRRLGKVYQSLAVKVQESLAKSTQVALEALSAMPTVRSFANEEGEAQKFRQKLEEMKPLNKKEALAYVTEVWTMSVSGMLLKVGILYLGGQLVVRGAVSSGNLVSFVLYQLQFTRAVEVLLSIYPSMQKSVGASEKIFEYLDRTPCSPLSGSLAPLNMKGLVKFQDVSFAYPNHPNVQVLQGLTFTLYPGKVTALVGPNGSGKSTVAALLQNLYQPTGGKVLLDGELLVQYDHHYLHTQVAAVGQEPLLFGRSFRENIAYGLTRTPTMEEITAVAMESGAHDFISGFPQGYDTEVGETGNQLSGGQRQAVALARALIRKPRLLILDDATSALDAGNQLRVQRLLYESPEWASRTVLLITQQLSLAERAHHILFLKEGSVCEQGTHLQLMERGGCYRSMVEALAAPSD

Target ORF information:

RefSeq Version	NM_032055.4
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus transporter 1, ATP binding cassette subfamily B member (Tap1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032055.4

ORF Insert Sequence:

ATGGCTGCGC ACGCCTGGCC GACGGCCGCC TTGCTGCTGC TGCTGGTGGA CTGGCTGCTG 
CTGCGGCCCG TGCTCCCGGG AATCTTCTCC CTGTTGGTTC CCGAGGTGCC GCTGCTCCGG 
GTCTGGGCCG TGGGCTTGAG TCGCTGGGCT ATCCTGGGAC TAGGGGTCCG CGGGGTCCTC 
GGGGTCACCG CGGGAGCCCG TGGCTGGCTG GCTGCTTTGC AGCCGCTGGT GGCGGCGCTG 
GGTTTGGCCC TGCCTGGACT TGCCTCGTTC CGAAAGCTGT CCGCCTGGGG AGCACTCCGG 
GAGGGTGACA ACGCTGGACT GCTCCACTGG AACAGTCGCT TAGATGCCTT CGTTCTCAGT 
TATGTGGCCG CATTGCCCGC AGCTGCCCTG TGGCACAAGT TGGGGGGCTT CTGGGCGCCC 
AGTGGCCACA AGGGCGCTGG AGACATGCTG TGTCGGATGC TAGGCTTCCT GGACTCCAAG 
AAGGGGCGTC TCCACCTGGT TCTGGTTCTC TTGATCCTCT CCTGCCTTGG GGAAATGGCC 
ATTCCCTTCT TCACAGGCCG CATCACTGAC TGGATCCTTC AGGATAAGAC AGCCCCCAGC 
TTCGCCCGCA ACATGTGGCT CATGTGTATT CTTACCGTAG CCAGTACAGC GCTGGAGTTT 
GCAGGAGATG GAATCTACAA CATCACCATG GGCCACATGC ACAGCCGCGT GCATGGAGAG 
GTGTTTCGGG CCGTCCTTCA CCAGGAGACA GGATTTTTCC TGAAGAACCC AACAGGTTCC 
ATCACATCTC GGGTGACTGA GGACACCTCC AACGTGTGCG AGTCCATTAG TGACAAGCTG 
AACCTGTTCC TGTGGTACCT GGGGCGAGGC CTGTGTCTCC TGGCGTTCAT GATTTGGGGG 
TCATTCTACC TCACTGTGGT CACCCTGCTC AGCCTGCCTC TGCTTTTCCT TCTGCCCAGG 
AGGCTGGGGA AAGTGTACCA GTCACTGGCA GTGAAGGTGC AGGAGTCTCT AGCAAAGTCC 
ACGCAGGTGG CCCTCGAGGC CCTGTCGGCG ATGCCTACCG TACGGAGCTT TGCCAACGAG 
GAGGGAGAGG CCCAGAAGTT TAGGCAGAAG TTGGAAGAAA TGAAGCCGCT AAACAAGAAA 
GAGGCCCTGG CTTACGTCAC CGAAGTCTGG ACCATGAGTG TCTCGGGAAT GCTGCTGAAG 
GTGGGAATTC TGTACCTCGG TGGGCAGCTG GTGGTCAGAG GGGCTGTCAG CAGCGGCAAC 
CTCGTCTCCT TTGTTCTCTA CCAGCTTCAG TTCACCAGGG CCGTGGAGGT CCTGCTCTCC 
ATCTATCCCT CCATGCAGAA GTCCGTGGGC GCCTCGGAGA AAATATTCGA ATACCTGGAC 
CGGACTCCCT GCTCTCCGCT CAGTGGCTCA CTGGCACCTT TAAACATGAA AGGCCTCGTC 
AAGTTCCAAG ATGTCTCCTT TGCCTACCCA AACCATCCCA ACGTCCAGGT GCTTCAGGGG 
CTGACTTTTA CGCTGTATCC CGGGAAGGTG ACTGCCTTGG TGGGACCCAA TGGGTCAGGG 
AAGAGCACCG TGGCCGCCCT GCTGCAGAAC CTGTACCAGC CCACCGGGGG CAAGGTGCTC 
CTGGATGGCG AGCTCCTGGT CCAGTATGAT CACCACTACC TGCACACGCA GGTGGCCGCA 
GTGGGACAAG AGCCACTGCT ATTTGGAAGA AGTTTTCGGG AAAATATTGC CTATGGCCTG 
ACGCGGACTC CAACCATGGA GGAAATCACA GCTGTGGCCA TGGAGTCCGG AGCCCACGAT 
TTCATCTCTG GATTCCCTCA GGGCTATGAC ACAGAGGTAG GTGAAACTGG GAACCAGCTG 
TCAGGAGGTC AGCGACAGGC GGTGGCCTTG GCTCGAGCCT TGATCCGGAA GCCACGCCTG 
CTTATCTTGG ACGATGCCAC CAGTGCCCTG GATGCTGGCA ACCAGCTACG GGTCCAGCGG 
CTCCTGTATG AGAGCCCCGA GTGGGCCTCT CGGACGGTTC TTCTGATCAC CCAGCAGCTC 
AGCCTGGCAG AGCGGGCCCA CCACATCCTC TTCCTCAAAG AAGGCTCTGT CTGCGAGCAG 
GGCACCCACC TGCAGCTCAT GGAGAGAGGA GGGTGTTACC GGTCCATGGT GGAGGCTCTT 
GCGGCTCCTT CAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

D-helix influences dimerization of the ATP-binding cassette (ABC) transporter associated with antigen processing 1 (TAP1) nucleotide-binding domain.
PloS one12(5)e0178238(2017)
Vakkasoglu AS,Srikant S,Gaudet R

Natural polymorphisms in Tap2 influence negative selection and CD4?CD8 lineage commitment in the rat.
PLoS genetics10(2)e1004151(2014 Feb)
Tuncel J,Haag S,Yau AC,Norin U,Baud A,L?nnblom E,Maratou K,Ytterberg AJ,Ekman D,Thordardottir S,Johannesson M,Gillett A,,Stridh P,Jagodic M,Olsson T,Fern?ndez-Teruel A,Zubarev RA,Mott R,Aitman TJ,Flint J,Holmdahl R

Association of TAP 1 and 2 gene polymorphisms with human immunodeficiency virus-tuberculosis co-infection.
Human immunology72(10)908-11(2011 Oct)
Sunder SR,Hanumanth SR,Gaddam S,Jonnalagada S,Valluri VL

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

Down-regulation of HLA class I antigen-processing machinery components in esophageal squamous cell carcinomas: association with disease progression.
Scandinavian journal of gastroenterology44(8)960-9(2009)
Liu Q,Hao C,Su P,Shi J

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Tap1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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