TAP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TAP1
Entrez Gene ID	6890
Full Name	transporter 1, ATP binding cassette subfamily B member
Synonyms	ABC17,ABCB2,APT1,D6S114E,PSF-1,PSF1,RING4,TAP1*0102N,TAP1N
General protein information	Preferred Names transporter 1, ATP binding cassette subfamily B member Names antigen peptide transporter 1 ABC transporter, MHC 1 ATP-binding cassette sub-family B member 2 ATP-binding cassette, sub-family B (MDR/TAP), member 2 peptide supply factor 1 peptide transporter PSF1 peptide transporter TAP1 peptide transporter involved in antigen processing 1 really interesting new gene 4 protein transporter 1 ATP-binding cassette sub-family B transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) transporter associated with antigen processing transporter, ATP-binding cassette, major histocompatibility complex, 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.32
Summary	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014].
Disorder MIM:	170260
Disorder Html:	Bare lymphocyte syndrome, type I, 604571 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000593.5	NP_000584.2	antigen peptide transporter 1 isoform 1
NM_001292022.2	NP_001278951.1	antigen peptide transporter 1 isoform 2
NM_001292022.1	NP_001278951.1	antigen peptide transporter 1 isoform 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Tap1	NP_038711.2
Rattus norvegicus (Norway rat)	Tap1	NP_114444.2
Xenopus tropicalis (tropical clawed frog)	LOC100488534	XP_002942646.1
Danio rerio (zebrafish)	tap1	XP_002665053.1
Canis lupus familiaris (dog)	TAP1	XP_005627251.1
Gallus gallus (chicken)	TAP1	NP_001129440.1
Homo sapiens (human)	TAP1	NP_000584.2
Pan troglodytes (chimpanzee)	TAP1	XP_001166911.2
	TAP1	XP_001115506.1
Bos taurus (cattle)	TAP1	NP_001091527.1

Gene Ontology
Bibliography

Related articles in PubMed

Downregulation of TAP1 and TAP2 in early stage breast cancer.
Henle AM, Nassar A, Puglisi-Knutson D, Youssef B, Knutson KL
PloS one12(11)e0187323(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study shows that TAP1 plays a novel role in the negative regulation of virus-triggered NF-kappaB signaling and the innate immune response by targeting the TAK1 complex
Title: Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex.

Significant associations between sorafenib exposure and the studied polymorphisms were observed for ABCB2
Title: Correlation between clinical response to sorafenib in hepatocellular carcinoma treatment and polymorphisms of P-glycoprotein (ABCB1) and of breast cancer resistance protein (ABCG2): monocentric study.

PSMB8 rs2071464 was associated with generalized and active vitiligo from Gujarat whereas TAP1 rs1135216 showed no association. The down-regulation of PSMB8 in patients with risk genotype 'CC' advocates the vital role of PSMB8 in the autoimmune basis of vitiligo.
Title: A case-control study on association of proteasome subunit beta 8 (PSMB8) and transporter associated with antigen processing 1 (TAP1) polymorphisms and their transcript levels in vitiligo from Gujarat.

Both TAP1 and TAP2 overexpression in breast cancer might be an indicator of an aggressive breast tumor
Title: Downregulation of TAP1 and TAP2 in early stage breast cancer.

Study compared the biochemical properties of the nucleotide-binding domains (NBD) of human and rat TAP1; suggests that although the D-helix sequence is not conserved in ABC transporters, its precise positioning within the NBD structure has a critical role in NBD dimerization.
Title: D-helix influences dimerization of the ATP-binding cassette (ABC) transporter associated with antigen processing 1 (TAP1) nucleotide-binding domain.

The following TAP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TAP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24630	NM_000593.5 Latest version!	Homo sapiens transporter 1, ATP binding cassette subfamily B member (TAP1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu24644	NM_001292022.2 Latest version!	Homo sapiens transporter 1, ATP binding cassette subfamily B member (TAP1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu24644	NM_001292022.1	Homo sapiens transporter 1, ATP binding cassette subfamily B member (TAP1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TAP1 ( NM_000593.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000584.2 Homo sapiens transporter 1, ATP binding cassette subfamily B member (TAP1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu24630
Clone ID Related Accession (Same CDS sequence)	NM_000593.5
Accession Version	NM_000593.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2427bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	antigen peptide transporter 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC014081.2. This sequence is a reference standard in the RefSeqGene project. On Oct 4, 2004 this sequence version replaced NM_000593.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC014081.2, SRR1803613.188287.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGAGC TTCTCGCCAG CGCAGGATCA GCCTGTTCCT GGGACTTTCC GAGAGCCCCG 
CCCTCGTTCC CTCCCCCAGC CGCCAGTAGG GGAGGACTCG GCGGTACCCG GAGCTTCAGG 
CCCCACCGGG GCGCGGAGAG TCCCAGGCCC GGCCGGGACC GGGACGGCGT CCGAGTGCCA 
ATGGCTAGCT CTAGGTGTCC CGCTCCCCGC GGGTGCCGCT GCCTCCCCGG AGCTTCTCTC 
GCATGGCTGG GGACAGTACT GCTACTTCTC GCCGACTGGG TGCTGCTCCG GACCGCGCTG 
CCCCGCATAT TCTCCCTGCT GGTGCCCACC GCGCTGCCAC TGCTCCGGGT CTGGGCGGTG 
GGCCTGAGCC GCTGGGCCGT GCTCTGGCTG GGGGCCTGCG GGGTCCTCAG GGCAACGGTT 
GGCTCCAAGA GCGAAAACGC AGGTGCCCAG GGCTGGCTGG CTGCTTTGAA GCCATTAGCT 
GCGGCACTGG GCTTGGCCCT GCCGGGACTT GCCTTGTTCC GAGAGCTGAT CTCATGGGGA 
GCCCCCGGGT CCGCGGATAG CACCAGGCTA CTGCACTGGG GAAGTCACCC TACCGCCTTC 
GTTGTCAGTT ATGCAGCGGC ACTGCCCGCA GCAGCCCTGT GGCACAAACT CGGGAGCCTC 
TGGGTGCCCG GCGGTCAGGG CGGCTCTGGA AACCCTGTGC GTCGGCTTCT AGGCTGCCTG 
GGCTCGGAGA CGCGCCGCCT CTCGCTGTTC CTGGTCCTGG TGGTCCTCTC CTCTCTTGGG 
GAGATGGCCA TTCCATTCTT TACGGGCCGC CTCACTGACT GGATTCTACA AGATGGCTCA 
GCCGATACCT TCACTCGAAA CTTAACTCTC ATGTCCATTC TCACCATAGC CAGTGCAGTG 
CTGGAGTTCG TGGGTGACGG GATCTATAAC AACACCATGG GCCACGTGCA CAGCCACTTG 
CAGGGAGAGG TGTTTGGGGC TGTCCTGCGC CAGGAGACGG AGTTTTTCCA ACAGAACCAG 
ACAGGTAACA TCATGTCTCG GGTAACAGAG GACACGTCCA CCCTGAGTGA TTCTCTGAGT 
GAGAATCTGA GCTTATTTCT GTGGTACCTG GTGCGAGGCC TATGTCTCTT GGGGATCATG 
CTCTGGGGAT CAGTGTCCCT CACCATGGTC ACCCTGATCA CCCTGCCTCT GCTTTTCCTT 
CTGCCCAAGA AGGTGGGAAA ATGGTACCAG TTGCTGGAAG TGCAGGTGCG GGAATCTCTG 
GCAAAGTCCA GCCAGGTGGC CATTGAGGCT CTGTCGGCCA TGCCTACAGT TCGAAGCTTT 
GCCAACGAGG AGGGCGAAGC CCAGAAGTTT AGGGAAAAGC TGCAAGAAAT AAAGACACTC 
AACCAGAAGG AGGCTGTGGC CTATGCAGTC AACTCCTGGA CCACTAGTAT TTCAGGTATG 
CTGCTGAAAG TGGGAATCCT CTACATTGGT GGGCAGCTGG TGACCAGTGG GGCTGTAAGC 
AGTGGGAACC TTGTCACATT TGTTCTCTAC CAGATGCAGT TCACCCAGGC TGTGGAGGTA 
CTGCTCTCCA TCTACCCCAG AGTACAGAAG GCTGTGGGCT CCTCAGAGAA AATATTTGAG 
TACCTGGACC GCACCCCTCG CTGCCCACCC AGTGGTCTGT TGACTCCCTT ACACTTGGAG 
GGCCTTGTCC AGTTCCAAGA TGTCTCCTTT GCCTACCCAA ACCGCCCAGA TGTCTTAGTG 
CTACAGGGGC TGACATTCAC CCTACGCCCT GGCGAGGTGA CGGCGCTGGT GGGACCCAAT 
GGGTCTGGGA AGAGCACAGT GGCTGCCCTG CTGCAGAATC TGTACCAGCC CACCGGGGGA 
CAGCTGCTGT TGGATGGGAA GCCCCTTCCC CAATATGAGC ACCGCTACCT GCACAGGCAG 
GTGGCTGCAG TGGGACAAGA GCCACAGGTA TTTGGAAGAA GTCTTCAAGA AAATATTGCC 
TATGGCCTGA CCCAGAAGCC AACTATGGAG GAAATCACAG CTGCTGCAGT AAAGTCTGGG 
GCCCATAGTT TCATCTCTGG ACTCCCTCAG GGCTATGACA CAGAGGTAGA CGAGGCTGGG 
AGCCAGCTGT CAGGGGGTCA GCGACAGGCA GTGGCGTTGG CCCGAGCATT GATCCGGAAA 
CCGTGTGTAC TTATCCTGGA TGATGCCACC AGTGCCCTGG ATGCAAACAG CCAGTTACAG 
GTGGAGCAGC TCCTGTACGA AAGCCCTGAG CGGTACTCCC GCTCAGTGCT TCTCATCACC 
CAGCACCTCA GCCTGGTGGA GCAGGCTGAC CACATCCTCT TTCTGGAAGG AGGCGCTATC 
CGGGAGGGGG GAACCCACCA GCAGCTCATG GAGAAAAAGG GGTGCTACTG GGCCATGGTG 
CAGGCTCCTG CAGATGCTCC AGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000584.2
CDS	156..2582
Translation	MAELLASAGSACSWDFPRAPPSFPPPAASRGGLGGTRSFRPHRGAESPRPGRDRDGVRVPMASSRCPAPRGCRCLPGASLAWLGTVLLLLADWVLLRTALPRIFSLLVPTALPLLRVWAVGLSRWAVLWLGACGVLRATVGSKSENAGAQGWLAALKPLAAALGLALPGLALFRELISWGAPGSADSTRLLHWGSHPTAFVVSYAAALPAAALWHKLGSLWVPGGQGGSGNPVRRLLGCLGSETRRLSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSADTFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMVQAPADAPE

Target ORF information:

RefSeq Version	NM_000593.5
Organism	Homo sapiens(human)
Definition	Homo sapiens transporter 1, ATP binding cassette subfamily B member (TAP1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000593.5

ORF Insert Sequence:

ATGGCTGAGC TTCTCGCCAG CGCAGGATCA GCCTGTTCCT GGGACTTTCC GAGAGCCCCG 
CCCTCGTTCC CTCCCCCAGC CGCCAGTAGG GGAGGACTCG GCGGTACCCG GAGCTTCAGG 
CCCCACCGGG GCGCGGAGAG TCCCAGGCCC GGCCGGGACC GGGACGGCGT CCGAGTGCCA 
ATGGCTAGCT CTAGGTGTCC CGCTCCCCGC GGGTGCCGCT GCCTCCCCGG AGCTTCTCTC 
GCATGGCTGG GGACAGTACT GCTACTTCTC GCCGACTGGG TGCTGCTCCG GACCGCGCTG 
CCCCGCATAT TCTCCCTGCT GGTGCCCACC GCGCTGCCAC TGCTCCGGGT CTGGGCGGTG 
GGCCTGAGCC GCTGGGCCGT GCTCTGGCTG GGGGCCTGCG GGGTCCTCAG GGCAACGGTT 
GGCTCCAAGA GCGAAAACGC AGGTGCCCAG GGCTGGCTGG CTGCTTTGAA GCCATTAGCT 
GCGGCACTGG GCTTGGCCCT GCCGGGACTT GCCTTGTTCC GAGAGCTGAT CTCATGGGGA 
GCCCCCGGGT CCGCGGATAG CACCAGGCTA CTGCACTGGG GAAGTCACCC TACCGCCTTC 
GTTGTCAGTT ATGCAGCGGC ACTGCCCGCA GCAGCCCTGT GGCACAAACT CGGGAGCCTC 
TGGGTGCCCG GCGGTCAGGG CGGCTCTGGA AACCCTGTGC GTCGGCTTCT AGGCTGCCTG 
GGCTCGGAGA CGCGCCGCCT CTCGCTGTTC CTGGTCCTGG TGGTCCTCTC CTCTCTTGGG 
GAGATGGCCA TTCCATTCTT TACGGGCCGC CTCACTGACT GGATTCTACA AGATGGCTCA 
GCCGATACCT TCACTCGAAA CTTAACTCTC ATGTCCATTC TCACCATAGC CAGTGCAGTG 
CTGGAGTTCG TGGGTGACGG GATCTATAAC AACACCATGG GCCACGTGCA CAGCCACTTG 
CAGGGAGAGG TGTTTGGGGC TGTCCTGCGC CAGGAGACGG AGTTTTTCCA ACAGAACCAG 
ACAGGTAACA TCATGTCTCG GGTAACAGAG GACACGTCCA CCCTGAGTGA TTCTCTGAGT 
GAGAATCTGA GCTTATTTCT GTGGTACCTG GTGCGAGGCC TATGTCTCTT GGGGATCATG 
CTCTGGGGAT CAGTGTCCCT CACCATGGTC ACCCTGATCA CCCTGCCTCT GCTTTTCCTT 
CTGCCCAAGA AGGTGGGAAA ATGGTACCAG TTGCTGGAAG TGCAGGTGCG GGAATCTCTG 
GCAAAGTCCA GCCAGGTGGC CATTGAGGCT CTGTCGGCCA TGCCTACAGT TCGAAGCTTT 
GCCAACGAGG AGGGCGAAGC CCAGAAGTTT AGGGAAAAGC TGCAAGAAAT AAAGACACTC 
AACCAGAAGG AGGCTGTGGC CTATGCAGTC AACTCCTGGA CCACTAGTAT TTCAGGTATG 
CTGCTGAAAG TGGGAATCCT CTACATTGGT GGGCAGCTGG TGACCAGTGG GGCTGTAAGC 
AGTGGGAACC TTGTCACATT TGTTCTCTAC CAGATGCAGT TCACCCAGGC TGTGGAGGTA 
CTGCTCTCCA TCTACCCCAG AGTACAGAAG GCTGTGGGCT CCTCAGAGAA AATATTTGAG 
TACCTGGACC GCACCCCTCG CTGCCCACCC AGTGGTCTGT TGACTCCCTT ACACTTGGAG 
GGCCTTGTCC AGTTCCAAGA TGTCTCCTTT GCCTACCCAA ACCGCCCAGA TGTCTTAGTG 
CTACAGGGGC TGACATTCAC CCTACGCCCT GGCGAGGTGA CGGCGCTGGT GGGACCCAAT 
GGGTCTGGGA AGAGCACAGT GGCTGCCCTG CTGCAGAATC TGTACCAGCC CACCGGGGGA 
CAGCTGCTGT TGGATGGGAA GCCCCTTCCC CAATATGAGC ACCGCTACCT GCACAGGCAG 
GTGGCTGCAG TGGGACAAGA GCCACAGGTA TTTGGAAGAA GTCTTCAAGA AAATATTGCC 
TATGGCCTGA CCCAGAAGCC AACTATGGAG GAAATCACAG CTGCTGCAGT AAAGTCTGGG 
GCCCATAGTT TCATCTCTGG ACTCCCTCAG GGCTATGACA CAGAGGTAGA CGAGGCTGGG 
AGCCAGCTGT CAGGGGGTCA GCGACAGGCA GTGGCGTTGG CCCGAGCATT GATCCGGAAA 
CCGTGTGTAC TTATCCTGGA TGATGCCACC AGTGCCCTGG ATGCAAACAG CCAGTTACAG 
GTGGAGCAGC TCCTGTACGA AAGCCCTGAG CGGTACTCCC GCTCAGTGCT TCTCATCACC 
CAGCACCTCA GCCTGGTGGA GCAGGCTGAC CACATCCTCT TTCTGGAAGG AGGCGCTATC 
CGGGAGGGGG GAACCCACCA GCAGCTCATG GAGAAAAAGG GGTGCTACTG GGCCATGGTG 
CAGGCTCCTG CAGATGCTCC AGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TAP1 ( NM_001292022.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001278951.1 Homo sapiens transporter 1, ATP binding cassette subfamily B member (TAP1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu24644
Clone ID Related Accession (Same CDS sequence)	NM_001292022.2 , NM_001292022.1
Accession Version	NM_001292022.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1644bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-29
Organism	Homo sapiens(human)
Product	antigen peptide transporter 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC354917.1, AK302340.1 and BC014081.2. On Jun 2, 2019 this sequence version replaced NM_001292022.1. Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK302340.1, SRR1803616.249579.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCATTC CATTCTTTAC GGGCCGCCTC ACTGACTGGA TTCTACAAGA TGGCTCAGCC 
GATACCTTCA CTCGAAACTT AACTCTCATG TCCATTCTCA CCATAGCCAG TGCAGTGCTG 
GAGTTCGTGG GTGACGGGAT CTATAACAAC ACCATGGGCC ACGTGCACAG CCACTTGCAG 
GGAGAGGTGT TTGGGGCTGT CCTGCGCCAG GAGACGGAGT TTTTCCAACA GAACCAGACA 
GGTAACATCA TGTCTCGGGT AACAGAGGAC ACGTCCACCC TGAGTGATTC TCTGAGTGAG 
AATCTGAGCT TATTTCTGTG GTACCTGGTG CGAGGCCTAT GTCTCTTGGG GATCATGCTC 
TGGGGATCAG TGTCCCTCAC CATGGTCACC CTGATCACCC TGCCTCTGCT TTTCCTTCTG 
CCCAAGAAGG TGGGAAAATG GTACCAGTTG CTGGAAGTGC AGGTGCGGGA ATCTCTGGCA 
AAGTCCAGCC AGGTGGCCAT TGAGGCTCTG TCGGCCATGC CTACAGTTCG AAGCTTTGCC 
AACGAGGAGG GCGAAGCCCA GAAGTTTAGG GAAAAGCTGC AAGAAATAAA GACACTCAAC 
CAGAAGGAGG CTGTGGCCTA TGCAGTCAAC TCCTGGACCA CTAGTATTTC AGGTATGCTG 
CTGAAAGTGG GAATCCTCTA CATTGGTGGG CAGCTGGTGA CCAGTGGGGC TGTAAGCAGT 
GGGAACCTTG TCACATTTGT TCTCTACCAG ATGCAGTTCA CCCAGGCTGT GGAGGTACTG 
CTCTCCATCT ACCCCAGAGT ACAGAAGGCT GTGGGCTCCT CAGAGAAAAT ATTTGAGTAC 
CTGGACCGCA CCCCTCGCTG CCCACCCAGT GGTCTGTTGA CTCCCTTACA CTTGGAGGGC 
CTTGTCCAGT TCCAAGATGT CTCCTTTGCC TACCCAAACC GCCCAGATGT CTTAGTGCTA 
CAGGGGCTGA CATTCACCCT ACGCCCTGGC GAGGTGACGG CGCTGGTGGG ACCCAATGGG 
TCTGGGAAGA GCACAGTGGC TGCCCTGCTG CAGAATCTGT ACCAGCCCAC CGGGGGACAG 
CTGCTGTTGG ATGGGAAGCC CCTTCCCCAA TATGAGCACC GCTACCTGCA CAGGCAGGTG 
GCTGCAGTGG GACAAGAGCC ACAGGTATTT GGAAGAAGTC TTCAAGAAAA TATTGCCTAT 
GGCCTGACCC AGAAGCCAAC TATGGAGGAA ATCACAGCTG CTGCAGTAAA GTCTGGGGCC 
CATAGTTTCA TCTCTGGACT CCCTCAGGGC TATGACACAG AGGTAGACGA GGCTGGGAGC 
CAGCTGTCAG GGGGTCAGCG ACAGGCAGTG GCGTTGGCCC GAGCATTGAT CCGGAAACCG 
TGTGTACTTA TCCTGGATGA TGCCACCAGT GCCCTGGATG CAAACAGCCA GTTACAGGTG 
GAGCAGCTCC TGTACGAAAG CCCTGAGCGG TACTCCCGCT CAGTGCTTCT CATCACCCAG 
CACCTCAGCC TGGTGGAGCA GGCTGACCAC ATCCTCTTTC TGGAAGGAGG CGCTATCCGG 
GAGGGGGGAA CCCACCAGCA GCTCATGGAG AAAAAGGGGT GCTACTGGGC CATGGTGCAG 
GCTCCTGCAG ATGCTCCAGA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001278951.1
CDS	173..1816
Translation	MAIPFFTGRLTDWILQDGSADTFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMVQAPADAPE

Target ORF information:

RefSeq Version	NM_001292022.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transporter 1, ATP binding cassette subfamily B member (TAP1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001292022.2

ORF Insert Sequence:

ATGGCCATTC CATTCTTTAC GGGCCGCCTC ACTGACTGGA TTCTACAAGA TGGCTCAGCC 
GATACCTTCA CTCGAAACTT AACTCTCATG TCCATTCTCA CCATAGCCAG TGCAGTGCTG 
GAGTTCGTGG GTGACGGGAT CTATAACAAC ACCATGGGCC ACGTGCACAG CCACTTGCAG 
GGAGAGGTGT TTGGGGCTGT CCTGCGCCAG GAGACGGAGT TTTTCCAACA GAACCAGACA 
GGTAACATCA TGTCTCGGGT AACAGAGGAC ACGTCCACCC TGAGTGATTC TCTGAGTGAG 
AATCTGAGCT TATTTCTGTG GTACCTGGTG CGAGGCCTAT GTCTCTTGGG GATCATGCTC 
TGGGGATCAG TGTCCCTCAC CATGGTCACC CTGATCACCC TGCCTCTGCT TTTCCTTCTG 
CCCAAGAAGG TGGGAAAATG GTACCAGTTG CTGGAAGTGC AGGTGCGGGA ATCTCTGGCA 
AAGTCCAGCC AGGTGGCCAT TGAGGCTCTG TCGGCCATGC CTACAGTTCG AAGCTTTGCC 
AACGAGGAGG GCGAAGCCCA GAAGTTTAGG GAAAAGCTGC AAGAAATAAA GACACTCAAC 
CAGAAGGAGG CTGTGGCCTA TGCAGTCAAC TCCTGGACCA CTAGTATTTC AGGTATGCTG 
CTGAAAGTGG GAATCCTCTA CATTGGTGGG CAGCTGGTGA CCAGTGGGGC TGTAAGCAGT 
GGGAACCTTG TCACATTTGT TCTCTACCAG ATGCAGTTCA CCCAGGCTGT GGAGGTACTG 
CTCTCCATCT ACCCCAGAGT ACAGAAGGCT GTGGGCTCCT CAGAGAAAAT ATTTGAGTAC 
CTGGACCGCA CCCCTCGCTG CCCACCCAGT GGTCTGTTGA CTCCCTTACA CTTGGAGGGC 
CTTGTCCAGT TCCAAGATGT CTCCTTTGCC TACCCAAACC GCCCAGATGT CTTAGTGCTA 
CAGGGGCTGA CATTCACCCT ACGCCCTGGC GAGGTGACGG CGCTGGTGGG ACCCAATGGG 
TCTGGGAAGA GCACAGTGGC TGCCCTGCTG CAGAATCTGT ACCAGCCCAC CGGGGGACAG 
CTGCTGTTGG ATGGGAAGCC CCTTCCCCAA TATGAGCACC GCTACCTGCA CAGGCAGGTG 
GCTGCAGTGG GACAAGAGCC ACAGGTATTT GGAAGAAGTC TTCAAGAAAA TATTGCCTAT 
GGCCTGACCC AGAAGCCAAC TATGGAGGAA ATCACAGCTG CTGCAGTAAA GTCTGGGGCC 
CATAGTTTCA TCTCTGGACT CCCTCAGGGC TATGACACAG AGGTAGACGA GGCTGGGAGC 
CAGCTGTCAG GGGGTCAGCG ACAGGCAGTG GCGTTGGCCC GAGCATTGAT CCGGAAACCG 
TGTGTACTTA TCCTGGATGA TGCCACCAGT GCCCTGGATG CAAACAGCCA GTTACAGGTG 
GAGCAGCTCC TGTACGAAAG CCCTGAGCGG TACTCCCGCT CAGTGCTTCT CATCACCCAG 
CACCTCAGCC TGGTGGAGCA GGCTGACCAC ATCCTCTTTC TGGAAGGAGG CGCTATCCGG 
GAGGGGGGAA CCCACCAGCA GCTCATGGAG AAAAAGGGGT GCTACTGGGC CATGGTGCAG 
GCTCCTGCAG ATGCTCCAGA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TAP1 ( NM_001292022.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001278951.1 Homo sapiens transporter 1, ATP binding cassette subfamily B member (TAP1), transcript variant 2, mRNA.

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CloneID	OHu24644
Clone ID Related Accession (Same CDS sequence)	NM_001292022.2 , NM_001292022.1
Accession Version	NM_001292022.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1644bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-15
Organism	Homo sapiens(human)
Product	antigen peptide transporter 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC354917.1, AK302340.1 and BC014081.2. Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK302340.1, SRR1803616.249579.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCATTC CATTCTTTAC GGGCCGCCTC ACTGACTGGA TTCTACAAGA TGGCTCAGCC 
GATACCTTCA CTCGAAACTT AACTCTCATG TCCATTCTCA CCATAGCCAG TGCAGTGCTG 
GAGTTCGTGG GTGACGGGAT CTATAACAAC ACCATGGGCC ACGTGCACAG CCACTTGCAG 
GGAGAGGTGT TTGGGGCTGT CCTGCGCCAG GAGACGGAGT TTTTCCAACA GAACCAGACA 
GGTAACATCA TGTCTCGGGT AACAGAGGAC ACGTCCACCC TGAGTGATTC TCTGAGTGAG 
AATCTGAGCT TATTTCTGTG GTACCTGGTG CGAGGCCTAT GTCTCTTGGG GATCATGCTC 
TGGGGATCAG TGTCCCTCAC CATGGTCACC CTGATCACCC TGCCTCTGCT TTTCCTTCTG 
CCCAAGAAGG TGGGAAAATG GTACCAGTTG CTGGAAGTGC AGGTGCGGGA ATCTCTGGCA 
AAGTCCAGCC AGGTGGCCAT TGAGGCTCTG TCGGCCATGC CTACAGTTCG AAGCTTTGCC 
AACGAGGAGG GCGAAGCCCA GAAGTTTAGG GAAAAGCTGC AAGAAATAAA GACACTCAAC 
CAGAAGGAGG CTGTGGCCTA TGCAGTCAAC TCCTGGACCA CTAGTATTTC AGGTATGCTG 
CTGAAAGTGG GAATCCTCTA CATTGGTGGG CAGCTGGTGA CCAGTGGGGC TGTAAGCAGT 
GGGAACCTTG TCACATTTGT TCTCTACCAG ATGCAGTTCA CCCAGGCTGT GGAGGTACTG 
CTCTCCATCT ACCCCAGAGT ACAGAAGGCT GTGGGCTCCT CAGAGAAAAT ATTTGAGTAC 
CTGGACCGCA CCCCTCGCTG CCCACCCAGT GGTCTGTTGA CTCCCTTACA CTTGGAGGGC 
CTTGTCCAGT TCCAAGATGT CTCCTTTGCC TACCCAAACC GCCCAGATGT CTTAGTGCTA 
CAGGGGCTGA CATTCACCCT ACGCCCTGGC GAGGTGACGG CGCTGGTGGG ACCCAATGGG 
TCTGGGAAGA GCACAGTGGC TGCCCTGCTG CAGAATCTGT ACCAGCCCAC CGGGGGACAG 
CTGCTGTTGG ATGGGAAGCC CCTTCCCCAA TATGAGCACC GCTACCTGCA CAGGCAGGTG 
GCTGCAGTGG GACAAGAGCC ACAGGTATTT GGAAGAAGTC TTCAAGAAAA TATTGCCTAT 
GGCCTGACCC AGAAGCCAAC TATGGAGGAA ATCACAGCTG CTGCAGTAAA GTCTGGGGCC 
CATAGTTTCA TCTCTGGACT CCCTCAGGGC TATGACACAG AGGTAGACGA GGCTGGGAGC 
CAGCTGTCAG GGGGTCAGCG ACAGGCAGTG GCGTTGGCCC GAGCATTGAT CCGGAAACCG 
TGTGTACTTA TCCTGGATGA TGCCACCAGT GCCCTGGATG CAAACAGCCA GTTACAGGTG 
GAGCAGCTCC TGTACGAAAG CCCTGAGCGG TACTCCCGCT CAGTGCTTCT CATCACCCAG 
CACCTCAGCC TGGTGGAGCA GGCTGACCAC ATCCTCTTTC TGGAAGGAGG CGCTATCCGG 
GAGGGGGGAA CCCACCAGCA GCTCATGGAG AAAAAGGGGT GCTACTGGGC CATGGTGCAG 
GCTCCTGCAG ATGCTCCAGA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001278951.1
CDS	199..1842
Translation	MAIPFFTGRLTDWILQDGSADTFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMVQAPADAPE

Target ORF information:

RefSeq Version	NM_001292022.1
Organism	Homo sapiens(human)
Definition	Homo sapiens transporter 1, ATP binding cassette subfamily B member (TAP1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001292022.1

ORF Insert Sequence:

ATGGCCATTC CATTCTTTAC GGGCCGCCTC ACTGACTGGA TTCTACAAGA TGGCTCAGCC 
GATACCTTCA CTCGAAACTT AACTCTCATG TCCATTCTCA CCATAGCCAG TGCAGTGCTG 
GAGTTCGTGG GTGACGGGAT CTATAACAAC ACCATGGGCC ACGTGCACAG CCACTTGCAG 
GGAGAGGTGT TTGGGGCTGT CCTGCGCCAG GAGACGGAGT TTTTCCAACA GAACCAGACA 
GGTAACATCA TGTCTCGGGT AACAGAGGAC ACGTCCACCC TGAGTGATTC TCTGAGTGAG 
AATCTGAGCT TATTTCTGTG GTACCTGGTG CGAGGCCTAT GTCTCTTGGG GATCATGCTC 
TGGGGATCAG TGTCCCTCAC CATGGTCACC CTGATCACCC TGCCTCTGCT TTTCCTTCTG 
CCCAAGAAGG TGGGAAAATG GTACCAGTTG CTGGAAGTGC AGGTGCGGGA ATCTCTGGCA 
AAGTCCAGCC AGGTGGCCAT TGAGGCTCTG TCGGCCATGC CTACAGTTCG AAGCTTTGCC 
AACGAGGAGG GCGAAGCCCA GAAGTTTAGG GAAAAGCTGC AAGAAATAAA GACACTCAAC 
CAGAAGGAGG CTGTGGCCTA TGCAGTCAAC TCCTGGACCA CTAGTATTTC AGGTATGCTG 
CTGAAAGTGG GAATCCTCTA CATTGGTGGG CAGCTGGTGA CCAGTGGGGC TGTAAGCAGT 
GGGAACCTTG TCACATTTGT TCTCTACCAG ATGCAGTTCA CCCAGGCTGT GGAGGTACTG 
CTCTCCATCT ACCCCAGAGT ACAGAAGGCT GTGGGCTCCT CAGAGAAAAT ATTTGAGTAC 
CTGGACCGCA CCCCTCGCTG CCCACCCAGT GGTCTGTTGA CTCCCTTACA CTTGGAGGGC 
CTTGTCCAGT TCCAAGATGT CTCCTTTGCC TACCCAAACC GCCCAGATGT CTTAGTGCTA 
CAGGGGCTGA CATTCACCCT ACGCCCTGGC GAGGTGACGG CGCTGGTGGG ACCCAATGGG 
TCTGGGAAGA GCACAGTGGC TGCCCTGCTG CAGAATCTGT ACCAGCCCAC CGGGGGACAG 
CTGCTGTTGG ATGGGAAGCC CCTTCCCCAA TATGAGCACC GCTACCTGCA CAGGCAGGTG 
GCTGCAGTGG GACAAGAGCC ACAGGTATTT GGAAGAAGTC TTCAAGAAAA TATTGCCTAT 
GGCCTGACCC AGAAGCCAAC TATGGAGGAA ATCACAGCTG CTGCAGTAAA GTCTGGGGCC 
CATAGTTTCA TCTCTGGACT CCCTCAGGGC TATGACACAG AGGTAGACGA GGCTGGGAGC 
CAGCTGTCAG GGGGTCAGCG ACAGGCAGTG GCGTTGGCCC GAGCATTGAT CCGGAAACCG 
TGTGTACTTA TCCTGGATGA TGCCACCAGT GCCCTGGATG CAAACAGCCA GTTACAGGTG 
GAGCAGCTCC TGTACGAAAG CCCTGAGCGG TACTCCCGCT CAGTGCTTCT CATCACCCAG 
CACCTCAGCC TGGTGGAGCA GGCTGACCAC ATCCTCTTTC TGGAAGGAGG CGCTATCCGG 
GAGGGGGGAA CCCACCAGCA GCTCATGGAG AAAAAGGGGT GCTACTGGGC CATGGTGCAG 
GCTCCTGCAG ATGCTCCAGA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Downregulation of TAP1 and TAP2 in early stage breast cancer.
PloS one12(11)e0187323(2017)
Henle AM,Nassar A,Puglisi-Knutson D,Youssef B,Knutson KL

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TAP1 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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