Ptgs1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ptgs1
Entrez Gene ID	24693
Full Name	prostaglandin-endoperoxide synthase 1
Synonyms	Cox-1,Cox-3,Cox1,Cox3,Pghs-1
General protein information	Preferred Names prostaglandin-endoperoxide synthase 1 Names prostaglandin G/H synthase 1 PGH synthase 1 PHS 1 cyclooxygenase 3 cyclooxygenase-1 prostaglandin G/H synthase and cyclooxygenase prostaglandin H2 synthase 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3p11
Summary	This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. [provided by RefSeq, Jan 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017043.4	NP_058739.4	prostaglandin G/H synthase 1 precursor
XM_006234063.2	XP_006234125.1	prostaglandin G/H synthase 1 isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Ptgs1	NP_058739.3
	PTGS1	XP_001088157.1
Bos taurus (cattle)	PTGS1	NP_001098793.1
Mus musculus (house mouse)	Ptgs1	NP_032995.1
Homo sapiens (human)	PTGS1	NP_000953.2
Pan troglodytes (chimpanzee)	PTGS1	XP_520238.2
Canis lupus familiaris (dog)	PTGS1	NP_001003023.1
Gallus gallus (chicken)	PTGS1	XP_425326.4
Danio rerio (zebrafish)	ptgs1	NP_705942.1
Xenopus tropicalis (tropical clawed frog)	ptgs1	NP_001258184.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetic and Histological Alterations Reveal Key Role of Prostaglandin Synthase and Cyclooxygenase 1 and 2 in Traumatic Brain Injury-Induced Neuroinflammation in the Cerebral Cortex of Rats Exposed to Moderate Fluid Percussion Injury.
Shojo H, Borlongan CV, Mabuchi T
Cell transplantation26(7)1301-1313(2017 Jul)

Differential contribution of COX-1 and COX-2 derived prostanoids to cortical spreading depression-Evoked cerebral oligemia.
Gariepy H, Zhao J, Levy D
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism37(3)1060-1068(2017 Mar)

Type of supplemented simple sugar, not merely calorie intake, determines adverse effects on metabolism and aortic function in female rats.
Sang?esa G, Shaligram S, Akther F, Roglans N, Laguna JC, Rahimian R, Alegret M
American journal of physiology. Heart and circulatory physiology312(2)H289-H304(2017 Feb)

Inhibition of COX1/2 alters the host response and reduces ECM scaffold mediated constructive tissue remodeling in a rodent model of skeletal muscle injury.
Dearth CL, Slivka PF, Stewart SA, Keane TJ, Tay JK, Londono R, Goh Q, Pizza FX, Badylak SF
Acta biomaterialia3150-60(2016 Feb)

Cyclooxygenase as a target in chemoprevention by probiotics during 1,2-dimethylhydrazine induced colon carcinogenesis in rats.
Walia S, Kamal R, Kanwar SS, Dhawan DK
Nutrition and cancer67(4)603-11(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the long-lasting oligemia following cortical spreading depression consists of at least two distinct temporal phases, mediated by preferential actions of COX-1- and COX-2-derived prostanoids: an initial phase mediated by COX-1 that involves TXA2 followed by a later phase, mediated by COX-2 and PGF2alpha.
Title: Differential contribution of COX-1 and COX-2 derived prostanoids to cortical spreading depression-Evoked cerebral oligemia.

COX1/2 inhibition alters the host response and reduces ECM scaffold mediated constructive tissue remodeling in a rodent model of skeletal muscle injury
Title: Inhibition of COX1/2 alters the host response and reduces ECM scaffold mediated constructive tissue remodeling in a rodent model of skeletal muscle injury.

Protein expression of COX-1 remained unaltered in all the treatment groups including 1,2-dimethylhydrazine treated animals.
Title: Cyclooxygenase as a target in chemoprevention by probiotics during 1,2-dimethylhydrazine induced colon carcinogenesis in rats.

Nitric oxide synthase (NOS) and cyclooxygenase (COX) isoform expression patterns were determined in femoral artery of obese Zucker rats.
Title: Diminished neurogenic femoral artery vasoconstrictor response in a Zucker obese rat model: differential regulation of NOS and COX derivatives.

Suggest that COX-1 products are critical for sympathoexcitation and the full development of ANG II-salt hypertension in rats.
Title: Cyclooxygenase-1 inhibition attenuates angiotensin II-salt hypertension and neurogenic pressor activity in the rat.

The following Ptgs1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ptgs1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13611	NM_017043.4 Latest version!	Rattus norvegicus prostaglandin-endoperoxide synthase 1 (Ptgs1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
ORa25780	XM_006234063.2 Latest version!	Rattus norvegicus prostaglandin-endoperoxide synthase 1 (Ptgs1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ptgs1 ( NM_017043.4 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058739.4 Rattus norvegicus prostaglandin-endoperoxide synthase 1 (Ptgs1), mRNA.

Price & Availability↑

CloneID	ORa13611
Clone ID Related Accession (Same CDS sequence)	NM_017043.4
Accession Version	NM_017043.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1809bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	prostaglandin G/H synthase 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC081816.1. On Feb 1, 2014 this sequence version replaced NM_017043.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC081816.1, S67721.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689597 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## multifunctional gene product(s) :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTCGAA GGAGTCTCTC GCTCCAGTTT CCCCTGCTGC TGCTCCTGCT GCTGCTCCCA 
CCACCCCCGG TACTGCTCAC AGATGCTGGG GTACCCTCAC CAGTCAATCC CTGTTGTTAC 
TATCCATGCC AGAACCAGGG TGTCTGTGTC CGCTTCGGCC TCGACCACTA CCAATGTGAC 
TGTACTCGCA CGGGCTACTC GGGCCCCAAC TGTACTATCC CTGAGATCTG GACCTGGCTT 
CGGAGTTCCC TGCGGCCCAG CCCCTCATTC ACCCATTTCC TGCTGACACA CGGGTACTGG 
ATCTGGGAGT TTGTGAATGC CACCTTCATC CGAGAAGTAC TCATGCGCCT GGTACTCACG 
GTGCGGTCCA ACCTTATCCC CAGCCCTCCA ACCTACAACA CAGCACATGA CTACATCAGC 
TGGGAGTCCT TCTCCAACGT GAGCTACTAT ACTCGCATTC TGCCCTCTGT ACCCAAAGAC 
TGTCCCACAC CCATGGGAAC CAAAGGGAAG AAGCAGTTAC CAGATATTCA TCTTCTGGCC 
CAACGATTGC TGCTGAGAAG GGAGTTCATT CCCGCCCCGC AGGGGACCAA CGTCTTGTTT 
GCTTTCTTTG CACAACACTT CACCCACCAG TTCTTCAAGA CCTCTGGAAA GATGGGTCCT 
GGCTTTACCA AGGCCTTAGG CCATGGGGTA GACCTTGGCC ACATTTATGG AGATAGTCTG 
GAACGACAGT ACCACCTGCG GCTCTTCAAG GATGGGAAAC TTAAGTACCA GGTGCTGGAT 
GGAGAGGTGT ACCCACCTTC CGTAGAACAG GCGTCCGTGT TGATGCGCTA CCCACCAGGT 
GTCCCGCCCG AAAAGCAGAT GGCTGTGGGC CAGGAGGTGT TTGGGTTGCT CCCGGGTCTG 
ATGCTCTTCT CCACGATCTG GCTGCGCGAG CATAACCGTG TGTGTGACTT GCTGAAGGAG 
GAGCATCCTA CATGGGATGA CGAGCAGCTC TTCCAGACCA CTCGCCTCAT CCTTATAGGG 
GAAACCATCA AGATTATCAT CGAGGAGTAC GTACAGCACT TGAGTGGCTA TTTCCTGCAG 
CTCAAGTTTG ACCCGGAGCT GCTGTTCCGA GCCCAGTTCC AGTATCGCAA CCGCATCGCC 
TTGGAATTCA ACCACCTCTA TCACTGGCAT CCGCTCATGC CTGATTCCTT CCAAGTGGGC 
TCACAAGAGT ACAGCTATGA GCAGTTTTTA TTTAACACAT CTATGCTGGT GGACTACGGT 
GTCGAGGCAC TGGTGGATGC CTTCTCTCGC CAGAGGGCTG GCCGGATTGG TGGGGGTAGG 
AACTTTGACT ACCATGTTCT GCATGTGGCC GAGGATGTCA TCAAGGAGTC CCGAGAAATG 
CGCCTGCAGT CCTTCAATGA ATACCGAAAG AGGTTTGGCC TGAAGCCTTA CACTTCTTTC 
CAGGAGTTCA CAGGAGAGAA GGAGATGGCC GCTGAGTTGG AGGAGCTATA TGGTGACATC 
GATGCTTTAG AGTTCTACCC GGGGCTGATG CTGGAGAAGT GCCAGCCCAA CTCCCTCTTT 
GGGGAGAGCA TGATAGAGAT GGGGGCTCCT TTCTCCCTCA AGGGCCTCCT AGGGAATCCC 
ATCTGTTCCC CAGAGTACTG GAAACCCAGC ACATTCGGTG GTGATGTGGG TTTCAACATC 
GTTAACACAG CCTCACTGAA GAAACTGGTC TGCCTCAACA CCAAGACCTG CCCCTATGTC 
TCCTTCCGTG TGCCAGATTA CCCTGGAGAT GACGGGTCTG TCTTCGTGAG ACCTTCCACT 
GAGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058739.4
CDS	60..1868
Translation	MSRRSLSLQFPLLLLLLLLPPPPVLLTDAGVPSPVNPCCYYPCQNQGVCVRFGLDHYQCDCTRTGYSGPNCTIPEIWTWLRSSLRPSPSFTHFLLTHGYWIWEFVNATFIREVLMRLVLTVRSNLIPSPPTYNTAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDIHLLAQRLLLRREFIPAPQGTNVLFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDSLERQYHLRLFKDGKLKYQVLDGEVYPPSVEQASVLMRYPPGVPPEKQMAVGQEVFGLLPGLMLFSTIWLREHNRVCDLLKEEHPTWDDEQLFQTTRLILIGETIKIIIEEYVQHLSGYFLQLKFDPELLFRAQFQYRNRIALEFNHLYHWHPLMPDSFQVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQRAGRIGGGRNFDYHVLHVAEDVIKESREMRLQSFNEYRKRFGLKPYTSFQEFTGEKEMAAELEELYGDIDALEFYPGLMLEKCQPNSLFGESMIEMGAPFSLKGLLGNPICSPEYWKPSTFGGDVGFNIVNTASLKKLVCLNTKTCPYVSFRVPDYPGDDGSVFVRPSTEL

Target ORF information:

RefSeq Version	NM_017043.4
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus prostaglandin-endoperoxide synthase 1 (Ptgs1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017043.4

ORF Insert Sequence:

ATGAGTCGAA GGAGTCTCTC GCTCCAGTTT CCCCTGCTGC TGCTCCTGCT GCTGCTCCCA 
CCACCCCCGG TACTGCTCAC AGATGCTGGG GTACCCTCAC CAGTCAATCC CTGTTGTTAC 
TATCCATGCC AGAACCAGGG TGTCTGTGTC CGCTTCGGCC TCGACCACTA CCAATGTGAC 
TGTACTCGCA CGGGCTACTC GGGCCCCAAC TGTACTATCC CTGAGATCTG GACCTGGCTT 
CGGAGTTCCC TGCGGCCCAG CCCCTCATTC ACCCATTTCC TGCTGACACA CGGGTACTGG 
ATCTGGGAGT TTGTGAATGC CACCTTCATC CGAGAAGTAC TCATGCGCCT GGTACTCACG 
GTGCGGTCCA ACCTTATCCC CAGCCCTCCA ACCTACAACA CAGCACATGA CTACATCAGC 
TGGGAGTCCT TCTCCAACGT GAGCTACTAT ACTCGCATTC TGCCCTCTGT ACCCAAAGAC 
TGTCCCACAC CCATGGGAAC CAAAGGGAAG AAGCAGTTAC CAGATATTCA TCTTCTGGCC 
CAACGATTGC TGCTGAGAAG GGAGTTCATT CCCGCCCCGC AGGGGACCAA CGTCTTGTTT 
GCTTTCTTTG CACAACACTT CACCCACCAG TTCTTCAAGA CCTCTGGAAA GATGGGTCCT 
GGCTTTACCA AGGCCTTAGG CCATGGGGTA GACCTTGGCC ACATTTATGG AGATAGTCTG 
GAACGACAGT ACCACCTGCG GCTCTTCAAG GATGGGAAAC TTAAGTACCA GGTGCTGGAT 
GGAGAGGTGT ACCCACCTTC CGTAGAACAG GCGTCCGTGT TGATGCGCTA CCCACCAGGT 
GTCCCGCCCG AAAAGCAGAT GGCTGTGGGC CAGGAGGTGT TTGGGTTGCT CCCGGGTCTG 
ATGCTCTTCT CCACGATCTG GCTGCGCGAG CATAACCGTG TGTGTGACTT GCTGAAGGAG 
GAGCATCCTA CATGGGATGA CGAGCAGCTC TTCCAGACCA CTCGCCTCAT CCTTATAGGG 
GAAACCATCA AGATTATCAT CGAGGAGTAC GTACAGCACT TGAGTGGCTA TTTCCTGCAG 
CTCAAGTTTG ACCCGGAGCT GCTGTTCCGA GCCCAGTTCC AGTATCGCAA CCGCATCGCC 
TTGGAATTCA ACCACCTCTA TCACTGGCAT CCGCTCATGC CTGATTCCTT CCAAGTGGGC 
TCACAAGAGT ACAGCTATGA GCAGTTTTTA TTTAACACAT CTATGCTGGT GGACTACGGT 
GTCGAGGCAC TGGTGGATGC CTTCTCTCGC CAGAGGGCTG GCCGGATTGG TGGGGGTAGG 
AACTTTGACT ACCATGTTCT GCATGTGGCC GAGGATGTCA TCAAGGAGTC CCGAGAAATG 
CGCCTGCAGT CCTTCAATGA ATACCGAAAG AGGTTTGGCC TGAAGCCTTA CACTTCTTTC 
CAGGAGTTCA CAGGAGAGAA GGAGATGGCC GCTGAGTTGG AGGAGCTATA TGGTGACATC 
GATGCTTTAG AGTTCTACCC GGGGCTGATG CTGGAGAAGT GCCAGCCCAA CTCCCTCTTT 
GGGGAGAGCA TGATAGAGAT GGGGGCTCCT TTCTCCCTCA AGGGCCTCCT AGGGAATCCC 
ATCTGTTCCC CAGAGTACTG GAAACCCAGC ACATTCGGTG GTGATGTGGG TTTCAACATC 
GTTAACACAG CCTCACTGAA GAAACTGGTC TGCCTCAACA CCAAGACCTG CCCCTATGTC 
TCCTTCCGTG TGCCAGATTA CCCTGGAGAT GACGGGTCTG TCTTCGTGAG ACCTTCCACT 
GAGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ptgs1 ( XM_006234063.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006234125.1 Rattus norvegicus prostaglandin-endoperoxide synthase 1 (Ptgs1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa25780
Clone ID Related Accession (Same CDS sequence)	XM_006234063.2
Accession Version	XM_006234063.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1770bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	prostaglandin G/H synthase 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006234063.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTCGAA GGAGTCTCTC GCTCCAGTTT CCCCTGCTGC TGCTCCTGCT GCTGCTCCCA 
CCACCCCCGG TACTGCTCAC AGATGCTGGG GTACCCTCAC CAGTCAATCC CTGTTGTTAC 
TATCCATGCC AGAACCAGGG TGTCTGTGTC CGCTTCGGCC TCGACCACTA CCAATGTGAC 
TGTACTCGCA CGGGCTACTC GGGCCCCAAC TGTACTATCC CTGAGATCTG GACCTGGCTT 
CGGAGTTCCC TGCGGCCCAG CCCCTCATTC ACCCATTTCC TGCTGACACA CGGGTACTGG 
ATCTGGGAGT TTGTGAATGC CACCTTCATC CGAGAAGTAC TCATGCGCCT GGTACTCACG 
GTGCGGTCCA ACCTTATCCC CAGCCCTCCA ACCTACAACA CAGCACATGA CTACATCAGC 
TGGGAGTCCT TCTCCAACGT GAGCTACTAT ACTCGCATTC TGCCCTCTGT ACCCAAAGAC 
TGTCCCACAC CCATGGGAAC CAAAGGGAAG AAGCAGTTAC CAGATATTCA TCTTCTGGCC 
CAACGATTGC TGCTGAGAAG GGAGTTCATT CCCGCCCCGC AGGGGACCAA CGTCTTGTTT 
GCTTTCTTTG CACAACACTT CACCCACCAG TTCTTCAAGA CCTCTGGAAA GATGGGTCCT 
GGCTTTACCA AGGCCTTAGG CCATGGGGTA GACCTTGGCC ACATTTATGG AGATAGTCTG 
GAACGACAGT ACCACCTGCG GCTCTTCAAG GATGGGAAAC TTAAGTACCA GGCGTCCGTG 
TTGATGCGCT ACCCACCAGG TGTCCCGCCC GAAAAGCAGA TGGCTGTGGG CCAGGAGGTG 
TTTGGGTTGC TCCCGGGTCT GATGCTCTTC TCCACGATCT GGCTGCGCGA GCATAACCGT 
GTGTGTGACT TGCTGAAGGA GGAGCATCCT ACATGGGATG ACGAGCAGCT CTTCCAGACC 
ACTCGCCTCA TCCTTATAGG GGAAACCATC AAGATTATCA TCGAGGAGTA CGTACAGCAC 
TTGAGTGGCT ATTTCCTGCA GCTCAAGTTT GACCCGGAGC TGCTGTTCCG AGCCCAGTTC 
CAGTATCGCA ACCGCATCGC CTTGGAATTC AACCACCTCT ATCACTGGCA TCCGCTCATG 
CCTGATTCCT TCCAAGTGGG CTCACAAGAG TACAGCTATG AGCAGTTTTT ATTTAACACA 
TCTATGCTGG TGGACTACGG TGTCGAGGCA CTGGTGGATG CCTTCTCTCG CCAGAGGGCT 
GGCCGGATTG GTGGGGGTAG GAACTTTGAC TACCATGTTC TGCATGTGGC CGAGGATGTC 
ATCAAGGAGT CCCGAGAAAT GCGCCTGCAG TCCTTCAATG AATACCGAAA GAGGTTTGGC 
CTGAAGCCTT ACACTTCTTT CCAGGAGTTC ACAGGAGAGA AGGAGATGGC CGCTGAGTTG 
GAGGAGCTAT ATGGTGACAT CGATGCTTTA GAGTTCTACC CGGGGCTGAT GCTGGAGAAG 
TGCCAGCCCA ACTCCCTCTT TGGGGAGAGC ATGATAGAGA TGGGGGCTCC TTTCTCCCTC 
AAGGGCCTCC TAGGGAATCC CATCTGTTCC CCAGAGTACT GGAAACCCAG CACATTCGGT 
GGTGATGTGG GTTTCAACAT CGTTAACACA GCCTCACTGA AGAAACTGGT CTGCCTCAAC 
ACCAAGACCT GCCCCTATGT CTCCTTCCGT GTGCCAGATT ACCCTGGAGA TGACGGGTCT 
GTCTTCGTGA GACCGTCCAC TGAGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006234125.1
CDS	98..1867
Translation	MSRRSLSLQFPLLLLLLLLPPPPVLLTDAGVPSPVNPCCYYPCQNQGVCVRFGLDHYQCDCTRTGYSGPNCTIPEIWTWLRSSLRPSPSFTHFLLTHGYWIWEFVNATFIREVLMRLVLTVRSNLIPSPPTYNTAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDIHLLAQRLLLRREFIPAPQGTNVLFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDSLERQYHLRLFKDGKLKYQASVLMRYPPGVPPEKQMAVGQEVFGLLPGLMLFSTIWLREHNRVCDLLKEEHPTWDDEQLFQTTRLILIGETIKIIIEEYVQHLSGYFLQLKFDPELLFRAQFQYRNRIALEFNHLYHWHPLMPDSFQVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQRAGRIGGGRNFDYHVLHVAEDVIKESREMRLQSFNEYRKRFGLKPYTSFQEFTGEKEMAAELEELYGDIDALEFYPGLMLEKCQPNSLFGESMIEMGAPFSLKGLLGNPICSPEYWKPSTFGGDVGFNIVNTASLKKLVCLNTKTCPYVSFRVPDYPGDDGSVFVRPSTEL

Target ORF information:

RefSeq Version	XM_006234063.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus prostaglandin-endoperoxide synthase 1 (Ptgs1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006234063.2

ORF Insert Sequence:

ATGAGTCGAA GGAGTCTCTC GCTCCAGTTT CCCCTGCTGC TGCTCCTGCT GCTGCTCCCA 
CCACCCCCGG TACTGCTCAC AGATGCTGGG GTACCCTCAC CAGTCAATCC CTGTTGTTAC 
TATCCATGCC AGAACCAGGG TGTCTGTGTC CGCTTCGGCC TCGACCACTA CCAATGTGAC 
TGTACTCGCA CGGGCTACTC GGGCCCCAAC TGTACTATCC CTGAGATCTG GACCTGGCTT 
CGGAGTTCCC TGCGGCCCAG CCCCTCATTC ACCCATTTCC TGCTGACACA CGGGTACTGG 
ATCTGGGAGT TTGTGAATGC CACCTTCATC CGAGAAGTAC TCATGCGCCT GGTACTCACG 
GTGCGGTCCA ACCTTATCCC CAGCCCTCCA ACCTACAACA CAGCACATGA CTACATCAGC 
TGGGAGTCCT TCTCCAACGT GAGCTACTAT ACTCGCATTC TGCCCTCTGT ACCCAAAGAC 
TGTCCCACAC CCATGGGAAC CAAAGGGAAG AAGCAGTTAC CAGATATTCA TCTTCTGGCC 
CAACGATTGC TGCTGAGAAG GGAGTTCATT CCCGCCCCGC AGGGGACCAA CGTCTTGTTT 
GCTTTCTTTG CACAACACTT CACCCACCAG TTCTTCAAGA CCTCTGGAAA GATGGGTCCT 
GGCTTTACCA AGGCCTTAGG CCATGGGGTA GACCTTGGCC ACATTTATGG AGATAGTCTG 
GAACGACAGT ACCACCTGCG GCTCTTCAAG GATGGGAAAC TTAAGTACCA GGCGTCCGTG 
TTGATGCGCT ACCCACCAGG TGTCCCGCCC GAAAAGCAGA TGGCTGTGGG CCAGGAGGTG 
TTTGGGTTGC TCCCGGGTCT GATGCTCTTC TCCACGATCT GGCTGCGCGA GCATAACCGT 
GTGTGTGACT TGCTGAAGGA GGAGCATCCT ACATGGGATG ACGAGCAGCT CTTCCAGACC 
ACTCGCCTCA TCCTTATAGG GGAAACCATC AAGATTATCA TCGAGGAGTA CGTACAGCAC 
TTGAGTGGCT ATTTCCTGCA GCTCAAGTTT GACCCGGAGC TGCTGTTCCG AGCCCAGTTC 
CAGTATCGCA ACCGCATCGC CTTGGAATTC AACCACCTCT ATCACTGGCA TCCGCTCATG 
CCTGATTCCT TCCAAGTGGG CTCACAAGAG TACAGCTATG AGCAGTTTTT ATTTAACACA 
TCTATGCTGG TGGACTACGG TGTCGAGGCA CTGGTGGATG CCTTCTCTCG CCAGAGGGCT 
GGCCGGATTG GTGGGGGTAG GAACTTTGAC TACCATGTTC TGCATGTGGC CGAGGATGTC 
ATCAAGGAGT CCCGAGAAAT GCGCCTGCAG TCCTTCAATG AATACCGAAA GAGGTTTGGC 
CTGAAGCCTT ACACTTCTTT CCAGGAGTTC ACAGGAGAGA AGGAGATGGC CGCTGAGTTG 
GAGGAGCTAT ATGGTGACAT CGATGCTTTA GAGTTCTACC CGGGGCTGAT GCTGGAGAAG 
TGCCAGCCCA ACTCCCTCTT TGGGGAGAGC ATGATAGAGA TGGGGGCTCC TTTCTCCCTC 
AAGGGCCTCC TAGGGAATCC CATCTGTTCC CCAGAGTACT GGAAACCCAG CACATTCGGT 
GGTGATGTGG GTTTCAACAT CGTTAACACA GCCTCACTGA AGAAACTGGT CTGCCTCAAC 
ACCAAGACCT GCCCCTATGT CTCCTTCCGT GTGCCAGATT ACCCTGGAGA TGACGGGTCT 
GTCTTCGTGA GACCGTCCAC TGAGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic and Histological Alterations Reveal Key Role of Prostaglandin Synthase and Cyclooxygenase 1 and 2 in Traumatic Brain Injury-Induced Neuroinflammation in the Cerebral Cortex of Rats Exposed to Moderate Fluid Percussion Injury.
Cell transplantation26(7)1301-1313(2017 Jul)
Shojo H,Borlongan CV,Mabuchi T

Differential contribution of COX-1 and COX-2 derived prostanoids to cortical spreading depression-Evoked cerebral oligemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism37(3)1060-1068(2017 Mar)
Gariepy H,Zhao J,Levy D

Type of supplemented simple sugar, not merely calorie intake, determines adverse effects on metabolism and aortic function in female rats.
American journal of physiology. Heart and circulatory physiology312(2)H289-H304(2017 Feb)
Sang?esa G,Shaligram S,Akther F,Roglans N,Laguna JC,Rahimian R,Alegret M

Inhibition of COX1/2 alters the host response and reduces ECM scaffold mediated constructive tissue remodeling in a rodent model of skeletal muscle injury.
Acta biomaterialia3150-60(2016 Feb)
Dearth CL,Slivka PF,Stewart SA,Keane TJ,Tay JK,Londono R,Goh Q,Pizza FX,Badylak SF

Cyclooxygenase as a target in chemoprevention by probiotics during 1,2-dimethylhydrazine induced colon carcinogenesis in rats.
Nutrition and cancer67(4)603-11(2015)
Walia S,Kamal R,Kanwar SS,Dhawan DK

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Ptgs1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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