Il23a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Il23a
Entrez Gene ID	155140
Full Name	interleukin 23 subunit alpha
General protein information	Preferred Names interleukin 23 subunit alpha Names interleukin-23 subunit alpha IL-23 subunit alpha IL-23-A IL-23p19 Interleukin 23, alpha subunit p19 interleukin-23 subunit p19
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q11
Summary	mouse homolog is a pro-inflammatory cytokine; high levels of expression may be associated with rheumatoid arthritis, psoriasis, and multiple sclerosis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_130410.2	NP_569094.1	interleukin-23 subunit alpha precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	IL23A	NP_057668.1
	IL23A	XP_001115026.1
Canis lupus familiaris (dog)	IL23A	XP_538231.2
Bos taurus (cattle)	IL23A	NP_001192617.1
Mus musculus (house mouse)	Il23a	NP_112542.1
Pan troglodytes (chimpanzee)	IL23A	XP_522436.1
Rattus norvegicus (Norway rat)	Il23a	NP_569094.1

Gene Ontology
Bibliography

Related articles in PubMed

Promoting effects of IL?23 on myocardial ischemia and reperfusion are associated with increased expression of IL?17A and upregulation of the JAK2?STAT3 signaling pathway.
Liao Y, Hu X, Guo X, Zhang B, Xu W, Jiang H
Molecular medicine reports16(6)9309-9316(2017 Dec)

IL-23 Promotes Myocardial I/R Injury by Increasing the Inflammatory Responses and Oxidative Stress Reactions.
Hu X, Ma R, Lu J, Zhang K, Xu W, Jiang H, Da Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology38(6)2163-72(2016)

Zinc regulates expression of IL-23 p19 mRNA via activation of eIF2?/ATF4 axis in HAPI cells.
Doi T, Hara H, Kajita M, Kamiya T, Adachi T
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine28(5)891-902(2015 Oct)

Damage effect of interleukin (IL)-23 on oxygen-glucose-deprived cells of the neurovascular unit via IL-23 receptor.
Wang M, Zhong D, Zheng Y, Li H, Chen H, Ma S, Sun Y, Yan W, Li G
Neuroscience289406-16(2015 Mar)

Gene from a psoriasis susceptibility locus primes the skin for inflammation.
Wolf R, Mascia F, Dharamsi A, Howard OM, Cataisson C, Bliskovski V, Winston J, Feigenbaum L, Lichti U, Ruzicka T, Chavakis T, Yuspa SH
Science translational medicine2(61)61ra90(2010 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The present study suggested that IL-23 may promote myocardial ischemia and reperfusion (I/R) injury by increasing the inflammatory responses and oxidative stress reaction.
Title: IL-23 Promotes Myocardial I/R Injury by Increasing the Inflammatory Responses and Oxidative Stress Reactions.

Zn(2+) stimulated the phosphorylation of eIF2a and promoted the nuclear accumulation of activating transcription factor 4 (ATF4). Treatment with salubrinal enhanced Zn(2+)-induced ATF4 accumulation and IL-23 p19 mRNA expression.
Title: Zinc regulates expression of IL-23 p19 mRNA via activation of eIF2?/ATF4 axis in HAPI cells.

Study provides evidence that IL-23/IL-23R plays a critical role in brain ischemic injury
Title: Damage effect of interleukin (IL)-23 on oxygen-glucose-deprived cells of the neurovascular unit via IL-23 receptor.

The IL-23/IL-17 axis is strongly activated in the colon of B27/Hubeta(2)m-transgenic rats with spondylarthritis-like disease.
Title: HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats.

These data support the hypothesis that the E2F1-p19(ARF)-p53 pathway forms a negative feedback loop to regulate the cell cycle of renal tubular cells in the ischemic ARF.
Title: Role of the E2F1-p19-p53 pathway in ischemic acute renal failure.

The following Il23a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Il23a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00364	NM_130410.2 Latest version!	Rattus norvegicus interleukin 23 subunit alpha (Il23a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Il23a ( NM_130410.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_569094.1 Rattus norvegicus interleukin 23 subunit alpha (Il23a), mRNA.

Price & Availability↑

CloneID	ORa00364
Clone ID Related Accession (Same CDS sequence)	NM_130410.2
Accession Version	NM_130410.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 591bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	interleukin-23 subunit alpha precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC098907.1. On Jul 13, 2005 this sequence version replaced NM_130410.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC098907.1, AY055379.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCTGGATT GCAGAGCAAT AATACTCCTG TGGCTGTTGC CCTGGGCCAC TCAGGGGCTG 
GCTGTGCCTA GGAGTAGCAG TCCTGACTGG GCTCAGTGCC AGCAGCTCTC CCGGAATCTC 
TGCACACTAG CCTGGAGTGC ACACACACCA GTGGGACAAA TGGATCTACT AAGAGAAGAA 
GGGGAAGAAG AGACTAAAAG TGACGTGCCC CGTATCCAGT GTGGTGATGG TTGTGATCCC 
CAAGGTCTCA AGGACAACAG CCAGTTCTGT TTGCAAAGGA TCCGCCAAGG TCTGGTGTTT 
TATAAGCACC TGCTGGACTC GGACATCTTC ACAGGGGAGC CTTCTCTACT CCCGGATAGC 
CCTGTGGACC AGCTTCATAC CTCCCTACTG GGCCTCAGCC AGCTCCTCCA GCCAGAGGAT 
CACCACTGGG AGACTCAACA GATGCCTCGC CTGAGTCCCA GCCAGCAGTG GCAGCGTTCT 
CTTCTCCGTT CCAAGATCCT TCGCAGCCTC CAAGCCTTTC TGGCCATAGC TGCCCGGGTC 
TTTGCCCACG GAGCAGCAAC TCTGACTGAG CCCTTAGTGC CAACGGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_569094.1
CDS	308..898
Translation	MLDCRAIILLWLLPWATQGLAVPRSSSPDWAQCQQLSRNLCTLAWSAHTPVGQMDLLREEGEEETKSDVPRIQCGDGCDPQGLKDNSQFCLQRIRQGLVFYKHLLDSDIFTGEPSLLPDSPVDQLHTSLLGLSQLLQPEDHHWETQQMPRLSPSQQWQRSLLRSKILRSLQAFLAIAARVFAHGAATLTEPLVPTA

Target ORF information:

RefSeq Version	NM_130410.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus interleukin 23 subunit alpha (Il23a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130410.2

ORF Insert Sequence:

ATGCTGGATT GCAGAGCAAT AATACTCCTG TGGCTGTTGC CCTGGGCCAC TCAGGGGCTG 
GCTGTGCCTA GGAGTAGCAG TCCTGACTGG GCTCAGTGCC AGCAGCTCTC CCGGAATCTC 
TGCACACTAG CCTGGAGTGC ACACACACCA GTGGGACAAA TGGATCTACT AAGAGAAGAA 
GGGGAAGAAG AGACTAAAAG TGACGTGCCC CGTATCCAGT GTGGTGATGG TTGTGATCCC 
CAAGGTCTCA AGGACAACAG CCAGTTCTGT TTGCAAAGGA TCCGCCAAGG TCTGGTGTTT 
TATAAGCACC TGCTGGACTC GGACATCTTC ACAGGGGAGC CTTCTCTACT CCCGGATAGC 
CCTGTGGACC AGCTTCATAC CTCCCTACTG GGCCTCAGCC AGCTCCTCCA GCCAGAGGAT 
CACCACTGGG AGACTCAACA GATGCCTCGC CTGAGTCCCA GCCAGCAGTG GCAGCGTTCT 
CTTCTCCGTT CCAAGATCCT TCGCAGCCTC CAAGCCTTTC TGGCCATAGC TGCCCGGGTC 
TTTGCCCACG GAGCAGCAAC TCTGACTGAG CCCTTAGTGC CAACGGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Promoting effects of IL?23 on myocardial ischemia and reperfusion are associated with increased expression of IL?17A and upregulation of the JAK2?STAT3 signaling pathway.
Molecular medicine reports16(6)9309-9316(2017 Dec)
Liao Y,Hu X,Guo X,Zhang B,Xu W,Jiang H

IL-23 Promotes Myocardial I/R Injury by Increasing the Inflammatory Responses and Oxidative Stress Reactions.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology38(6)2163-72(2016)
Hu X,Ma R,Lu J,Zhang K,Xu W,Jiang H,Da Y

Zinc regulates expression of IL-23 p19 mRNA via activation of eIF2?/ATF4 axis in HAPI cells.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine28(5)891-902(2015 Oct)
Doi T,Hara H,Kajita M,Kamiya T,Adachi T

Damage effect of interleukin (IL)-23 on oxygen-glucose-deprived cells of the neurovascular unit via IL-23 receptor.
Neuroscience289406-16(2015 Mar)
Wang M,Zhong D,Zheng Y,Li H,Chen H,Ma S,Sun Y,Yan W,Li G

Gene from a psoriasis susceptibility locus primes the skin for inflammation.
Science translational medicine2(61)61ra90(2010 Dec)
Wolf R,Mascia F,Dharamsi A,Howard OM,Cataisson C,Bliskovski V,Winston J,Feigenbaum L,Lichti U,Ruzicka T,Chavakis T,Yuspa SH

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Il23a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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