Mmp10 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mmp10
Entrez Gene ID	117061
Full Name	matrix metallopeptidase 10
General protein information	Preferred Names matrix metallopeptidase 10 Names stromelysin-2 MMP-10 SL-2 matrix metalloproteinase-10 transformation-associated protein 34A transin-2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q11
Summary	enzyme and a transformation-associated protein; activates procollagenase and degrades fibronectin and some gelatins [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_133514.1	NP_598198.1	stromelysin-2 precursor

Pathways from BioSystems

Homologies

	MMP10	XP_001086245.1
Rattus norvegicus (Norway rat)	Mmp10	NP_598198.1
Mus musculus (house mouse)	Mmp10	NP_062344.1
Pan troglodytes (chimpanzee)	MMP10	XP_001153881.1
Homo sapiens (human)	MMP10	NP_002416.1
Gallus gallus (chicken)	MMP10	NP_001265018.1

Gene Ontology
Bibliography

Related articles in PubMed

Aldose reductase inhibitor counteracts the enhanced expression of matrix metalloproteinase-10 and improves corneal wound healing in galactose-fed rats.
Takamura Y, Matsumoto T, Tomomatsu T, Matsumura T, Takihara Y, Inatani M
Molecular vision192477-86(2013)

Cerebrospinal fluid matrix metalloproteinases are elevated in cerebral adrenoleukodystrophy and correlate with MRI severity and neurologic dysfunction.
Thibert KA, Raymond GV, Nascene DR, Miller WP, Tolar J, Orchard PJ, Lund TC
PloS one7(11)e50430(2012)

Matrix metalloproteinases: discrete elevations in essential hypertension and hypertensive end-stage renal disease.
Friese RS, Rao F, Khandrika S, Thomas B, Ziegler MG, Schmid-Sch?nbein GW, O'Connor DT
Clinical and experimental hypertension (New York, N.Y. : 1993)31(7)521-33(2009 Oct)

Matrix metalloproteinases regulate mesonephric cell migration in developing XY gonads which correlates with the inhibition of tissue inhibitor of metalloproteinase-3 by Sry.
Nishino K, Yamanouchi K, Naito K, Tojo H
Development, growth & differentiation44(1)35-43(2002 Feb)

Overexpression of matrix metalloproteinase-10 and matrix metalloproteinase-3 in human diabetic corneas: a possible mechanism of basement membrane and integrin alterations.
Saghizadeh M, Brown DJ, Castellon R, Chwa M, Huang GH, Ljubimova JY, Rosenberg S, Spirin KS, Stolitenko RB, Adachi W, Kinoshita S, Murphy G, Windsor LJ, Kenney MC, Ljubimov AV
The American journal of pathology158(2)723-34(2001 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MMP-10 modulates corneal epithelial wound healing.
Title: Aldose reductase inhibitor counteracts the enhanced expression of matrix metalloproteinase-10 and improves corneal wound healing in galactose-fed rats.

The following Mmp10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mmp10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00798	NM_133514.1 Latest version!	Rattus norvegicus matrix metallopeptidase 10 (Mmp10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mmp10 ( NM_133514.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_598198.1 Rattus norvegicus matrix metallopeptidase 10 (Mmp10), mRNA.

Price & Availability↑

CloneID	ORa00798
Clone ID Related Accession (Same CDS sequence)	NM_133514.1
Accession Version	NM_133514.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1431bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	stromelysin-2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M65253.1. ##Evidence-Data-START## Transcript exon combination :: M65253.1, X05083.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2689602, SAMEA2689605 [ECO:0000350] ##Evidence-Data-END##

ATGGAGCCAC TGGCCATCCT GGTGCTGCTG TGCTTTCCGA TCTGCTCAGC ATATCCTCTG 
CATGGGGCAG TGAGACAAGA CCACTCAACC ATGGATCTTG CTCAGCAATA CCTAGAAAAA 
TACTACAACT TTAGAAAAAA TGAGAAACAA TTTTTCAAAA GAAAGGACAG TAGTCCTGTT 
GTCAAAAAAA TTGAAGAAAT GCAGAAGTTC CTTGGGCTGG AGATGACAGG GAAGCTGGAC 
TCGAACACTG TGGAGATGAT GCACAAGCCC CGGTGTGGTG TTCCCGACGT TGGTGGCTTC 
AGTACCTTTC CAGGTTCACC CAAATGGAGG AAAAACCACA TCTCCTACAG GATTGTGAAT 
TATACACTGG ATTTACCAAG AGAGAGTGTG GATTCTGCCA TTGAGAGAGC TTTGAAGGTC 
TGGGAGGAGG TGACCCCACT CACATTCTCC AGGATCTCTG AAGGAGAGGC TGACATAATG 
ATCTCCTTTG CAGTTGGAGA ACATGGAGAC TTTTACCCTT TTGATGGAGT GGGACAGAGC 
TTGGCTCATG CCTACCCACC TGGCCCTGGA TTTTATGGAG ATGCTCACTT CGATGATGAT 
GAGAAATGGT CACTGGGACC CTCAGGGACC AATTTATTCC TGGTTGCTGC GCATGAACTT 
GGTCACTCCC TGGGTCTCTT TCACTCAAAC AACAAAGAAT CTCTGATGTA CCCAGTCTAC 
AGGTTCTCCA CGAGCCAAGC CAACATTCGC CTTTCTCAGG ATGATATAGA GGGCATTCAA 
TCCCTGTATG GAGCCCGCCC CTCCTCTGAT GCCACAGTGG TTCCTGTGCC CTCTGTCTCT 
CCAAAACCTG AGACCCCAGT CAAATGTGAT CCTGCTTTGT CCTTTGATGC AGTCACCATG 
CTGAGAGGGG AATTCCTATT CTTTAAAGAC AGGCACTTCT GGCGTAGAAC CCAGTGGAAT 
CCCGAGCCTG AATTCCATTT GATTTCAGCA TTTTGGCCCT CTCTTCCTTC AGGCTTAGAT 
GCTGCCTATG AGGCAAATAA CAAGGACAGA GTTCTGATTT TTAAAGGAAG TCAGTTCTGG 
GCAGTCCGAG GAAATGAAGT CCAAGCAGGT TACCCAAAGA GGATCCACAC TCTTGGCTTT 
CCTCCCACCG TGAAGAAGAT TGATGCAGCT GTTTTTGAAA AGGAGAAGAA GAAGACGTAT 
TTCTTTGTAG GTGACAAATA CTGGAGATTT GATGAGACAA GACAGCTTAT GGATAAAGGC 
TTCCCGAGAC TGATAACAGA TGACTTCCCA GGAATTGAGC CACAAGTTGA TGCTGTGTTA 
CATGCATTTG GGTTTTTTTA TTTCTTCTGT GGATCATCAC AGTTCGAGTT TGACCCCAAT 
GCCAGGACGG TGACACACAC ACTGAAGAGC AACAGCTGGC TGTTGTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598198.1
CDS	38..1468
Translation	MEPLAILVLLCFPICSAYPLHGAVRQDHSTMDLAQQYLEKYYNFRKNEKQFFKRKDSSPVVKKIEEMQKFLGLEMTGKLDSNTVEMMHKPRCGVPDVGGFSTFPGSPKWRKNHISYRIVNYTLDLPRESVDSAIERALKVWEEVTPLTFSRISEGEADIMISFAVGEHGDFYPFDGVGQSLAHAYPPGPGFYGDAHFDDDEKWSLGPSGTNLFLVAAHELGHSLGLFHSNNKESLMYPVYRFSTSQANIRLSQDDIEGIQSLYGARPSSDATVVPVPSVSPKPETPVKCDPALSFDAVTMLRGEFLFFKDRHFWRRTQWNPEPEFHLISAFWPSLPSGLDAAYEANNKDRVLIFKGSQFWAVRGNEVQAGYPKRIHTLGFPPTVKKIDAAVFEKEKKKTYFFVGDKYWRFDETRQLMDKGFPRLITDDFPGIEPQVDAVLHAFGFFYFFCGSSQFEFDPNARTVTHTLKSNSWLLC

Target ORF information:

RefSeq Version	NM_133514.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus matrix metallopeptidase 10 (Mmp10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133514.1

ORF Insert Sequence:

ATGGAGCCAC TGGCCATCCT GGTGCTGCTG TGCTTTCCGA TCTGCTCAGC ATATCCTCTG 
CATGGGGCAG TGAGACAAGA CCACTCAACC ATGGATCTTG CTCAGCAATA CCTAGAAAAA 
TACTACAACT TTAGAAAAAA TGAGAAACAA TTTTTCAAAA GAAAGGACAG TAGTCCTGTT 
GTCAAAAAAA TTGAAGAAAT GCAGAAGTTC CTTGGGCTGG AGATGACAGG GAAGCTGGAC 
TCGAACACTG TGGAGATGAT GCACAAGCCC CGGTGTGGTG TTCCCGACGT TGGTGGCTTC 
AGTACCTTTC CAGGTTCACC CAAATGGAGG AAAAACCACA TCTCCTACAG GATTGTGAAT 
TATACACTGG ATTTACCAAG AGAGAGTGTG GATTCTGCCA TTGAGAGAGC TTTGAAGGTC 
TGGGAGGAGG TGACCCCACT CACATTCTCC AGGATCTCTG AAGGAGAGGC TGACATAATG 
ATCTCCTTTG CAGTTGGAGA ACATGGAGAC TTTTACCCTT TTGATGGAGT GGGACAGAGC 
TTGGCTCATG CCTACCCACC TGGCCCTGGA TTTTATGGAG ATGCTCACTT CGATGATGAT 
GAGAAATGGT CACTGGGACC CTCAGGGACC AATTTATTCC TGGTTGCTGC GCATGAACTT 
GGTCACTCCC TGGGTCTCTT TCACTCAAAC AACAAAGAAT CTCTGATGTA CCCAGTCTAC 
AGGTTCTCCA CGAGCCAAGC CAACATTCGC CTTTCTCAGG ATGATATAGA GGGCATTCAA 
TCCCTGTATG GAGCCCGCCC CTCCTCTGAT GCCACAGTGG TTCCTGTGCC CTCTGTCTCT 
CCAAAACCTG AGACCCCAGT CAAATGTGAT CCTGCTTTGT CCTTTGATGC AGTCACCATG 
CTGAGAGGGG AATTCCTATT CTTTAAAGAC AGGCACTTCT GGCGTAGAAC CCAGTGGAAT 
CCCGAGCCTG AATTCCATTT GATTTCAGCA TTTTGGCCCT CTCTTCCTTC AGGCTTAGAT 
GCTGCCTATG AGGCAAATAA CAAGGACAGA GTTCTGATTT TTAAAGGAAG TCAGTTCTGG 
GCAGTCCGAG GAAATGAAGT CCAAGCAGGT TACCCAAAGA GGATCCACAC TCTTGGCTTT 
CCTCCCACCG TGAAGAAGAT TGATGCAGCT GTTTTTGAAA AGGAGAAGAA GAAGACGTAT 
TTCTTTGTAG GTGACAAATA CTGGAGATTT GATGAGACAA GACAGCTTAT GGATAAAGGC 
TTCCCGAGAC TGATAACAGA TGACTTCCCA GGAATTGAGC CACAAGTTGA TGCTGTGTTA 
CATGCATTTG GGTTTTTTTA TTTCTTCTGT GGATCATCAC AGTTCGAGTT TGACCCCAAT 
GCCAGGACGG TGACACACAC ACTGAAGAGC AACAGCTGGC TGTTGTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Aldose reductase inhibitor counteracts the enhanced expression of matrix metalloproteinase-10 and improves corneal wound healing in galactose-fed rats.
Molecular vision192477-86(2013)
Takamura Y,Matsumoto T,Tomomatsu T,Matsumura T,Takihara Y,Inatani M

Cerebrospinal fluid matrix metalloproteinases are elevated in cerebral adrenoleukodystrophy and correlate with MRI severity and neurologic dysfunction.
PloS one7(11)e50430(2012)
Thibert KA,Raymond GV,Nascene DR,Miller WP,Tolar J,Orchard PJ,Lund TC

Matrix metalloproteinases: discrete elevations in essential hypertension and hypertensive end-stage renal disease.
Clinical and experimental hypertension (New York, N.Y. : 1993)31(7)521-33(2009 Oct)
Friese RS,Rao F,Khandrika S,Thomas B,Ziegler MG,Schmid-Sch?nbein GW,O'Connor DT

Matrix metalloproteinases regulate mesonephric cell migration in developing XY gonads which correlates with the inhibition of tissue inhibitor of metalloproteinase-3 by Sry.
Development, growth & differentiation44(1)35-43(2002 Feb)
Nishino K,Yamanouchi K,Naito K,Tojo H

Overexpression of matrix metalloproteinase-10 and matrix metalloproteinase-3 in human diabetic corneas: a possible mechanism of basement membrane and integrin alterations.
The American journal of pathology158(2)723-34(2001 Feb)
Saghizadeh M,Brown DJ,Castellon R,Chwa M,Huang GH,Ljubimova JY,Rosenberg S,Spirin KS,Stolitenko RB,Adachi W,Kinoshita S,Murphy G,Windsor LJ,Kenney MC,Ljubimov AV

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Mmp10 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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