Mmp10 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mmp10
Entrez Gene ID	17384
Full Name	matrix metallopeptidase 10
Synonyms	AV377895,MMP-10,SL-2
General protein information	Preferred Names matrix metallopeptidase 10 Names stromelysin-2 matrix metalloproteinase 10 transin-2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 A1
Summary	This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. The lack of encoded protein in mice promotes experimental lung cancer formation, exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019471.3	NP_062344.1	stromelysin-2 preproprotein

Pathways from BioSystems

Homologies

	MMP10	XP_001086245.1
Rattus norvegicus (Norway rat)	Mmp10	NP_598198.1
Mus musculus (house mouse)	Mmp10	NP_062344.1
Pan troglodytes (chimpanzee)	MMP10	XP_001153881.1
Homo sapiens (human)	MMP10	NP_002416.1
Gallus gallus (chicken)	MMP10	NP_001265018.1

Gene Ontology
Bibliography

Related articles in PubMed

Stromelysin-2 (MMP-10) facilitates clearance and moderates inflammation and cell death following lung exposure to long multiwalled carbon nanotubes.
Vandivort TC, Birkland TP, Domiciano TP, Mitra S, Kavanagh TJ, Parks WC
International journal of nanomedicine121019-1031(2017)

Stromelysin-2 (MMP10) Moderates Inflammation by Controlling Macrophage Activation.
McMahan RS, Birkland TP, Smigiel KS, Vandivort TC, Rohani MG, Manicone AM, McGuire JK, Gharib SA, Parks WC
Journal of immunology (Baltimore, Md. : 1950)197(3)899-909(2016 08)

Integrative pathway genomics of lung function and airflow obstruction.
Gharib SA, Loth DW, Soler Artigas M, Birkland TP, Wilk JB, Wain LV, Brody JA, Obeidat M, Hancock DB, Tang W, Rawal R, Boezen HM, Imboden M, Huffman JE, Lahousse L, Alves AC, Manichaikul A, Hui J, Morrison AC, Ramasamy A, Smith AV, Gudnason V, Surakka I, Vitart V, Evans DM, Strachan DP, Deary IJ, Hofman A, Gl?ser S, Wilson JF, North KE, Zhao JH, Heckbert SR, Jarvis DL, Probst-Hensch N, Schulz H, Barr RG, Jarvelin MR, O'Connor GT, K?h?nen M, Cassano PA, Hysi PG, Dupuis J, Hayward C, Psaty BM, Hall IP, Parks WC, Tobin MD, London SJ, ,
Human molecular genetics24(23)6836-48(2015 12)

Matrix Metalloproteinase 10 Degradomics in Keratinocytes and Epidermal Tissue Identifies Bioactive Substrates With Pleiotropic Functions.
Schlage P, Kockmann T, Sabino F, Kizhakkedathu JN, Auf dem Keller U
Molecular & cellular proteomics : MCP14(12)3234-46(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MMP-10 facilitates the clearance of multiwalled carbon nanotubesand moderates the pro-inflammatory response of exposed alveolar and infiltrated macrophages.
Title: Stromelysin-2 (MMP-10) facilitates clearance and moderates inflammation and cell death following lung exposure to long multiwalled carbon nanotubes.

These results indicate that MMP10 serves a beneficial role in response to acute infection by moderating the proinflammatory response of resident and infiltrating macrophages.
Title: Stromelysin-2 (MMP10) Moderates Inflammation by Controlling Macrophage Activation.

crosstalk between MMP10 and the CXCR4/SDF1 axis contributes to hepatocarcinogenesis
Title: Matrix metalloproteinase 10 contributes to hepatocarcinogenesis in a novel crosstalk with the stromal derived factor 1/C-X-C chemokine receptor 4 axis.

our findings support a model in which MMP-10 activity modulates CXCR4/SDF1 signaling, which is essential for efficient skeletal muscle regeneration.
Title: The CXCR4/SDF1 axis improves muscle regeneration through MMP-10 activity.

Dissection of the matrix metalloproteinase 10 (MMP10) substrate degradome in fibroblast secretomes.
Title: Time-resolved analysis of the matrix metalloproteinase 10 substrate degradome.

The following Mmp10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mmp10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18246	NM_019471.3 Latest version!	Mus musculus matrix metallopeptidase 10 (Mmp10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$279.30 $399.00

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mmp10 ( NM_019471.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062344.1 Mus musculus matrix metallopeptidase 10 (Mmp10), mRNA.

Price & Availability↑

CloneID	OMu18246
Clone ID Related Accession (Same CDS sequence)	NM_019471.3
Accession Version	NM_019471.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1431bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-25
Organism	Mus musculus(house mouse)
Product	stromelysin-2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK020292.1. On Dec 18, 2013 this sequence version replaced NM_019471.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK020292.1, Y13185.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN01164133 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCCAC TAGCCATCCT GGCACTGCTG AGCCTACCAA TCTGCTCAGC GTATCCTCTG 
CATGGGGCAG TGACACAAGG CCACCCAAGC ATGGATCTTG CTCAGCAATA CCTAGAAAAA 
TACTACAACT TTAAAAAAAA TGAGAAACAA ATTTTCAAAA GAAAGGACAG TAGTCCTGTT 
GTCAAAAAAA TTCAAGAAAT GCAGAAGTTC CTCGGGTTGG AGATGACAGG GAAGCTGGAC 
TCCAACACTA TGGAGCTGAT GCACAAGCCC AGGTGTGGTG TTCCTGATGT TGGTGGCTTC 
AGTACCTTCC CAGGTTCGCC AAAATGGAGG AAATCCCACA TCACCTACAG GATTGTGAAT 
TATACACCAG ATTTGCCAAG ACAGAGTGTG GATTCTGCCA TTGAGAAAGC TTTGAAGGTC 
TGGGAGGAGG TGACCCCACT CACTTTCTCC AGGATCTCTG AAGGAGAGGC TGACATAATG 
ATCTCCTTTG CAGTTGGAGA ACACGGAGAC TTTTACCCTT TTGATGGGCC AGGACAGAGT 
CTGGCTCATG CCTACCCACC TGGCCCTGGA TTTTATGGAG ATGTTCACTT CGATGATGAT 
GAGAAATGGA CACTTGCACC CTCAGGGACC AACTTATTCC TGGTTGCAGC CCATGAACTT 
GGCCACTCCC TGGGTCTCTT TCATTCCGAC AAGAAAGAAT CTCTGATGTA CCCAGTCTAC 
AGGTTCTCCA CAAGCCCAGC TAACTTCCAC CTTTCTCAAG ATGATATAGA GGGCATTCAA 
TCCCTGTATG GAGCCGGTCC CTCCTCCGAT GCCACAGTGG TTCCTGTGTT GTCTGTCTCT 
CCAAGACCTG AGACCCCAGA CAAATGTGAT CCTGCTTTGT CCTTTGATTC AGTCAGCACG 
CTGAGAGGGG AAGTCCTATT CTTTAAAGAC AGGTACTTCT GGCGCAGATC CCATTGGAAT 
CCCGAGCCTG AATTTCATTT GATATCAGCA TTTTGGCCCA CTCTTCCTTC AGACTTAGAT 
GCTGCCTATG AGGCTCACAA CACGGACAGT GTTCTGATTT TTAAAGGAAG TCAGTTCTGG 
GCAGTCCGAG GAAATGAAGT CCAAGCAGGC TACCCAAAGG GGATCCACAC TCTCGGTTTT 
CCTCCCACCG TGAAGAAGAT TGATGCAGCT GTTTTTGAAA AGGAGAAGAA GAAAACGTAC 
TTCTTTGTAG GGGACAAATA CTGGAGATTT GATGAGACAA GACATGTTAT GGATAAAGGC 
TTCCCAAGAC AGATAACAGA TGATTTTCCA GGAATTGAGC CACAAGTTGA TGCTGTGTTA 
CACGAATTTG GGTTTTTTTA TTTCTTCCGA GGATCATCAC AGTTCGAGTT TGACCCCAAT 
GCCAGGACGG TGACACACAT ACTGAAGAGC AACAGCTGGC TGCTGTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062344.1
CDS	53..1483
Translation	MEPLAILALLSLPICSAYPLHGAVTQGHPSMDLAQQYLEKYYNFKKNEKQIFKRKDSSPVVKKIQEMQKFLGLEMTGKLDSNTMELMHKPRCGVPDVGGFSTFPGSPKWRKSHITYRIVNYTPDLPRQSVDSAIEKALKVWEEVTPLTFSRISEGEADIMISFAVGEHGDFYPFDGPGQSLAHAYPPGPGFYGDVHFDDDEKWTLAPSGTNLFLVAAHELGHSLGLFHSDKKESLMYPVYRFSTSPANFHLSQDDIEGIQSLYGAGPSSDATVVPVLSVSPRPETPDKCDPALSFDSVSTLRGEVLFFKDRYFWRRSHWNPEPEFHLISAFWPTLPSDLDAAYEAHNTDSVLIFKGSQFWAVRGNEVQAGYPKGIHTLGFPPTVKKIDAAVFEKEKKKTYFFVGDKYWRFDETRHVMDKGFPRQITDDFPGIEPQVDAVLHEFGFFYFFRGSSQFEFDPNARTVTHILKSNSWLLC

Target ORF information:

RefSeq Version	NM_019471.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus matrix metallopeptidase 10 (Mmp10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019471.3

ORF Insert Sequence:

ATGGAGCCAC TAGCCATCCT GGCACTGCTG AGCCTACCAA TCTGCTCAGC GTATCCTCTG 
CATGGGGCAG TGACACAAGG CCACCCAAGC ATGGATCTTG CTCAGCAATA CCTAGAAAAA 
TACTACAACT TTAAAAAAAA TGAGAAACAA ATTTTCAAAA GAAAGGACAG TAGTCCTGTT 
GTCAAAAAAA TTCAAGAAAT GCAGAAGTTC CTCGGGTTGG AGATGACAGG GAAGCTGGAC 
TCCAACACTA TGGAGCTGAT GCACAAGCCC AGGTGTGGTG TTCCTGATGT TGGTGGCTTC 
AGTACCTTCC CAGGTTCGCC AAAATGGAGG AAATCCCACA TCACCTACAG GATTGTGAAT 
TATACACCAG ATTTGCCAAG ACAGAGTGTG GATTCTGCCA TTGAGAAAGC TTTGAAGGTC 
TGGGAGGAGG TGACCCCACT CACTTTCTCC AGGATCTCTG AAGGAGAGGC TGACATAATG 
ATCTCCTTTG CAGTTGGAGA ACACGGAGAC TTTTACCCTT TTGATGGGCC AGGACAGAGT 
CTGGCTCATG CCTACCCACC TGGCCCTGGA TTTTATGGAG ATGTTCACTT CGATGATGAT 
GAGAAATGGA CACTTGCACC CTCAGGGACC AACTTATTCC TGGTTGCAGC CCATGAACTT 
GGCCACTCCC TGGGTCTCTT TCATTCCGAC AAGAAAGAAT CTCTGATGTA CCCAGTCTAC 
AGGTTCTCCA CAAGCCCAGC TAACTTCCAC CTTTCTCAAG ATGATATAGA GGGCATTCAA 
TCCCTGTATG GAGCCGGTCC CTCCTCCGAT GCCACAGTGG TTCCTGTGTT GTCTGTCTCT 
CCAAGACCTG AGACCCCAGA CAAATGTGAT CCTGCTTTGT CCTTTGATTC AGTCAGCACG 
CTGAGAGGGG AAGTCCTATT CTTTAAAGAC AGGTACTTCT GGCGCAGATC CCATTGGAAT 
CCCGAGCCTG AATTTCATTT GATATCAGCA TTTTGGCCCA CTCTTCCTTC AGACTTAGAT 
GCTGCCTATG AGGCTCACAA CACGGACAGT GTTCTGATTT TTAAAGGAAG TCAGTTCTGG 
GCAGTCCGAG GAAATGAAGT CCAAGCAGGC TACCCAAAGG GGATCCACAC TCTCGGTTTT 
CCTCCCACCG TGAAGAAGAT TGATGCAGCT GTTTTTGAAA AGGAGAAGAA GAAAACGTAC 
TTCTTTGTAG GGGACAAATA CTGGAGATTT GATGAGACAA GACATGTTAT GGATAAAGGC 
TTCCCAAGAC AGATAACAGA TGATTTTCCA GGAATTGAGC CACAAGTTGA TGCTGTGTTA 
CACGAATTTG GGTTTTTTTA TTTCTTCCGA GGATCATCAC AGTTCGAGTT TGACCCCAAT 
GCCAGGACGG TGACACACAT ACTGAAGAGC AACAGCTGGC TGCTGTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Stromelysin-2 (MMP-10) facilitates clearance and moderates inflammation and cell death following lung exposure to long multiwalled carbon nanotubes.
International journal of nanomedicine121019-1031(2017)
Vandivort TC,Birkland TP,Domiciano TP,Mitra S,Kavanagh TJ,Parks WC

Stromelysin-2 (MMP10) Moderates Inflammation by Controlling Macrophage Activation.
Journal of immunology (Baltimore, Md. : 1950)197(3)899-909(2016 08)
McMahan RS,Birkland TP,Smigiel KS,Vandivort TC,Rohani MG,Manicone AM,McGuire JK,Gharib SA,Parks WC

Integrative pathway genomics of lung function and airflow obstruction.
Human molecular genetics24(23)6836-48(2015 12)
Gharib SA,Loth DW,Soler Artigas M,Birkland TP,Wilk JB,Wain LV,Brody JA,Obeidat M,Hancock DB,Tang W,Rawal R,Boezen HM,Imboden M,Huffman JE,Lahousse L,Alves AC,Manichaikul A,Hui J,Morrison AC,Ramasamy A,Smith AV,Gudnason V,Surakka I,Vitart V,Evans DM,Strachan DP,Deary IJ,Hofman A,Gl?ser S,Wilson JF,North KE,Zhao JH,Heckbert SR,Jarvis DL,Probst-Hensch N,Schulz H,Barr RG,Jarvelin MR,O'Connor GT,K?h?nen M,Cassano PA,Hysi PG,Dupuis J,Hayward C,Psaty BM,Hall IP,Parks WC,Tobin MD,London SJ,,

Matrix Metalloproteinase 10 Degradomics in Keratinocytes and Epidermal Tissue Identifies Bioactive Substrates With Pleiotropic Functions.
Molecular & cellular proteomics : MCP14(12)3234-46(2015 Dec)
Schlage P,Kockmann T,Sabino F,Kizhakkedathu JN,Auf dem Keller U

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Mmp10 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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