Six1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Six1
Entrez Gene ID	114634
Full Name	SIX homeobox 1
General protein information	Preferred Names SIX homeobox 1 Names homeobox protein SIX1 sine oculis homeobox homolog 1 sine oculis-related homeobox 1 homolog
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q24
Summary	homeobox gene; may be involved in transcription of optic nerve genes [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053759.1	NP_446211.1	homeobox protein SIX1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SIX1	XP_547841.3
Mus musculus (house mouse)	Six1	NP_033215.2
Gallus gallus (chicken)	SIX1	NP_001038150.1
Danio rerio (zebrafish)	six1b	NP_996978.1
Pan troglodytes (chimpanzee)	SIX1	XP_509988.2
	SIX1	XP_001096585.1
Rattus norvegicus (Norway rat)	Six1	NP_446211.1
Xenopus tropicalis (tropical clawed frog)	six1	NP_001093693.1
Homo sapiens (human)	SIX1	NP_005973.1
Bos taurus (cattle)	SIX1	XP_002691065.3
Drosophila melanogaster (fruit fly)	so	NP_476733.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011695	XP_320814.4

Gene Ontology
Bibliography

Related articles in PubMed

Eya4 Induces Hypertrophy via Regulation of p27kip1.
Williams T, Hundertmark M, Nordbeck P, Voll S, Arias-Loza PA, Oppelt D, M?hlfelder M, Schraut S, Elsner I, Czolbe M, Seidlmayer L, Heinze B, Hahner S, Heinze K, Sch?nberger J, Jakob P, Ritter O
Circulation. Cardiovascular genetics8(6)752-64(2015 Dec)

Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors.
Wegert J, Ishaque N, Vardapour R, Ge?rg C, Gu Z, Bieg M, Ziegler B, Bausenwein S, Nourkami N, Ludwig N, Keller A, Grimm C, Kneitz S, Williams RD, Chagtai T, Pritchard-Jones K, van Sluis P, Volckmann R, Koster J, Versteeg R, Acha T, O'Sullivan MJ, Bode PK, Niggli F, Tytgat GA, van Tinteren H, van den Heuvel-Eibrink MM, Meese E, Vokuhl C, Leuschner I, Graf N, Eils R, Pfister SM, Kool M, Gessler M
Cancer cell27(2)298-311(2015 Feb)

Expression of Eya1 and Six1 is decreased in distal airways of rats with experimental pulmonary hypoplasia.
Friedmacher F, Fujiwara N, Hofmann AD, Takahashi H, Gosemann JH, Puri P
Journal of pediatric surgery49(2)301-4(2014 Feb)

Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome.
Patrick AN, Cabrera JH, Smith AL, Chen XS, Ford HL, Zhao R
Nature structural & molecular biology20(4)447-53(2013 Apr)

EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.
Ahmed M, Xu J, Xu PX
Development (Cambridge, England)139(11)1965-77(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Downregulation of Eya1 and Six1 gene expression in nitrofen-induced PH suggests that decreased Eya1 and Six1 expression during the late pseudoglandular stage may interfere with epithelial branching and distal airway maturation, thus resulting in PH.
Title: Expression of Eya1 and Six1 is decreased in distal airways of rats with experimental pulmonary hypoplasia.

The following Six1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Six1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10543	NM_053759.1 Latest version!	Rattus norvegicus SIX homeobox 1 (Six1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Six1 ( NM_053759.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446211.1 Rattus norvegicus SIX homeobox 1 (Six1), mRNA.

Price & Availability↑

CloneID	ORa10543
Clone ID Related Accession (Same CDS sequence)	NM_053759.1
Accession Version	NM_053759.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	homeobox protein SIX1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07064811.1. On or before Oct 25, 2008 this sequence version replaced XM_001080688.1, XM_343079.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF323957.1, DY320834.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689600, SAMEA2689602 [ECO:0000348] ##Evidence-Data-END##

ATGTCGATGC TGCCGTCGTT TGGTTTTACT CAAGAGCAAG TGGCGTGCGT GTGCGAGGTT 
CTGCAGCAAG GAGGGAACCT GGAACGCCTG GGCAGGTTCT TGTGGTCGTT GCCCGCCTGC 
GATCACCTGC ACAAGAACGA GAGCGTGCTC AAGGCCAAGG CGGTGGTCGC CTTCCACCGC 
GGCAACTTCC GCGAGCTCTA CAAGATCCTG GAGAGCCACC AGTTCTCGCC TCACAACCAT 
CCCAAATTGC AGCAGCTGTG GCTGAAAGCG CACTACGTGG AGGCCGAGAA ACTTCGCGGC 
CGACCCCTGG GTGCCGTGGG CAAATATCGG GTGCGCCGAA AATTCCCGTT GCCGCGCACC 
ATCTGGGATG GCGAAGAGAC TAGCTACTGT TTTAAGGAGA AGTCTCGGGG CGTGCTGAGG 
GAGTGGTACG CGCACAACCC CTACCCCTCG CCGCGGGAGA AGCGGGAGCT GGCCGAGGCT 
ACGGGCCTCA CCACCACCCA GGTCAGCAAC TGGTTTAAGA ACCGGAGGCA AAGAGACCGG 
GCCGCCGAGG CCAAGGAAAG GGAGAACACC GAAAACAATA ACTCCTCCTC CAACAAGCAG 
AATCAACTCT CTCCTCTGGA AGGGGGCAAG CCGCTCATGT CCAGCTCAGA AGAGGAATTC 
TCACCTCCCC AAAGTCCAGA CCAGAACTCG GTCCTCCTGC TCCAGAGCAA TATGGGCCAT 
GCCAGGAGCT CAAACTATTC TCTTCCGGGC CTAACGGCCT CACAGCCCAG CCATGGCCTG 
CAGGCTCATC AGCACCAGCT CCAGGACTCT CTGCTGGGCC CGCTCACCTC CAGTCTGGTG 
GACTTGGGTT CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446211.1
CDS	616..1470
Translation	MSMLPSFGFTQEQVACVCEVLQQGGNLERLGRFLWSLPACDHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENTENNNSSSNKQNQLSPLEGGKPLMSSSEEEFSPPQSPDQNSVLLLQSNMGHARSSNYSLPGLTASQPSHGLQAHQHQLQDSLLGPLTSSLVDLGS

Target ORF information:

RefSeq Version	NM_053759.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus SIX homeobox 1 (Six1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053759.1

ORF Insert Sequence:

ATGTCGATGC TGCCGTCGTT TGGTTTTACT CAAGAGCAAG TGGCGTGCGT GTGCGAGGTT 
CTGCAGCAAG GAGGGAACCT GGAACGCCTG GGCAGGTTCT TGTGGTCGTT GCCCGCCTGC 
GATCACCTGC ACAAGAACGA GAGCGTGCTC AAGGCCAAGG CGGTGGTCGC CTTCCACCGC 
GGCAACTTCC GCGAGCTCTA CAAGATCCTG GAGAGCCACC AGTTCTCGCC TCACAACCAT 
CCCAAATTGC AGCAGCTGTG GCTGAAAGCG CACTACGTGG AGGCCGAGAA ACTTCGCGGC 
CGACCCCTGG GTGCCGTGGG CAAATATCGG GTGCGCCGAA AATTCCCGTT GCCGCGCACC 
ATCTGGGATG GCGAAGAGAC TAGCTACTGT TTTAAGGAGA AGTCTCGGGG CGTGCTGAGG 
GAGTGGTACG CGCACAACCC CTACCCCTCG CCGCGGGAGA AGCGGGAGCT GGCCGAGGCT 
ACGGGCCTCA CCACCACCCA GGTCAGCAAC TGGTTTAAGA ACCGGAGGCA AAGAGACCGG 
GCCGCCGAGG CCAAGGAAAG GGAGAACACC GAAAACAATA ACTCCTCCTC CAACAAGCAG 
AATCAACTCT CTCCTCTGGA AGGGGGCAAG CCGCTCATGT CCAGCTCAGA AGAGGAATTC 
TCACCTCCCC AAAGTCCAGA CCAGAACTCG GTCCTCCTGC TCCAGAGCAA TATGGGCCAT 
GCCAGGAGCT CAAACTATTC TCTTCCGGGC CTAACGGCCT CACAGCCCAG CCATGGCCTG 
CAGGCTCATC AGCACCAGCT CCAGGACTCT CTGCTGGGCC CGCTCACCTC CAGTCTGGTG 
GACTTGGGTT CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Eya4 Induces Hypertrophy via Regulation of p27kip1.
Circulation. Cardiovascular genetics8(6)752-64(2015 Dec)
Williams T,Hundertmark M,Nordbeck P,Voll S,Arias-Loza PA,Oppelt D,M?hlfelder M,Schraut S,Elsner I,Czolbe M,Seidlmayer L,Heinze B,Hahner S,Heinze K,Sch?nberger J,Jakob P,Ritter O

Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors.
Cancer cell27(2)298-311(2015 Feb)
Wegert J,Ishaque N,Vardapour R,Ge?rg C,Gu Z,Bieg M,Ziegler B,Bausenwein S,Nourkami N,Ludwig N,Keller A,Grimm C,Kneitz S,Williams RD,Chagtai T,Pritchard-Jones K,van Sluis P,Volckmann R,Koster J,Versteeg R,Acha T,O'Sullivan MJ,Bode PK,Niggli F,Tytgat GA,van Tinteren H,van den Heuvel-Eibrink MM,Meese E,Vokuhl C,Leuschner I,Graf N,Eils R,Pfister SM,Kool M,Gessler M

Expression of Eya1 and Six1 is decreased in distal airways of rats with experimental pulmonary hypoplasia.
Journal of pediatric surgery49(2)301-4(2014 Feb)
Friedmacher F,Fujiwara N,Hofmann AD,Takahashi H,Gosemann JH,Puri P

Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome.
Nature structural & molecular biology20(4)447-53(2013 Apr)
Patrick AN,Cabrera JH,Smith AL,Chen XS,Ford HL,Zhao R

EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.
Development (Cambridge, England)139(11)1965-77(2012 Jun)
Ahmed M,Xu J,Xu PX

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Six1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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