so cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	so
Entrez Gene ID	35662
Full Name	sine oculis
Synonyms	CG11121,Dmel\CG11121,Drl,SO,So,ami,mda,med,old,somda
General protein information	Preferred Names sine oculis Names CG11121 gene product from transcript CG11121-RA CG11121-PA absent minded droplet medusa optic lobe defective sine oculus sinus oculis so-PA
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2R Map Location: 43B3-43C1\|2-57.1 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_057385.5	NP_476733.1	sine oculis

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SIX1	XP_547841.3
Mus musculus (house mouse)	Six1	NP_033215.2
Gallus gallus (chicken)	SIX1	NP_001038150.1
Danio rerio (zebrafish)	six1b	NP_996978.1
Pan troglodytes (chimpanzee)	SIX1	XP_509988.2
	SIX1	XP_001096585.1
Rattus norvegicus (Norway rat)	Six1	NP_446211.1
Xenopus tropicalis (tropical clawed frog)	six1	NP_001093693.1
Homo sapiens (human)	SIX1	NP_005973.1
Bos taurus (cattle)	SIX1	XP_002691065.3
Drosophila melanogaster (fruit fly)	so	NP_476733.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011695	XP_320814.4

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Uncover a novel role for Eya and So in promoting cell cycle exit in the retinal second mitotic wave (SMW), a synchronized, terminal cell division that occurs several hours after passage of the furrow. We show that Combgap (Cg), a zinc-finger transcription factor, antagonizes Eya-So function in the SMW.
Title: Antagonistic regulation of the second mitotic wave by Eyes absent-Sine oculis and Combgap coordinates proliferation and specification in the

By removing gene function in differentiating cells, the study shows that so is dispensable for larval photoreceptor differentiation, but is required for differentiation during pupal development.
Title: Conditional knockout of retinal determination genes in differentiating cells in Drosophila.

atonal expression in Drosophila retinal progenitors involves redundant and synergistic contributions of Ey/Pax6 and So binding sites within two distant enhancers
Title: Onset of atonal expression in Drosophila retinal progenitors involves redundant and synergistic contributions of Ey/Pax6 and So binding sites within two distant enhancers.

mapping of So-enriched regions throughout the genome in third instar larval eye discs; study found 7,566 So-enriched regions, which map to approximately 5,952 genes, including previously characterized So targets in the eye
Title: Regulation of Drosophila eye development by the transcription factor Sine oculis.

Loss of So in the eye disc caused ectopic antenna development in the eye.
Title: Segregation of eye and antenna fates maintained by mutual antagonism in Drosophila.

The following so gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the so cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa12453	NM_057385.5 Latest version!	Drosophila melanogaster sine oculis (so), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

so ( NM_057385.5 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_476733.1 Drosophila melanogaster sine oculis (so), mRNA.

Price & Availability↑

CloneID	OFa12453
Clone ID Related Accession (Same CDS sequence)	NM_057385.5
Accession Version	NM_057385.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1251bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	sine oculis
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jan 16, 2013 this sequence version replaced NM_057385.4. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTTACAGC ATCCCGCCAC AGATTTCTAC GACTTGGCCG CGGCCAATGC GGCTGCCGTT 
CTCACCGCCC GTCACACGCC TCCTTATAGT CCCACCGGTC TCAGCGGATC GGTGGCCCTG 
CACAACAACA ACAACAATAA CAGCAGCACC AGCAATAACA ACAACAGCAC TCTGGACATC 
ATGGCGCACA ACGGCGGCGG AGCAGGCGGT GGCCTCCATC TGAACAGCAG CAGCAACGGC 
GGCGGCGGCG GCGGAGTGGT CAGTGGTGGA GGCTCCGGCG GCAGGGAGAA CCTGCCCAGC 
TTCGGCTTCA CCCAGGAGCA GGTGGCCTGT GTTTGCGAGG TTCTCCAGCA GGCGGGCAAC 
ATCGAAAGAC TGGGCCGCTT CCTCTGGTCG CTGCCACAAT GTGATAAGCT GCAGCTGAAC 
GAGTCCGTGC TGAAGGCCAA GGCGGTCGTC GCATTCCACC GGGGACAATA CAAGGAGCTG 
TACCGCCTGC TCGAGCATCA CCACTTCTCG GCCCAGAATC ACGCCAAGCT CCAGGCCCTG 
TGGTTGAAAG CGCATTATGT GGAAGCCGAA AAACTGCGCG GAAGACCCTT GGGTGCTGTT 
GGCAAATATC GTGTTCGCCG TAAATTTCCA TTGCCCCGCA CCATCTGGGA TGGCGAGGAG 
ACGAGCTACT GTTTTAAGGA AAAATCGCGC TCCGTACTGA GGGACTGGTA CTCGCACAAT 
CCGTATCCAT CGCCGCGGGA GAAACGCGAT CTGGCCGAGG CCACAGGACT GACCACCACG 
CAGGTTTCCA ATTGGTTCAA GAACCGACGA CAAAGAGATC GAGCTGCCGA ACACAAAGAC 
GGCTCCACGG ACAAGCAGCA CCTTGACTCC TCCAGCGACT CCGAGATGGA GGGCAGCATG 
TTGCCCAGCC AGAGTGCGCA GCACCAGCAG CAGCAGCAAC AGCAGCAGCA TTCACCCGGC 
AACAGCAGCG GCAACAACAA CGGCCTGCAT CAGCAGCAGC TGCAGCATGT CGCCGCCGAG 
CAAGGCCTGC AGCACCATCC GCACCAGCCA CATCCCGCCA GCAATATCGC CAATGTCGCC 
GCCACCAAGA GCAGTGGCGG CGGCGGCGGA GGAGGCGTGA GTGCGGCGGC CGCTGCCCAG 
ATGCAAATGC CTCCACTGAC CGCCGCCGTG GCCTATTCGC ACCTGCACAG CGTGATGGGC 
GCCATGCCCA TGACCGCCAT GTACGACATG GGCGAGTACC AGCACTTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476733.1
CDS	796..2046
Translation	MLQHPATDFYDLAAANAAAVLTARHTPPYSPTGLSGSVALHNNNNNNSSTSNNNNSTLDIMAHNGGGAGGGLHLNSSSNGGGGGGVVSGGGSGGRENLPSFGFTQEQVACVCEVLQQAGNIERLGRFLWSLPQCDKLQLNESVLKAKAVVAFHRGQYKELYRLLEHHHFSAQNHAKLQALWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRSVLRDWYSHNPYPSPREKRDLAEATGLTTTQVSNWFKNRRQRDRAAEHKDGSTDKQHLDSSSDSEMEGSMLPSQSAQHQQQQQQQQHSPGNSSGNNNGLHQQQLQHVAAEQGLQHHPHQPHPASNIANVAATKSSGGGGGGGVSAAAAAQMQMPPLTAAVAYSHLHSVMGAMPMTAMYDMGEYQHL

Target ORF information:

RefSeq Version	NM_057385.5
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster sine oculis (so), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057385.5

ORF Insert Sequence:

ATGTTACAGC ATCCCGCCAC AGATTTCTAC GACTTGGCCG CGGCCAATGC GGCTGCCGTT 
CTCACCGCCC GTCACACGCC TCCTTATAGT CCCACCGGTC TCAGCGGATC GGTGGCCCTG 
CACAACAACA ACAACAATAA CAGCAGCACC AGCAATAACA ACAACAGCAC TCTGGACATC 
ATGGCGCACA ACGGCGGCGG AGCAGGCGGT GGCCTCCATC TGAACAGCAG CAGCAACGGC 
GGCGGCGGCG GCGGAGTGGT CAGTGGTGGA GGCTCCGGCG GCAGGGAGAA CCTGCCCAGC 
TTCGGCTTCA CCCAGGAGCA GGTGGCCTGT GTTTGCGAGG TTCTCCAGCA GGCGGGCAAC 
ATCGAAAGAC TGGGCCGCTT CCTCTGGTCG CTGCCACAAT GTGATAAGCT GCAGCTGAAC 
GAGTCCGTGC TGAAGGCCAA GGCGGTCGTC GCATTCCACC GGGGACAATA CAAGGAGCTG 
TACCGCCTGC TCGAGCATCA CCACTTCTCG GCCCAGAATC ACGCCAAGCT CCAGGCCCTG 
TGGTTGAAAG CGCATTATGT GGAAGCCGAA AAACTGCGCG GAAGACCCTT GGGTGCTGTT 
GGCAAATATC GTGTTCGCCG TAAATTTCCA TTGCCCCGCA CCATCTGGGA TGGCGAGGAG 
ACGAGCTACT GTTTTAAGGA AAAATCGCGC TCCGTACTGA GGGACTGGTA CTCGCACAAT 
CCGTATCCAT CGCCGCGGGA GAAACGCGAT CTGGCCGAGG CCACAGGACT GACCACCACG 
CAGGTTTCCA ATTGGTTCAA GAACCGACGA CAAAGAGATC GAGCTGCCGA ACACAAAGAC 
GGCTCCACGG ACAAGCAGCA CCTTGACTCC TCCAGCGACT CCGAGATGGA GGGCAGCATG 
TTGCCCAGCC AGAGTGCGCA GCACCAGCAG CAGCAGCAAC AGCAGCAGCA TTCACCCGGC 
AACAGCAGCG GCAACAACAA CGGCCTGCAT CAGCAGCAGC TGCAGCATGT CGCCGCCGAG 
CAAGGCCTGC AGCACCATCC GCACCAGCCA CATCCCGCCA GCAATATCGC CAATGTCGCC 
GCCACCAAGA GCAGTGGCGG CGGCGGCGGA GGAGGCGTGA GTGCGGCGGC CGCTGCCCAG 
ATGCAAATGC CTCCACTGAC CGCCGCCGTG GCCTATTCGC ACCTGCACAG CGTGATGGGC 
GCCATGCCCA TGACCGCCAT GTACGACATG GGCGAGTACC AGCACTTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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so cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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