Dlk1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dlk1
Entrez Gene ID	114587
Full Name	delta like non-canonical Notch ligand 1
Synonyms	Pref-1,Zog
General protein information	Preferred Names delta like non-canonical Notch ligand 1 Names protein delta homolog 1 delta-like 1 homolog preadipocyte factor 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q32
Summary	involved in maintaining the undifferentiated status of the preadipocyte [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_008764917.1	XP_008763139.1	protein delta homolog 1 isoform X1
NM_053744.1	NP_446196.1	protein delta homolog 1 precursor

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	LOC101883341	XP_005173621.1
Mus musculus (house mouse)	Dlk1	NP_034182.2
Gallus gallus (chicken)	DLK1	NP_001135726.1
Homo sapiens (human)	DLK1	NP_003827.3
	DLK1	XP_001106331.1
Xenopus tropicalis (tropical clawed frog)	dlk1	XP_002936624.1
Pan troglodytes (chimpanzee)	DLK1	XP_003314552.2
Canis lupus familiaris (dog)	DLK1	XP_547982.4
Rattus norvegicus (Norway rat)	Dlk1	NP_446196.1

Gene Ontology
Bibliography

Related articles in PubMed

Preadipocyte factor 1 induces pancreatic ductal cell differentiation into insulin-producing cells.
Rhee M, Lee SH, Kim JW, Ham DS, Park HS, Yang HK, Shin JY, Cho JH, Kim YB, Youn BS, Sul HS, Yoon KH
Scientific reports623960(2016 Apr)

Characterization of fetal antigen 1/delta-like 1 homologue expressing cells in the rat nigrostriatal system: effects of a unilateral 6-hydroxydopamine lesion.
Liechti R, Ducray AD, Jensen P, Di Santo S, Seiler S, Jensen CH, Meyer M, Widmer HR
PloS one10(2)e0116088(2015)

Delta-like 1 homologue (DLK1) protein in neurons of the arcuate nucleus that control weight homeostasis and effect of fasting on hypothalamic DLK1 mRNA.
Persson-Augner D, Lee YW, Tovar S, Dieguez C, Meister B
Neuroendocrinology100(2-3)209-20(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Pref-1 induces insulin synthesis and secretion via two independent pathways
Title: Preadipocyte factor 1 induces pancreatic ductal cell differentiation into insulin-producing cells.

The differential expression of FA1/dlk1 in the SNc and the striatum of dopamine-depleted rats could indicate a potential involvement of FA1/dlk1 in the cellular response to the degenerative processes.
Title: Characterization of fetal antigen 1/delta-like 1 homologue expressing cells in the rat nigrostriatal system: effects of a unilateral 6-hydroxydopamine lesion.

The Dlk1-Dio3-imprinted domain on 6q32, is associated with the syntenic human locus in schizophrenia.
Title: Alteration of imprinted Dlk1-Dio3 miRNA cluster expression in the entorhinal cortex induced by maternal immune activation and adolescent cannabinoid exposure.

Study shows that the expression of hypothalamus-enriched DLK1 is regulated by nutritional challenge and that the DLK1 protein is present in many neurons of the arcuate nucleus, the ventromedial subdivision in particular
Title: Delta-like 1 homologue (DLK1) protein in neurons of the arcuate nucleus that control weight homeostasis and effect of fasting on hypothalamic DLK1 mRNA.

presence of DLK1 in a population of lateral hypothalamic neurones suggests a functional role for DLK1 in orexin/hypocretin/dynorphin neurones
Title: Delta-like 1 homologue is a hypothalamus-enriched protein that is present in orexin-containing neurones of the lateral hypothalamic area.

The following Dlk1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dlk1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10491	NM_053744.1 Latest version!	Rattus norvegicus delta like non-canonical Notch ligand 1 (Dlk1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa43950	XM_008764917.1 Latest version!	Rattus norvegicus delta like non-canonical Notch ligand 1 (Dlk1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dlk1 ( NM_053744.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446196.1 Rattus norvegicus delta like non-canonical Notch ligand 1 (Dlk1), mRNA.

Price & Availability↑

CloneID	ORa10491
Clone ID Related Accession (Same CDS sequence)	NM_053744.1
Accession Version	NM_053744.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1152bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	protein delta homolog 1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D84336.1. On Dec 17, 2003 this sequence version replaced XM_346776.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D84336.1, BC167752.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGATCGCGA CCGGAGCCCT CCTGCGCGTC CTCTTGCTCC TGCTGGCTTT CGGCCACAGC 
ACCTATGGGG CTGAGTGCGA CCCGGCCTGT GACCCTCAGC ATGGATTCTG TGAGGCTGAC 
AATGTCTGCA GGTGTGAGCC TGGCTGGGAG GGCCCCCTGT GTGAGAAGTG CGTAACCTCC 
CCTGGCTGTG TTAATGGACT CTGTGAAGAA CCATGGCAGT GTGTCTGCAA GGAAGGCTGG 
GACGGGAAAT TCTGCGAAAT AGATATTCGG GCTTGCACCT CTACCCCCTG CGCCAACAAT 
GGGACTTGCG TGGACCTCGA GAAAGGCCAG TACGAATGCT CCTGCACCCC TGGATTCTCT 
GGAAAGGACT GTCAGCACAA GGCTGGGCCC TGCGTGATCA ATGGTTCTCC CTGCCAGCAC 
GGAGGCGCCT GCGTGGATGA TGAGGGCCGG GCCTCGCATG CTTCCTGCCT GTGCCCCCCT 
GGCTTCTCGG GCAACTTCTG TGAGATCGTG ACCAACAGCT GTACCCCTAA CCCATGCGAG 
AACGATGGCG TCTGCACCGA CATCGGGGGC GACTTCCGTT GCCGCTGCCC AGCTGGATTC 
GTCGACAAGA CCTGCAGCCG TCCGGTGAGC AACTGCGCCA GTGGCCCGTG CCTGAACGGG 
GGCACCTGCC TCCAGCACAC CCAGGTGAGC TTCGAGTGTC TGTGCAAGCC CCCGTTCATG 
GGTCCCACAT GCGCGAAGAA GCGCGGGACC AGCCCCGTGC AGGTCACCCA CCTACCCAGC 
GGCTACGGGC TCACCTACCG CCTGACCCCC GGGGTGCACG AGCTACCTGT CCAGCAGCCC 
GAGCACCACA TCCTGAAGGT GTCCATGAAA GAGCTCAACA AGAGTGCCCC TCTCCTCACC 
GAGGGACAGG CCATCTGCTT CACCATCCTG GGCGTGCTCA CCAGCCTGGT TGTGCTGGGC 
ACCGTGGCCA TCGTCTTTCT CAACAAGTGC GAGGCCTGGG TGTCCAACCT GCGCTACAAC 
CACATGCTTC GCAAGAAGAA GAACCTGCTG TTGCAGTACA ACAGCGGCGA GGAGCTGGCG 
GTCAATATCA TCTTCCCGGA GAAGATCGAC ATGACCACCT TCAACAAGGA GGCTGGTGAT 
GAGGATATCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446196.1
CDS	136..1287
Translation	MIATGALLRVLLLLLAFGHSTYGAECDPACDPQHGFCEADNVCRCEPGWEGPLCEKCVTSPGCVNGLCEEPWQCVCKEGWDGKFCEIDIRACTSTPCANNGTCVDLEKGQYECSCTPGFSGKDCQHKAGPCVINGSPCQHGGACVDDEGRASHASCLCPPGFSGNFCEIVTNSCTPNPCENDGVCTDIGGDFRCRCPAGFVDKTCSRPVSNCASGPCLNGGTCLQHTQVSFECLCKPPFMGPTCAKKRGTSPVQVTHLPSGYGLTYRLTPGVHELPVQQPEHHILKVSMKELNKSAPLLTEGQAICFTILGVLTSLVVLGTVAIVFLNKCEAWVSNLRYNHMLRKKKNLLLQYNSGEELAVNIIFPEKIDMTTFNKEAGDEDI

Target ORF information:

RefSeq Version	NM_053744.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus delta like non-canonical Notch ligand 1 (Dlk1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053744.1

ORF Insert Sequence:

ATGATCGCGA CCGGAGCCCT CCTGCGCGTC CTCTTGCTCC TGCTGGCTTT CGGCCACAGC 
ACCTATGGGG CTGAGTGCGA CCCGGCCTGT GACCCTCAGC ATGGATTCTG TGAGGCTGAC 
AATGTCTGCA GGTGTGAGCC TGGCTGGGAG GGCCCCCTGT GTGAGAAGTG CGTAACCTCC 
CCTGGCTGTG TTAATGGACT CTGTGAAGAA CCATGGCAGT GTGTCTGCAA GGAAGGCTGG 
GACGGGAAAT TCTGCGAAAT AGATATTCGG GCTTGCACCT CTACCCCCTG CGCCAACAAT 
GGGACTTGCG TGGACCTCGA GAAAGGCCAG TACGAATGCT CCTGCACCCC TGGATTCTCT 
GGAAAGGACT GTCAGCACAA GGCTGGGCCC TGCGTGATCA ATGGTTCTCC CTGCCAGCAC 
GGAGGCGCCT GCGTGGATGA TGAGGGCCGG GCCTCGCATG CTTCCTGCCT GTGCCCCCCT 
GGCTTCTCGG GCAACTTCTG TGAGATCGTG ACCAACAGCT GTACCCCTAA CCCATGCGAG 
AACGATGGCG TCTGCACCGA CATCGGGGGC GACTTCCGTT GCCGCTGCCC AGCTGGATTC 
GTCGACAAGA CCTGCAGCCG TCCGGTGAGC AACTGCGCCA GTGGCCCGTG CCTGAACGGG 
GGCACCTGCC TCCAGCACAC CCAGGTGAGC TTCGAGTGTC TGTGCAAGCC CCCGTTCATG 
GGTCCCACAT GCGCGAAGAA GCGCGGGACC AGCCCCGTGC AGGTCACCCA CCTACCCAGC 
GGCTACGGGC TCACCTACCG CCTGACCCCC GGGGTGCACG AGCTACCTGT CCAGCAGCCC 
GAGCACCACA TCCTGAAGGT GTCCATGAAA GAGCTCAACA AGAGTGCCCC TCTCCTCACC 
GAGGGACAGG CCATCTGCTT CACCATCCTG GGCGTGCTCA CCAGCCTGGT TGTGCTGGGC 
ACCGTGGCCA TCGTCTTTCT CAACAAGTGC GAGGCCTGGG TGTCCAACCT GCGCTACAAC 
CACATGCTTC GCAAGAAGAA GAACCTGCTG TTGCAGTACA ACAGCGGCGA GGAGCTGGCG 
GTCAATATCA TCTTCCCGGA GAAGATCGAC ATGACCACCT TCAACAAGGA GGCTGGTGAT 
GAGGATATCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dlk1 ( XM_008764917.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008763139.1 Rattus norvegicus delta like non-canonical Notch ligand 1 (Dlk1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa43950
Clone ID Related Accession (Same CDS sequence)	XM_008764917.1
Accession Version	XM_008764917.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	protein delta homolog 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATCGCGA CCGGAGCCCT CCTGCGCGTC CTCTTGCTCC TGCTGGCTTT CGGCCACAGC 
ACCTATGGGG CTGAGTGCGA CCCGGCCTGT GACCCTCAGC ATGGATTCTG TGAGGCTGAC 
AATGTCTGCA GGTGTGAGCC TGGCTGGGAG GGCCCCCTGT GTGAGAAGTG CGTAACCTCC 
CCTGGCTGTG TTAATGGACT CTGTGAAGAA CCATGGCAGT GTGTCTGCAA GGAAGGCTGG 
GACGGGAAAT TCTGCGAAAT AGATATTCGG GCTTGCACCT CTACCCCCTG CGCCAACAAT 
GGGACTTGCG TGGACCTCGA GAAAGGCCAG TACGAATGCT CCTGCACCCC TGGATTCTCT 
GGAAAGGACT GTCAGCACAA GGCTGGGCCC TGCGTGATCA ATGGTTCTCC CTGCCAGCAC 
GGAGGCGCCT GCGTGGATGA TGAGGGCCGG GCCTCGCATG CTTCCTGCCT GTGCCCCCCT 
GGCTTCTCGG GCAACTTCTG TGAGATCGTG ACCAACAGCT GTACCCCTAA CCCATGCGAG 
AACGATGGCG TCTGCACCGA CATCGGGGGC GACTTCCGTT GCCGCTGCCC AGCTGGATTC 
GTCGACAAGA CCTGCAGCCG TCCGGTGAGC AACTGCGCCA GTGGCCCGTG CCTGAACGGG 
GGCACCTGCC TCCAGCACAC CCAGCCCGAG CACCACATCC TGAAGGTGTC CATGAAAGAG 
CTCAACAAGA GTGCCCCTCT CCTCACCGAG GGACAGGCCA TCTGCTTCAC CATCCTGGGC 
GTGCTCACCA GCCTGGTTGT GCTGGGCACC GTGGCCATCG TCTTTCTCAA CAAGTGCGAG 
GCCTGGGTGT CCAACCTGCG CTACAACCAC ATGCTTCGCA AGAAGAAGAA CCTGCTGTTG 
CAGTACAACA GCGGCGAGGA GCTGGCGGTC AATATCATCT TCCCGGAGAA GATCGACATG 
ACCACCTTCA ACAAGGAGGC TGGTGATGAG GATATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008763139.1
CDS	192..1190
Translation	MIATGALLRVLLLLLAFGHSTYGAECDPACDPQHGFCEADNVCRCEPGWEGPLCEKCVTSPGCVNGLCEEPWQCVCKEGWDGKFCEIDIRACTSTPCANNGTCVDLEKGQYECSCTPGFSGKDCQHKAGPCVINGSPCQHGGACVDDEGRASHASCLCPPGFSGNFCEIVTNSCTPNPCENDGVCTDIGGDFRCRCPAGFVDKTCSRPVSNCASGPCLNGGTCLQHTQPEHHILKVSMKELNKSAPLLTEGQAICFTILGVLTSLVVLGTVAIVFLNKCEAWVSNLRYNHMLRKKKNLLLQYNSGEELAVNIIFPEKIDMTTFNKEAGDEDI

Target ORF information:

RefSeq Version	XM_008764917.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus delta like non-canonical Notch ligand 1 (Dlk1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008764917.1

ORF Insert Sequence:

ATGATCGCGA CCGGAGCCCT CCTGCGCGTC CTCTTGCTCC TGCTGGCTTT CGGCCACAGC 
ACCTATGGGG CTGAGTGCGA CCCGGCCTGT GACCCTCAGC ATGGATTCTG TGAGGCTGAC 
AATGTCTGCA GGTGTGAGCC TGGCTGGGAG GGCCCCCTGT GTGAGAAGTG CGTAACCTCC 
CCTGGCTGTG TTAATGGACT CTGTGAAGAA CCATGGCAGT GTGTCTGCAA GGAAGGCTGG 
GACGGGAAAT TCTGCGAAAT AGATATTCGG GCTTGCACCT CTACCCCCTG CGCCAACAAT 
GGGACTTGCG TGGACCTCGA GAAAGGCCAG TACGAATGCT CCTGCACCCC TGGATTCTCT 
GGAAAGGACT GTCAGCACAA GGCTGGGCCC TGCGTGATCA ATGGTTCTCC CTGCCAGCAC 
GGAGGCGCCT GCGTGGATGA TGAGGGCCGG GCCTCGCATG CTTCCTGCCT GTGCCCCCCT 
GGCTTCTCGG GCAACTTCTG TGAGATCGTG ACCAACAGCT GTACCCCTAA CCCATGCGAG 
AACGATGGCG TCTGCACCGA CATCGGGGGC GACTTCCGTT GCCGCTGCCC AGCTGGATTC 
GTCGACAAGA CCTGCAGCCG TCCGGTGAGC AACTGCGCCA GTGGCCCGTG CCTGAACGGG 
GGCACCTGCC TCCAGCACAC CCAGCCCGAG CACCACATCC TGAAGGTGTC CATGAAAGAG 
CTCAACAAGA GTGCCCCTCT CCTCACCGAG GGACAGGCCA TCTGCTTCAC CATCCTGGGC 
GTGCTCACCA GCCTGGTTGT GCTGGGCACC GTGGCCATCG TCTTTCTCAA CAAGTGCGAG 
GCCTGGGTGT CCAACCTGCG CTACAACCAC ATGCTTCGCA AGAAGAAGAA CCTGCTGTTG 
CAGTACAACA GCGGCGAGGA GCTGGCGGTC AATATCATCT TCCCGGAGAA GATCGACATG 
ACCACCTTCA ACAAGGAGGC TGGTGATGAG GATATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Preadipocyte factor 1 induces pancreatic ductal cell differentiation into insulin-producing cells.
Scientific reports623960(2016 Apr)
Rhee M,Lee SH,Kim JW,Ham DS,Park HS,Yang HK,Shin JY,Cho JH,Kim YB,Youn BS,Sul HS,Yoon KH

Characterization of fetal antigen 1/delta-like 1 homologue expressing cells in the rat nigrostriatal system: effects of a unilateral 6-hydroxydopamine lesion.
PloS one10(2)e0116088(2015)
Liechti R,Ducray AD,Jensen P,Di Santo S,Seiler S,Jensen CH,Meyer M,Widmer HR

Delta-like 1 homologue (DLK1) protein in neurons of the arcuate nucleus that control weight homeostasis and effect of fasting on hypothalamic DLK1 mRNA.
Neuroendocrinology100(2-3)209-20(2014)
Persson-Augner D,Lee YW,Tovar S,Dieguez C,Meister B

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Dlk1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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