DLK1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DLK1
Entrez Gene ID	8788
Full Name	delta like non-canonical Notch ligand 1
Synonyms	DLK,DLK-1,Delta1,FA1,PREF1,Pref-1,ZOG,pG2
General protein information	Preferred Names delta like non-canonical Notch ligand 1 Names protein delta homolog 1 delta-like 1 homolog fetal antigen 1 preadipocyte factor 1 secredeltin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q32.2
Summary	This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal. [provided by RefSeq, Nov 2015].
Disorder MIM:	176290

mRNA and Protein(s)

mRNA	Protein	Name
NM_001317172.1	NP_001304101.1	protein delta homolog 1 isoform 2 preproprotein
NM_003836.6	NP_003827.3	protein delta homolog 1 isoform 1 preproprotein
NM_003836.5	NP_003827.3	protein delta homolog 1 precursor
NM_001317172.2	NP_001304101.2	protein delta homolog 1 isoform 2 preproprotein

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	LOC101883341	XP_005173621.1
Mus musculus (house mouse)	Dlk1	NP_034182.2
Gallus gallus (chicken)	DLK1	NP_001135726.1
Homo sapiens (human)	DLK1	NP_003827.3
	DLK1	XP_001106331.1
Xenopus tropicalis (tropical clawed frog)	dlk1	XP_002936624.1
Pan troglodytes (chimpanzee)	DLK1	XP_003314552.2
Canis lupus familiaris (dog)	DLK1	XP_547982.4
Rattus norvegicus (Norway rat)	Dlk1	NP_446196.1

Gene Ontology
Bibliography

Related articles in PubMed

Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans.
Wermter AK, Scherag A, Meyre D, Reichwald K, Durand E, Nguyen TT, Koberwitz K, Lichtner P, Meitinger T, Sch?fer H, Hinney A, Froguel P, Hebebrand J, Br?nner G
European journal of human genetics : EJHG16(9)1126-34(2008 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SASH1 acts through NOTCH1 and its inhibitor DLK1 in a three-dimensional model of lumenogenesis involving CEACAM1.
Title: The adaptor SASH1 acts through NOTCH1 and its inhibitor DLK1 in a 3D model of lumenogenesis involving CEACAM1.

The data presented in this work suggest that a fine regulation of NOTCH signaling BY DLK1 plays an important role in the control of breast cancer cell proliferation and invasion.
Title: Different expression levels of DLK1 inversely modulate the oncogenic potential of human MDA-MB-231 breast cancer cells through inhibition of NOTCH1 signaling.

results demonstrate that miR-129-5p inhibits non-small cell lung cancer stemness and chemoresistance through direct targeting of DLK1
Title: MiR-129-5p inhibits non-small cell lung cancer cell stemness and chemoresistance through targeting DLK1.

A complex defect of DLK1 ( approximately 14-kb deletion and 269-bp duplication) was identified in a family with central precocious puberty. This deletion included the 5' untranslated region and the first exon of DLK1, including the translational start site. Only family members who inherited the defect from their father have precocious puberty, consistent with the known imprinting of DLK1.
Title: Paternally Inherited DLK1 Deletion Associated With Familial Central Precocious Puberty.

NOTCH1 ligand Delta-like 1 homolog (DLK1) self interacts
Title: The non-canonical NOTCH1 ligand Delta-like 1 homolog (DLK1) self interacts in mammals.

The following DLK1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DLK1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20339	NM_003836.6 Latest version!	Homo sapiens delta like non-canonical Notch ligand 1 (DLK1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu102082	NM_001317172.1 Latest version!	Homo sapiens delta like non-canonical Notch ligand 1 (DLK1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu108499	NM_001317172.2 Latest version!	Homo sapiens delta like non-canonical Notch ligand 1 (DLK1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu20339	NM_003836.5	Homo sapiens delta-like 1 homolog (Drosophila) (DLK1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DLK1 ( NM_003836.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_003827.3 Homo sapiens delta like non-canonical Notch ligand 1 (DLK1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20339
Clone ID Related Accession (Same CDS sequence)	NM_003836.6 , NM_003836.5
Accession Version	NM_003836.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1152bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	protein delta homolog 1 isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB498121.1, AK289384.1, U15979.1, BX408554.2, AL132711.5 and AA668326.1. This sequence is a reference standard in the RefSeqGene project. On Nov 19, 2015 this sequence version replaced NM_003836.5. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK289384.1, BC007741.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 11076856 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACCGCGA CCGAAGCCCT CCTGCGCGTC CTCTTGCTCC TGCTGGCTTT CGGCCACAGC 
ACCTATGGGG CTGAATGCTT CCCGGCCTGC AACCCCCAAA ATGGATTCTG CGAGGATGAC 
AATGTTTGCA GGTGCCAGCC TGGCTGGCAG GGTCCCCTTT GTGACCAGTG CGTGACCTCT 
CCCGGCTGCC TTCACGGACT CTGTGGAGAA CCCGGGCAGT GCATTTGCAC CGACGGCTGG 
GACGGGGAGC TCTGTGATAG AGATGTTCGG GCCTGCTCCT CGGCCCCCTG TGCCAACAAC 
GGGACCTGCG TGAGCCTGGA CGATGGCCTC TATGAATGCT CCTGTGCCCC CGGGTACTCG 
GGAAAGGACT GCCAGAAAAA GGACGGGCCC TGTGTGATCA ACGGCTCCCC CTGCCAGCAC 
GGAGGCACCT GCGTGGATGA TGAGGGCCGG GCCTCCCATG CCTCCTGCCT GTGCCCCCCT 
GGCTTCTCAG GCAATTTCTG CGAGATCGTG GCCAACAGCT GCACCCCCAA CCCATGCGAG 
AACGACGGCG TCTGCACTGA CATTGGGGGC GACTTCCGCT GCCGGTGCCC AGCCGGCTTC 
ATCGACAAGA CCTGCAGCCG CCCGGTGACC AACTGCGCCA GCAGCCCGTG CCAGAACGGG 
GGCACCTGCC TGCAGCACAC CCAGGTGAGC TACGAGTGTC TGTGCAAGCC CGAGTTCACA 
GGTCTCACCT GTGTCAAGAA GCGCGCGCTG AGCCCCCAGC AGGTCACCCG TCTGCCCAGC 
GGCTATGGGC TGGCCTACCG CCTGACCCCT GGGGTGCACG AGCTGCCGGT GCAGCAGCCG 
GAGCACCGCA TCCTGAAGGT GTCCATGAAA GAGCTCAACA AGAAAACCCC TCTCCTCACC 
GAGGGCCAGG CCATCTGCTT CACCATCCTG GGCGTGCTCA CCAGCCTGGT GGTGCTGGGC 
ACTGTGGGTA TCGTCTTCCT CAACAAGTGC GAGACCTGGG TGTCCAACCT GCGCTACAAC 
CACATGCTGC GGAAGAAGAA GAACCTGCTG CTTCAGTACA ACAGCGGGGA GGACCTGGCC 
GTCAACATCA TCTTCCCCGA GAAGATCGAC ATGACCACCT TCAGCAAGGA GGCCGGCGAC 
GAGGAGATCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003827.3
CDS	205..1356
Translation	MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLAVNIIFPEKIDMTTFSKEAGDEEI

Target ORF information:

RefSeq Version	NM_003836.6
Organism	Homo sapiens(human)
Definition	Homo sapiens delta like non-canonical Notch ligand 1 (DLK1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003836.6

ORF Insert Sequence:

ATGACCGCGA CCGAAGCCCT CCTGCGCGTC CTCTTGCTCC TGCTGGCTTT CGGCCACAGC 
ACCTATGGGG CTGAATGCTT CCCGGCCTGC AACCCCCAAA ATGGATTCTG CGAGGATGAC 
AATGTTTGCA GGTGCCAGCC TGGCTGGCAG GGTCCCCTTT GTGACCAGTG CGTGACCTCT 
CCCGGCTGCC TTCACGGACT CTGTGGAGAA CCCGGGCAGT GCATTTGCAC CGACGGCTGG 
GACGGGGAGC TCTGTGATAG AGATGTTCGG GCCTGCTCCT CGGCCCCCTG TGCCAACAAC 
GGGACCTGCG TGAGCCTGGA CGATGGCCTC TATGAATGCT CCTGTGCCCC CGGGTACTCG 
GGAAAGGACT GCCAGAAAAA GGACGGGCCC TGTGTGATCA ACGGCTCCCC CTGCCAGCAC 
GGAGGCACCT GCGTGGATGA TGAGGGCCGG GCCTCCCATG CCTCCTGCCT GTGCCCCCCT 
GGCTTCTCAG GCAATTTCTG CGAGATCGTG GCCAACAGCT GCACCCCCAA CCCATGCGAG 
AACGACGGCG TCTGCACTGA CATTGGGGGC GACTTCCGCT GCCGGTGCCC AGCCGGCTTC 
ATCGACAAGA CCTGCAGCCG CCCGGTGACC AACTGCGCCA GCAGCCCGTG CCAGAACGGG 
GGCACCTGCC TGCAGCACAC CCAGGTGAGC TACGAGTGTC TGTGCAAGCC CGAGTTCACA 
GGTCTCACCT GTGTCAAGAA GCGCGCGCTG AGCCCCCAGC AGGTCACCCG TCTGCCCAGC 
GGCTATGGGC TGGCCTACCG CCTGACCCCT GGGGTGCACG AGCTGCCGGT GCAGCAGCCG 
GAGCACCGCA TCCTGAAGGT GTCCATGAAA GAGCTCAACA AGAAAACCCC TCTCCTCACC 
GAGGGCCAGG CCATCTGCTT CACCATCCTG GGCGTGCTCA CCAGCCTGGT GGTGCTGGGC 
ACTGTGGGTA TCGTCTTCCT CAACAAGTGC GAGACCTGGG TGTCCAACCT GCGCTACAAC 
CACATGCTGC GGAAGAAGAA GAACCTGCTG CTTCAGTACA ACAGCGGGGA GGACCTGGCC 
GTCAACATCA TCTTCCCCGA GAAGATCGAC ATGACCACCT TCAGCAAGGA GGCCGGCGAC 
GAGGAGATCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DLK1 ( NM_003836.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_003827.3 Homo sapiens delta-like 1 homolog (Drosophila) (DLK1), mRNA.

Price & Availability↑

CloneID	OHu20339
Clone ID Related Accession (Same CDS sequence)	NM_003836.6 , NM_003836.5
Accession Version	NM_003836.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1152bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	protein delta homolog 1 precursor
Comment

ATGACCGCGA CCGAAGCCCT CCTGCGCGTC CTCTTGCTCC TGCTGGCTTT CGGCCACAGC 
ACCTATGGGG CTGAATGCTT CCCGGCCTGC AACCCCCAAA ATGGATTCTG CGAGGATGAC 
AATGTTTGCA GGTGCCAGCC TGGCTGGCAG GGTCCCCTTT GTGACCAGTG CGTGACCTCT 
CCCGGCTGCC TTCACGGACT CTGTGGAGAA CCCGGGCAGT GCATTTGCAC CGACGGCTGG 
GACGGGGAGC TCTGTGATAG AGATGTTCGG GCCTGCTCCT CGGCCCCCTG TGCCAACAAC 
GGGACCTGCG TGAGCCTGGA CGATGGCCTC TATGAATGCT CCTGTGCCCC CGGGTACTCG 
GGAAAGGACT GCCAGAAAAA GGACGGGCCC TGTGTGATCA ACGGCTCCCC CTGCCAGCAC 
GGAGGCACCT GCGTGGATGA TGAGGGCCGG GCCTCCCATG CCTCCTGCCT GTGCCCCCCT 
GGCTTCTCAG GCAATTTCTG CGAGATCGTG GCCAACAGCT GCACCCCCAA CCCATGCGAG 
AACGACGGCG TCTGCACTGA CATTGGGGGC GACTTCCGCT GCCGGTGCCC AGCCGGCTTC 
ATCGACAAGA CCTGCAGCCG CCCGGTGACC AACTGCGCCA GCAGCCCGTG CCAGAACGGG 
GGCACCTGCC TGCAGCACAC CCAGGTGAGC TACGAGTGTC TGTGCAAGCC CGAGTTCACA 
GGTCTCACCT GTGTCAAGAA GCGCGCGCTG AGCCCCCAGC AGGTCACCCG TCTGCCCAGC 
GGCTATGGGC TGGCCTACCG CCTGACCCCT GGGGTGCACG AGCTGCCGGT GCAGCAGCCG 
GAGCACCGCA TCCTGAAGGT GTCCATGAAA GAGCTCAACA AGAAAACCCC TCTCCTCACC 
GAGGGCCAGG CCATCTGCTT CACCATCCTG GGCGTGCTCA CCAGCCTGGT GGTGCTGGGC 
ACTGTGGGTA TCGTCTTCCT CAACAAGTGC GAGACCTGGG TGTCCAACCT GCGCTACAAC 
CACATGCTGC GGAAGAAGAA GAACCTGCTG CTTCAGTACA ACAGCGGGGA GGACCTGGCC 
GTCAACATCA TCTTCCCCGA GAAGATCGAC ATGACCACCT TCAGCAAGGA GGCCGGCGAC 
GAGGAGATCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003827.3
Translation	MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLAVNIIFPEKIDMTTFSKEAGDEEI

Target ORF information:

RefSeq Version	NM_003836.5
Organism	Homo sapiens(Human)
Definition	Homo sapiens delta-like 1 homolog (Drosophila) (DLK1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003836.5

ORF Insert Sequence:

ATGACCGCGA CCGAAGCCCT CCTGCGCGTC CTCTTGCTCC TGCTGGCTTT CGGCCACAGC 
ACCTATGGGG CTGAATGCTT CCCGGCCTGC AACCCCCAAA ATGGATTCTG CGAGGATGAC 
AATGTTTGCA GGTGCCAGCC TGGCTGGCAG GGTCCCCTTT GTGACCAGTG CGTGACCTCT 
CCCGGCTGCC TTCACGGACT CTGTGGAGAA CCCGGGCAGT GCATTTGCAC CGACGGCTGG 
GACGGGGAGC TCTGTGATAG AGATGTTCGG GCCTGCTCCT CGGCCCCCTG TGCCAACAAC 
GGGACCTGCG TGAGCCTGGA CGATGGCCTC TATGAATGCT CCTGTGCCCC CGGGTACTCG 
GGAAAGGACT GCCAGAAAAA GGACGGGCCC TGTGTGATCA ACGGCTCCCC CTGCCAGCAC 
GGAGGCACCT GCGTGGATGA TGAGGGCCGG GCCTCCCATG CCTCCTGCCT GTGCCCCCCT 
GGCTTCTCAG GCAATTTCTG CGAGATCGTG GCCAACAGCT GCACCCCCAA CCCATGCGAG 
AACGACGGCG TCTGCACTGA CATTGGGGGC GACTTCCGCT GCCGGTGCCC AGCCGGCTTC 
ATCGACAAGA CCTGCAGCCG CCCGGTGACC AACTGCGCCA GCAGCCCGTG CCAGAACGGG 
GGCACCTGCC TGCAGCACAC CCAGGTGAGC TACGAGTGTC TGTGCAAGCC CGAGTTCACA 
GGTCTCACCT GTGTCAAGAA GCGCGCGCTG AGCCCCCAGC AGGTCACCCG TCTGCCCAGC 
GGCTATGGGC TGGCCTACCG CCTGACCCCT GGGGTGCACG AGCTGCCGGT GCAGCAGCCG 
GAGCACCGCA TCCTGAAGGT GTCCATGAAA GAGCTCAACA AGAAAACCCC TCTCCTCACC 
GAGGGCCAGG CCATCTGCTT CACCATCCTG GGCGTGCTCA CCAGCCTGGT GGTGCTGGGC 
ACTGTGGGTA TCGTCTTCCT CAACAAGTGC GAGACCTGGG TGTCCAACCT GCGCTACAAC 
CACATGCTGC GGAAGAAGAA GAACCTGCTG CTTCAGTACA ACAGCGGGGA GGACCTGGCC 
GTCAACATCA TCTTCCCCGA GAAGATCGAC ATGACCACCT TCAGCAAGGA GGCCGGCGAC 
GAGGAGATCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DLK1 ( NM_001317172.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001304101.1 Homo sapiens delta like non-canonical Notch ligand 1 (DLK1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu102082
Clone ID Related Accession (Same CDS sequence)	NM_001317172.1
Accession Version	NM_001317172.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 933bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-26
Organism	Homo sapiens(human)
Product	protein delta homolog 1 isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB498121.1, AK289384.1, U15981.1, AL132711.5 and AA668326.1. Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U15981.1, BX417544.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 11076856 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACCGCGA CCGAAGCCCT CCTGCGCGTC CTCTTGCTCC TGCTGGCTTT CGGCCACAGC 
ACCTATGGGG CTGAATGCTT CCCGGCCTGC AACCCCCAAA ATGGATTCTG CGAGGATGAC 
AATGTTTGCA GGTGCCAGCC TGGCTGGCAG GGTCCCCTTT GTGACCAGTG CGTGACCTCT 
CCCGGCTGCC TTCACGGACT CTGTGGAGAA CCCGGGCAGT GCATTTGCAC CGACGGCTGG 
GACGGGGAGC TCTGTGATAG AGATGTTCGG GCCTGCTCCT CGGCCCCCTG TGCCAACAAC 
GGGACCTGCG TGAGCCTGGA CGATGGCCTC TATGAATGCT CCTGTGCCCC CGGGTACTCG 
GGAAAGGACT GCCAGAAAAA GGACGGGCCC TGTGTGATCA ACGGCTCCCC CTGCCAGCAC 
GGAGGCACCT GCGTGGATGA TGAGGGCCGG GCCTCCCATG CCTCCTGCCT GTGCCCCCCT 
GGCTTCTCAG GCAATTTCTG CGAGATCGTG GCCAACAGCT GCACCCCCAA CCCATGCGAG 
AACGACGGCG TCTGCACTGA CATTGGGGGC GACTTCCGCT GCCGGTGCCC AGCCGGCTTC 
ATCGACAAGA CCTGCAGCCG CCCGGTGACC AACTGCGCCA GCAGCCCGTG CCAGAACGGG 
GGCACCTGCC TGCAGCACAC CCAGGGCCAG GCCATCTGCT TCACCATCCT GGGCGTGCTC 
ACCAGCCTGG TGGTGCTGGG CACTGTGGGT ATCGTCTTCC TCAACAAGTG CGAGACCTGG 
GTGTCCAACC TGCGCTACAA CCACATGCTG CGGAAGAAGA AGAACCTGCT GCTTCAGTAC 
AACAGCGGGG AGGACCTGGC CGTCAACATC ATCTTCCCCG AGAAGATCGA CATGACCACC 
TTCAGCAAGG AGGCCGGCGA CGAGGAGATC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001304101.1
CDS	205..1137
Translation	MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLAVNIIFPEKIDMTTFSKEAGDEEI

Target ORF information:

RefSeq Version	NM_001317172.1
Organism	Homo sapiens(human)
Definition	Homo sapiens delta like non-canonical Notch ligand 1 (DLK1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001317172.1

ORF Insert Sequence:

ATGACCGCGA CCGAAGCCCT CCTGCGCGTC CTCTTGCTCC TGCTGGCTTT CGGCCACAGC 
ACCTATGGGG CTGAATGCTT CCCGGCCTGC AACCCCCAAA ATGGATTCTG CGAGGATGAC 
AATGTTTGCA GGTGCCAGCC TGGCTGGCAG GGTCCCCTTT GTGACCAGTG CGTGACCTCT 
CCCGGCTGCC TTCACGGACT CTGTGGAGAA CCCGGGCAGT GCATTTGCAC CGACGGCTGG 
GACGGGGAGC TCTGTGATAG AGATGTTCGG GCCTGCTCCT CGGCCCCCTG TGCCAACAAC 
GGGACCTGCG TGAGCCTGGA CGATGGCCTC TATGAATGCT CCTGTGCCCC CGGGTACTCG 
GGAAAGGACT GCCAGAAAAA GGACGGGCCC TGTGTGATCA ACGGCTCCCC CTGCCAGCAC 
GGAGGCACCT GCGTGGATGA TGAGGGCCGG GCCTCCCATG CCTCCTGCCT GTGCCCCCCT 
GGCTTCTCAG GCAATTTCTG CGAGATCGTG GCCAACAGCT GCACCCCCAA CCCATGCGAG 
AACGACGGCG TCTGCACTGA CATTGGGGGC GACTTCCGCT GCCGGTGCCC AGCCGGCTTC 
ATCGACAAGA CCTGCAGCCG CCCGGTGACC AACTGCGCCA GCAGCCCGTG CCAGAACGGG 
GGCACCTGCC TGCAGCACAC CCAGGGCCAG GCCATCTGCT TCACCATCCT GGGCGTGCTC 
ACCAGCCTGG TGGTGCTGGG CACTGTGGGT ATCGTCTTCC TCAACAAGTG CGAGACCTGG 
GTGTCCAACC TGCGCTACAA CCACATGCTG CGGAAGAAGA AGAACCTGCT GCTTCAGTAC 
AACAGCGGGG AGGACCTGGC CGTCAACATC ATCTTCCCCG AGAAGATCGA CATGACCACC 
TTCAGCAAGG AGGCCGGCGA CGAGGAGATC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DLK1 ( NM_001317172.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001304101.2 Homo sapiens delta like non-canonical Notch ligand 1 (DLK1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu108499
Clone ID Related Accession (Same CDS sequence)	NM_001317172.2
Accession Version	NM_001317172.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 933bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Homo sapiens(human)
Product	protein delta homolog 1 isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL132711.5. On Jun 2, 2019 this sequence version replaced NM_001317172.1. Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U15981.1, BX417544.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 11076856 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACCGCGA CCGAAGCCCT CCTGCGCGTC CTCTTGCTCC TGCTGGCTTT CGGCCACAGC 
ACCTATGGGG CTGAATGCTT CCCGGCCTGC AACCCCCAAA ATGGATTCTG CGAGGATGAC 
AATGTTTGCA GGTGCCAGCC TGGCTGGCAG GGTCCCCTTT GTGACCAGTG CGTGACCTCT 
CCCGGCTGCC TTCACGGACT CTGTGGAGAA CCCGGGCAGT GCATTTGCAC CGACGGCTGG 
GACGGGGAGC TCTGTGATAG AGATGTTCGG GCCTGCTCCT CGGCCCCCTG TGCCAACAAC 
AGGACCTGCG TGAGCCTGGA CGATGGCCTC TATGAATGCT CCTGTGCCCC CGGGTACTCG 
GGAAAGGACT GCCAGAAAAA GGACGGGCCC TGTGTGATCA ACGGCTCCCC CTGCCAGCAC 
GGAGGCACCT GCGTGGATGA TGAGGGCCGG GCCTCCCATG CCTCCTGCCT GTGCCCCCCT 
GGCTTCTCAG GCAATTTCTG CGAGATCGTG GCCAACAGCT GCACCCCCAA CCCATGCGAG 
AACGACGGCG TCTGCACTGA CATTGGGGGC GACTTCCGCT GCCGGTGCCC AGCCGGCTTC 
ATCGACAAGA CCTGCAGCCG CCCGGTGACC AACTGCGCCA GCAGCCCGTG CCAGAACGGG 
GGCACCTGCC TGCAGCACAC CCAGGGCCAG GCCATCTGCT TCACCATCCT GGGCGTGCTC 
ACCAGCCTGG TGGTGCTGGG CACTGTGGGT ATCGTCTTCC TCAACAAGTG CGAGACCTGG 
GTGTCCAACC TGCGCTACAA CCACATGCTG CGGAAGAAGA AGAACCTGCT GCTTCAGTAC 
AACAGCGGGG AGGACCTGGC CGTCAACATC ATCTTCCCCG AGAAGATCGA CATGACCACC 
TTCAGCAAGG AGGCCGGCGA CGAGGAGATC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001304101.2
CDS	178..1110
Translation	MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNRTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLAVNIIFPEKIDMTTFSKEAGDEEI

Target ORF information:

RefSeq Version	NM_001317172.2
Organism	Homo sapiens(human)
Definition	Homo sapiens delta like non-canonical Notch ligand 1 (DLK1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001317172.2

ORF Insert Sequence:

ATGACCGCGA CCGAAGCCCT CCTGCGCGTC CTCTTGCTCC TGCTGGCTTT CGGCCACAGC 
ACCTATGGGG CTGAATGCTT CCCGGCCTGC AACCCCCAAA ATGGATTCTG CGAGGATGAC 
AATGTTTGCA GGTGCCAGCC TGGCTGGCAG GGTCCCCTTT GTGACCAGTG CGTGACCTCT 
CCCGGCTGCC TTCACGGACT CTGTGGAGAA CCCGGGCAGT GCATTTGCAC CGACGGCTGG 
GACGGGGAGC TCTGTGATAG AGATGTTCGG GCCTGCTCCT CGGCCCCCTG TGCCAACAAC 
AGGACCTGCG TGAGCCTGGA CGATGGCCTC TATGAATGCT CCTGTGCCCC CGGGTACTCG 
GGAAAGGACT GCCAGAAAAA GGACGGGCCC TGTGTGATCA ACGGCTCCCC CTGCCAGCAC 
GGAGGCACCT GCGTGGATGA TGAGGGCCGG GCCTCCCATG CCTCCTGCCT GTGCCCCCCT 
GGCTTCTCAG GCAATTTCTG CGAGATCGTG GCCAACAGCT GCACCCCCAA CCCATGCGAG 
AACGACGGCG TCTGCACTGA CATTGGGGGC GACTTCCGCT GCCGGTGCCC AGCCGGCTTC 
ATCGACAAGA CCTGCAGCCG CCCGGTGACC AACTGCGCCA GCAGCCCGTG CCAGAACGGG 
GGCACCTGCC TGCAGCACAC CCAGGGCCAG GCCATCTGCT TCACCATCCT GGGCGTGCTC 
ACCAGCCTGG TGGTGCTGGG CACTGTGGGT ATCGTCTTCC TCAACAAGTG CGAGACCTGG 
GTGTCCAACC TGCGCTACAA CCACATGCTG CGGAAGAAGA AGAACCTGCT GCTTCAGTAC 
AACAGCGGGG AGGACCTGGC CGTCAACATC ATCTTCCCCG AGAAGATCGA CATGACCACC 
TTCAGCAAGG AGGCCGGCGA CGAGGAGATC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans.
European journal of human genetics : EJHG16(9)1126-34(2008 Sep)
Wermter AK,Scherag A,Meyre D,Reichwald K,Durand E,Nguyen TT,Koberwitz K,Lichtner P,Meitinger T,Sch?fer H,Hinney A,Froguel P,Hebebrand J,Br?nner G

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DLK1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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