Klf4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Klf4
Entrez Gene ID	114505
Full Name	Kruppel like factor 4
Synonyms	GKLF
General protein information	Preferred Names Kruppel like factor 4 Names Krueppel-like factor 4 Kruppel-like factor 4 (gut)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q24
Summary	a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053713.1	NP_446165.1	Krueppel-like factor 4

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	KLF4	XP_001141754.1
Bos taurus (cattle)	KLF4	NP_001098855.1
Mus musculus (house mouse)	Klf4	NP_034767.2
Homo sapiens (human)	KLF4	NP_004226.3
Rattus norvegicus (Norway rat)	Klf4	NP_446165.1
Danio rerio (zebrafish)	klf4a	NP_001106955.1
Gallus gallus (chicken)	KLF4	XP_004949426.1
	KLF4	NP_001136265.1
Canis lupus familiaris (dog)	KLF4	XP_005627053.1
Xenopus tropicalis (tropical clawed frog)	klf4	NP_001017280.1

Gene Ontology
Bibliography

Related articles in PubMed

?MicroRNA-146b regulates hepatic stellate cell activation via targeting of KLF4.
Ge S, Zhang L, Xie J, Liu F, He J, He J, Wang X, Xiang T
Annals of hepatology15(6)918-928(2016 Nov-Dec 2016)

Interferon Regulatory Factor 4 Inhibits Neointima Formation by Engaging Kr?ppel-Like Factor 4 Signaling.
Cheng WL, She ZG, Qin JJ, Guo JH, Gong FH, Zhang P, Fang C, Tian S, Zhu XY, Gong J, Wang ZH, Huang Z, Li H
Circulation136(15)1412-1433(2017 Oct)

Physiological stress-induced corticosterone increases heme uptake via KLF4-HCP1 signaling pathway in hippocampus neurons.
Li H, Zhang C, Shen H, Shen Z, Wu L, Mo F, Li M
Scientific reports7(1)5745(2017 Jul)

Forkhead Box C1 Regulates Human Primary Keratinocyte Terminal Differentiation.
Bin L, Deng L, Yang H, Zhu L, Wang X, Edwards MG, Richers B, Leung DY
PloS one11(12)e0167392(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Suggest miR-146b as a novel upstream effector of hepatic stellate cell activation in liver fibrosis via direct targeting of KLF4.
Title: ?MicroRNA-146b regulates hepatic stellate cell activation via targeting of KLF4.

IRF4 protects arteries against neointima formation by promoting the expression of KLF4 by directly binding to its promoter.
Title: Interferon Regulatory Factor 4 Inhibits Neointima Formation by Engaging Kr?ppel-Like Factor 4 Signaling.

the results provide critical insights into the newly discovered role of Shh in phenotypic modulation of vascular smooth muscle cells which depends on KLF4.
Title: Shh mediates PDGF-induced contractile-to-synthetic phenotypic modulation in vascular smooth muscle cells through regulation of KLF4.

SUMOylated KLF4 plays an important role in cell proliferation by reversing the transactivation action of KLF4 on p21 induced with PDGF-BB.
Title: SUMOylation of KLF4 acts as a switch in transcriptional programs that control VSMC proliferation.

these findings identify KLF4 as a nodal transcriptional regulator of mitochondrial homeostasis.
Title: Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis.

The following Klf4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klf4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12373	NM_053713.1 Latest version!	Rattus norvegicus Kruppel like factor 4 (Klf4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$286.30 $409.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Klf4 ( NM_053713.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446165.1 Rattus norvegicus Kruppel like factor 4 (Klf4), mRNA.

Price & Availability↑

CloneID	ORa12373
Clone ID Related Accession (Same CDS sequence)	NM_053713.1
Accession Version	NM_053713.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1449bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Rattus norvegicus(Norway rat)
Product	Krueppel-like factor 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF390546.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF390546.1, BC085720.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAGGCAGC CACCTGGCGA GTCTGACATG GCTGTCAGCG ACGCTCTGCT CCCGTCCTTC 
TCCACGTTCG CGTCCGGCCC GGCGGGAAGG GAGAAGACAC TGCGTCCAGC AGGTGCCCCG 
ACTAACCGTT GGCGAGAGGA ACTCTCTCAC ATGAAGCGAC TTCCCCCACT TCCCGGCCGC 
CCCTACGACC TGGCGGCGAC GGTGGCCACA GACCTGGAAA GTGGTGGAGC TGGTGCAGCT 
TGCAGCAGTA ACAACCCGGC CCTACCCCGG AGGGAGACCG AGGAGTTCAA CGATCTCCTG 
GACCTAGACT TTATCCTTTC CAACTCGCTA TCCCACCAGG AATCGGTGGC CGCCACCGTG 
ACCACCTCGG CGTCAGCTTC ATCCTCGTCT TCCCCAGCTA GCAGCGGCCC TGCCAGCGCG 
CCCTCCACCT GCAGCTTCAG CTATCCGATC CGGGCCGGGG GTGACCCGGG CGTGGCTGCG 
GGCAACACAG GTGGAGGGCT CCTCTACAGC CGAGAATCTG CGCCACCTCC CACGGCCCCC 
TTCAACCTGG CGGACATCAA TGACGTGAGC CCCTCGGGCG GCTTCGTGGC TGAGCTCCTG 
CGGCCGGAGT TGGACCCAGT ATACATTCCG CCACAGCAGC CTCAGCCGCC AGGTGGCGGG 
CTGATGGGCA AGTTTGTGCT GAAGGCGTCT CTGAGCACCC CTGGCAGCGA GTACACCAGC 
CCTTCGGTCA TCAGTGTTAG CAAAGGAAGC CCAGACGGCA GCCACCCTGT GGTAGTGGCG 
CCCTACAGCG GTGGCCCGCC GCGTATGTGC CCCAAGATTA AGCAAGAGGC CGTCCCGTCC 
TGCACGGTCA GCCGGTCCCT AGAGGCCCAC TTGAGCGCTG GACCCCAGCT CAGCAACGGC 
CACAGGCCCA ACACACACGA CTTCCCCCTG GGGCGGCAGC TCCCCACCAG GACTACCCCT 
ACACTGAGTC CCGAGGAACT GCTGAACAGC AGGGACTGTC ACCCTGGCCT GCCTCTTCCC 
CCAGGATTCC ATCCCCATCC GGGGCCCAGC TACCCTCCTT TCCTGCCAGA CCAGATGCAG 
TCGCAAGTCC CCTCTCTCCA TTATCAAGAG CTCATGCCAC CGGGATCCTG CCTGCCAGAG 
GAGCCCAAGC CAAAGAGGGG AAGAAGGTCT TGGCCCCGGA AAAGAACAGC CACCCACACT 
TGTGACTATG CAGGCTGTGG CAAAACCTAT ACGAAGAGTT CTCATCTCAA GGCACACCTG 
CGAACTCACA CAGGCGAGAA ACCTTACCAC TGTGACTGGG ACGGCTGTGG GTGGAAATTC 
GCCCGCTCAG ATGAACTGAC CAGGCACTAC CGCAAACACA CCGGGCACCG GCCCTTTCAG 
TGCCAGAAGT GCGACAGGGC CTTTTCCAGG TCGGACCACC TTGCCTTACA CATGAAGAGG 
CACTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446165.1
CDS	77..1525
Translation	MRQPPGESDMAVSDALLPSFSTFASGPAGREKTLRPAGAPTNRWREELSHMKRLPPLPGRPYDLAATVATDLESGGAGAACSSNNPALPRRETEEFNDLLDLDFILSNSLSHQESVAATVTTSASASSSSSPASSGPASAPSTCSFSYPIRAGGDPGVAAGNTGGGLLYSRESAPPPTAPFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPGGGLMGKFVLKASLSTPGSEYTSPSVISVSKGSPDGSHPVVVAPYSGGPPRMCPKIKQEAVPSCTVSRSLEAHLSAGPQLSNGHRPNTHDFPLGRQLPTRTTPTLSPEELLNSRDCHPGLPLPPGFHPHPGPSYPPFLPDQMQSQVPSLHYQELMPPGSCLPEEPKPKRGRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF

Target ORF information:

RefSeq Version	NM_053713.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Kruppel like factor 4 (Klf4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053713.1

ORF Insert Sequence:

ATGAGGCAGC CACCTGGCGA GTCTGACATG GCTGTCAGCG ACGCTCTGCT CCCGTCCTTC 
TCCACGTTCG CGTCCGGCCC GGCGGGAAGG GAGAAGACAC TGCGTCCAGC AGGTGCCCCG 
ACTAACCGTT GGCGAGAGGA ACTCTCTCAC ATGAAGCGAC TTCCCCCACT TCCCGGCCGC 
CCCTACGACC TGGCGGCGAC GGTGGCCACA GACCTGGAAA GTGGTGGAGC TGGTGCAGCT 
TGCAGCAGTA ACAACCCGGC CCTACCCCGG AGGGAGACCG AGGAGTTCAA CGATCTCCTG 
GACCTAGACT TTATCCTTTC CAACTCGCTA TCCCACCAGG AATCGGTGGC CGCCACCGTG 
ACCACCTCGG CGTCAGCTTC ATCCTCGTCT TCCCCAGCTA GCAGCGGCCC TGCCAGCGCG 
CCCTCCACCT GCAGCTTCAG CTATCCGATC CGGGCCGGGG GTGACCCGGG CGTGGCTGCG 
GGCAACACAG GTGGAGGGCT CCTCTACAGC CGAGAATCTG CGCCACCTCC CACGGCCCCC 
TTCAACCTGG CGGACATCAA TGACGTGAGC CCCTCGGGCG GCTTCGTGGC TGAGCTCCTG 
CGGCCGGAGT TGGACCCAGT ATACATTCCG CCACAGCAGC CTCAGCCGCC AGGTGGCGGG 
CTGATGGGCA AGTTTGTGCT GAAGGCGTCT CTGAGCACCC CTGGCAGCGA GTACACCAGC 
CCTTCGGTCA TCAGTGTTAG CAAAGGAAGC CCAGACGGCA GCCACCCTGT GGTAGTGGCG 
CCCTACAGCG GTGGCCCGCC GCGTATGTGC CCCAAGATTA AGCAAGAGGC CGTCCCGTCC 
TGCACGGTCA GCCGGTCCCT AGAGGCCCAC TTGAGCGCTG GACCCCAGCT CAGCAACGGC 
CACAGGCCCA ACACACACGA CTTCCCCCTG GGGCGGCAGC TCCCCACCAG GACTACCCCT 
ACACTGAGTC CCGAGGAACT GCTGAACAGC AGGGACTGTC ACCCTGGCCT GCCTCTTCCC 
CCAGGATTCC ATCCCCATCC GGGGCCCAGC TACCCTCCTT TCCTGCCAGA CCAGATGCAG 
TCGCAAGTCC CCTCTCTCCA TTATCAAGAG CTCATGCCAC CGGGATCCTG CCTGCCAGAG 
GAGCCCAAGC CAAAGAGGGG AAGAAGGTCT TGGCCCCGGA AAAGAACAGC CACCCACACT 
TGTGACTATG CAGGCTGTGG CAAAACCTAT ACGAAGAGTT CTCATCTCAA GGCACACCTG 
CGAACTCACA CAGGCGAGAA ACCTTACCAC TGTGACTGGG ACGGCTGTGG GTGGAAATTC 
GCCCGCTCAG ATGAACTGAC CAGGCACTAC CGCAAACACA CCGGGCACCG GCCCTTTCAG 
TGCCAGAAGT GCGACAGGGC CTTTTCCAGG TCGGACCACC TTGCCTTACA CATGAAGAGG 
CACTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

?MicroRNA-146b regulates hepatic stellate cell activation via targeting of KLF4.
Annals of hepatology15(6)918-928(2016 Nov-Dec 2016)
Ge S,Zhang L,Xie J,Liu F,He J,He J,Wang X,Xiang T

Interferon Regulatory Factor 4 Inhibits Neointima Formation by Engaging Kr?ppel-Like Factor 4 Signaling.
Circulation136(15)1412-1433(2017 Oct)
Cheng WL,She ZG,Qin JJ,Guo JH,Gong FH,Zhang P,Fang C,Tian S,Zhu XY,Gong J,Wang ZH,Huang Z,Li H

Physiological stress-induced corticosterone increases heme uptake via KLF4-HCP1 signaling pathway in hippocampus neurons.
Scientific reports7(1)5745(2017 Jul)
Li H,Zhang C,Shen H,Shen Z,Wu L,Mo F,Li M

Forkhead Box C1 Regulates Human Primary Keratinocyte Terminal Differentiation.
PloS one11(12)e0167392(2016)
Bin L,Deng L,Yang H,Zhu L,Wang X,Edwards MG,Richers B,Leung DY

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Klf4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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