Cdk6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cdk6
Entrez Gene ID	114483
Full Name	cyclin-dependent kinase 6
General protein information	Preferred Names cyclin-dependent kinase 6 Names cyclin-dependent kinase 6 cell division protein kinase 6
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q13
Summary	displays amplification and increased expression in the BDII rat model of endometrial cancer [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006236021.2	XP_006236083.1	cyclin-dependent kinase 6 isoform X1
NM_001191861.1	NP_001178790.1	cyclin-dependent kinase 6
XM_008762679.2	XP_008760901.1	cyclin-dependent kinase 6 isoform X1
XM_006236019.3	XP_006236081.1	cyclin-dependent kinase 6 isoform X1
XM_006236020.3	XP_006236082.1	cyclin-dependent kinase 6 isoform X1

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	cdk6	NP_001137525.1
Drosophila melanogaster (fruit fly)	Cdk4	NP_725595.1
Xenopus tropicalis (tropical clawed frog)	cdk6	XP_002934637.2
	CDK6	XP_001100307.1
Canis lupus familiaris (dog)	CDK6	XP_852360.1
Bos taurus (cattle)	CDK6	NP_001179230.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005817	XP_315841.3
Homo sapiens (human)	CDK6	NP_001138778.1
Gallus gallus (chicken)	CDK6	NP_001007893.1
Pan troglodytes (chimpanzee)	CDK6	XP_003318627.1
Mus musculus (house mouse)	Cdk6	NP_034003.1
Rattus norvegicus (Norway rat)	Cdk6	NP_001178790.1
Caenorhabditis elegans (roundworm)	cdk-4	NP_510256.1
Caenorhabditis elegans (roundworm)	cdk-4	NP_001024591.1

Gene Ontology
Bibliography

Related articles in PubMed

Transcriptional alterations in hereditary and sporadic nonfunctioning pancreatic neuroendocrine tumors according to genotype.
Keutgen XM, Kumar S, Gara S, Boufraqech M, Agarwal S, Hruban RH, Nilubol N, Quezado M, Finney R, Cam M, Kebebew E
Cancer124(3)636-647(2018 Feb)

miR-377 inhibited tumorous behaviors of non-small cell lung cancer through directly targeting CDK6.
Zhang J, Zhao M, Xue ZQ, Liu Y, Wang YX
European review for medical and pharmacological sciences20(21)4494-4499(2016 Nov)

CDK6 mediates the effect of attenuation of miR-1 on provoking cardiomyocyte hypertrophy.
Yuan W, Tang C, Zhu W, Zhu J, Lin Q, Fu Y, Deng C, Xue Y, Yang M, Wu S, Shan Z
Molecular and cellular biochemistry412(1-2)289-96(2016 Jan)

Nanog interact with CDK6 to regulates astrocyte cells proliferation following spinal cord injury.
Gu J, Ni Y, Xu L, Xu H, Cai Z
Biochemical and biophysical research communications469(4)1097-103(2016 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results reveal that derepression of CDK6 and activation of Rb pathway contributes to the effect of attenuation of miR-1 on provoking cardiomyocyte hypertrophy
Title: CDK6 mediates the effect of attenuation of miR-1 on provoking cardiomyocyte hypertrophy.

Taken together, these data suggested that both Nanog may play important roles in spinal cord pathophysiology via interact with CDK6.
Title: Nanog interact with CDK6 to regulates astrocyte cells proliferation following spinal cord injury.

Protein kinase N1 is a novel substrate of NFATc1-mediated cyclin D1-CDK6 activity and modulates vascular smooth muscle cell division and migration leading to inward blood vessel wall remodeling.
Title: Protein kinase N1 is a novel substrate of NFATc1-mediated cyclin D1-CDK6 activity and modulates vascular smooth muscle cell division and migration leading to inward blood vessel wall remodeling.

Activation of mTORC1 overrides the absence of the anchorage and stabilizes Cdc6 at least partly via activating Cdk4/6 that induces Emi1, an APC/C(Cdh1) ubiquitin ligase inhibitor.
Title: Mammalian target of rapamycin complex 1 signaling opposes the effects of anchorage loss, leading to activation of Cdk4 and Cdc6 stabilization.

Oviductus Ranae treatment can lower the expressions of Cyclin D1 and CDK6 in the liver to enhance the liver cell proliferation in aged male rats.
Title: [Effect of Oviductus Ranae on Cyclin D1, CDK6 and P15 expressions in the liver tissue of aged male rats].

The following Cdk6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cdk6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa07852	NM_001191861.1 Latest version!	Rattus norvegicus cyclin-dependent kinase 6 (Cdk6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa07852	XM_006236021.2 Latest version!	Rattus norvegicus cyclin-dependent kinase 6 (Cdk6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa07852	XM_008762679.2 Latest version!	Rattus norvegicus cyclin-dependent kinase 6 (Cdk6), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa07852	XM_006236020.3 Latest version!	Rattus norvegicus cyclin-dependent kinase 6 (Cdk6), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa07852	XM_006236019.3 Latest version!	Rattus norvegicus cyclin-dependent kinase 6 (Cdk6), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cdk6 ( NM_001191861.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001178790.1 Rattus norvegicus cyclin-dependent kinase 6 (Cdk6), mRNA.

Price & Availability↑

CloneID	ORa07852
Clone ID Related Accession (Same CDS sequence)	XM_006236021.2 , NM_001191861.1 , XM_008762679.2 , XM_006236019.3 , XM_006236020.3
Accession Version	NM_001191861.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 981bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	cyclin-dependent kinase 6
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR07059626.1, AABR07059625.1, AABR07059623.1 and AABR07059622.1. On Jul 17, 2010 this sequence version replaced XM_342638.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01906348, SAMN01906350 [ECO:0000348] ##Evidence-Data-END##

ATGGAGAAGG ACAGCCTGAG TCGCGCCGAC CAGCAGTATG AGTGCGTGGC GGAGATCGGG 
GAAGGCGCCT ACGGGAAGGT GTTCAAGGCC CGCGACCTGA AGAACGGCGG CCGCTTCGTG 
GCTCTGAAGC GCGTGCGAGT GCAGACCGGA GAGGAGGGCA TGCCGCTCTC CACCATCCGC 
GAGGTGGCGG TGCTGAGGCA CCTGGAGACC TTTGAGCACC CCAACGTGGT CAGGTTGTTT 
GACGTGTGCA CAGTGTCACG GACAGACAGA GAAACTAAAC TTACGCTAGT GTTTGAGCAT 
GTTGATCAAG ACTTGACCAC TTACTTGGAT AAAGTTCCAG AACCCGGTGT GCCCACAGAG 
ACCATAAAGG ATATGATGTT TCAGCTTCTC CGAGGTCTGG ACTTCCTCCA TTCTCACAGA 
GTAGTGCATC GTGACCTGAA GCCACAGAAC ATTCTGGTGA CCAGCAGTGG ACAAATAAAA 
CTGGCTGACT TCGGCCTTGC CCGCATCTAC AGTTTTCAGA TGGCCCTTAC CTCGGTGGTC 
GTCACGCTGT GGTACCGAGC CCCGGAAGTC CTGCTCCAGT CCAGCTACGC CACCCCCGTG 
GACCTCTGGA GTGTTGGCTG CATCTTTGCA GAACTGTTTC GCAGAAAGCC TCTTTTTCGT 
GGAAGTTCAG ACGTGGATCA ACTAGGGAAA ATCTTGGACG TCATCGGACT CCCAGGAGAA 
GAAGACTGGC CTAGGGATGT TGCTCTTCCC AGACAGGCTT TTCACTCCAA ATCTGCCCAA 
CCCATCGAGA AGTTTGTGAC AGACATCGAC GAGCTAGGCA AAGACCTCCT TCTGAAATGC 
TTGACGTTTA ATCCAGCTAA AAGAATATCC GCTTATGGCG CCCTGAATCA CCCGTACTTC 
CAAGACCTGG AGAGATACAA GGACAACCTG CATTCTCACC TGTCGTCCAG CCAGAGCACC 
TCGGAGCTGA ACACAGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001178790.1
CDS	1..981
Translation	MEKDSLSRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAELFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYGALNHPYFQDLERYKDNLHSHLSSSQSTSELNTA

Target ORF information:

RefSeq Version	NM_001191861.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cyclin-dependent kinase 6 (Cdk6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001191861.1

ORF Insert Sequence:

ATGGAGAAGG ACAGCCTGAG TCGCGCCGAC CAGCAGTATG AGTGCGTGGC GGAGATCGGG 
GAAGGCGCCT ACGGGAAGGT GTTCAAGGCC CGCGACCTGA AGAACGGCGG CCGCTTCGTG 
GCTCTGAAGC GCGTGCGAGT GCAGACCGGA GAGGAGGGCA TGCCGCTCTC CACCATCCGC 
GAGGTGGCGG TGCTGAGGCA CCTGGAGACC TTTGAGCACC CCAACGTGGT CAGGTTGTTT 
GACGTGTGCA CAGTGTCACG GACAGACAGA GAAACTAAAC TTACGCTAGT GTTTGAGCAT 
GTTGATCAAG ACTTGACCAC TTACTTGGAT AAAGTTCCAG AACCCGGTGT GCCCACAGAG 
ACCATAAAGG ATATGATGTT TCAGCTTCTC CGAGGTCTGG ACTTCCTCCA TTCTCACAGA 
GTAGTGCATC GTGACCTGAA GCCACAGAAC ATTCTGGTGA CCAGCAGTGG ACAAATAAAA 
CTGGCTGACT TCGGCCTTGC CCGCATCTAC AGTTTTCAGA TGGCCCTTAC CTCGGTGGTC 
GTCACGCTGT GGTACCGAGC CCCGGAAGTC CTGCTCCAGT CCAGCTACGC CACCCCCGTG 
GACCTCTGGA GTGTTGGCTG CATCTTTGCA GAACTGTTTC GCAGAAAGCC TCTTTTTCGT 
GGAAGTTCAG ACGTGGATCA ACTAGGGAAA ATCTTGGACG TCATCGGACT CCCAGGAGAA 
GAAGACTGGC CTAGGGATGT TGCTCTTCCC AGACAGGCTT TTCACTCCAA ATCTGCCCAA 
CCCATCGAGA AGTTTGTGAC AGACATCGAC GAGCTAGGCA AAGACCTCCT TCTGAAATGC 
TTGACGTTTA ATCCAGCTAA AAGAATATCC GCTTATGGCG CCCTGAATCA CCCGTACTTC 
CAAGACCTGG AGAGATACAA GGACAACCTG CATTCTCACC TGTCGTCCAG CCAGAGCACC 
TCGGAGCTGA ACACAGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cdk6 ( XM_006236021.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006236083.1 Rattus norvegicus cyclin-dependent kinase 6 (Cdk6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa07852
Clone ID Related Accession (Same CDS sequence)	XM_006236021.2 , NM_001191861.1 , XM_008762679.2 , XM_006236019.3 , XM_006236020.3
Accession Version	XM_006236021.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 981bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cyclin-dependent kinase 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006236021.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGAAGG ACAGCCTGAG TCGCGCCGAC CAGCAGTATG AGTGCGTGGC GGAGATCGGG 
GAAGGCGCCT ACGGGAAGGT GTTCAAGGCC CGCGACCTGA AGAACGGCGG CCGCTTCGTG 
GCTCTGAAGC GCGTGCGAGT GCAGACCGGA GAGGAGGGCA TGCCGCTCTC CACCATCCGC 
GAGGTGGCGG TGCTGAGGCA CCTGGAGACC TTTGAGCACC CCAACGTGGT CAGGTTGTTT 
GACGTGTGCA CAGTGTCACG GACAGACAGA GAAACTAAAC TTACGCTAGT GTTTGAGCAT 
GTTGATCAAG ACTTGACCAC TTACTTGGAT AAAGTTCCAG AACCCGGTGT GCCCACAGAG 
ACCATAAAGG ATATGATGTT TCAGCTTCTC CGAGGTCTGG ACTTCCTCCA TTCTCACAGA 
GTAGTGCATC GTGACCTGAA GCCACAGAAC ATTCTGGTGA CCAGCAGTGG ACAAATAAAA 
CTGGCTGACT TCGGCCTTGC CCGCATCTAC AGTTTTCAGA TGGCCCTTAC CTCGGTGGTC 
GTCACGCTGT GGTACCGAGC CCCGGAAGTC CTGCTCCAGT CCAGCTACGC CACCCCCGTG 
GACCTCTGGA GTGTTGGCTG CATCTTTGCA GAACTGTTTC GCAGAAAGCC TCTTTTTCGT 
GGAAGTTCAG ACGTGGATCA ACTAGGGAAA ATCTTGGACG TCATCGGACT CCCAGGAGAA 
GAAGACTGGC CTAGGGATGT TGCTCTTCCC AGACAGGCTT TTCACTCCAA ATCTGCCCAA 
CCCATCGAGA AGTTTGTGAC AGACATCGAC GAGCTAGGCA AAGACCTCCT TCTGAAATGC 
TTGACGTTTA ATCCAGCTAA AAGAATATCC GCTTATGGCG CCCTGAATCA CCCGTACTTC 
CAAGACCTGG AGAGATACAA GGACAACCTG CATTCTCACC TGTCGTCCAG CCAGAGCACC 
TCGGAGCTGA ACACAGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006236083.1
CDS	742..1722
Translation	MEKDSLSRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAELFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYGALNHPYFQDLERYKDNLHSHLSSSQSTSELNTA

Target ORF information:

RefSeq Version	XM_006236021.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cyclin-dependent kinase 6 (Cdk6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006236021.2

ORF Insert Sequence:

ATGGAGAAGG ACAGCCTGAG TCGCGCCGAC CAGCAGTATG AGTGCGTGGC GGAGATCGGG 
GAAGGCGCCT ACGGGAAGGT GTTCAAGGCC CGCGACCTGA AGAACGGCGG CCGCTTCGTG 
GCTCTGAAGC GCGTGCGAGT GCAGACCGGA GAGGAGGGCA TGCCGCTCTC CACCATCCGC 
GAGGTGGCGG TGCTGAGGCA CCTGGAGACC TTTGAGCACC CCAACGTGGT CAGGTTGTTT 
GACGTGTGCA CAGTGTCACG GACAGACAGA GAAACTAAAC TTACGCTAGT GTTTGAGCAT 
GTTGATCAAG ACTTGACCAC TTACTTGGAT AAAGTTCCAG AACCCGGTGT GCCCACAGAG 
ACCATAAAGG ATATGATGTT TCAGCTTCTC CGAGGTCTGG ACTTCCTCCA TTCTCACAGA 
GTAGTGCATC GTGACCTGAA GCCACAGAAC ATTCTGGTGA CCAGCAGTGG ACAAATAAAA 
CTGGCTGACT TCGGCCTTGC CCGCATCTAC AGTTTTCAGA TGGCCCTTAC CTCGGTGGTC 
GTCACGCTGT GGTACCGAGC CCCGGAAGTC CTGCTCCAGT CCAGCTACGC CACCCCCGTG 
GACCTCTGGA GTGTTGGCTG CATCTTTGCA GAACTGTTTC GCAGAAAGCC TCTTTTTCGT 
GGAAGTTCAG ACGTGGATCA ACTAGGGAAA ATCTTGGACG TCATCGGACT CCCAGGAGAA 
GAAGACTGGC CTAGGGATGT TGCTCTTCCC AGACAGGCTT TTCACTCCAA ATCTGCCCAA 
CCCATCGAGA AGTTTGTGAC AGACATCGAC GAGCTAGGCA AAGACCTCCT TCTGAAATGC 
TTGACGTTTA ATCCAGCTAA AAGAATATCC GCTTATGGCG CCCTGAATCA CCCGTACTTC 
CAAGACCTGG AGAGATACAA GGACAACCTG CATTCTCACC TGTCGTCCAG CCAGAGCACC 
TCGGAGCTGA ACACAGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cdk6 ( XM_008762679.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008760901.1 Rattus norvegicus cyclin-dependent kinase 6 (Cdk6), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa07852
Clone ID Related Accession (Same CDS sequence)	XM_006236021.2 , NM_001191861.1 , XM_008762679.2 , XM_006236019.3 , XM_006236020.3
Accession Version	XM_008762679.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 981bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cyclin-dependent kinase 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008762679.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGAAGG ACAGCCTGAG TCGCGCCGAC CAGCAGTATG AGTGCGTGGC GGAGATCGGG 
GAAGGCGCCT ACGGGAAGGT GTTCAAGGCC CGCGACCTGA AGAACGGCGG CCGCTTCGTG 
GCTCTGAAGC GCGTGCGAGT GCAGACCGGA GAGGAGGGCA TGCCGCTCTC CACCATCCGC 
GAGGTGGCGG TGCTGAGGCA CCTGGAGACC TTTGAGCACC CCAACGTGGT CAGGTTGTTT 
GACGTGTGCA CAGTGTCACG GACAGACAGA GAAACTAAAC TTACGCTAGT GTTTGAGCAT 
GTTGATCAAG ACTTGACCAC TTACTTGGAT AAAGTTCCAG AACCCGGTGT GCCCACAGAG 
ACCATAAAGG ATATGATGTT TCAGCTTCTC CGAGGTCTGG ACTTCCTCCA TTCTCACAGA 
GTAGTGCATC GTGACCTGAA GCCACAGAAC ATTCTGGTGA CCAGCAGTGG ACAAATAAAA 
CTGGCTGACT TCGGCCTTGC CCGCATCTAC AGTTTTCAGA TGGCCCTTAC CTCGGTGGTC 
GTCACGCTGT GGTACCGAGC CCCGGAAGTC CTGCTCCAGT CCAGCTACGC CACCCCCGTG 
GACCTCTGGA GTGTTGGCTG CATCTTTGCA GAACTGTTTC GCAGAAAGCC TCTTTTTCGT 
GGAAGTTCAG ACGTGGATCA ACTAGGGAAA ATCTTGGACG TCATCGGACT CCCAGGAGAA 
GAAGACTGGC CTAGGGATGT TGCTCTTCCC AGACAGGCTT TTCACTCCAA ATCTGCCCAA 
CCCATCGAGA AGTTTGTGAC AGACATCGAC GAGCTAGGCA AAGACCTCCT TCTGAAATGC 
TTGACGTTTA ATCCAGCTAA AAGAATATCC GCTTATGGCG CCCTGAATCA CCCGTACTTC 
CAAGACCTGG AGAGATACAA GGACAACCTG CATTCTCACC TGTCGTCCAG CCAGAGCACC 
TCGGAGCTGA ACACAGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008760901.1
CDS	1143..2123
Translation	MEKDSLSRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAELFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYGALNHPYFQDLERYKDNLHSHLSSSQSTSELNTA

Target ORF information:

RefSeq Version	XM_008762679.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cyclin-dependent kinase 6 (Cdk6), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008762679.2

ORF Insert Sequence:

ATGGAGAAGG ACAGCCTGAG TCGCGCCGAC CAGCAGTATG AGTGCGTGGC GGAGATCGGG 
GAAGGCGCCT ACGGGAAGGT GTTCAAGGCC CGCGACCTGA AGAACGGCGG CCGCTTCGTG 
GCTCTGAAGC GCGTGCGAGT GCAGACCGGA GAGGAGGGCA TGCCGCTCTC CACCATCCGC 
GAGGTGGCGG TGCTGAGGCA CCTGGAGACC TTTGAGCACC CCAACGTGGT CAGGTTGTTT 
GACGTGTGCA CAGTGTCACG GACAGACAGA GAAACTAAAC TTACGCTAGT GTTTGAGCAT 
GTTGATCAAG ACTTGACCAC TTACTTGGAT AAAGTTCCAG AACCCGGTGT GCCCACAGAG 
ACCATAAAGG ATATGATGTT TCAGCTTCTC CGAGGTCTGG ACTTCCTCCA TTCTCACAGA 
GTAGTGCATC GTGACCTGAA GCCACAGAAC ATTCTGGTGA CCAGCAGTGG ACAAATAAAA 
CTGGCTGACT TCGGCCTTGC CCGCATCTAC AGTTTTCAGA TGGCCCTTAC CTCGGTGGTC 
GTCACGCTGT GGTACCGAGC CCCGGAAGTC CTGCTCCAGT CCAGCTACGC CACCCCCGTG 
GACCTCTGGA GTGTTGGCTG CATCTTTGCA GAACTGTTTC GCAGAAAGCC TCTTTTTCGT 
GGAAGTTCAG ACGTGGATCA ACTAGGGAAA ATCTTGGACG TCATCGGACT CCCAGGAGAA 
GAAGACTGGC CTAGGGATGT TGCTCTTCCC AGACAGGCTT TTCACTCCAA ATCTGCCCAA 
CCCATCGAGA AGTTTGTGAC AGACATCGAC GAGCTAGGCA AAGACCTCCT TCTGAAATGC 
TTGACGTTTA ATCCAGCTAA AAGAATATCC GCTTATGGCG CCCTGAATCA CCCGTACTTC 
CAAGACCTGG AGAGATACAA GGACAACCTG CATTCTCACC TGTCGTCCAG CCAGAGCACC 
TCGGAGCTGA ACACAGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cdk6 ( XM_006236019.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006236081.1 Rattus norvegicus cyclin-dependent kinase 6 (Cdk6), transcript variant X4, mRNA.

Price & Availability↑

CloneID	ORa07852
Clone ID Related Accession (Same CDS sequence)	XM_006236021.2 , NM_001191861.1 , XM_008762679.2 , XM_006236019.3 , XM_006236020.3
Accession Version	XM_006236019.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 981bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cyclin-dependent kinase 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006236019.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGAAGG ACAGCCTGAG TCGCGCCGAC CAGCAGTATG AGTGCGTGGC GGAGATCGGG 
GAAGGCGCCT ACGGGAAGGT GTTCAAGGCC CGCGACCTGA AGAACGGCGG CCGCTTCGTG 
GCTCTGAAGC GCGTGCGAGT GCAGACCGGA GAGGAGGGCA TGCCGCTCTC CACCATCCGC 
GAGGTGGCGG TGCTGAGGCA CCTGGAGACC TTTGAGCACC CCAACGTGGT CAGGTTGTTT 
GACGTGTGCA CAGTGTCACG GACAGACAGA GAAACTAAAC TTACGCTAGT GTTTGAGCAT 
GTTGATCAAG ACTTGACCAC TTACTTGGAT AAAGTTCCAG AACCCGGTGT GCCCACAGAG 
ACCATAAAGG ATATGATGTT TCAGCTTCTC CGAGGTCTGG ACTTCCTCCA TTCTCACAGA 
GTAGTGCATC GTGACCTGAA GCCACAGAAC ATTCTGGTGA CCAGCAGTGG ACAAATAAAA 
CTGGCTGACT TCGGCCTTGC CCGCATCTAC AGTTTTCAGA TGGCCCTTAC CTCGGTGGTC 
GTCACGCTGT GGTACCGAGC CCCGGAAGTC CTGCTCCAGT CCAGCTACGC CACCCCCGTG 
GACCTCTGGA GTGTTGGCTG CATCTTTGCA GAACTGTTTC GCAGAAAGCC TCTTTTTCGT 
GGAAGTTCAG ACGTGGATCA ACTAGGGAAA ATCTTGGACG TCATCGGACT CCCAGGAGAA 
GAAGACTGGC CTAGGGATGT TGCTCTTCCC AGACAGGCTT TTCACTCCAA ATCTGCCCAA 
CCCATCGAGA AGTTTGTGAC AGACATCGAC GAGCTAGGCA AAGACCTCCT TCTGAAATGC 
TTGACGTTTA ATCCAGCTAA AAGAATATCC GCTTATGGCG CCCTGAATCA CCCGTACTTC 
CAAGACCTGG AGAGATACAA GGACAACCTG CATTCTCACC TGTCGTCCAG CCAGAGCACC 
TCGGAGCTGA ACACAGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006236081.1
CDS	497..1477
Translation	MEKDSLSRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAELFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYGALNHPYFQDLERYKDNLHSHLSSSQSTSELNTA

Target ORF information:

RefSeq Version	XM_006236019.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cyclin-dependent kinase 6 (Cdk6), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006236019.3

ORF Insert Sequence:

ATGGAGAAGG ACAGCCTGAG TCGCGCCGAC CAGCAGTATG AGTGCGTGGC GGAGATCGGG 
GAAGGCGCCT ACGGGAAGGT GTTCAAGGCC CGCGACCTGA AGAACGGCGG CCGCTTCGTG 
GCTCTGAAGC GCGTGCGAGT GCAGACCGGA GAGGAGGGCA TGCCGCTCTC CACCATCCGC 
GAGGTGGCGG TGCTGAGGCA CCTGGAGACC TTTGAGCACC CCAACGTGGT CAGGTTGTTT 
GACGTGTGCA CAGTGTCACG GACAGACAGA GAAACTAAAC TTACGCTAGT GTTTGAGCAT 
GTTGATCAAG ACTTGACCAC TTACTTGGAT AAAGTTCCAG AACCCGGTGT GCCCACAGAG 
ACCATAAAGG ATATGATGTT TCAGCTTCTC CGAGGTCTGG ACTTCCTCCA TTCTCACAGA 
GTAGTGCATC GTGACCTGAA GCCACAGAAC ATTCTGGTGA CCAGCAGTGG ACAAATAAAA 
CTGGCTGACT TCGGCCTTGC CCGCATCTAC AGTTTTCAGA TGGCCCTTAC CTCGGTGGTC 
GTCACGCTGT GGTACCGAGC CCCGGAAGTC CTGCTCCAGT CCAGCTACGC CACCCCCGTG 
GACCTCTGGA GTGTTGGCTG CATCTTTGCA GAACTGTTTC GCAGAAAGCC TCTTTTTCGT 
GGAAGTTCAG ACGTGGATCA ACTAGGGAAA ATCTTGGACG TCATCGGACT CCCAGGAGAA 
GAAGACTGGC CTAGGGATGT TGCTCTTCCC AGACAGGCTT TTCACTCCAA ATCTGCCCAA 
CCCATCGAGA AGTTTGTGAC AGACATCGAC GAGCTAGGCA AAGACCTCCT TCTGAAATGC 
TTGACGTTTA ATCCAGCTAA AAGAATATCC GCTTATGGCG CCCTGAATCA CCCGTACTTC 
CAAGACCTGG AGAGATACAA GGACAACCTG CATTCTCACC TGTCGTCCAG CCAGAGCACC 
TCGGAGCTGA ACACAGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cdk6 ( XM_006236020.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006236082.1 Rattus norvegicus cyclin-dependent kinase 6 (Cdk6), transcript variant X2, mRNA.

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CloneID	ORa07852
Clone ID Related Accession (Same CDS sequence)	XM_006236021.2 , NM_001191861.1 , XM_008762679.2 , XM_006236019.3 , XM_006236020.3
Accession Version	XM_006236020.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 981bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cyclin-dependent kinase 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006236020.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGAAGG ACAGCCTGAG TCGCGCCGAC CAGCAGTATG AGTGCGTGGC GGAGATCGGG 
GAAGGCGCCT ACGGGAAGGT GTTCAAGGCC CGCGACCTGA AGAACGGCGG CCGCTTCGTG 
GCTCTGAAGC GCGTGCGAGT GCAGACCGGA GAGGAGGGCA TGCCGCTCTC CACCATCCGC 
GAGGTGGCGG TGCTGAGGCA CCTGGAGACC TTTGAGCACC CCAACGTGGT CAGGTTGTTT 
GACGTGTGCA CAGTGTCACG GACAGACAGA GAAACTAAAC TTACGCTAGT GTTTGAGCAT 
GTTGATCAAG ACTTGACCAC TTACTTGGAT AAAGTTCCAG AACCCGGTGT GCCCACAGAG 
ACCATAAAGG ATATGATGTT TCAGCTTCTC CGAGGTCTGG ACTTCCTCCA TTCTCACAGA 
GTAGTGCATC GTGACCTGAA GCCACAGAAC ATTCTGGTGA CCAGCAGTGG ACAAATAAAA 
CTGGCTGACT TCGGCCTTGC CCGCATCTAC AGTTTTCAGA TGGCCCTTAC CTCGGTGGTC 
GTCACGCTGT GGTACCGAGC CCCGGAAGTC CTGCTCCAGT CCAGCTACGC CACCCCCGTG 
GACCTCTGGA GTGTTGGCTG CATCTTTGCA GAACTGTTTC GCAGAAAGCC TCTTTTTCGT 
GGAAGTTCAG ACGTGGATCA ACTAGGGAAA ATCTTGGACG TCATCGGACT CCCAGGAGAA 
GAAGACTGGC CTAGGGATGT TGCTCTTCCC AGACAGGCTT TTCACTCCAA ATCTGCCCAA 
CCCATCGAGA AGTTTGTGAC AGACATCGAC GAGCTAGGCA AAGACCTCCT TCTGAAATGC 
TTGACGTTTA ATCCAGCTAA AAGAATATCC GCTTATGGCG CCCTGAATCA CCCGTACTTC 
CAAGACCTGG AGAGATACAA GGACAACCTG CATTCTCACC TGTCGTCCAG CCAGAGCACC 
TCGGAGCTGA ACACAGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006236082.1
CDS	1326..2306
Translation	MEKDSLSRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAELFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYGALNHPYFQDLERYKDNLHSHLSSSQSTSELNTA

Target ORF information:

RefSeq Version	XM_006236020.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cyclin-dependent kinase 6 (Cdk6), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006236020.3

ORF Insert Sequence:

ATGGAGAAGG ACAGCCTGAG TCGCGCCGAC CAGCAGTATG AGTGCGTGGC GGAGATCGGG 
GAAGGCGCCT ACGGGAAGGT GTTCAAGGCC CGCGACCTGA AGAACGGCGG CCGCTTCGTG 
GCTCTGAAGC GCGTGCGAGT GCAGACCGGA GAGGAGGGCA TGCCGCTCTC CACCATCCGC 
GAGGTGGCGG TGCTGAGGCA CCTGGAGACC TTTGAGCACC CCAACGTGGT CAGGTTGTTT 
GACGTGTGCA CAGTGTCACG GACAGACAGA GAAACTAAAC TTACGCTAGT GTTTGAGCAT 
GTTGATCAAG ACTTGACCAC TTACTTGGAT AAAGTTCCAG AACCCGGTGT GCCCACAGAG 
ACCATAAAGG ATATGATGTT TCAGCTTCTC CGAGGTCTGG ACTTCCTCCA TTCTCACAGA 
GTAGTGCATC GTGACCTGAA GCCACAGAAC ATTCTGGTGA CCAGCAGTGG ACAAATAAAA 
CTGGCTGACT TCGGCCTTGC CCGCATCTAC AGTTTTCAGA TGGCCCTTAC CTCGGTGGTC 
GTCACGCTGT GGTACCGAGC CCCGGAAGTC CTGCTCCAGT CCAGCTACGC CACCCCCGTG 
GACCTCTGGA GTGTTGGCTG CATCTTTGCA GAACTGTTTC GCAGAAAGCC TCTTTTTCGT 
GGAAGTTCAG ACGTGGATCA ACTAGGGAAA ATCTTGGACG TCATCGGACT CCCAGGAGAA 
GAAGACTGGC CTAGGGATGT TGCTCTTCCC AGACAGGCTT TTCACTCCAA ATCTGCCCAA 
CCCATCGAGA AGTTTGTGAC AGACATCGAC GAGCTAGGCA AAGACCTCCT TCTGAAATGC 
TTGACGTTTA ATCCAGCTAA AAGAATATCC GCTTATGGCG CCCTGAATCA CCCGTACTTC 
CAAGACCTGG AGAGATACAA GGACAACCTG CATTCTCACC TGTCGTCCAG CCAGAGCACC 
TCGGAGCTGA ACACAGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Transcriptional alterations in hereditary and sporadic nonfunctioning pancreatic neuroendocrine tumors according to genotype.
Cancer124(3)636-647(2018 Feb)
Keutgen XM,Kumar S,Gara S,Boufraqech M,Agarwal S,Hruban RH,Nilubol N,Quezado M,Finney R,Cam M,Kebebew E

miR-377 inhibited tumorous behaviors of non-small cell lung cancer through directly targeting CDK6.
European review for medical and pharmacological sciences20(21)4494-4499(2016 Nov)
Zhang J,Zhao M,Xue ZQ,Liu Y,Wang YX

CDK6 mediates the effect of attenuation of miR-1 on provoking cardiomyocyte hypertrophy.
Molecular and cellular biochemistry412(1-2)289-96(2016 Jan)
Yuan W,Tang C,Zhu W,Zhu J,Lin Q,Fu Y,Deng C,Xue Y,Yang M,Wu S,Shan Z

Nanog interact with CDK6 to regulates astrocyte cells proliferation following spinal cord injury.
Biochemical and biophysical research communications469(4)1097-103(2016 Jan)
Gu J,Ni Y,Xu L,Xu H,Cai Z

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Cdk6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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