Trex1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Trex1
Entrez Gene ID	100049583
Full Name	three prime repair exonuclease 1
Synonyms	RGD1309596
General protein information	Preferred Names three prime repair exonuclease 1 Names three-prime repair exonuclease 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q32

mRNA and Protein(s)

mRNA	Protein	Name
NM_001024989.1	NP_001020160.1	three-prime repair exonuclease 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	TREX1	NP_057465.1
	LOC100429168	XP_002802855.1
Canis lupus familiaris (dog)	TREX1	XP_005632646.1
Bos taurus (cattle)	TREX1	NP_776900.2
Mus musculus (house mouse)	Trex1	NP_001012236.1
Rattus norvegicus (Norway rat)	Trex1	NP_001020160.1
Pan troglodytes (chimpanzee)	TREX1	XP_003309834.1

Gene Ontology
Bibliography

Related articles in PubMed

Lack of Trex1 Causes Systemic Autoimmunity despite the Presence of Antiretroviral Drugs.
Achleitner M, Kleefisch M, Hennig A, Peschke K, Polikarpova A, Oertel R, Gabriel B, Schulze L, Lindeman D, Gerbaulet A, Fiebig U, Lee-Kirsch MA, Roers A, Behrendt R
Journal of immunology (Baltimore, Md. : 1950)199(7)2261-2269(2017 Oct)

Immunostimulatory Endogenous Nucleic Acids Drive the Lesional Inflammation in Cutaneous Lupus Erythematosus.
Scholtissek B, Zahn S, Maier J, Klaeschen S, Braegelmann C, Hoelzel M, Bieber T, Barchet W, Wenzel J
The Journal of investigative dermatology137(7)1484-1492(2017 Jul)

Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism.
Hasan M, Gonugunta VK, Dobbs N, Ali A, Palchik G, Calvaruso MA, DeBerardinis RJ, Yan N
Proceedings of the National Academy of Sciences of the United States of America114(4)746-751(2017 Jan)

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases.
Gao D, Li T, Li XD, Chen X, Li QZ, Wight-Carter M, Chen ZJ
Proceedings of the National Academy of Sciences of the United States of America112(42)E5699-705(2015 Oct)

Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation.
Hasan M, Fermaintt CS, Gao N, Sakai T, Miyazaki T, Jiang S, Li QZ, Atkinson JP, Morse HC 3rd, Lehrman MA, Yan N
Immunity43(3)463-74(2015 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Trex1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Trex1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13894	NM_001024989.1 Latest version!	Rattus norvegicus three prime repair exonuclease 1 (Trex1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Trex1 ( NM_001024989.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001020160.1 Rattus norvegicus three prime repair exonuclease 1 (Trex1), mRNA.

Price & Availability↑

CloneID	ORa13894
Clone ID Related Accession (Same CDS sequence)	NM_001024989.1
Accession Version	NM_001024989.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 951bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	three-prime repair exonuclease 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC091242.1. On or before May 30, 2007 this sequence version replaced XM_345983.1, XM_217284.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC091242.1, FQ233170.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGCTCAC AGGCCCTGCC CCACGGTCAC ATGCAGACCC TCATCTTCTT AGACCTGGAA 
GCCACTGGCC TGCCTTACTC TCAGCCCAAA ATCACAGAGC TGTGCCTGCT GGCTGTCCAC 
AGACATGCCC TGGAGAACTC CTCCATGTCT GAGGGGCAGC CACCTCCGGT GCCCAAACCA 
CCCCGTGTGG TGGACAAGCT CTCTCTCTGC ATTGCTCCAG GGAAACCCTG CAGTTCTGGG 
GCCAGTGAGA TCACAGGTCT GACCACAGCT GGGCTGGAAG CACACGGGCG TCAACGCTTC 
AATGACAACC TGGCCACCCT GCTCCAAGTC TTCCTGCAGC GCCAGCCACA GCCCTGCTGC 
CTTGTGGCCC ACAACGGTGA CCGCTACGAC TTTCCTCTGC TCCAGGCAGA GCTTGCTTCG 
CTGAGCGTTA TCAGTCCTCT GGACGGTACC TTCTGTGTGG ATAGCATCGC TGCCCTGAAG 
ACCTTGGAGC AAGCCAGCAG CCCCTCAGAG CATGGTCCGA GGAAAAGCTA TAGCCTGGGT 
AGTATCTACA CCCGCCTGTA CGGGCAAGCA CCAACAGACT CACACACTGC TGAAGGCGAC 
GTTCTAGCCC TGCTCAGCAT CTGTCAGTGG AAGCCACAGG CCCTACTGCA GTGGGTGGAC 
AAACACGCCC GGCCCTTTAG CACCATCAAG CCCATGTATG GCATGGCAGC TACTACTGGA 
ACGGCCAGCC CAAGGCTGTG TGCTGCCACA ACCTCCTCAC CCCTGGCCAC AGCCAACTTA 
AGTCCCAGCA ATGGCAGGAG CAGGGGCAAG CGACCTACGA GTCCTCCTCC AGAGAACGTC 
CCAGAAGCCC CATCACGGGA GGGGCTGCTG GCCCCACTGG GCCTGCTGAC CTTCCTGACC 
TTGGCAATAG CCGTTCTGTA TGGAATCTTC CTGGCCTCAC CTGGGCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001020160.1
CDS	26..976
Translation	MGSQALPHGHMQTLIFLDLEATGLPYSQPKITELCLLAVHRHALENSSMSEGQPPPVPKPPRVVDKLSLCIAPGKPCSSGASEITGLTTAGLEAHGRQRFNDNLATLLQVFLQRQPQPCCLVAHNGDRYDFPLLQAELASLSVISPLDGTFCVDSIAALKTLEQASSPSEHGPRKSYSLGSIYTRLYGQAPTDSHTAEGDVLALLSICQWKPQALLQWVDKHARPFSTIKPMYGMAATTGTASPRLCAATTSSPLATANLSPSNGRSRGKRPTSPPPENVPEAPSREGLLAPLGLLTFLTLAIAVLYGIFLASPGQ

Target ORF information:

RefSeq Version	NM_001024989.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus three prime repair exonuclease 1 (Trex1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001024989.1

ORF Insert Sequence:

ATGGGCTCAC AGGCCCTGCC CCACGGTCAC ATGCAGACCC TCATCTTCTT AGACCTGGAA 
GCCACTGGCC TGCCTTACTC TCAGCCCAAA ATCACAGAGC TGTGCCTGCT GGCTGTCCAC 
AGACATGCCC TGGAGAACTC CTCCATGTCT GAGGGGCAGC CACCTCCGGT GCCCAAACCA 
CCCCGTGTGG TGGACAAGCT CTCTCTCTGC ATTGCTCCAG GGAAACCCTG CAGTTCTGGG 
GCCAGTGAGA TCACAGGTCT GACCACAGCT GGGCTGGAAG CACACGGGCG TCAACGCTTC 
AATGACAACC TGGCCACCCT GCTCCAAGTC TTCCTGCAGC GCCAGCCACA GCCCTGCTGC 
CTTGTGGCCC ACAACGGTGA CCGCTACGAC TTTCCTCTGC TCCAGGCAGA GCTTGCTTCG 
CTGAGCGTTA TCAGTCCTCT GGACGGTACC TTCTGTGTGG ATAGCATCGC TGCCCTGAAG 
ACCTTGGAGC AAGCCAGCAG CCCCTCAGAG CATGGTCCGA GGAAAAGCTA TAGCCTGGGT 
AGTATCTACA CCCGCCTGTA CGGGCAAGCA CCAACAGACT CACACACTGC TGAAGGCGAC 
GTTCTAGCCC TGCTCAGCAT CTGTCAGTGG AAGCCACAGG CCCTACTGCA GTGGGTGGAC 
AAACACGCCC GGCCCTTTAG CACCATCAAG CCCATGTATG GCATGGCAGC TACTACTGGA 
ACGGCCAGCC CAAGGCTGTG TGCTGCCACA ACCTCCTCAC CCCTGGCCAC AGCCAACTTA 
AGTCCCAGCA ATGGCAGGAG CAGGGGCAAG CGACCTACGA GTCCTCCTCC AGAGAACGTC 
CCAGAAGCCC CATCACGGGA GGGGCTGCTG GCCCCACTGG GCCTGCTGAC CTTCCTGACC 
TTGGCAATAG CCGTTCTGTA TGGAATCTTC CTGGCCTCAC CTGGGCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lack of Trex1 Causes Systemic Autoimmunity despite the Presence of Antiretroviral Drugs.
Journal of immunology (Baltimore, Md. : 1950)199(7)2261-2269(2017 Oct)
Achleitner M,Kleefisch M,Hennig A,Peschke K,Polikarpova A,Oertel R,Gabriel B,Schulze L,Lindeman D,Gerbaulet A,Fiebig U,Lee-Kirsch MA,Roers A,Behrendt R

Immunostimulatory Endogenous Nucleic Acids Drive the Lesional Inflammation in Cutaneous Lupus Erythematosus.
The Journal of investigative dermatology137(7)1484-1492(2017 Jul)
Scholtissek B,Zahn S,Maier J,Klaeschen S,Braegelmann C,Hoelzel M,Bieber T,Barchet W,Wenzel J

Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism.
Proceedings of the National Academy of Sciences of the United States of America114(4)746-751(2017 Jan)
Hasan M,Gonugunta VK,Dobbs N,Ali A,Palchik G,Calvaruso MA,DeBerardinis RJ,Yan N

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases.
Proceedings of the National Academy of Sciences of the United States of America112(42)E5699-705(2015 Oct)
Gao D,Li T,Li XD,Chen X,Li QZ,Wight-Carter M,Chen ZJ

Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation.
Immunity43(3)463-74(2015 Sep)
Hasan M,Fermaintt CS,Gao N,Sakai T,Miyazaki T,Jiang S,Li QZ,Atkinson JP,Morse HC 3rd,Lehrman MA,Yan N