TREX1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TREX1
Entrez Gene ID	11277
Full Name	three prime repair exonuclease 1
Synonyms	AGS1,CRV,DRN3,HERNS
General protein information	Preferred Names three prime repair exonuclease 1 Names three-prime repair exonuclease 1 3' repair exonuclease 1 3'-5' exonuclease TREX1 DNase III deoxyribonuclease III
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3p21.31
Summary	This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012].
Disorder MIM:	606609
Disorder Html:	Aicardi-Goutieres syndrome 1, dominant and recessive, 225750 (3); Chilblain lupus, 610448 (3); Vasculopathy, retinal, with cerebral leukodystrophy, 192315 (3); {Systemic lupus erythematosus, susceptibility to}, 152700 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_007248.3	NP_009179.2	three-prime repair exonuclease 1 isoform c
NM_007248.4	NP_009179.2	three-prime repair exonuclease 1 isoform c
NM_033629.6	NP_338599.1	three-prime repair exonuclease 1 isoform b
NM_007248.5	NP_009179.2	three-prime repair exonuclease 1 isoform c
NM_033629.4	NP_338599.1	three-prime repair exonuclease 1 isoform b
NM_016381.5	NP_057465.1	three-prime repair exonuclease 1 isoform a

Pathways from BioSystems

Homologies

Homo sapiens (human)	TREX1	NP_057465.1
	LOC100429168	XP_002802855.1
Canis lupus familiaris (dog)	TREX1	XP_005632646.1
Bos taurus (cattle)	TREX1	NP_776900.2
Mus musculus (house mouse)	Trex1	NP_001012236.1
Rattus norvegicus (Norway rat)	Trex1	NP_001020160.1
Pan troglodytes (chimpanzee)	TREX1	XP_003309834.1

Gene Ontology
Bibliography

Related articles in PubMed

Lack of Trex1 Causes Systemic Autoimmunity despite the Presence of Antiretroviral Drugs.
Achleitner M, Kleefisch M, Hennig A, Peschke K, Polikarpova A, Oertel R, Gabriel B, Schulze L, Lindeman D, Gerbaulet A, Fiebig U, Lee-Kirsch MA, Roers A, Behrendt R
Journal of immunology (Baltimore, Md. : 1950)199(7)2261-2269(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data do not support the concept of retroelement-derived cDNA as key triggers of systemic autoimmunity in Trex1-deficient humans and mice
Title: Lack of Trex1 Causes Systemic Autoimmunity despite the Presence of Antiretroviral Drugs.

Aicardi-Goutieres syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion.
Title: Aicardi-Gouti?res syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion.

Aicardie-Goutieres syndrome is described in a patient with a homozygous p.Arg114His mutation in the TREX1 gene.
Title: Inflammatory myopathy in a patient with Aicardi-Gouti?res syndrome.

the cell-cycle-dependent post-translation modification of TREX1 regulates its interaction with OST.
Title: Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex.

Analysis of mRNA expression profiles in breast tumors demonstrates that those with lower Trex1 and higher BLM and EXO1 expression levels are associated with poor prognosis
Title: A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1.

The following TREX1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TREX1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27689	NM_007248.5 Latest version!	Homo sapiens three prime repair exonuclease 1 (TREX1), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu27695	NM_033629.6 Latest version!	Homo sapiens three prime repair exonuclease 1 (TREX1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu27696	NM_016381.5 Latest version!	Homo sapiens three prime repair exonuclease 1 (TREX1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu27689	NM_007248.3	Homo sapiens three prime repair exonuclease 1 (TREX1), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu27689	NM_007248.4	Homo sapiens three prime repair exonuclease 1 (TREX1), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu27695	NM_033629.4	Homo sapiens three prime repair exonuclease 1 (TREX1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TREX1 ( NM_007248.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_009179.2 Homo sapiens three prime repair exonuclease 1 (TREX1), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OHu27689
Clone ID Related Accession (Same CDS sequence)	NM_007248.3 , NM_007248.4 , NM_007248.5
Accession Version	NM_007248.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	three-prime repair exonuclease 1 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL137745.1, AJ243797.1 and AC134772.2. On Jan 17, 2014 this sequence version replaced NM_007248.2. Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The resulting isoform (c) has a shorter N-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ243797.1, W24304.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGACCC TCATCTTTTT CGACATGGAG GCCACTGGCT TGCCCTTCTC CCAGCCCAAG 
GTCACGGAGC TGTGCCTGCT GGCTGTCCAC AGATGTGCCC TGGAGAGCCC CCCCACCTCT 
CAGGGGCCAC CTCCCACAGT TCCTCCACCA CCGCGTGTGG TAGACAAGCT CTCCCTGTGT 
GTGGCTCCGG GGAAGGCCTG CAGCCCTGCA GCCAGCGAGA TCACAGGTCT GAGCACAGCT 
GTGCTGGCAG CGCATGGGCG TCAATGTTTT GATGACAACC TGGCCAACCT GCTCCTAGCC 
TTCCTGCGGC GCCAGCCACA GCCCTGGTGC CTGGTGGCAC ACAATGGTGA CCGCTACGAC 
TTCCCCCTGC TCCAAGCAGA GCTGGCTATG CTGGGCCTCA CCAGTGCTCT GGATGGTGCC 
TTCTGTGTGG ATAGCATCAC TGCGCTGAAG GCCCTGGAGC GAGCAAGCAG CCCCTCAGAA 
CACGGCCCAA GGAAGAGCTA TAGCCTAGGC AGCATCTACA CTCGCCTGTA TGGGCAGTCC 
CCTCCAGACT CGCACACGGC TGAGGGTGAT GTCCTGGCCC TGCTCAGCAT CTGTCAGTGG 
AGACCACAGG CCCTGCTGCG GTGGGTGGAT GCTCACGCCA GGCCTTTCGG CACCATCAGG 
CCCATGTATG GGGTCACAGC CTCTGCTAGG ACCAAGCCAA GACCATCTGC TGTCACAACC 
ACTGCACACC TGGCCACAAC CAGGAACACT AGTCCCAGCC TTGGAGAGAG CAGGGGTACC 
AAGGATCTTC CTCCAGTGAA GGACCCTGGA GCCCTATCCA GGGAGGGGCT GCTGGCCCCA 
CTGGGTCTGC TGGCCATCCT GACCTTGGCA GTAGCCACAC TGTATGGACT ATCCCTGGCC 
ACACCTGGGG AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009179.2
CDS	669..1583
Translation	MQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTSQGPPPTVPPPPRVVDKLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFLRRQPQPWCLVAHNGDRYDFPLLQAELAMLGLTSALDGAFCVDSITALKALERASSPSEHGPRKSYSLGSIYTRLYGQSPPDSHTAEGDVLALLSICQWRPQALLRWVDAHARPFGTIRPMYGVTASARTKPRPSAVTTTAHLATTRNTSPSLGESRGTKDLPPVKDPGALSREGLLAPLGLLAILTLAVATLYGLSLATPGE

Target ORF information:

RefSeq Version	NM_007248.3
Organism	Homo sapiens(human)
Definition	Homo sapiens three prime repair exonuclease 1 (TREX1), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007248.3

ORF Insert Sequence:

ATGCAGACCC TCATCTTTTT CGACATGGAG GCCACTGGCT TGCCCTTCTC CCAGCCCAAG 
GTCACGGAGC TGTGCCTGCT GGCTGTCCAC AGATGTGCCC TGGAGAGCCC CCCCACCTCT 
CAGGGGCCAC CTCCCACAGT TCCTCCACCA CCGCGTGTGG TAGACAAGCT CTCCCTGTGT 
GTGGCTCCGG GGAAGGCCTG CAGCCCTGCA GCCAGCGAGA TCACAGGTCT GAGCACAGCT 
GTGCTGGCAG CGCATGGGCG TCAATGTTTT GATGACAACC TGGCCAACCT GCTCCTAGCC 
TTCCTGCGGC GCCAGCCACA GCCCTGGTGC CTGGTGGCAC ACAATGGTGA CCGCTACGAC 
TTCCCCCTGC TCCAAGCAGA GCTGGCTATG CTGGGCCTCA CCAGTGCTCT GGATGGTGCC 
TTCTGTGTGG ATAGCATCAC TGCGCTGAAG GCCCTGGAGC GAGCAAGCAG CCCCTCAGAA 
CACGGCCCAA GGAAGAGCTA TAGCCTAGGC AGCATCTACA CTCGCCTGTA TGGGCAGTCC 
CCTCCAGACT CGCACACGGC TGAGGGTGAT GTCCTGGCCC TGCTCAGCAT CTGTCAGTGG 
AGACCACAGG CCCTGCTGCG GTGGGTGGAT GCTCACGCCA GGCCTTTCGG CACCATCAGG 
CCCATGTATG GGGTCACAGC CTCTGCTAGG ACCAAGCCAA GACCATCTGC TGTCACAACC 
ACTGCACACC TGGCCACAAC CAGGAACACT AGTCCCAGCC TTGGAGAGAG CAGGGGTACC 
AAGGATCTTC CTCCAGTGAA GGACCCTGGA GCCCTATCCA GGGAGGGGCT GCTGGCCCCA 
CTGGGTCTGC TGGCCATCCT GACCTTGGCA GTAGCCACAC TGTATGGACT ATCCCTGGCC 
ACACCTGGGG AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TREX1 ( NM_007248.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_009179.2 Homo sapiens three prime repair exonuclease 1 (TREX1), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OHu27689
Clone ID Related Accession (Same CDS sequence)	NM_007248.3 , NM_007248.4 , NM_007248.5
Accession Version	NM_007248.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-26
Organism	Homo sapiens(human)
Product	three-prime repair exonuclease 1 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ243797.1, AC134772.2, W24304.1, AF319569.1, BT020053.1 and AF319566.1. On Jan 27, 2018 this sequence version replaced NM_007248.3. Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The resulting isoform (c) has a shorter N-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ243797.1, W24304.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGACCC TCATCTTTTT CGACATGGAG GCCACTGGCT TGCCCTTCTC CCAGCCCAAG 
GTCACGGAGC TGTGCCTGCT GGCTGTCCAC AGATGTGCCC TGGAGAGCCC CCCCACCTCT 
CAGGGGCCAC CTCCCACAGT TCCTCCACCA CCGCGTGTGG TAGACAAGCT CTCCCTGTGT 
GTGGCTCCGG GGAAGGCCTG CAGCCCTGCA GCCAGCGAGA TCACAGGTCT GAGCACAGCT 
GTGCTGGCAG CGCATGGGCG TCAATGTTTT GATGACAACC TGGCCAACCT GCTCCTAGCC 
TTCCTGCGGC GCCAGCCACA GCCCTGGTGC CTGGTGGCAC ACAATGGTGA CCGCTACGAC 
TTCCCCCTGC TCCAAGCAGA GCTGGCTATG CTGGGCCTCA CCAGTGCTCT GGATGGTGCC 
TTCTGTGTGG ATAGCATCAC TGCGCTGAAG GCCCTGGAGC GAGCAAGCAG CCCCTCAGAA 
CACGGCCCAA GGAAGAGCTA TAGCCTAGGC AGCATCTACA CTCGCCTGTA TGGGCAGTCC 
CCTCCAGACT CGCACACGGC TGAGGGTGAT GTCCTGGCCC TGCTCAGCAT CTGTCAGTGG 
AGACCACAGG CCCTGCTGCG GTGGGTGGAT GCTCACGCCA GGCCTTTCGG CACCATCAGG 
CCCATGTATG GGGTCACAGC CTCTGCTAGG ACCAAGCCAA GACCATCTGC TGTCACAACC 
ACTGCACACC TGGCCACAAC CAGGAACACT AGTCCCAGCC TTGGAGAGAG CAGGGGTACC 
AAGGATCTTC CTCCAGTGAA GGACCCTGGA GCCCTATCCA GGGAGGGGCT GCTGGCCCCA 
CTGGGTCTGC TGGCCATCCT GACCTTGGCA GTAGCCACAC TGTATGGACT ATCCCTGGCC 
ACACCTGGGG AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009179.2
CDS	237..1151
Translation	MQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTSQGPPPTVPPPPRVVDKLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFLRRQPQPWCLVAHNGDRYDFPLLQAELAMLGLTSALDGAFCVDSITALKALERASSPSEHGPRKSYSLGSIYTRLYGQSPPDSHTAEGDVLALLSICQWRPQALLRWVDAHARPFGTIRPMYGVTASARTKPRPSAVTTTAHLATTRNTSPSLGESRGTKDLPPVKDPGALSREGLLAPLGLLAILTLAVATLYGLSLATPGE

Target ORF information:

RefSeq Version	NM_007248.4
Organism	Homo sapiens(human)
Definition	Homo sapiens three prime repair exonuclease 1 (TREX1), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007248.4

ORF Insert Sequence:

ATGCAGACCC TCATCTTTTT CGACATGGAG GCCACTGGCT TGCCCTTCTC CCAGCCCAAG 
GTCACGGAGC TGTGCCTGCT GGCTGTCCAC AGATGTGCCC TGGAGAGCCC CCCCACCTCT 
CAGGGGCCAC CTCCCACAGT TCCTCCACCA CCGCGTGTGG TAGACAAGCT CTCCCTGTGT 
GTGGCTCCGG GGAAGGCCTG CAGCCCTGCA GCCAGCGAGA TCACAGGTCT GAGCACAGCT 
GTGCTGGCAG CGCATGGGCG TCAATGTTTT GATGACAACC TGGCCAACCT GCTCCTAGCC 
TTCCTGCGGC GCCAGCCACA GCCCTGGTGC CTGGTGGCAC ACAATGGTGA CCGCTACGAC 
TTCCCCCTGC TCCAAGCAGA GCTGGCTATG CTGGGCCTCA CCAGTGCTCT GGATGGTGCC 
TTCTGTGTGG ATAGCATCAC TGCGCTGAAG GCCCTGGAGC GAGCAAGCAG CCCCTCAGAA 
CACGGCCCAA GGAAGAGCTA TAGCCTAGGC AGCATCTACA CTCGCCTGTA TGGGCAGTCC 
CCTCCAGACT CGCACACGGC TGAGGGTGAT GTCCTGGCCC TGCTCAGCAT CTGTCAGTGG 
AGACCACAGG CCCTGCTGCG GTGGGTGGAT GCTCACGCCA GGCCTTTCGG CACCATCAGG 
CCCATGTATG GGGTCACAGC CTCTGCTAGG ACCAAGCCAA GACCATCTGC TGTCACAACC 
ACTGCACACC TGGCCACAAC CAGGAACACT AGTCCCAGCC TTGGAGAGAG CAGGGGTACC 
AAGGATCTTC CTCCAGTGAA GGACCCTGGA GCCCTATCCA GGGAGGGGCT GCTGGCCCCA 
CTGGGTCTGC TGGCCATCCT GACCTTGGCA GTAGCCACAC TGTATGGACT ATCCCTGGCC 
ACACCTGGGG AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TREX1 ( NM_007248.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_009179.2 Homo sapiens three prime repair exonuclease 1 (TREX1), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OHu27689
Clone ID Related Accession (Same CDS sequence)	NM_007248.3 , NM_007248.4 , NM_007248.5
Accession Version	NM_007248.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	three-prime repair exonuclease 1 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC134772.2, AJ243797.1, W24304.1, AF319569.1, BT020053.1 and AF319566.1. On May 31, 2019 this sequence version replaced NM_007248.4. Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The resulting isoform (c) has a shorter N-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ243797.1, W24304.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGACCC TCATCTTTTT CGACATGGAG GCCACTGGCT TGCCCTTCTC CCAGCCCAAG 
GTCACGGAGC TGTGCCTGCT GGCTGTCCAC AGATGTGCCC TGGAGAGCCC CCCCACCTCT 
CAGGGGCCAC CTCCCACAGT TCCTCCACCA CCGCGTGTGG TAGACAAGCT CTCCCTGTGT 
GTGGCTCCGG GGAAGGCCTG CAGCCCTGCA GCCAGCGAGA TCACAGGTCT GAGCACAGCT 
GTGCTGGCAG CGCATGGGCG TCAATGTTTT GATGACAACC TGGCCAACCT GCTCCTAGCC 
TTCCTGCGGC GCCAGCCACA GCCCTGGTGC CTGGTGGCAC ACAATGGTGA CCGCTACGAC 
TTCCCCCTGC TCCAAGCAGA GCTGGCTATG CTGGGCCTCA CCAGTGCTCT GGATGGTGCC 
TTCTGTGTGG ATAGCATCAC TGCGCTGAAG GCCCTGGAGC GAGCAAGCAG CCCCTCAGAA 
CACGGCCCAA GGAAGAGCTA TAGCCTAGGC AGCATCTACA CTCGCCTGTA TGGGCAGTCC 
CCTCCAGACT CGCACACGGC TGAGGGTGAT GTCCTGGCCC TGCTCAGCAT CTGTCAGTGG 
AGACCACAGG CCCTGCTGCG GTGGGTGGAT GCTCACGCCA GGCCTTTCGG CACCATCAGG 
CCCATGTATG GGGTCACAGC CTCTGCTAGG ACCAAGCCAA GACCATCTGC TGTCACAACC 
ACTGCACACC TGGCCACAAC CAGGAACACT AGTCCCAGCC TTGGAGAGAG CAGGGGTACC 
AAGGATCTTC CTCCAGTGAA GGACCCTGGA GCCCTATCCA GGGAGGGGCT GCTGGCCCCA 
CTGGGTCTGC TGGCCATCCT GACCTTGGCA GTAGCCACAC TGTATGGACT ATCCCTGGCC 
ACACCTGGGG AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009179.2
CDS	359..1273
Translation	MQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTSQGPPPTVPPPPRVVDKLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFLRRQPQPWCLVAHNGDRYDFPLLQAELAMLGLTSALDGAFCVDSITALKALERASSPSEHGPRKSYSLGSIYTRLYGQSPPDSHTAEGDVLALLSICQWRPQALLRWVDAHARPFGTIRPMYGVTASARTKPRPSAVTTTAHLATTRNTSPSLGESRGTKDLPPVKDPGALSREGLLAPLGLLAILTLAVATLYGLSLATPGE

Target ORF information:

RefSeq Version	NM_007248.5
Organism	Homo sapiens(human)
Definition	Homo sapiens three prime repair exonuclease 1 (TREX1), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007248.5

ORF Insert Sequence:

ATGCAGACCC TCATCTTTTT CGACATGGAG GCCACTGGCT TGCCCTTCTC CCAGCCCAAG 
GTCACGGAGC TGTGCCTGCT GGCTGTCCAC AGATGTGCCC TGGAGAGCCC CCCCACCTCT 
CAGGGGCCAC CTCCCACAGT TCCTCCACCA CCGCGTGTGG TAGACAAGCT CTCCCTGTGT 
GTGGCTCCGG GGAAGGCCTG CAGCCCTGCA GCCAGCGAGA TCACAGGTCT GAGCACAGCT 
GTGCTGGCAG CGCATGGGCG TCAATGTTTT GATGACAACC TGGCCAACCT GCTCCTAGCC 
TTCCTGCGGC GCCAGCCACA GCCCTGGTGC CTGGTGGCAC ACAATGGTGA CCGCTACGAC 
TTCCCCCTGC TCCAAGCAGA GCTGGCTATG CTGGGCCTCA CCAGTGCTCT GGATGGTGCC 
TTCTGTGTGG ATAGCATCAC TGCGCTGAAG GCCCTGGAGC GAGCAAGCAG CCCCTCAGAA 
CACGGCCCAA GGAAGAGCTA TAGCCTAGGC AGCATCTACA CTCGCCTGTA TGGGCAGTCC 
CCTCCAGACT CGCACACGGC TGAGGGTGAT GTCCTGGCCC TGCTCAGCAT CTGTCAGTGG 
AGACCACAGG CCCTGCTGCG GTGGGTGGAT GCTCACGCCA GGCCTTTCGG CACCATCAGG 
CCCATGTATG GGGTCACAGC CTCTGCTAGG ACCAAGCCAA GACCATCTGC TGTCACAACC 
ACTGCACACC TGGCCACAAC CAGGAACACT AGTCCCAGCC TTGGAGAGAG CAGGGGTACC 
AAGGATCTTC CTCCAGTGAA GGACCCTGGA GCCCTATCCA GGGAGGGGCT GCTGGCCCCA 
CTGGGTCTGC TGGCCATCCT GACCTTGGCA GTAGCCACAC TGTATGGACT ATCCCTGGCC 
ACACCTGGGG AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TREX1 ( NM_033629.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_338599.1 Homo sapiens three prime repair exonuclease 1 (TREX1), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu27695
Clone ID Related Accession (Same CDS sequence)	NM_033629.6 , NM_033629.4
Accession Version	NM_033629.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	three-prime repair exonuclease 1 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF319569.1, AL137745.1 and BT020053.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_033629.5. Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The resulting isoform (b) has a shorter N-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1127528.1, SRR3476690.1162093.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000625293.3/ ENSP00000486676.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCTCGC AGGCCCTGCC CCCGGGGCCC ATGCAGACCC TCATCTTTTT CGACATGGAG 
GCCACTGGCT TGCCCTTCTC CCAGCCCAAG GTCACGGAGC TGTGCCTGCT GGCTGTCCAC 
AGATGTGCCC TGGAGAGCCC CCCCACCTCT CAGGGGCCAC CTCCCACAGT TCCTCCACCA 
CCGCGTGTGG TAGACAAGCT CTCCCTGTGT GTGGCTCCGG GGAAGGCCTG CAGCCCTGCA 
GCCAGCGAGA TCACAGGTCT GAGCACAGCT GTGCTGGCAG CGCATGGGCG TCAATGTTTT 
GATGACAACC TGGCCAACCT GCTCCTAGCC TTCCTGCGGC GCCAGCCACA GCCCTGGTGC 
CTGGTGGCAC ACAATGGTGA CCGCTACGAC TTCCCCCTGC TCCAAGCAGA GCTGGCTATG 
CTGGGCCTCA CCAGTGCTCT GGATGGTGCC TTCTGTGTGG ATAGCATCAC TGCGCTGAAG 
GCCCTGGAGC GAGCAAGCAG CCCCTCAGAA CACGGCCCAA GGAAGAGCTA TAGCCTAGGC 
AGCATCTACA CTCGCCTGTA TGGGCAGTCC CCTCCAGACT CGCACACGGC TGAGGGTGAT 
GTCCTGGCCC TGCTCAGCAT CTGTCAGTGG AGACCACAGG CCCTGCTGCG GTGGGTGGAT 
GCTCACGCCA GGCCTTTCGG CACCATCAGG CCCATGTATG GGGTCACAGC CTCTGCTAGG 
ACCAAGCCAA GACCATCTGC TGTCACAACC ACTGCACACC TGGCCACAAC CAGGAACACT 
AGTCCCAGCC TTGGAGAGAG CAGGGGTACC AAGGATCTTC CTCCAGTGAA GGACCCTGGA 
GCCCTATCCA GGGAGGGGCT GCTGGCCCCA CTGGGTCTGC TGGCCATCCT GACCTTGGCA 
GTAGCCACAC TGTATGGACT ATCCCTGGCC ACACCTGGGG AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_338599.1
CDS	107..1051
Translation	MGSQALPPGPMQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTSQGPPPTVPPPPRVVDKLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFLRRQPQPWCLVAHNGDRYDFPLLQAELAMLGLTSALDGAFCVDSITALKALERASSPSEHGPRKSYSLGSIYTRLYGQSPPDSHTAEGDVLALLSICQWRPQALLRWVDAHARPFGTIRPMYGVTASARTKPRPSAVTTTAHLATTRNTSPSLGESRGTKDLPPVKDPGALSREGLLAPLGLLAILTLAVATLYGLSLATPGE

Target ORF information:

RefSeq Version	NM_033629.6
Organism	Homo sapiens(human)
Definition	Homo sapiens three prime repair exonuclease 1 (TREX1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033629.6

ORF Insert Sequence:

ATGGGCTCGC AGGCCCTGCC CCCGGGGCCC ATGCAGACCC TCATCTTTTT CGACATGGAG 
GCCACTGGCT TGCCCTTCTC CCAGCCCAAG GTCACGGAGC TGTGCCTGCT GGCTGTCCAC 
AGATGTGCCC TGGAGAGCCC CCCCACCTCT CAGGGGCCAC CTCCCACAGT TCCTCCACCA 
CCGCGTGTGG TAGACAAGCT CTCCCTGTGT GTGGCTCCGG GGAAGGCCTG CAGCCCTGCA 
GCCAGCGAGA TCACAGGTCT GAGCACAGCT GTGCTGGCAG CGCATGGGCG TCAATGTTTT 
GATGACAACC TGGCCAACCT GCTCCTAGCC TTCCTGCGGC GCCAGCCACA GCCCTGGTGC 
CTGGTGGCAC ACAATGGTGA CCGCTACGAC TTCCCCCTGC TCCAAGCAGA GCTGGCTATG 
CTGGGCCTCA CCAGTGCTCT GGATGGTGCC TTCTGTGTGG ATAGCATCAC TGCGCTGAAG 
GCCCTGGAGC GAGCAAGCAG CCCCTCAGAA CACGGCCCAA GGAAGAGCTA TAGCCTAGGC 
AGCATCTACA CTCGCCTGTA TGGGCAGTCC CCTCCAGACT CGCACACGGC TGAGGGTGAT 
GTCCTGGCCC TGCTCAGCAT CTGTCAGTGG AGACCACAGG CCCTGCTGCG GTGGGTGGAT 
GCTCACGCCA GGCCTTTCGG CACCATCAGG CCCATGTATG GGGTCACAGC CTCTGCTAGG 
ACCAAGCCAA GACCATCTGC TGTCACAACC ACTGCACACC TGGCCACAAC CAGGAACACT 
AGTCCCAGCC TTGGAGAGAG CAGGGGTACC AAGGATCTTC CTCCAGTGAA GGACCCTGGA 
GCCCTATCCA GGGAGGGGCT GCTGGCCCCA CTGGGTCTGC TGGCCATCCT GACCTTGGCA 
GTAGCCACAC TGTATGGACT ATCCCTGGCC ACACCTGGGG AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TREX1 ( NM_033629.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_338599.1 Homo sapiens three prime repair exonuclease 1 (TREX1), transcript variant 4, mRNA.

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CloneID	OHu27695
Clone ID Related Accession (Same CDS sequence)	NM_033629.6 , NM_033629.4
Accession Version	NM_033629.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	three-prime repair exonuclease 1 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL137745.1, BQ933154.1 and AC134772.2. This sequence is a reference standard in the RefSeqGene project. On Jan 17, 2014 this sequence version replaced NM_033629.3. Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The resulting isoform (b) has a shorter N-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.282011.1, SRR1163658.357006.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCTCGC AGGCCCTGCC CCCGGGGCCC ATGCAGACCC TCATCTTTTT CGACATGGAG 
GCCACTGGCT TGCCCTTCTC CCAGCCCAAG GTCACGGAGC TGTGCCTGCT GGCTGTCCAC 
AGATGTGCCC TGGAGAGCCC CCCCACCTCT CAGGGGCCAC CTCCCACAGT TCCTCCACCA 
CCGCGTGTGG TAGACAAGCT CTCCCTGTGT GTGGCTCCGG GGAAGGCCTG CAGCCCTGCA 
GCCAGCGAGA TCACAGGTCT GAGCACAGCT GTGCTGGCAG CGCATGGGCG TCAATGTTTT 
GATGACAACC TGGCCAACCT GCTCCTAGCC TTCCTGCGGC GCCAGCCACA GCCCTGGTGC 
CTGGTGGCAC ACAATGGTGA CCGCTACGAC TTCCCCCTGC TCCAAGCAGA GCTGGCTATG 
CTGGGCCTCA CCAGTGCTCT GGATGGTGCC TTCTGTGTGG ATAGCATCAC TGCGCTGAAG 
GCCCTGGAGC GAGCAAGCAG CCCCTCAGAA CACGGCCCAA GGAAGAGCTA TAGCCTAGGC 
AGCATCTACA CTCGCCTGTA TGGGCAGTCC CCTCCAGACT CGCACACGGC TGAGGGTGAT 
GTCCTGGCCC TGCTCAGCAT CTGTCAGTGG AGACCACAGG CCCTGCTGCG GTGGGTGGAT 
GCTCACGCCA GGCCTTTCGG CACCATCAGG CCCATGTATG GGGTCACAGC CTCTGCTAGG 
ACCAAGCCAA GACCATCTGC TGTCACAACC ACTGCACACC TGGCCACAAC CAGGAACACT 
AGTCCCAGCC TTGGAGAGAG CAGGGGTACC AAGGATCTTC CTCCAGTGAA GGACCCTGGA 
GCCCTATCCA GGGAGGGGCT GCTGGCCCCA CTGGGTCTGC TGGCCATCCT GACCTTGGCA 
GTAGCCACAC TGTATGGACT ATCCCTGGCC ACACCTGGGG AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_338599.1
CDS	817..1761
Translation	MGSQALPPGPMQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTSQGPPPTVPPPPRVVDKLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFLRRQPQPWCLVAHNGDRYDFPLLQAELAMLGLTSALDGAFCVDSITALKALERASSPSEHGPRKSYSLGSIYTRLYGQSPPDSHTAEGDVLALLSICQWRPQALLRWVDAHARPFGTIRPMYGVTASARTKPRPSAVTTTAHLATTRNTSPSLGESRGTKDLPPVKDPGALSREGLLAPLGLLAILTLAVATLYGLSLATPGE

Target ORF information:

RefSeq Version	NM_033629.4
Organism	Homo sapiens(human)
Definition	Homo sapiens three prime repair exonuclease 1 (TREX1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033629.4

ORF Insert Sequence:

ATGGGCTCGC AGGCCCTGCC CCCGGGGCCC ATGCAGACCC TCATCTTTTT CGACATGGAG 
GCCACTGGCT TGCCCTTCTC CCAGCCCAAG GTCACGGAGC TGTGCCTGCT GGCTGTCCAC 
AGATGTGCCC TGGAGAGCCC CCCCACCTCT CAGGGGCCAC CTCCCACAGT TCCTCCACCA 
CCGCGTGTGG TAGACAAGCT CTCCCTGTGT GTGGCTCCGG GGAAGGCCTG CAGCCCTGCA 
GCCAGCGAGA TCACAGGTCT GAGCACAGCT GTGCTGGCAG CGCATGGGCG TCAATGTTTT 
GATGACAACC TGGCCAACCT GCTCCTAGCC TTCCTGCGGC GCCAGCCACA GCCCTGGTGC 
CTGGTGGCAC ACAATGGTGA CCGCTACGAC TTCCCCCTGC TCCAAGCAGA GCTGGCTATG 
CTGGGCCTCA CCAGTGCTCT GGATGGTGCC TTCTGTGTGG ATAGCATCAC TGCGCTGAAG 
GCCCTGGAGC GAGCAAGCAG CCCCTCAGAA CACGGCCCAA GGAAGAGCTA TAGCCTAGGC 
AGCATCTACA CTCGCCTGTA TGGGCAGTCC CCTCCAGACT CGCACACGGC TGAGGGTGAT 
GTCCTGGCCC TGCTCAGCAT CTGTCAGTGG AGACCACAGG CCCTGCTGCG GTGGGTGGAT 
GCTCACGCCA GGCCTTTCGG CACCATCAGG CCCATGTATG GGGTCACAGC CTCTGCTAGG 
ACCAAGCCAA GACCATCTGC TGTCACAACC ACTGCACACC TGGCCACAAC CAGGAACACT 
AGTCCCAGCC TTGGAGAGAG CAGGGGTACC AAGGATCTTC CTCCAGTGAA GGACCCTGGA 
GCCCTATCCA GGGAGGGGCT GCTGGCCCCA CTGGGTCTGC TGGCCATCCT GACCTTGGCA 
GTAGCCACAC TGTATGGACT ATCCCTGGCC ACACCTGGGG AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TREX1 ( NM_016381.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_057465.1 Homo sapiens three prime repair exonuclease 1 (TREX1), transcript variant 1, mRNA.

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CloneID	OHu27696
Clone ID Related Accession (Same CDS sequence)	NM_016381.5
Accession Version	NM_016381.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1110bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	three-prime repair exonuclease 1 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL137745.1 and AC134772.2. This sequence is a reference standard in the RefSeqGene project. On Jan 17, 2014 this sequence version replaced NM_016381.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AL137745.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCCCTG GAGCTCGCAG ACAGGGCAGG ATTGTGCAGG GAAGGCCTGA GATGTGCTTC 
TGCCCACCCC CTACCCCACT CCCTCCCCTT CGGATCTTAA CACTGGGCAC TCACACACCC 
ACCCCATGCT CCTCTCCAGG CTCAGCAGCA GGTACGTACC CAACCATGGG CTCGCAGGCC 
CTGCCCCCGG GGCCCATGCA GACCCTCATC TTTTTCGACA TGGAGGCCAC TGGCTTGCCC 
TTCTCCCAGC CCAAGGTCAC GGAGCTGTGC CTGCTGGCTG TCCACAGATG TGCCCTGGAG 
AGCCCCCCCA CCTCTCAGGG GCCACCTCCC ACAGTTCCTC CACCACCGCG TGTGGTAGAC 
AAGCTCTCCC TGTGTGTGGC TCCGGGGAAG GCCTGCAGCC CTGCAGCCAG CGAGATCACA 
GGTCTGAGCA CAGCTGTGCT GGCAGCGCAT GGGCGTCAAT GTTTTGATGA CAACCTGGCC 
AACCTGCTCC TAGCCTTCCT GCGGCGCCAG CCACAGCCCT GGTGCCTGGT GGCACACAAT 
GGTGACCGCT ACGACTTCCC CCTGCTCCAA GCAGAGCTGG CTATGCTGGG CCTCACCAGT 
GCTCTGGATG GTGCCTTCTG TGTGGATAGC ATCACTGCGC TGAAGGCCCT GGAGCGAGCA 
AGCAGCCCCT CAGAACACGG CCCAAGGAAG AGCTATAGCC TAGGCAGCAT CTACACTCGC 
CTGTATGGGC AGTCCCCTCC AGACTCGCAC ACGGCTGAGG GTGATGTCCT GGCCCTGCTC 
AGCATCTGTC AGTGGAGACC ACAGGCCCTG CTGCGGTGGG TGGATGCTCA CGCCAGGCCT 
TTCGGCACCA TCAGGCCCAT GTATGGGGTC ACAGCCTCTG CTAGGACCAA GCCAAGACCA 
TCTGCTGTCA CAACCACTGC ACACCTGGCC ACAACCAGGA ACACTAGTCC CAGCCTTGGA 
GAGAGCAGGG GTACCAAGGA TCTTCCTCCA GTGAAGGACC CTGGAGCCCT ATCCAGGGAG 
GGGCTGCTGG CCCCACTGGG TCTGCTGGCC ATCCTGACCT TGGCAGTAGC CACACTGTAT 
GGACTATCCC TGGCCACACC TGGGGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057465.1
CDS	972..2081
Translation	MGPGARRQGRIVQGRPEMCFCPPPTPLPPLRILTLGTHTPTPCSSPGSAAGTYPTMGSQALPPGPMQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTSQGPPPTVPPPPRVVDKLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFLRRQPQPWCLVAHNGDRYDFPLLQAELAMLGLTSALDGAFCVDSITALKALERASSPSEHGPRKSYSLGSIYTRLYGQSPPDSHTAEGDVLALLSICQWRPQALLRWVDAHARPFGTIRPMYGVTASARTKPRPSAVTTTAHLATTRNTSPSLGESRGTKDLPPVKDPGALSREGLLAPLGLLAILTLAVATLYGLSLATPGE

Target ORF information:

RefSeq Version	NM_016381.5
Organism	Homo sapiens(human)
Definition	Homo sapiens three prime repair exonuclease 1 (TREX1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016381.5

ORF Insert Sequence:

ATGGGCCCTG GAGCTCGCAG ACAGGGCAGG ATTGTGCAGG GAAGGCCTGA GATGTGCTTC 
TGCCCACCCC CTACCCCACT CCCTCCCCTT CGGATCTTAA CACTGGGCAC TCACACACCC 
ACCCCATGCT CCTCTCCAGG CTCAGCAGCA GGTACGTACC CAACCATGGG CTCGCAGGCC 
CTGCCCCCGG GGCCCATGCA GACCCTCATC TTTTTCGACA TGGAGGCCAC TGGCTTGCCC 
TTCTCCCAGC CCAAGGTCAC GGAGCTGTGC CTGCTGGCTG TCCACAGATG TGCCCTGGAG 
AGCCCCCCCA CCTCTCAGGG GCCACCTCCC ACAGTTCCTC CACCACCGCG TGTGGTAGAC 
AAGCTCTCCC TGTGTGTGGC TCCGGGGAAG GCCTGCAGCC CTGCAGCCAG CGAGATCACA 
GGTCTGAGCA CAGCTGTGCT GGCAGCGCAT GGGCGTCAAT GTTTTGATGA CAACCTGGCC 
AACCTGCTCC TAGCCTTCCT GCGGCGCCAG CCACAGCCCT GGTGCCTGGT GGCACACAAT 
GGTGACCGCT ACGACTTCCC CCTGCTCCAA GCAGAGCTGG CTATGCTGGG CCTCACCAGT 
GCTCTGGATG GTGCCTTCTG TGTGGATAGC ATCACTGCGC TGAAGGCCCT GGAGCGAGCA 
AGCAGCCCCT CAGAACACGG CCCAAGGAAG AGCTATAGCC TAGGCAGCAT CTACACTCGC 
CTGTATGGGC AGTCCCCTCC AGACTCGCAC ACGGCTGAGG GTGATGTCCT GGCCCTGCTC 
AGCATCTGTC AGTGGAGACC ACAGGCCCTG CTGCGGTGGG TGGATGCTCA CGCCAGGCCT 
TTCGGCACCA TCAGGCCCAT GTATGGGGTC ACAGCCTCTG CTAGGACCAA GCCAAGACCA 
TCTGCTGTCA CAACCACTGC ACACCTGGCC ACAACCAGGA ACACTAGTCC CAGCCTTGGA 
GAGAGCAGGG GTACCAAGGA TCTTCCTCCA GTGAAGGACC CTGGAGCCCT ATCCAGGGAG 
GGGCTGCTGG CCCCACTGGG TCTGCTGGCC ATCCTGACCT TGGCAGTAGC CACACTGTAT 
GGACTATCCC TGGCCACACC TGGGGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lack of Trex1 Causes Systemic Autoimmunity despite the Presence of Antiretroviral Drugs.
Journal of immunology (Baltimore, Md. : 1950)199(7)2261-2269(2017 Oct)
Achleitner M,Kleefisch M,Hennig A,Peschke K,Polikarpova A,Oertel R,Gabriel B,Schulze L,Lindeman D,Gerbaulet A,Fiebig U,Lee-Kirsch MA,Roers A,Behrendt R

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TREX1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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