Gene Symbol | TLR8 |
Entrez Gene ID | 574292 |
Full Name | toll like receptor 8 |
Gene Type | protein-coding |
Organism | Macaca mulatta(Rhesus monkey) |
ORF » Species Summary » Macaca mulatta » TLR8 cDNA ORF clone
Gene Symbol | TLR8 |
Entrez Gene ID | 574292 |
Full Name | toll like receptor 8 |
Gene Type | protein-coding |
Organism | Macaca mulatta(Rhesus monkey) |
mRNA | Protein | Name |
---|---|---|
NM_001130427.1 | NP_001123899.1 | toll-like receptor 8 precursor |
TLR8 | NP_001123899.1 | |
Mus musculus (house mouse) | Tlr8 | NP_573475.2 |
Xenopus tropicalis (tropical clawed frog) | LOC100495962 | XP_004912402.1 |
Homo sapiens (human) | TLR8 | NP_619542.1 |
Rattus norvegicus (Norway rat) | Tlr8 | NP_001094479.1 |
Bos taurus (cattle) | TLR8 | NP_001029109.1 |
Danio rerio (zebrafish) | LOC100332583 | XP_002665954.3 |
Xenopus tropicalis (tropical clawed frog) | tlr8 | XP_002933859.1 |
Pan troglodytes (chimpanzee) | TLR8 | NP_001123944.1 |
Canis lupus familiaris (dog) | TLR8 | XP_005641176.1 |
Danio rerio (zebrafish) | tlr8a | XP_001920594.3 |
Whole blood stimulation with Toll-like receptor (TLR)-7/8 and TLR-9 agonists induces interleukin-12p40 expression in plasmacytoid dendritic cells in rhesus macaques but not in humans.
Koopman G, Beenhakker N, Burm S, Bouwhuis O, Bajramovic J, Sommandas V, Mudde G, Mooij P, 't Hart BA, Bogers WM
Clinical and experimental immunology174(1)161-71(2013 Oct)
Human and rhesus plasmacytoid dendritic cell and B-cell responses to Toll-like receptor stimulation.
Gujer C, Sundling C, Seder RA, Karlsson Hedestam GB, Lor? K
Immunology134(3)257-69(2011 Nov)
Natural selection in the TLR-related genes in the course of primate evolution.
Nakajima T, Ohtani H, Satta Y, Uno Y, Akari H, Ishida T, Kimura A
Immunogenetics60(12)727-35(2008 Dec)
Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections.
Mandl JN, Barry AP, Vanderford TH, Kozyr N, Chavan R, Klucking S, Barrat FJ, Coffman RL, Staprans SI, Feinberg MB
Nature medicine14(10)1077-87(2008 Oct)
Differentiation of primary adult microglia alters their response to TLR8-mediated activation but not their capacity as APC.
Zuiderwijk-Sick EA, van der Putten C, Bsibsi M, Deuzing IP, de Boer W, Persoon-Deen C, Kondova I, Boven LA, van Noort JM, 't Hart BA, Amor S, Bajramovic JJ
Glia55(15)1589-600(2007 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
In contrast to humans, plasmacytoid dendritic cells (pDC) in rhesus macaques express the interleukin (IL)-12p40 subunit in response to TLR-7/8 as well as TLR-9 agonist stimulation.
Title: Whole blood stimulation with Toll-like receptor (TLR)-7/8 and TLR-9 agonists induces interleukin-12p40 expression in plasmacytoid dendritic cells in rhesus macaques but not in humans.
Data suggest that the response pattern of human and rhesus B cells and pDCs to TLR7/8 and TLR9 is similar, although some differences in the cell surface phenotype of the differentiating cells exist.
Title: Human and rhesus plasmacytoid dendritic cell and B-cell responses to Toll-like receptor stimulation.
M-CSF-differentiated microglia expressed higher levels of TLR8-encoding mRNA and protein
Title: Differentiation of primary adult microglia alters their response to TLR8-mediated activation but not their capacity as APC.
The following TLR8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TLR8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMb04808 | |
Clone ID Related Accession (Same CDS sequence) | NM_001130427.1 | |
Accession Version | NM_001130427.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3123bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-03-02 | |
Organism | Macaca mulatta(Rhesus monkey) | |
Product | toll-like receptor 8 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB445672.1. On Jul 24, 2008 this sequence version replaced XM_001095602.1. ##Evidence-Data-START## Transcript is intronless :: AB445672.1, EU204944.1 [ECO:0000345] ##Evidence-Data-END## |
1 | ATGGAAAACA TGTTCCTTCA GTCGTCAATG CTGACCTGCC TTTTCCTGCT AATACCTGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001123899.1 |
CDS | 1..3123 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001130427.1 |
1 | ATGGAAAACA TGTTCCTTCA GTCGTCAATG CTGACCTGCC TTTTCCTGCT AATACCTGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Whole blood stimulation with Toll-like receptor (TLR)-7/8 and TLR-9 agonists induces interleukin-12p40 expression in plasmacytoid dendritic cells in rhesus macaques but not in humans. |
Human and rhesus plasmacytoid dendritic cell and B-cell responses to Toll-like receptor stimulation. |
Natural selection in the TLR-related genes in the course of primate evolution. |
Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections. |
Differentiation of primary adult microglia alters their response to TLR8-mediated activation but not their capacity as APC. |