GPX6 cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene
Clones
gRNAs

Summary

Gene Symbol	GPX6
Entrez Gene ID	100286832
Full Name	glutathione peroxidase 6
Gene Type	protein-coding
Organism	Macaca mulatta(Rhesus monkey)
Summary	The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. Expression of this gene has been observed in embryos and olfactory epithelium; however, the exact function of this gene is not known. This isozyme, as in human, is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The orthologs of this gene in mouse and rat (and some other species) contain a cysteine (Cys) residue in place of the Sec residue, and their corresponding mRNAs lack SECIS element. [provided by RefSeq, Jul 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001159358.2	NP_001152830.1	glutathione peroxidase 6 precursor
NM_001159358.3	NP_001152830.2	glutathione peroxidase 6 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GPX6	NP_001139297.1
Rattus norvegicus (Norway rat)	Gpx6	NP_671694.1
Mus musculus (house mouse)	Gpx6	NP_663426.2
Homo sapiens (human)	GPX6	NP_874360.1
	GPX6	NP_001152830.1
Canis lupus familiaris (dog)	GPX6	NP_001243249.1
Bos taurus (cattle)	GPX6	NP_001156614.1

Gene Ontology
Bibliography

Related articles in PubMed

Glutathione peroxidases.
Brigelius-Floh? R, Maiorino M
Biochimica et biophysica acta1830(5)3289-303(2013 May)

Composition and evolution of the vertebrate and mammalian selenoproteomes.
Mariotti M, Ridge PG, Zhang Y, Lobanov AV, Pringle TH, Guigo R, Hatfield DL, Gladyshev VN
PloS one7(3)e33066(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GPX6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPX6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMb24083	NM_001159358.2 Latest version!	Macaca mulatta glutathione peroxidase 6 (GPX6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OMb94930	NM_001159358.3 Latest version!	Macaca mulatta glutathione peroxidase 6 (GPX6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GPX6 ( NM_001159358.2 ) cDNA ORF clone, Macaca mulatta(Rhesus monkey) -> NP_001152830.1 Macaca mulatta glutathione peroxidase 6 (GPX6), mRNA.

Price & Availability↑

CloneID	OMb24083
Clone ID Related Accession (Same CDS sequence)	NM_001159358.2
Accession Version	NM_001159358.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 666bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-27
Organism	Macaca mulatta(Rhesus monkey)
Product	glutathione peroxidase 6 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from JSUE03030490.1. On Oct 19, 2016 this sequence version replaced NM_001159358.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA4688444 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END##

ATGATCCGGC AGTTTCAGGC CTGCTGTCTT GTCCTGCTGT TCCTGGTTGG CTTTGCTCAG 
CAGACCCTAA AGCCTCAAAA TAGGAAGGTG GATTGCAACA AAAGAGTGAC AGGCACCATC 
TATGAGTATG GAGCCCTCAC CCTCAACAGT GAGGAGTACA TCCAGTTCAA GCAGTTTGCA 
GGCAAGCACG TCCTGTTTGT CAATGTAGCC ACCTACTGAG GCTTGGCAGC TCAGTATCCT 
GAACTGAATG CACTACAGGA GGAGCTGAAG AATTTTGGTG TCGTTGTGTT GGCCTTTCCC 
TGCAACCAGT TTGGAAAACA AGAACCAGGA ACAAACTCAG AAATACTTCT TGGACTCAAG 
TATGTGCGTC CAGGTAGTGG CTTTGTCCCT AATTTCCAGC TCTTTGAGAA AGGGGATGTG 
AATGGAGAAA AAGAACAGAA GGTCTTTACT TTCCTGAAGA ACTCCTGCCC TCCAACCTCT 
GATCTTTTGG GCTCATCAAG CCAGCTCTTC TGGGAGCCCA TGAAAGTCCA TGACATCCGC 
TGGAACTTTG AGAAATTTCT AGTGGGGCCC GATGGAGTCC CTGTCATGCG CTGGTTCCAC 
CGGGCTCCAG TCAGCACAGT CAAATCAGAC ATCCTGGAGT ACCTAAAGCA GTTCAATGCC 
CACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001152830.1
CDS	51..716
Translation	MIRQFQACCLVLLFLVGFAQQTLKPQNRKVDCNKRVTGTIYEYGALTLNSEEYIQFKQFAGKHVLFVNVATY*GLAAQYPELNALQEELKNFGVVVLAFPCNQFGKQEPGTNSEILLGLKYVRPGSGFVPNFQLFEKGDVNGEKEQKVFTFLKNSCPPTSDLLGSSSQLFWEPMKVHDIRWNFEKFLVGPDGVPVMRWFHRAPVSTVKSDILEYLKQFNAH

Target ORF information:

RefSeq Version	NM_001159358.2
Organism	Macaca mulatta(Rhesus monkey)
Definition	Macaca mulatta glutathione peroxidase 6 (GPX6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001159358.2

ORF Insert Sequence:

ATGATCCGGC AGTTTCAGGC CTGCTGTCTT GTCCTGCTGT TCCTGGTTGG CTTTGCTCAG 
CAGACCCTAA AGCCTCAAAA TAGGAAGGTG GATTGCAACA AAAGAGTGAC AGGCACCATC 
TATGAGTATG GAGCCCTCAC CCTCAACAGT GAGGAGTACA TCCAGTTCAA GCAGTTTGCA 
GGCAAGCACG TCCTGTTTGT CAATGTAGCC ACCTACTGAG GCTTGGCAGC TCAGTATCCT 
GAACTGAATG CACTACAGGA GGAGCTGAAG AATTTTGGTG TCGTTGTGTT GGCCTTTCCC 
TGCAACCAGT TTGGAAAACA AGAACCAGGA ACAAACTCAG AAATACTTCT TGGACTCAAG 
TATGTGCGTC CAGGTAGTGG CTTTGTCCCT AATTTCCAGC TCTTTGAGAA AGGGGATGTG 
AATGGAGAAA AAGAACAGAA GGTCTTTACT TTCCTGAAGA ACTCCTGCCC TCCAACCTCT 
GATCTTTTGG GCTCATCAAG CCAGCTCTTC TGGGAGCCCA TGAAAGTCCA TGACATCCGC 
TGGAACTTTG AGAAATTTCT AGTGGGGCCC GATGGAGTCC CTGTCATGCG CTGGTTCCAC 
CGGGCTCCAG TCAGCACAGT CAAATCAGAC ATCCTGGAGT ACCTAAAGCA GTTCAATGCC 
CACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GPX6 ( NM_001159358.3 ) cDNA ORF clone, Macaca mulatta(Rhesus monkey) -> NP_001152830.2 Macaca mulatta glutathione peroxidase 6 (GPX6), mRNA.

Price & Availability↑

CloneID	OMb94930
Clone ID Related Accession (Same CDS sequence)	NM_001159358.3
Accession Version	NM_001159358.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 666bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-17
Organism	Macaca mulatta(Rhesus monkey)
Product	glutathione peroxidase 6 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from QNVO02000338.1. On Dec 18, 2019 this sequence version replaced NM_001159358.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA4688444 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END##

ATGATCCGGC AGTTTCAGGC CTGCTGTCTT GTCCTGCTGT TCCTGGTTGG CTTTGCTCAG 
CAGACCCTAA AGCCTCAAAA TAGGAAGGTG GATTGCAACA AAAGAGTGAC AGGCACCATC 
TATGAGTATG GAGCCCTCAC CCTCAACGGT GAGGAGTACA TCCAGTTCAA GCAGTTTGCA 
GGCAAGCACG TCCTGTTTGT CAATGTAGCC ACCTATTGAG GCTTGGCAGC TCAGTATCCT 
GAACTGAATG CACTACAGGA GGAGCTGAAG AATTTTGGTG TCGTTGTGTT GGCCTTTCCC 
TGCAACCAGT TTGGAAAACA AGAACCAGGA ACAAACTCAG AAATACTTCT TGGACTCAAG 
TATGTGCGTC CAGGTAGTGG CTTTGTCCCT AATTTCCAGC TCTTTGAGAA AGGGGATGTG 
AATGGAGAAA AAGAACAGAA GGTCTTTACT TTCCTGAAGA ACTCCTGCCC TCCAACCTCT 
GATCTTTTGG GCTCATCAAG CCAGCTCTTC TGGGAGCCCA TGAAAGTCCA TGACATCCGC 
TGGAACTTTG AGAAATTTCT AGTGGGGCCC GATGGAGTCC CTGTCATGCG CTGGTTCCAC 
CGGGCTCCAG TCAGCACAGT CAAATCAGAC ATCCTGGAGT ACCTAAAGCA GTTCAATGCC 
CACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001152830.2
CDS	51..716
Translation	MIRQFQACCLVLLFLVGFAQQTLKPQNRKVDCNKRVTGTIYEYGALTLNGEEYIQFKQFAGKHVLFVNVATY*GLAAQYPELNALQEELKNFGVVVLAFPCNQFGKQEPGTNSEILLGLKYVRPGSGFVPNFQLFEKGDVNGEKEQKVFTFLKNSCPPTSDLLGSSSQLFWEPMKVHDIRWNFEKFLVGPDGVPVMRWFHRAPVSTVKSDILEYLKQFNAH

Target ORF information:

RefSeq Version	NM_001159358.3
Organism	Macaca mulatta(Rhesus monkey)
Definition	Macaca mulatta glutathione peroxidase 6 (GPX6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001159358.3

ORF Insert Sequence:

ATGATCCGGC AGTTTCAGGC CTGCTGTCTT GTCCTGCTGT TCCTGGTTGG CTTTGCTCAG 
CAGACCCTAA AGCCTCAAAA TAGGAAGGTG GATTGCAACA AAAGAGTGAC AGGCACCATC 
TATGAGTATG GAGCCCTCAC CCTCAACGGT GAGGAGTACA TCCAGTTCAA GCAGTTTGCA 
GGCAAGCACG TCCTGTTTGT CAATGTAGCC ACCTATTGAG GCTTGGCAGC TCAGTATCCT 
GAACTGAATG CACTACAGGA GGAGCTGAAG AATTTTGGTG TCGTTGTGTT GGCCTTTCCC 
TGCAACCAGT TTGGAAAACA AGAACCAGGA ACAAACTCAG AAATACTTCT TGGACTCAAG 
TATGTGCGTC CAGGTAGTGG CTTTGTCCCT AATTTCCAGC TCTTTGAGAA AGGGGATGTG 
AATGGAGAAA AAGAACAGAA GGTCTTTACT TTCCTGAAGA ACTCCTGCCC TCCAACCTCT 
GATCTTTTGG GCTCATCAAG CCAGCTCTTC TGGGAGCCCA TGAAAGTCCA TGACATCCGC 
TGGAACTTTG AGAAATTTCT AGTGGGGCCC GATGGAGTCC CTGTCATGCG CTGGTTCCAC 
CGGGCTCCAG TCAGCACAGT CAAATCAGAC ATCCTGGAGT ACCTAAAGCA GTTCAATGCC 
CACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Glutathione peroxidases.
Biochimica et biophysica acta1830(5)3289-303(2013 May)
Brigelius-Floh? R,Maiorino M

Composition and evolution of the vertebrate and mammalian selenoproteomes.
PloS one7(3)e33066(2012)
Mariotti M,Ridge PG,Zhang Y,Lobanov AV,Pringle TH,Guigo R,Hatfield DL,Gladyshev VN

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GPX6 cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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