GPX6 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	GPX6
Entrez Gene ID	519280
Full Name	glutathione peroxidase 6
Gene Type	protein-coding
Organism	Bos taurus(cattle)
Summary	The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. Expression of this gene has been observed in embryos and olfactory epithelium; however, the exact function of this gene is not known. This isozyme, as in human, is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The orthologs of this gene in mouse and rat (and some other species) contain a cysteine (Cys) residue in place of the Sec residue, and their corresponding mRNAs lack SECIS element. [provided by RefSeq, Jul 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001163142.2	NP_001156614.1	glutathione peroxidase 6 precursor
NM_001163142.1	NP_001156614.1	glutathione peroxidase 6 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GPX6	NP_001139297.1
Rattus norvegicus (Norway rat)	Gpx6	NP_671694.1
Mus musculus (house mouse)	Gpx6	NP_663426.2
Homo sapiens (human)	GPX6	NP_874360.1
	GPX6	NP_001152830.1
Canis lupus familiaris (dog)	GPX6	NP_001243249.1
Bos taurus (cattle)	GPX6	NP_001156614.1

Gene Ontology
Bibliography

Related articles in PubMed

Composition and evolution of the vertebrate and mammalian selenoproteomes.
Mariotti M, Ridge PG, Zhang Y, Lobanov AV, Pringle TH, Guigo R, Hatfield DL, Gladyshev VN
PloS one7(3)e33066(2012)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Characterization of mammalian selenoproteomes.
Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guig? R, Gladyshev VN
Science (New York, N.Y.)300(5624)1439-43(2003 May)

Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle.
Smith TP, Grosse WM, Freking BA, Roberts AJ, Stone RT, Casas E, Wray JE, White J, Cho J, Fahrenkrug SC, Bennett GL, Heaton MP, Laegreid WW, Rohrer GA, Chitko-McKown CG, Pertea G, Holt I, Karamycheva S, Liang F, Quackenbush J, Keele JW
Genome research11(4)626-30(2001 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GPX6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPX6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OBa35879	NM_001163142.2 Latest version!	Bos taurus glutathione peroxidase 6 (GPX6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
View Old Accession Versions >>
OBa35879	NM_001163142.1	Bos taurus glutathione peroxidase 6 (GPX6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GPX6 ( NM_001163142.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001156614.1 Bos taurus glutathione peroxidase 6 (GPX6), mRNA.

Price & Availability↑

CloneID	OBa35879
Clone ID Related Accession (Same CDS sequence)	NM_001163142.2 , NM_001163142.1
Accession Version	NM_001163142.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 666bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-19
Organism	Bos taurus(cattle)
Product	glutathione peroxidase 6 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DY215541.1, DY110071.1, DY143862.1, DY121921.1 and CK846086.1. On Jun 20, 2018 this sequence version replaced NM_001163142.1. ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATCCTGC AGCTCTGGGC CTCATGTCTT TTCCCACTGT TCCTGGTCGG CTTAGCTCAG 
CTGACTCCGA AGCAGCAACA GATGAAGGTG GATTGCTATA AGGGGGTGAC AGGCACCATC 
TATGAGTATG GAGCCCTCAC CCTCAATGGT GAGGAGTATA TCCAGTTCAA GCAGTATGTG 
GGCAAGCATG TCCTGTTTGT CAATGTGGCC ACCTATTGAG GCTTGACAGC TCAGTATCCA 
GAACTGAATG CACTACAGGA GGAGCTGAAG CCTTTCGGTG TAGTTGTGCT GGGCTTTCCC 
TGCAATCAAT TTGGAAAACA AGAGCCAGCA AAGAACTCAG AGATCCTTAT GGGGCTCAAG 
TATGTACGTC CAGGTGGTGG CTTTGTTCCC AATTTTCAGC TCTTTGAGAA AGGGGATGTG 
AATGGAGAAA AAGAACAGAA GGTCTTTACC TTCCTGAAGA ACGCCTGCCC TCCAACCTCT 
GATCTTTTGG GCTCATCAAG TCAGCTCTTC TGGGAGCCCA TGAAGGTCCA TGACATTCGC 
TGGAACTTTG AGAAGTTTCT AGTGGGGCCT GATGGCGTCC CTGTCATGCG TTGGTACCAC 
CGGGCTTCAG TCAGCACAGT TAAATCAGAC ATGCTGGAGT ACCTGAAGCA GTTCAAAAGC 
GAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001156614.1
CDS	20..685
Translation	MILQLWASCLFPLFLVGLAQLTPKQQQMKVDCYKGVTGTIYEYGALTLNGEEYIQFKQYVGKHVLFVNVATY*GLTAQYPELNALQEELKPFGVVVLGFPCNQFGKQEPAKNSEILMGLKYVRPGGGFVPNFQLFEKGDVNGEKEQKVFTFLKNACPPTSDLLGSSSQLFWEPMKVHDIRWNFEKFLVGPDGVPVMRWYHRASVSTVKSDMLEYLKQFKSE

Target ORF information:

RefSeq Version	NM_001163142.2
Organism	Bos taurus(cattle)
Definition	Bos taurus glutathione peroxidase 6 (GPX6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001163142.2

ORF Insert Sequence:

ATGATCCTGC AGCTCTGGGC CTCATGTCTT TTCCCACTGT TCCTGGTCGG CTTAGCTCAG 
CTGACTCCGA AGCAGCAACA GATGAAGGTG GATTGCTATA AGGGGGTGAC AGGCACCATC 
TATGAGTATG GAGCCCTCAC CCTCAATGGT GAGGAGTATA TCCAGTTCAA GCAGTATGTG 
GGCAAGCATG TCCTGTTTGT CAATGTGGCC ACCTATTGAG GCTTGACAGC TCAGTATCCA 
GAACTGAATG CACTACAGGA GGAGCTGAAG CCTTTCGGTG TAGTTGTGCT GGGCTTTCCC 
TGCAATCAAT TTGGAAAACA AGAGCCAGCA AAGAACTCAG AGATCCTTAT GGGGCTCAAG 
TATGTACGTC CAGGTGGTGG CTTTGTTCCC AATTTTCAGC TCTTTGAGAA AGGGGATGTG 
AATGGAGAAA AAGAACAGAA GGTCTTTACC TTCCTGAAGA ACGCCTGCCC TCCAACCTCT 
GATCTTTTGG GCTCATCAAG TCAGCTCTTC TGGGAGCCCA TGAAGGTCCA TGACATTCGC 
TGGAACTTTG AGAAGTTTCT AGTGGGGCCT GATGGCGTCC CTGTCATGCG TTGGTACCAC 
CGGGCTTCAG TCAGCACAGT TAAATCAGAC ATGCTGGAGT ACCTGAAGCA GTTCAAAAGC 
GAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GPX6 ( NM_001163142.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001156614.1 Bos taurus glutathione peroxidase 6 (GPX6), mRNA.

Price & Availability↑

CloneID	OBa35879
Clone ID Related Accession (Same CDS sequence)	NM_001163142.2 , NM_001163142.1
Accession Version	NM_001163142.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 666bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-22
Organism	Bos taurus(cattle)
Product	glutathione peroxidase 6 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DY215541.1, DY110071.1, DAAA02002174.1 and CK846086.1. On Aug 8, 2009 this sequence version replaced XR_028144.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: DY110071.1, DY179349.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02822095, SAMN02822100 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATCCTGC AGCTCTGGGC CTCATGTCTT TTCCCACTGT TCCTGGTCGG CTTAGCTCAG 
CTGACTCCGA AGCAGCAACA GATGAAGGTG GATTGCTATA AGGGGGTGAC AGGCACCATC 
TATGAGTATG GAGCCCTCAC CCTCAATGGT GAGGAGTATA TCCAGTTCAA GCAGTATGTG 
GGCAAGCATG TCCTGTTTGT CAATGTGGCC ACCTATTGAG GCTTGACAGC TCAGTATCCA 
GAACTGAATG CACTACAGGA GGAGCTGAAG CCTTTCGGTG TAGTTGTGCT GGGCTTTCCC 
TGCAATCAAT TTGGAAAACA AGAGCCAGCA AAGAACTCAG AGATCCTTAT GGGGCTCAAG 
TATGTACGTC CAGGTGGTGG CTTTGTTCCC AATTTTCAGC TCTTTGAGAA AGGGGATGTG 
AATGGAGAAA AAGAACAGAA GGTCTTTACC TTCCTGAAGA ACGCCTGCCC TCCAACCTCT 
GATCTTTTGG GCTCATCAAG TCAGCTCTTC TGGGAGCCCA TGAAGGTCCA TGACATTCGC 
TGGAACTTTG AGAAGTTTCT AGTGGGGCCT GATGGCGTCC CTGTCATGCG TTGGTACCAC 
CGGGCTTCAG TCAGCACAGT TAAATCAGAC ATGCTGGAGT ACCTGAAGCA GTTCAAAAGC 
GAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001156614.1
CDS	20..685
Translation	MILQLWASCLFPLFLVGLAQLTPKQQQMKVDCYKGVTGTIYEYGALTLNGEEYIQFKQYVGKHVLFVNVATY*GLTAQYPELNALQEELKPFGVVVLGFPCNQFGKQEPAKNSEILMGLKYVRPGGGFVPNFQLFEKGDVNGEKEQKVFTFLKNACPPTSDLLGSSSQLFWEPMKVHDIRWNFEKFLVGPDGVPVMRWYHRASVSTVKSDMLEYLKQFKSE

Target ORF information:

RefSeq Version	NM_001163142.1
Organism	Bos taurus(cattle)
Definition	Bos taurus glutathione peroxidase 6 (GPX6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001163142.1

ORF Insert Sequence:

ATGATCCTGC AGCTCTGGGC CTCATGTCTT TTCCCACTGT TCCTGGTCGG CTTAGCTCAG 
CTGACTCCGA AGCAGCAACA GATGAAGGTG GATTGCTATA AGGGGGTGAC AGGCACCATC 
TATGAGTATG GAGCCCTCAC CCTCAATGGT GAGGAGTATA TCCAGTTCAA GCAGTATGTG 
GGCAAGCATG TCCTGTTTGT CAATGTGGCC ACCTATTGAG GCTTGACAGC TCAGTATCCA 
GAACTGAATG CACTACAGGA GGAGCTGAAG CCTTTCGGTG TAGTTGTGCT GGGCTTTCCC 
TGCAATCAAT TTGGAAAACA AGAGCCAGCA AAGAACTCAG AGATCCTTAT GGGGCTCAAG 
TATGTACGTC CAGGTGGTGG CTTTGTTCCC AATTTTCAGC TCTTTGAGAA AGGGGATGTG 
AATGGAGAAA AAGAACAGAA GGTCTTTACC TTCCTGAAGA ACGCCTGCCC TCCAACCTCT 
GATCTTTTGG GCTCATCAAG TCAGCTCTTC TGGGAGCCCA TGAAGGTCCA TGACATTCGC 
TGGAACTTTG AGAAGTTTCT AGTGGGGCCT GATGGCGTCC CTGTCATGCG TTGGTACCAC 
CGGGCTTCAG TCAGCACAGT TAAATCAGAC ATGCTGGAGT ACCTGAAGCA GTTCAAAAGC 
GAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Composition and evolution of the vertebrate and mammalian selenoproteomes.
PloS one7(3)e33066(2012)
Mariotti M,Ridge PG,Zhang Y,Lobanov AV,Pringle TH,Guigo R,Hatfield DL,Gladyshev VN

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Characterization of mammalian selenoproteomes.
Science (New York, N.Y.)300(5624)1439-43(2003 May)
Kryukov GV,Castellano S,Novoselov SV,Lobanov AV,Zehtab O,Guig? R,Gladyshev VN

Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle.
Genome research11(4)626-30(2001 Apr)
Smith TP,Grosse WM,Freking BA,Roberts AJ,Stone RT,Casas E,Wray JE,White J,Cho J,Fahrenkrug SC,Bennett GL,Heaton MP,Laegreid WW,Rohrer GA,Chitko-McKown CG,Pertea G,Holt I,Karamycheva S,Liang F,Quackenbush J,Keele JW

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GPX6 cDNA ORF clone, Bos taurus(cattle)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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