GPX6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GPX6
Entrez Gene ID	257202
Full Name	glutathione peroxidase 6
Synonyms	GPX5p,GPXP3,GPx-6,GSHPx-6,dJ1186N24,dJ1186N24.1
General protein information	Preferred Names glutathione peroxidase 6 Names glutathione peroxidase 6 glutathione peroxidase 6 (olfactory)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.1
Summary	The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. Expression of this gene has been observed in embryos and olfactory epithelium; however, the exact function of this gene is not known. This isozyme is a selenoprotein in humans, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The orthologs of this gene in mouse and rat (and some other species) contain a cysteine (Cys) residue in place of the Sec residue, and their corresponding mRNAs lack SECIS element. [provided by RefSeq, Jul 2017].
Disorder MIM:	607913

mRNA and Protein(s)

mRNA	Protein	Name
NM_182701.1	NP_874360.1	glutathione peroxidase 6 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GPX6	NP_001139297.1
Rattus norvegicus (Norway rat)	Gpx6	NP_671694.1
Mus musculus (house mouse)	Gpx6	NP_663426.2
Homo sapiens (human)	GPX6	NP_874360.1
	GPX6	NP_001152830.1
Canis lupus familiaris (dog)	GPX6	NP_001243249.1
Bos taurus (cattle)	GPX6	NP_001156614.1

Gene Ontology
Bibliography

Related articles in PubMed

Composition and evolution of the vertebrate and mammalian selenoproteomes.
Mariotti M, Ridge PG, Zhang Y, Lobanov AV, Pringle TH, Guigo R, Hatfield DL, Gladyshev VN
PloS one7(3)e33066(2012)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.
Moyer AM, Sun Z, Batzler AJ, Li L, Schaid DJ, Yang P, Weinshilboum RM
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology19(3)811-21(2010 Mar)

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, , ,
American journal of human genetics85(5)628-42(2009 Nov)

Characterization of mammalian selenoproteomes.
Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guig? R, Gladyshev VN
Science (New York, N.Y.)300(5624)1439-43(2003 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

The following GPX6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPX6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu29864	NM_182701.1 Latest version!	Homo sapiens glutathione peroxidase 6 (GPX6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GPX6 ( NM_182701.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_874360.1 Homo sapiens glutathione peroxidase 6 (GPX6), mRNA.

Price & Availability↑

CloneID	OHu29864
Clone ID Related Accession (Same CDS sequence)	NM_182701.1
Accession Version	NM_182701.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 666bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-29
Organism	Homo sapiens(human)
Product	glutathione peroxidase 6 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY324826.1. ##Evidence-Data-START## Transcript exon combination :: AY324826.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000361902.5/ ENSP00000354581.1 protein contains selenocysteine :: PMID: 12775843 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGTTCCAGC AGTTCCAGGC CTCCTGTCTT GTCCTGTTTT TCCTGGTTGG CTTTGCTCAG 
CAGACCCTAA AGCCTCAAAA TAGGAAGGTG GATTGCAACA AAGGGGTAAC AGGCACCATC 
TATGAGTATG GAGCCCTCAC CCTCAACGGC GAGGAGTACA TCCAATTCAA GCAGTTTGCA 
GGCAAGCACG TCCTGTTTGT CAATGTGGCC GCCTATTGAG GCTTGGCAGC TCAGTATCCT 
GAACTGAATG CACTACAGGA GGAGCTGAAG AATTTTGGTG TCATTGTGTT GGCCTTTCCC 
TGCAACCAGT TTGGAAAACA AGAACCAGGA ACAAACTCAG AAATACTTCT TGGTCTCAAG 
TATGTGTGTC CAGGTAGTGG CTTTGTCCCC AGTTTCCAGC TCTTTGAGAA AGGGGATGTG 
AATGGAGAAA AAGAACAGAA GGTCTTTACT TTCCTGAAGA ACTCCTGCCC TCCGACCTCT 
GATCTTTTGG GCTCATCAAG CCAACTCTTC TGGGAGCCCA TGAAGGTCCA TGATATCCGC 
TGGAACTTTG AGAAATTTCT GGTGGGGCCC GATGGAGTCC CTGTCATGCA TTGGTTCCAC 
CAGGCTCCAG TCAGCACAGT CAAGTCAGAC ATCCTGGAGT ACCTAAAGCA GTTCAATACC 
CACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_874360.1
CDS	51..716
Translation	MFQQFQASCLVLFFLVGFAQQTLKPQNRKVDCNKGVTGTIYEYGALTLNGEEYIQFKQFAGKHVLFVNVAAY*GLAAQYPELNALQEELKNFGVIVLAFPCNQFGKQEPGTNSEILLGLKYVCPGSGFVPSFQLFEKGDVNGEKEQKVFTFLKNSCPPTSDLLGSSSQLFWEPMKVHDIRWNFEKFLVGPDGVPVMHWFHQAPVSTVKSDILEYLKQFNTH

Target ORF information:

RefSeq Version	NM_182701.1
Organism	Homo sapiens(human)
Definition	Homo sapiens glutathione peroxidase 6 (GPX6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_182701.1

ORF Insert Sequence:

ATGTTCCAGC AGTTCCAGGC CTCCTGTCTT GTCCTGTTTT TCCTGGTTGG CTTTGCTCAG 
CAGACCCTAA AGCCTCAAAA TAGGAAGGTG GATTGCAACA AAGGGGTAAC AGGCACCATC 
TATGAGTATG GAGCCCTCAC CCTCAACGGC GAGGAGTACA TCCAATTCAA GCAGTTTGCA 
GGCAAGCACG TCCTGTTTGT CAATGTGGCC GCCTATTGAG GCTTGGCAGC TCAGTATCCT 
GAACTGAATG CACTACAGGA GGAGCTGAAG AATTTTGGTG TCATTGTGTT GGCCTTTCCC 
TGCAACCAGT TTGGAAAACA AGAACCAGGA ACAAACTCAG AAATACTTCT TGGTCTCAAG 
TATGTGTGTC CAGGTAGTGG CTTTGTCCCC AGTTTCCAGC TCTTTGAGAA AGGGGATGTG 
AATGGAGAAA AAGAACAGAA GGTCTTTACT TTCCTGAAGA ACTCCTGCCC TCCGACCTCT 
GATCTTTTGG GCTCATCAAG CCAACTCTTC TGGGAGCCCA TGAAGGTCCA TGATATCCGC 
TGGAACTTTG AGAAATTTCT GGTGGGGCCC GATGGAGTCC CTGTCATGCA TTGGTTCCAC 
CAGGCTCCAG TCAGCACAGT CAAGTCAGAC ATCCTGGAGT ACCTAAAGCA GTTCAATACC 
CACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Composition and evolution of the vertebrate and mammalian selenoproteomes.
PloS one7(3)e33066(2012)
Mariotti M,Ridge PG,Zhang Y,Lobanov AV,Pringle TH,Guigo R,Hatfield DL,Gladyshev VN

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,

Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology19(3)811-21(2010 Mar)
Moyer AM,Sun Z,Batzler AJ,Li L,Schaid DJ,Yang P,Weinshilboum RM

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
American journal of human genetics85(5)628-42(2009 Nov)
Talmud PJ,Drenos F,Shah S,Shah T,Palmen J,Verzilli C,Gaunt TR,Pallas J,Lovering R,Li K,Casas JP,Sofat R,Kumari M,Rodriguez S,Johnson T,Newhouse SJ,Dominiczak A,Samani NJ,Caulfield M,Sever P,Stanton A,Shields DC,Padmanabhan S,Melander O,Hastie C,Delles C,Ebrahim S,Marmot MG,Smith GD,Lawlor DA,Munroe PB,Day IN,Kivimaki M,Whittaker J,Humphries SE,Hingorani AD,,,

Characterization of mammalian selenoproteomes.
Science (New York, N.Y.)300(5624)1439-43(2003 May)
Kryukov GV,Castellano S,Novoselov SV,Lobanov AV,Zehtab O,Guig? R,Gladyshev VN

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GPX6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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