Tas1r2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tas1r2
Entrez Gene ID	83770
Full Name	taste receptor, type 1, member 2
Synonyms	Gpr71,T1r2,TR2
General protein information	Preferred Names taste receptor, type 1, member 2 Names taste receptor type 1 member 2 G-protein coupled receptor 71 candidate taste receptor T1R2 sweet taste receptor T1R2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4 D3\|4 70.82 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_031873.1	NP_114079.1	taste receptor type 1 member 2 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	TAS1R2	NP_689418.2
	TAS1R2	NP_001121561.1
Bos taurus (cattle)	TAS1R2	NP_001193458.1
Mus musculus (house mouse)	Tas1r2	NP_114079.1
Pan troglodytes (chimpanzee)	LOC100615078	XP_003949358.1
Canis lupus familiaris (dog)	TAS1R2	NP_001026989.1
Rattus norvegicus (Norway rat)	Tas1r2	NP_001258195.1

Gene Ontology
Bibliography

Related articles in PubMed

The downregulation of sweet taste receptor signaling in enteroendocrine L-cells mediates 3-deoxyglucosone-induced attenuation of high glucose-stimulated GLP-1 secretion.
Wang F, Song X, Zhou L, Liang G, Huang F, Jiang G, Zhang L
Archives of physiology and biochemistry1-6(2017 Dec)

Loss of the nutrient sensor TAS1R3 leads to reduced bone resorption.
Eaton MS, Weinstein N, Newby JB, Plattes MM, Foster HE, Arthur JW, Ward TD, Shively SR, Shor R, Nathan J, Davis HM, Plotkin LI, Wauson EM, Dewar BJ, Broege A, Lowery JW
Journal of physiology and biochemistry(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

mice lacking T1R2 + T1R3 and controls were tested in a taste discrimination task to determine whether maltodextrins are 1) detectable when both receptor subunits are absent and 2) perceptually distinct from that of sucrose. Some KO mice were only sensitive to the higher Polycose concentrations, implicating potential allelic variation in the putative polysaccharide receptor pathways unmasked by the absence of T1R2+T1R3.
Title: Detection of maltodextrin and its discrimination from sucrose are independent of the T1R2 + T1R3 heterodimer.

results implicate each subunit of the T1R2+T1R3 dimer in the behavioral response to P-containing taste compounds
Title: Phosphorus Taste Involves T1R2 and T1R3.

T1R2 plays an important role in glucose homeostasis during diet-induced obesity through the regulation of yet to be identified molecular mechanisms that alter energy disposal and utilization in peripheral tissues. T1r2 was upregulated in the adipose tissue of wild type mice in response to high fat/low carbohydrate diet, and their expression positively correlated with fat mass and glucose intolerance.
Title: Disruption of the sugar-sensing receptor T1R2 attenuates metabolic derangements associated with diet-induced obesity.

Mice possess two taste transduction pathways for sugars. One mediates behavioral attraction to sugars and requires an intact T1r2+T1r3. The other mediates cephalic phase insulin release but does not require an intact T1r2+T1r3.
Title: Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice.

human and mouse membrane trafficking systems for sweet taste receptors T1r2 and T1r3
Title: Distinct human and mouse membrane trafficking systems for sweet taste receptors T1r2 and T1r3.

The following Tas1r2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tas1r2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu58225	NM_031873.1 Latest version!	Mus musculus taste receptor, type 1, member 2 (Tas1r2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$496.30 $709.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tas1r2 ( NM_031873.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_114079.1 Mus musculus taste receptor, type 1, member 2 (Tas1r2), mRNA.

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CloneID	OMu58225
Clone ID Related Accession (Same CDS sequence)	NM_031873.1
Accession Version	NM_031873.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2532bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Mus musculus(house mouse)
Product	taste receptor type 1 member 2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF337041.1. On Dec 7, 2005 this sequence version replaced XM_914879.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF337041.1, AY032623.1 [ECO:0000332] ##Evidence-Data-END##

ATGGGACCCC AGGCGAGGAC ACTCCATTTG CTGTTTCTCC TGCTGCATGC TCTGCCTAAG 
CCAGTCATGC TGGTAGGGAA CTCCGACTTT CACCTGGCTG GGGACTACCT CCTGGGTGGC 
CTCTTTACCC TCCATGCCAA CGTGAAGAGC GTCTCTCACC TCAGCTACCT GCAGGTGCCC 
AAGTGCAATG AGTACAACAT GAAGGTCTTG GGCTACAACC TCATGCAGGC CATGCGATTC 
GCCGTGGAGG AAATCAACAA CTGTAGCTCT CTGCTGCCCG GCGTGCTGCT CGGCTACGAG 
ATGGTGGATG TCTGCTACCT CTCCAACAAT ATCCAGCCTG GGCTCTACTT CCTGTCACAG 
ATAGATGACT TCCTGCCCAT CCTCAAAGAC TACAGCCAGT ACAGGCCCCA AGTGGTGGCC 
GTCATTGGCC CAGACAACTC TGAGTCCGCC ATCACCGTGT CCAACATTCT CTCCTACTTC 
CTCGTGCCAC AGGTCACATA TAGCGCCATC ACCGACAAGC TGCGAGACAA GCGGCGCTTC 
CCTGCCATGC TGCGCACTGT GCCCAGCGCC ACCCACCACA TCGAGGCCAT GGTGCAACTG 
ATGGTTCACT TCCAGTGGAA CTGGATCGTG GTGCTGGTGA GCGATGACGA TTATGGCCGA 
GAGAACAGCC ACCTGCTGAG CCAGCGTCTG ACCAACACTG GCGATATCTG CATTGCCTTC 
CAGGAGGTTC TGCCTGTACC AGAACCCAAC CAGGCCGTGA GGCCTGAGGA GCAGGACCAA 
CTGGACAACA TCCTGGACAA GCTGCGGCGG ACCTCGGCGC GTGTGGTGGT GATATTCTCG 
CCAGAGCTGA GCCTGCACAA CTTCTTCCGC GAGGTGCTGC GCTGGAACTT CACAGGCTTT 
GTGTGGATTG CCTCTGAGTC CTGGGCCATC GACCCTGTTC TACACAACCT CACAGAGCTG 
CGCCACACGG GCACTTTCCT GGGCGTCACC ATCCAGAGGG TGTCCATCCC TGGCTTCAGC 
CAGTTCCGAG TGCGCCACGA CAAGCCAGAG TATCCCATGC CTAACGAGAC CAGCCTGAGG 
ACTACCTGTA ACCAGGACTG TGACGCCTGC ATGAACATCA CCGAGTCCTT TAACAACGTT 
CTCATGCTTT CGGGGGAGCG TGTGGTCTAC AGTGTGTACT CGGCCGTCTA CGCGGTAGCC 
CACACCCTCC ACAGACTCCT CCACTGCAAC CAGGTCCGCT GCACCAAGCA AATCGTCTAT 
CCATGGCAGC TACTCAGGGA GATCTGGCAT GTCAACTTCA CGCTCCTGGG CAACCAGCTC 
TTCTTCGACG AACAAGGGGA CATGCCGATG CTCCTGGACA TCATCCAGTG GCAATGGGGC 
CTGAGCCAGA ACCCCTTCCA AAGCATCGCC TCCTACTCCC CCACCGAGAC GAGGCTGACC 
TACATTAGCA ATGTGTCCTG GTACACCCCC AACAACACGG TCCCCATATC CATGTGTTCT 
AAGAGTTGCC AGCCTGGGCA AATGAAAAAA CCCATAGGCC TCCACCCGTG CTGCTTCGAG 
TGTGTGGACT GTCCGCCGGG CACCTACCTC AACCGATCAG TAGATGAGTT TAACTGTCTG 
TCCTGCCCGG GTTCCATGTG GTCTTACAAG AACAACATCG CTTGCTTCAA GCGGCGGCTG 
GCCTTCCTGG AGTGGCACGA AGTGCCCACT ATCGTGGTGA CCATCCTGGC CGCCCTGGGC 
TTCATCAGTA CGCTGGCCAT TCTGCTCATC TTCTGGAGAC ATTTCCAGAC GCCCATGGTG 
CGCTCGGCGG GCGGCCCCAT GTGCTTCCTG ATGCTGGTGC CCCTGCTGCT GGCGTTCGGG 
ATGGTCCCCG TGTATGTGGG CCCCCCCACG GTCTTCTCCT GTTTCTGCCG CCAGGCTTTC 
TTCACCGTTT GCTTCTCCGT CTGCCTCTCC TGCATCACGG TGCGCTCCTT CCAGATTGTG 
TGCGTCTTCA AGATGGCCAG ACGCCTGCCA AGCGCCTACG GTTTCTGGAT GCGTTACCAC 
GGGCCCTACG TCTTTGTGGC CTTCATCACG GCCGTCAAGG TGGCCCTGGT GGCAGGCAAC 
ATGCTGGCCA CCACCATCAA CCCCATTGGC CGGACCGACC CCGATGACCC CAATATCATA 
ATCCTCTCCT GCCACCCTAA CTACCGCAAC GGGCTACTCT TCAACACCAG CATGGACTTG 
CTGCTGTCCG TGCTGGGTTT CAGCTTCGCG TACGTGGGCA AGGAACTGCC CACCAACTAC 
AACGAAGCCA AGTTCATCAC CCTCAGCATG ACCTTCTCCT TCACCTCCTC CATCTCCCTC 
TGCACGTTCA TGTCTGTCCA CGATGGCGTG CTGGTCACCA TCATGGATCT CCTGGTCACT 
GTGCTCAACT TTCTGGCCAT CGGCTTGGGG TACTTTGGCC CCAAGTGTTA CATGATCCTT 
TTCTACCCGG AGCGCAACAC TTCAGCTTAT TTCAATAGCA TGATTCAGGG CTACACGATG 
AGGAAGAGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114079.1
CDS	32..2563
Translation	MGPQARTLHLLFLLLHALPKPVMLVGNSDFHLAGDYLLGGLFTLHANVKSVSHLSYLQVPKCNEYNMKVLGYNLMQAMRFAVEEINNCSSLLPGVLLGYEMVDVCYLSNNIQPGLYFLSQIDDFLPILKDYSQYRPQVVAVIGPDNSESAITVSNILSYFLVPQVTYSAITDKLRDKRRFPAMLRTVPSATHHIEAMVQLMVHFQWNWIVVLVSDDDYGRENSHLLSQRLTNTGDICIAFQEVLPVPEPNQAVRPEEQDQLDNILDKLRRTSARVVVIFSPELSLHNFFREVLRWNFTGFVWIASESWAIDPVLHNLTELRHTGTFLGVTIQRVSIPGFSQFRVRHDKPEYPMPNETSLRTTCNQDCDACMNITESFNNVLMLSGERVVYSVYSAVYAVAHTLHRLLHCNQVRCTKQIVYPWQLLREIWHVNFTLLGNQLFFDEQGDMPMLLDIIQWQWGLSQNPFQSIASYSPTETRLTYISNVSWYTPNNTVPISMCSKSCQPGQMKKPIGLHPCCFECVDCPPGTYLNRSVDEFNCLSCPGSMWSYKNNIACFKRRLAFLEWHEVPTIVVTILAALGFISTLAILLIFWRHFQTPMVRSAGGPMCFLMLVPLLLAFGMVPVYVGPPTVFSCFCRQAFFTVCFSVCLSCITVRSFQIVCVFKMARRLPSAYGFWMRYHGPYVFVAFITAVKVALVAGNMLATTINPIGRTDPDDPNIIILSCHPNYRNGLLFNTSMDLLLSVLGFSFAYVGKELPTNYNEAKFITLSMTFSFTSSISLCTFMSVHDGVLVTIMDLLVTVLNFLAIGLGYFGPKCYMILFYPERNTSAYFNSMIQGYTMRKS

Target ORF information:

RefSeq Version	NM_031873.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus taste receptor, type 1, member 2 (Tas1r2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031873.1

ORF Insert Sequence:

ATGGGACCCC AGGCGAGGAC ACTCCATTTG CTGTTTCTCC TGCTGCATGC TCTGCCTAAG 
CCAGTCATGC TGGTAGGGAA CTCCGACTTT CACCTGGCTG GGGACTACCT CCTGGGTGGC 
CTCTTTACCC TCCATGCCAA CGTGAAGAGC GTCTCTCACC TCAGCTACCT GCAGGTGCCC 
AAGTGCAATG AGTACAACAT GAAGGTCTTG GGCTACAACC TCATGCAGGC CATGCGATTC 
GCCGTGGAGG AAATCAACAA CTGTAGCTCT CTGCTGCCCG GCGTGCTGCT CGGCTACGAG 
ATGGTGGATG TCTGCTACCT CTCCAACAAT ATCCAGCCTG GGCTCTACTT CCTGTCACAG 
ATAGATGACT TCCTGCCCAT CCTCAAAGAC TACAGCCAGT ACAGGCCCCA AGTGGTGGCC 
GTCATTGGCC CAGACAACTC TGAGTCCGCC ATCACCGTGT CCAACATTCT CTCCTACTTC 
CTCGTGCCAC AGGTCACATA TAGCGCCATC ACCGACAAGC TGCGAGACAA GCGGCGCTTC 
CCTGCCATGC TGCGCACTGT GCCCAGCGCC ACCCACCACA TCGAGGCCAT GGTGCAACTG 
ATGGTTCACT TCCAGTGGAA CTGGATCGTG GTGCTGGTGA GCGATGACGA TTATGGCCGA 
GAGAACAGCC ACCTGCTGAG CCAGCGTCTG ACCAACACTG GCGATATCTG CATTGCCTTC 
CAGGAGGTTC TGCCTGTACC AGAACCCAAC CAGGCCGTGA GGCCTGAGGA GCAGGACCAA 
CTGGACAACA TCCTGGACAA GCTGCGGCGG ACCTCGGCGC GTGTGGTGGT GATATTCTCG 
CCAGAGCTGA GCCTGCACAA CTTCTTCCGC GAGGTGCTGC GCTGGAACTT CACAGGCTTT 
GTGTGGATTG CCTCTGAGTC CTGGGCCATC GACCCTGTTC TACACAACCT CACAGAGCTG 
CGCCACACGG GCACTTTCCT GGGCGTCACC ATCCAGAGGG TGTCCATCCC TGGCTTCAGC 
CAGTTCCGAG TGCGCCACGA CAAGCCAGAG TATCCCATGC CTAACGAGAC CAGCCTGAGG 
ACTACCTGTA ACCAGGACTG TGACGCCTGC ATGAACATCA CCGAGTCCTT TAACAACGTT 
CTCATGCTTT CGGGGGAGCG TGTGGTCTAC AGTGTGTACT CGGCCGTCTA CGCGGTAGCC 
CACACCCTCC ACAGACTCCT CCACTGCAAC CAGGTCCGCT GCACCAAGCA AATCGTCTAT 
CCATGGCAGC TACTCAGGGA GATCTGGCAT GTCAACTTCA CGCTCCTGGG CAACCAGCTC 
TTCTTCGACG AACAAGGGGA CATGCCGATG CTCCTGGACA TCATCCAGTG GCAATGGGGC 
CTGAGCCAGA ACCCCTTCCA AAGCATCGCC TCCTACTCCC CCACCGAGAC GAGGCTGACC 
TACATTAGCA ATGTGTCCTG GTACACCCCC AACAACACGG TCCCCATATC CATGTGTTCT 
AAGAGTTGCC AGCCTGGGCA AATGAAAAAA CCCATAGGCC TCCACCCGTG CTGCTTCGAG 
TGTGTGGACT GTCCGCCGGG CACCTACCTC AACCGATCAG TAGATGAGTT TAACTGTCTG 
TCCTGCCCGG GTTCCATGTG GTCTTACAAG AACAACATCG CTTGCTTCAA GCGGCGGCTG 
GCCTTCCTGG AGTGGCACGA AGTGCCCACT ATCGTGGTGA CCATCCTGGC CGCCCTGGGC 
TTCATCAGTA CGCTGGCCAT TCTGCTCATC TTCTGGAGAC ATTTCCAGAC GCCCATGGTG 
CGCTCGGCGG GCGGCCCCAT GTGCTTCCTG ATGCTGGTGC CCCTGCTGCT GGCGTTCGGG 
ATGGTCCCCG TGTATGTGGG CCCCCCCACG GTCTTCTCCT GTTTCTGCCG CCAGGCTTTC 
TTCACCGTTT GCTTCTCCGT CTGCCTCTCC TGCATCACGG TGCGCTCCTT CCAGATTGTG 
TGCGTCTTCA AGATGGCCAG ACGCCTGCCA AGCGCCTACG GTTTCTGGAT GCGTTACCAC 
GGGCCCTACG TCTTTGTGGC CTTCATCACG GCCGTCAAGG TGGCCCTGGT GGCAGGCAAC 
ATGCTGGCCA CCACCATCAA CCCCATTGGC CGGACCGACC CCGATGACCC CAATATCATA 
ATCCTCTCCT GCCACCCTAA CTACCGCAAC GGGCTACTCT TCAACACCAG CATGGACTTG 
CTGCTGTCCG TGCTGGGTTT CAGCTTCGCG TACGTGGGCA AGGAACTGCC CACCAACTAC 
AACGAAGCCA AGTTCATCAC CCTCAGCATG ACCTTCTCCT TCACCTCCTC CATCTCCCTC 
TGCACGTTCA TGTCTGTCCA CGATGGCGTG CTGGTCACCA TCATGGATCT CCTGGTCACT 
GTGCTCAACT TTCTGGCCAT CGGCTTGGGG TACTTTGGCC CCAAGTGTTA CATGATCCTT 
TTCTACCCGG AGCGCAACAC TTCAGCTTAT TTCAATAGCA TGATTCAGGG CTACACGATG 
AGGAAGAGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The downregulation of sweet taste receptor signaling in enteroendocrine L-cells mediates 3-deoxyglucosone-induced attenuation of high glucose-stimulated GLP-1 secretion.
Archives of physiology and biochemistry1-6(2017 Dec)
Wang F,Song X,Zhou L,Liang G,Huang F,Jiang G,Zhang L

Loss of the nutrient sensor TAS1R3 leads to reduced bone resorption.
Journal of physiology and biochemistry(2017 Oct)
Eaton MS,Weinstein N,Newby JB,Plattes MM,Foster HE,Arthur JW,Ward TD,Shively SR,Shor R,Nathan J,Davis HM,Plotkin LI,Wauson EM,Dewar BJ,Broege A,Lowery JW

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Tas1r2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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