Fgf16 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fgf16
Entrez Gene ID	80903
Full Name	fibroblast growth factor 16
General protein information	Preferred Names fibroblast growth factor 16 Names fibroblast growth factor 16 FGF-16
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X\|X D

mRNA and Protein(s)

mRNA	Protein	Name
NM_030614.2	NP_085117.2	fibroblast growth factor 16

Pathways from BioSystems

Homologies

Bos taurus (cattle)	FGF16	NP_001179706.1
	FGF16	XP_001098950.1
Canis lupus familiaris (dog)	FGF16	XP_549094.2
Mus musculus (house mouse)	Fgf16	NP_085117.2
Danio rerio (zebrafish)	fgf16	NP_001035497.1
Xenopus tropicalis (tropical clawed frog)	fgf16	XP_002931859.1
Homo sapiens (human)	FGF16	NP_003859.1
Pan troglodytes (chimpanzee)	FGF16	XP_529049.2
Rattus norvegicus (Norway rat)	Fgf16	NP_068639.1
Gallus gallus (chicken)	FGF16	NP_001038115.1

Gene Ontology
Bibliography

Related articles in PubMed

In Vitro and in Vivo Analyses Reveal Profound Effects of Fibroblast Growth Factor 16 as a Metabolic Regulator.
Rulifson IC, Collins P, Miao L, Nojima D, Lee KJ, Hardy M, Gupte J, Hensley K, Samayoa K, Cam C, Rottman JB, Ollmann M, Richards WG, Li Y
The Journal of biological chemistry292(5)1951-1969(2017 02)

Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines.
Lauriol J, Cabrera JR, Roy A, Keith K, Hough SM, Damilano F, Wang B, Segarra GC, Flessa ME, Miller LE, Das S, Bronson R, Lee KH, Kontaridis MI
The Journal of clinical investigation126(8)2989-3005(2016 Aug)

Expression of FGFs during early mouse tongue development.
Du W, Prochazka J, Prochazkova M, Klein OD
Gene expression patterns : GEP20(2)81-7(2016 Mar)

GATA4 regulates Fgf16 to promote heart repair after injury.
Yu W, Huang X, Tian X, Zhang H, He L, Wang Y, Nie Y, Hu S, Lin Z, Zhou B, Pu W, Lui KO, Zhou B
Development (Cambridge, England)143(6)936-49(2016 Mar)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Overexpression of Fgf16 in vivo recapitulated several of our in vitro findings, specifically the significant induction of the Ucp1 gene and UCP1 protein expression in inguinal white adipose tissue (iWAT)
Title: In Vitro and in Vivo Analyses Reveal Profound Effects of Fibroblast Growth Factor 16 as a Metabolic Regulator.

GATA4 is required for neonatal heart regeneration through regulation of Fgf16.
Title: GATA4 regulates Fgf16 to promote heart repair after injury.

results suggest a possible mechanism whereby Fgf16 prevents angiotensin II-induced cardiac hypertrophy and fibrosis by antagonizing Fgf2; the present findings should provide new insights into the roles of Fgf signaling in cardiac remodeling
Title: Angiotensin II-induced cardiac hypertrophy and fibrosis are promoted in mice lacking Fgf16.

After three generations, 25% of Fgf-16(-/Y) mice survived to adulthood, which could be reversed by reducing the contribution of the C57BL/6 genetic background by back crossing to another strain.
Title: Embryonic survival and severity of cardiac and craniofacial defects are affected by genetic background in fibroblast growth factor-16 null mice.

Fgf-16 gene is a target for NF-kappaB activation in the postnatal heart.
Title: FGF-16 is a target for adrenergic stimulation through NF-kappaB activation in postnatal cardiac cells and adult mouse heart.

The following Fgf16 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fgf16 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08323	NM_030614.2 Latest version!	Mus musculus fibroblast growth factor 16 (Fgf16), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fgf16 ( NM_030614.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_085117.2 Mus musculus fibroblast growth factor 16 (Fgf16), mRNA.

Price & Availability↑

CloneID	OMu08323
Clone ID Related Accession (Same CDS sequence)	NM_030614.2
Accession Version	NM_030614.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	fibroblast growth factor 16
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC132641.1, AL671893.7 and BB342405.2. On Feb 23, 2007 this sequence version replaced NM_030614.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC132641.1, AB049219.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAGG TCGGGGGCGT CTTTGCCTCC TTGGACTGGG ACCTGCACGG CTTCTCCTCC 
TCTCTGGGGA ACGTGCCCTT AGCTGACTCC CCGGGTTTCC TGAACGAGCG CCTGGGCCAG 
ATCGAGGGGA AGCTGCAGCG CGGCTCGCCC ACAGACTTCG CCCACCTGAA GGGGATCCTG 
CGGCGCCGCC AGCTCTACTG CCGCACCGGC TTCCACCTTG AGATCTTCCC CAACGGCACG 
GTGCACGGCA CCCGCCACGA CCACAGCCGC TTCGGAATTC TGGAATTTAT CAGCTTGGCT 
GTGGGGCTGA TCAGCATCAG GGGAGTGGAC TCTGGCCTGT ACCTAGGAAT GAATGAGCGA 
GGAGAGCTCT ATGGATCGAA GAAACTCACA CGTGAATGTG TTTTCCGGGA ACAGTTTGAA 
GAAAACTGGT ACAACACCTA TGCCTCCACC TTGTACAAAC ACTCGGACTC GGAGAGACAG 
TATTATGTGG CCCTGAATAA AGACGGCTCA CCCCGGGAGG GATACAGGAC TAAACGACAC 
CAGAAATTCA CTCACTTTTT ACCAAGGCCA GTAGATCCTT CTAAGTTGCC CTCCATGTCC 
AGAGATCTCT TCCGCTATAG GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_085117.2
CDS	65..688
Translation	MAEVGGVFASLDWDLHGFSSSLGNVPLADSPGFLNERLGQIEGKLQRGSPTDFAHLKGILRRRQLYCRTGFHLEIFPNGTVHGTRHDHSRFGILEFISLAVGLISIRGVDSGLYLGMNERGELYGSKKLTRECVFREQFEENWYNTYASTLYKHSDSERQYYVALNKDGSPREGYRTKRHQKFTHFLPRPVDPSKLPSMSRDLFRYR

Target ORF information:

RefSeq Version	NM_030614.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus fibroblast growth factor 16 (Fgf16), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030614.2

ORF Insert Sequence:

ATGGCGGAGG TCGGGGGCGT CTTTGCCTCC TTGGACTGGG ACCTGCACGG CTTCTCCTCC 
TCTCTGGGGA ACGTGCCCTT AGCTGACTCC CCGGGTTTCC TGAACGAGCG CCTGGGCCAG 
ATCGAGGGGA AGCTGCAGCG CGGCTCGCCC ACAGACTTCG CCCACCTGAA GGGGATCCTG 
CGGCGCCGCC AGCTCTACTG CCGCACCGGC TTCCACCTTG AGATCTTCCC CAACGGCACG 
GTGCACGGCA CCCGCCACGA CCACAGCCGC TTCGGAATTC TGGAATTTAT CAGCTTGGCT 
GTGGGGCTGA TCAGCATCAG GGGAGTGGAC TCTGGCCTGT ACCTAGGAAT GAATGAGCGA 
GGAGAGCTCT ATGGATCGAA GAAACTCACA CGTGAATGTG TTTTCCGGGA ACAGTTTGAA 
GAAAACTGGT ACAACACCTA TGCCTCCACC TTGTACAAAC ACTCGGACTC GGAGAGACAG 
TATTATGTGG CCCTGAATAA AGACGGCTCA CCCCGGGAGG GATACAGGAC TAAACGACAC 
CAGAAATTCA CTCACTTTTT ACCAAGGCCA GTAGATCCTT CTAAGTTGCC CTCCATGTCC 
AGAGATCTCT TCCGCTATAG GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

In Vitro and in Vivo Analyses Reveal Profound Effects of Fibroblast Growth Factor 16 as a Metabolic Regulator.
The Journal of biological chemistry292(5)1951-1969(2017 02)
Rulifson IC,Collins P,Miao L,Nojima D,Lee KJ,Hardy M,Gupte J,Hensley K,Samayoa K,Cam C,Rottman JB,Ollmann M,Richards WG,Li Y

Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines.
The Journal of clinical investigation126(8)2989-3005(2016 Aug)
Lauriol J,Cabrera JR,Roy A,Keith K,Hough SM,Damilano F,Wang B,Segarra GC,Flessa ME,Miller LE,Das S,Bronson R,Lee KH,Kontaridis MI

Expression of FGFs during early mouse tongue development.
Gene expression patterns : GEP20(2)81-7(2016 Mar)
Du W,Prochazka J,Prochazkova M,Klein OD

GATA4 regulates Fgf16 to promote heart repair after injury.
Development (Cambridge, England)143(6)936-49(2016 Mar)
Yu W,Huang X,Tian X,Zhang H,He L,Wang Y,Nie Y,Hu S,Lin Z,Zhou B,Pu W,Lui KO,Zhou B

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

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Fgf16 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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